Clinical trials: Nicotinamide
COVID
Effects of Nicotinamide Riboside on the Clinical Outcome of Covid-19 in the Elderly
The purpose of this study is to investigate whether nicotinamide riboside supplementation can attenuate the severity of SARS-CoV-2 infections in elderly patients.
- Trial name
- NR-COVID19 (NCT04407390)
- Testing
- Nicotinamide riboside
- Where
- Denmark
- Sponsor
- University of Copenhagen
IFN-Gamma Therapy, CGD Gene Mutation
Biochemical Response to Interferon-Gamma in Subjects With Specific Gene Mutation in Chronic Granulomatous Disease
Background: Chronic granulomatous disease (CGD) is an immunodeficiency disease in which white blood cells are unable to kill certain bacteria and fungi.
- Conditions
- IFN-Gamma Therapy, CGD Gene Mutation, CGD Response to IFNg, CGD - Chronic Granulomatous Disease
- Trial name
- NCT01147042
- Testing
- IFN-gamma
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pregnancy Induced Hypertension, Superimposed Preeclampsia
Phase I Study of Nicotinamide for Early Onset Preeclampsia
This is a Phase I study of vitamin B3-amide (nicotinamide) dietary supplementation in pregnant women with early onset preeclampsia.
- Conditions
- Pregnancy Induced Hypertension, Superimposed Preeclampsia, Hypertension
- Trial name
- NCT02213094
- Testing
- Nicotinamide 500 mg, Nicotinamide 1000 mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of North Carolina, Chapel Hill
Glucose Metabolism Disorders
Effect of "Nicotinamide Mononucleotide" (NMN) on Cardiometabolic Function
The purpose of the study is to understand the effect of the dietary supplement "Nicotinamide mononucleotide" on metabolic health in people.
- Trial name
- NMN (NCT03151239)
- Testing
- NMN supplement
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Dyslipidemia
Extended Release (ER) Niacin/Laropiprant Add on Study (0524A-082)
The purpose of this study is to test the effect of MK0524A (niacin (+) laropiprant) on lowering bad cholesterol and raising good cholesterol.
- Trial name
- NCT00664287
- Testing
- niacin (+) laropiprant
- Sponsor
- Merck Sharp & Dohme LLC
Metabolic Syndrome, Hypertriglyceridemia
Niacin, N-3 Fatty Acids and Insulin Resistance
This research study is being conducted to test the effects of two drugs on blood lipids (cholesterol and triglycerides) and blood sugar (glucose) levels in patients with diabetes or "pre-diabetes" (both of which have a condition…
- Trial name
- NCT00286234
- Testing
- omega-3 acid ethyl esters, extended release niacin, combined treatment
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of South Dakota
Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Liver Fibrosis/NASH
Stimulating Fat Tissue Storage With Niacin to Reduce Fat Accumulation in the Liver.
Metabolic dysfunction-associated steatotic liver disease (MASLD) (aka non-alcoholic fatty liver disease), commonly occurring in individuals with obesity and type 2 diabetes can lead to liver inflammation/ fibrosis.
- Conditions
- Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Liver Fibrosis/NASH, Non-Alcoholic Steato-Hepatitis (NASH)
- Trial name
- AGL13 (NCT06843148)
- Testing
- Niacin (250mg)
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Université de Sherbrooke
Hypertension
Nicotinamide Riboside as an Enhancer of Exercise Therapy in Hypertensive Older Adults (The NEET Trial)
More than 80% of older adults have hypertension, with higher prevalence of high systolic blood pressure (SBP) putting them at high risk for cardiovascular (CV) disease and death.
- Trial name
- NCT04112043
- Testing
- Walking Exercise, Nicotinamide Riboside (NR)
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- University of Florida
Hypertriglyceridemia With Low HDL-cholesterol
Comparison of Fenofibrate and Niacin in Patients With Hypertriglyceridemia and Low High-Density Lipoprotein (HDL)-Cholesterol
The purpose of the study is to compare the efficacy and tolerability of fenofibrate 160 mg and niacin 1500 mg in patients with hypertriglyceridemia and low HDL-cholesterol.
- Trial name
- NCT01122355
- Testing
- lipid modification
- Volunteers
- 240 people
- Sponsor
- Yonsei University
Glaucoma
Unravelling the Effects of Nicotinamide/Pyrroloquinolone Quinone /Citicoline/Homotaurine Fixed Combination on Contrast Sensitivity, Quality of Life, and Reading Performance in Glaucoma
Glaucoma is a chronic, progressive neuro-ophthalmic condition that leads to irreversible loss of retinal ganglion cells (RGCs) and is the second leading cause of blindness worldwide.
- Trial name
- NCT07861243
- Testing
- Citicoline 500 MG (Optigen) for 4 months, citicoline 500 mg + nicotinamide 54 mg + PQQ 5 mg + Homotaurine 50 mg fixed combination tablet (Neuprozin mito)
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Sickle Cell Disease
Niacin to Improve Blood Flow in People With Sickle Cell Disease
This study will determine whether niacin can improve blood flow in people with sickle cell disease, in which abnormal red blood cells interfere with blood flow to cause the disease symptoms.
- Trial name
- NCT00508989
- Testing
- Niacin-ER, L-NMMA, Acetylcholine
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aging, Frailty
Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults
This is a randomized, double-blind, placebo-controlled, two-arm crossover clinical trial evaluating the effects of nicotinamide mononucleotide (NMN) combined with trimethylglycine (TMG) supplementation, compared to NMN alone.
- Conditions
- Aging, Frailty, Exercise Tolerance, Healthy Male and Female Subjects
- Trial name
- NCT07144527
- Testing
- NMN and TMG (Euexia), Nicotinamide Mononucleotide (NMN)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scott Silveira
Acute Kidney Injury, Septic Shock
Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?
Sepsis is the most common cause of acute kidney injury (AKI) in critically ill patients and is associated with a high mortality rate. Currently there is no available specific treatment to prevent or treat AKI in this setting.
- Conditions
- Acute Kidney Injury, Septic Shock, Nicotinamide, Mortality
- Trial name
- VITAKI (NCT04589546)
- Testing
- Nicotinamide treatment
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hypercholesterolemia
The Effect of Niacin Administration on Oxidative Stress in Patients With Hypercholesterolmia, as Measured by the Use of a Novel Biomarker
1. Treatment of Hypercholesterolemic patients with niacin will cause a significant decrease in oxidative stress and a decrease in the atherogenecity in blood samples of the patients. 2.
- Trial name
- NCT01071525
- Testing
- Niacin\Laropiprant
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Major Depressive Disorder
PSIL201 Long-term Follow-up Study: Psilocybin or Niacin / Major Depressive Disorder
This is a Phase 2 double-blind, long-term observational follow-up study of participants from Study PSIL201. Participants providing informed consent were enrolled into this study and completed web surveys and telephone interviews…
- Trial name
- NCT04353921
- Testing
- No intervention will be administered as part of this study.
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Usona Institute
Polycystic Ovary Syndrome
Effect of Nicotinic Acid on Cardiovascular Risks Indices in Polycystic Ovary Syndrome
Niacin will improve postprandial hyperlipidaemia and cardiovascular risks indices via its lipid lowering as well as via pleiotropic effects in patients with polycystic ovary syndrome (PCOS).
- Trial name
- NCT01118598
- Testing
- tredaptive (nicotinic acid/ laropiprant)
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Glaucoma
Comparisons of NAD Precursors for Neuroenhancement in Glaucoma Patients
The goal of this clinical trial is to determine whether oral supplementation with different nicotinamide adenine dinucleotide (NAD) precursors can improve visual function in adults with primary open-angle glaucoma.
- Trial name
- NCT06991712
- Testing
- Nicotinamide Riboside, Nicotinamide, Nicotinamide Mononucleotide
- Where
- Hong Kong
- Volunteers
- 138 people
- Sponsor
- Christopher Kai Shun Leung
Peripheral Artery Disease
NAD Supplementation and Vascular Health in PAD
This pilot open-label clinical trial was designed to investigate whether 4-week supplementation with 1g daily NR impacts endothelial function in peripheral circulation, cerebrovascular hemodynamics, cognitive function in older…
- Trial name
- NCT06534944
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Oklahoma
Pre-Eclampsia, Pregnancy Related
Study of Nicotinamide in Early Onset Preeclampsia
Phase II Study of 2.5 gm of nicotinamide, given daily in 3 divided doses, to measure effect on maternal blood pressure in women with early onset preeclampsia and to determine peak and trough levels of nicotinamide.
- Trial name
- NCT03419364
- Testing
- nicotinamide
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of North Carolina, Chapel Hill
Bioavailability
A Study Investigating the Effects of Niagen™ in Healthy Adults.
This study will evaluate the effect of repeated doses of Niagen™ on Niagen™ metabolite concentrations in blood, urine and muscle. There will be 3 doses of Niagen™ compared to a placebo.
- Trial name
- 15NRHC (NCT02712593)
- Testing
- Niagen™ 100, Niagen™ 300, Niagen™ 1000
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.