Clinical trials: Niche
Stroke
Niche Trial: Navigated Inhibitory rTMS to Contralesional Hemisphere Trial
A pivotal, prospective, multi-center, randomized, controlled, double-blinded study combining active Nexstim NBS-guided 1Hz rTMS or sham-rTMS targeting the healthy hemisphere with standardized task oriented rehabilitation will be…
- Trial name
- NICHE (NCT02089464)
- Testing
- NBS-guided rTMS, Task oriented rehabilitation
- Where
- 12 sites in United States
- Volunteers
- 199 people
- Sponsor
- Nexstim Ltd
Cesarean Section Complications
Vasopressin vs. Uterine Artery Clamping for Laparoscopic Cesarean Scar Niche Repair
This study evaluates two methods for controlling intraoperative bleeding during laparoscopic surgery to repair a cesarean scar niche (CSN).
- Trial name
- NCT07446933
- Testing
- Vasopressin Group, Bulldog Clamping Group, Standard of Care
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Cesarean Wound Disruption
The Influence of Endometrial Suturing on the Risk of Uterine Scar Defect
Caesarean section (CS) is the commonest major operation performed on women worldwide with progressively rising incidence. Consequently, long-term adverse sequelae due to uterine scar defect have been increasing.
- Trial name
- NCT03851003
- Testing
- Endometrial suturing, Non- endometrial suturing, Vaginal ultrasonography
- Where
- Israel
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Niche, Uterine Disease
Hysteroscopic Intrauterine Suturing
Clinical trial The aim of the study is to evaluate the safety and feasibility of intrauterine suturing with Apollos X-tack, inserted into the uterus by hysteroscope.
- Trial name
- NCT06656286
- Testing
- Intra-Uterine suturing by X-TACK device and hysteroscope
- Where
- Israel
- Volunteers
- 2 people
- Sponsor
- HaEmek Medical Center, Israel
Cesarean Section; Dehiscence
Ultrasound Based Study For Niche Development In The Uterine Cesarean Section Scar
The aim of this study is to evaluate different factors affecting niche development in the uterine cesarean section scar in women enrolled 3 to 6 months after cesarean delivery using both TVS and SIS.
- Trial name
- NCT03859258
- Testing
- Transvaginal sonography
- Where
- Egypt
- Volunteers
- 221 people
- Sponsor
- Cairo University
Anteversion of Uterus, Retroflex Uterus
Relation Between Position of the Uterus (Anteversion or Retroversion Flexion) and Degree of Cesarean Scar Niche
This study aims to determine the association between the size of caesarean scar niche and uterine position in childbearing women.
- Conditions
- Anteversion of Uterus, Retroflex Uterus, CSD
- Trial name
- NCT06475924
- Testing
- Caesarean scar defect evlauation by ultraosund
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Ain Shams University
Cesarean Section Complications
Surgical Management of Cesarean Scar Ectopic Pregnancy: Hysteroscopy & Laparoscopy Outcomes
The study investigates the feasibility, safety, and outcomes of a simultaneous surgical approach for cesarean scar ectopic pregnancy (CSEP). CSEP is a prevalent and serious form of ectopic pregnancy requiring swift intervention.
- Trial name
- NCT07095647
- Testing
- Hysteroscopy
- Where
- Egypt
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Benha University
Niche
Niche In CEsarean Scar Trial (NICEST)
Rationale: Cesarean delivery (CD) rates are increasing rapidly worldwide. The consequences of cesarean section not only affect the next pregnancies such as uterine rupture or malplacentation but also cause many gynecological…
- Trial name
- NCT05312775
- Testing
- Double-layer uterine closure, Single-layer uterine closure
- Where
- Vietnam
- Volunteers
- 938 people, healthy volunteers welcome
- Sponsor
- Nguyen Thi Thu Ha
Colon Carcinoma
Neoadjuvant Immune Checkpoint Inhibition and Novel IO Combinations in Early-stage Colon Cancer
In this exploratory study, patients with stage 1-3 adenocarcinoma of the colon with no signs of distant metastases will be treated with short-term immunotherapy + novel IO combinations (i.e.
- Trial name
- NICHE (NCT03026140)
- Testing
- Nivolumab, Ipilimumab, Celecoxib 200mg
- Where
- 6 sites in Netherlands
- Volunteers
- 353 people
- Sponsor
- The Netherlands Cancer Institute
Appropriate Diagnostic Criteria of Uterine Niche With Detection of Prevalence , Risk Factors and Associated Symptomes
Prevalence and Risk Factors of Uterine Niche Following Different Caesarean Section Techniques:a Hospital Based Study
The primary objective of this study is to institute clically relevant and objective sonographic criteria for the diagnosis of ceasearan section scar defect(CSSD) once the appropriate diagnostic criteria are established the…
- Trial name
- NCT04933032
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sohag University
Isthmocele, Uterine Scar Defects
Cesarean Scar Defects After Uterine Closure by Double-layer Barbed or Smooth Suture
Late sequelae of a cesarean section related to a uterine scar defects include gynecological symptoms and obstetric complications.
- Conditions
- Isthmocele, Uterine Scar Defects, Cesarean Section Complications, Uterine Niche
- Trial name
- NCT04825821
- Testing
- Clinical and ultrasonographic assessment
- Where
- Italy
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Ospedale Policlinico San Martino
Isthmocele
Can Cesarean Scar Defects be Prevented?
In this study, uterotomy after cesarean section was performed using 3 different suture techniques and aimed to demonstrate the potential of the baseball suture technique to prevent the isthmusel complication known as cesarean…
- Trial name
- NCT06761495
- Testing
- Baseball Suturing Technique, Single-Layer Locked Continuous Suturing Technique, Single-Layer Unlocked Continuous Suturing Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istinye University
Abnormal Hematopoiesis, Allogenic Disease
Graft-versus-host Disease Associated Myelosuppression
The objective is to measure the frequency, functionality and phenotype of bone marrow-derived mesenchymal stromal cells in patients after allogeneic hematopoietic stem cell transplantation.
- Conditions
- Abnormal Hematopoiesis, Allogenic Disease, Graft vs Host Disease
- Trial name
- NCT02829216
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technische Universität Dresden
Glioblastoma
Feasibility of ORGAnoids in Routine Clinical Practice for Molecular Analysis of the GLIOvascular Niche in Patients With Primary Brain Tumors.
The main goal of ORGA-GLIO trial is to establish the feasibility in routine clinical practice of ex-vivo organoid cultures composed of tumor cells within their microenvironment (glioblastoma organoid - GBO) and intra- and…
- Trial name
- ORGA-GLIO (NCT07029100)
- Testing
- Ex-vivo organoid culture
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Henri Becquerel
Single Layer, Unlocked Sutures
Single Layer With Unlocked Sutures Versus Double Layer Closure of Cesarean Incision and the Risk of Niche Development
This study aimed to compare the development of the uterine niche after single and double closure of cesarean incision.
- Conditions
- Single Layer, Unlocked Sutures, Double Layer Closure, Cesarean Incision
- Trial name
- NCT07554001
- Testing
- Single layer unlocked sutures, Double layer unlocked sutures
- Where
- Egypt
- Volunteers
- 366 people
- Sponsor
- Kafrelsheikh University
Cesarean Section; Dehiscence, Uterine Bleeding
Impact of Single- Versus Double-layer Hysterotomy Closure on Cesarean Niche Development: a Randomized Controlled Trial
The objective of this randomized monocentric study is to assess potential variations in the incidence and severity of isthmocele morbidity among women undergoing cesarean section with either single or double-layer closure of the…
- Conditions
- Cesarean Section; Dehiscence, Uterine Bleeding, Uterus; Scar, Uterus Abnormal
- Trial name
- NCT06308172
- Testing
- Hysterotomy closure
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Cesarean Scar Niche
Laparoscopic Versus Combined Laparoscopic and Hysteroscopic Repair of CS Niche
Uterine niche is a frequent condition in patients with a history of cesarean section. Many treatment methods have been described for repair of niche with varying effectivities.
- Trial name
- NCT05777837
- Testing
- laparoscopic repair of cesarean scar niche, Combined hysteroscopic and laparoscopic repair of cesarean scar niche
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Zagazig University
Cesarean Scar Defect (Isthmococele), Pelvic Pain
Single-Layer Versus Double-Layer Uterine Closure After Primary Cesarean Section
This study compares two surgical techniques for closing the uterus after cesarean section: single-layer versus double-layer closure.
- Conditions
- Cesarean Scar Defect (Isthmococele), Pelvic Pain, Spotting, Amenorrhea Secondary
- Trial name
- NCT07611331
- Testing
- Double-layer hysterorrhaphy at primary cesarean section, Single-layer hysterorrhaphy at primary cesarean section
- Where
- Tunisia
- Volunteers
- 384 people
- Sponsor
- Hédi Chaker Hospital
Cesarean Section Complications, Abnormal Uterine Bleeding
Combined Hystroscopic and Laparoscopic Repair of CS Scar Disorder
Combined hystroscopic and laparoscopic repair of symptomatic uterine Niche as new technique to maximize resolution of symptoms after niche repair with concomitant increase in RMT
- Trial name
- NCT07183501
- Testing
- Combined hystroscopic and laparoscopic repair
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Cesarean Section Complications, Uterine Bleeding
Surgical Incision Closure Method to Prevent Niche Formation After Cesarean Section- Randomized Controlled Trial
In the last decade we have been exposed to the complication of a caesarean section called a "niche". A niche is an anaerobic defect in the location of the cesarean section, which represents the discontinuity of the endometrium…
- Trial name
- NCT04766073
- Testing
- Niche prevention suture
- Where
- Israel
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization