Clinical trials: Nickel Sensitivity
Knee Arthropathy, Allergic Reaction
Nickel Sensitivity
The purpose of this study is to compare clinical outcomes of patients with self reported nickel sensitivity undergoing primary total knee arthroplasty (TKA) with conventional, standard-of-care vs nickel-free implants.
- Trial name
- NCT04058743
- Testing
- TKA with nickel free components, TKA with standard cobalt chromium components
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Rush University Medical Center
Atrial Septal Defect, Patent Foramen Ovale
Nickel Allergy With Septal Closure Devices
This study is for patients who have been diagnosed with either a Patent Foramen Ovale [PFO] or an Atrial Septal Defect [ASD]. These are a type of hole located in the wall that separates the top two (2) chambers of the heart.
- Conditions
- Atrial Septal Defect, Patent Foramen Ovale, Allergic Reaction to Nickel
- Trial name
- NASAH (NCT01068366)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Utah
Delayed Type Hypersensitivity
Characterization of the Molecular Mechanisms Involved in Delayed-Type Hypersensitivity Reactions to House Dust Mite, Diphencyprone, Nickel, and Tuberculin Purified Protein Derivative in Healthy Volunteers
This study will be conducted in 2 cohorts. In Cohort A, approximately 40 subjects will participate in a single-center, open-label, non-randomized, parallel-group trial to investigate the molecular mechanisms involved in…
- Trial name
- NCT03625219
- Testing
- Prednisone
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Innovaderm Research Inc.
Saliva, Dental Crown
Interleukin-2 (IL-2), Interleukin-5 (IL-5) and Interleukin-17 (IL-17) Levels of Patients With Stainless Steel Crowns
The aim of this study is to investigate whether nickel hypersensitivity following stainless steel crown treatment in children aged 3-9 leads to an increase in IL-2, IL-5, and IL-17 levels by analyzing saliva samples.
- Conditions
- Saliva, Dental Crown, Nickel Sensitivity
- Trial name
- NCT06439095
- Testing
- Salivary Collection, Ph and ion level measurement of saliva
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people
- Sponsor
- Yuzuncu Yil University
Food Allergy, Food Hypersensitivity
Hydroponic Cultivation in Systemic Nickel Allergy Syndrome
Oral intake of nickel (Ni) is capable of causing the onset of systemic disorders in patients with Systemic Allergy to Nickel Syndrome (SNAS), an emerging allergic condition.
- Conditions
- Food Allergy, Food Hypersensitivity, Nickel Sensitivity
- Trial name
- DATTERINO (NCT05232890)
- Testing
- Datterino tomato purée from hydroponic technology, Datterino tomato puree from conventional cultivation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Catholic University of the Sacred Heart
Dermatitis, Allergic Contact
CP-481,715 Nickel Allergy Study.
To evaluate the suitability of contact allergy as a method for the evaluation of c-chemokine receptor-1 antagonist.
- Trial name
- NCT00141180
- Testing
- CP-481,715
- Where
- 5 sites in United States, Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Pfizer
Allergic Contact Dermatitis
Nickel Desensitization Using Topical Therapy
Nickel contact dermatitis (eczema) is one of the most common allergic conditions affecting the skin. This is a study looking at potentially desensitizing nickel-allergic patients to their allergy using anti-inflammatory ointments…
- Trial name
- NCT01413477
- Testing
- Calcipotriol, Betamethasone, Calcipotriol & Betamethasone
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of British Columbia
Non Celiac Wheat Sensitivity
Nickel Allergy and Systemic Nickel Allergy Syndrome in Non Celiac Wheat Sensitivity
In the last few years, a new clinical entity has emerged which includes patients who consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have celiac disease (CD) or…
- Trial name
- NCT02750735
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- University of Palermo
Dermatitis, Allergic Contact
Study of the Intradermal Injection of rHuPH20 or Placebo in Participants With Nickel Allergic Contact Dermatitis
The purpose of this study is to compare the effect and safety of rHuPH20 or placebo for the prevention and treatment of skin allergic reaction to nickel. The study drug and placebo will be administered by intradermal injection.
- Trial name
- NCT00928447
- Testing
- rHuPH20
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Halozyme Therapeutics
Systemic Nickel Allergy Syndrome, Quality of Life
Quality of Life in Systemic Nickel Allergy Syndrome
This study evaluates the effects of Nickel oral hyposensitization treatment (NiOHT) on health-related quality of life (HRQoL) of patients suffered from Systemic Nickel Allergy Syndrome (SNAS).
- Trial name
- NCT03731494
- Testing
- Nickel oral hyposensitization treatment
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Catholic University of the Sacred Heart
Nickel Sensitivity, Allergy
Systemic Nickel Allergy Syndrome: Intervention Study for the Assessment of the Dietary Indications
Background: Nickel is a silvery metal widely used in nature and contained in many foods. Exposure to nickel is responsible for two different types of adverse reactions: Allergic Contact Dermatitis (DAC) and Systemic Nickel…
- Conditions
- Nickel Sensitivity, Allergy, Nickel; Eczema, Women
- Trial name
- NCT04432896
- Testing
- Dietary protocol
- Where
- Italy
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Allergic Contact Dermatitis
NI-0801 in Allergic Contact Dermatitis
The purpose of the study is to assess the effect of a single dose of NI-0801 on the severity of nickel-induced allergic contact dermatitis.
- Trial name
- NCT01244607
- Testing
- NI-0801
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Light Chain Bioscience - Novimmune SA
Nickel; Eczema, Nickel Sensitivity
The Immunological Profile of Nickel Dermatitis
A dose-response study on the immune phenotype of allergic nickel dermatitis on a previously exposed skin area.
- Conditions
- Nickel; Eczema, Nickel Sensitivity, Allergy, Inflammatory Response
- Trial name
- NCT04438330
- Testing
- Nickel sulfate hexahydrate
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- National Allergy Research Center, Denmark
Allergic Contact Dermatitis, Metal Allergy
Environmental Exposure to Heavy Metals, Nanoparticles, and Emergent Contaminants and Risk of Allergic Diseases
The goal of this clinical trial is to collect environmental, bio-humoral, and clinical data derived from patients with allergic contact dermatitis (ACD) and systemic metal allergic syndromes related to the exposure to heavy…
- Conditions
- Allergic Contact Dermatitis, Metal Allergy, Food Allergy, Nickel Sensitivity
- Trial name
- MATRIOSKA (NCT06529913)
- Testing
- Collection of environmental, biological, and clinical data
- Where
- 2 sites in Italy
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Allergic Contact Dermatitis
MicroRNA-126 and Its Target VCAM-1Dermatitis to Nickel
Background. Allergic Contact Dermatitis (ACD) is an inflammatory skin disease mediated by direct contact with allergens as nickel, the most common allergen, that may be related with epigenetic changes. Objective.
- Trial name
- NCT04365140
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Systemic Nickel Allergic Syndrome
Telemedicine for SNAS Patients in COVID-19 Pandemic
Restrictions due to Covid-19 pandemic have brought negative social and psychological consequences on people and limited patients' access to hospital care.
- Trial name
- DISTANCE (NCT04894331)
- Testing
- Dietary intervention, Video call
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Catholic University of the Sacred Heart
Allergic Contact Dermatitis
Red Grape Polyphenol Oral Administration to Women Affected by Nickel-mediated Allergic Contact Dermatitis
Nickel (Ni)-mediated allergic contact dermatitis (ACD) is a very common disease worldwide. Our previous findings demonstrated that in vitro supplementation of polyphenols, extracted from seeds of red grape (Nero di Troia…
- Trial name
- Grapolyphen (NCT03902392)
- Testing
- NaturOx Group (A)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Bari
Foramen Ovale, Patent, Nickel Sensitivity
Investigation of Nickel Sensitization After Percutaneous Implantation of Patent Foramen Ovale Occluder
Percutaneous PFO closure has been established as a first-line therapy for preventing recurrent strokes in selected patients. The devices used for the specific purpose contain and release nickel, which is considered as the most…
- Conditions
- Foramen Ovale, Patent, Nickel Sensitivity, Dermatitis Contact Irritant, Metal Allergy
- Trial name
- INSPIRE (NCT04713683)
- Testing
- Percutaneous Patent Foramen Ovale Closure
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- National and Kapodistrian University of Athens
Allergic Reaction to Nickel
Safety Demonstration of Microneedle Insertion
Hypodermic needles are conventionally used to deliver drugs and vaccines into the muscle of humans and animals. Side effects of these needle injections are pain, bleeding, and anxiety in patients.
- Trial name
- NCT02995057
- Testing
- Gold- or silver-coated, or uncoated nickel microneedles
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Allergic Contact Dermatitis Due to Nickel
Short Repeated Nickel Exposures
The former Nickel Directive was introduced in EU in 1994 limiting the release of nickel from items intended for prolonged contact with skin.
- Trial name
- NCT03309215
- Testing
- Experimental stimulation with nickel discs
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital