Clinical trials: Nicotine
Depression, Smoking
Fluoxetine as a Quit Smoking Aid for Depression-Prone Smokers
This project is a treatment-matching study to test whether adding antidepressant pharmacotherapy to behavioral cessation treatment improves the depression-prone smoker's ability to quit, while not undermining cessation goals for…
- Trial name
- NCT00018174
- Testing
- Fluoxetine, Behavioral group smoking cessation treatment
- Where
- United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Overweight, Obesity
ACTION PAC: Adolescents Committed to Improvement of Nutrition & Physical Activity
Using a previously created weight management program for adolescents, the intervention will be implemented through school-based health centers (SBHC) and will be delivered by SBHC providers trained in Motivational Interviewing.
- Trial name
- ACTION PAC (NCT02502383)
- Testing
- ACTION PAC, Communication with parents
- Where
- United States
- Volunteers
- 991 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Smoking, Smoking Behaviors
Abuse Liability for Eight Electronic Nicotine Products
This will be a randomized, open-label, 8-way crossover, single-site study designed to evaluate elements of abuse liability (AL), including subjective effects and physiological measures (pharmacodynamics [PD]), and plasma nicotine…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT07323511
- Testing
- Product A, Product B, Product C
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Cesarean Section Complications, Pregnancy Related
Assessment of Transnasal Humidified Rapid-insufflation Ventilatory Exchange (THRIVE) for Maternal Pre-oxygenation
The main objective of this study is to determine if the use of transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) can reduce by 90 seconds the time between the entry into the operating room of the volunteer…
- Conditions
- Cesarean Section Complications, Pregnancy Related, Anesthesia
- Trial name
- PREOXCE (NCT04814628)
- Testing
- scenario 1 : pre-oxygenation with a face mask held by the anaesthetist, scenario 2: one anaesthetist in charge, face mask held by the patient for pre-oxygenation, scenario 3: one anaesthetist in charge, THRIVE used for pre-oxygenation
- Where
- France
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Smoking
Ginglival Health Among Smokers Visiting Dental Hospital
The effect of different forms of nicotine intake on the gingival health of dental patients that visited a public sector in Islamabad.
- Trial name
- NCT06424600
- Testing
- Gingival Index
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Cigarette Smoking, Nicotine Dependence
Reducing Tobacco Use Disparities Among Low-Income Adults
Most smokers, especially those who are poor, do not receive smoking cessation treatment during their healthcare visits. This study is evaluating a novel population health management intervention for low-income smokers.
- Trial name
- NCT03077737
- Testing
- Choose to Change, Enhanced usual care
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Tobacco-Related Carcinoma
Studying the Health Perceptions and Social Behaviors of Graduate Students at the Ohio State University for the Development of Effective Oral Nicotine Pouch Addictive Risk Communication
This clinical trial studies the health perceptions and social behaviors of Ohio State University (OSU) graduate students to develop an interactive, social norms-based approach that is effective in communicating the addictive…
- Trial name
- NCT07346092
- Testing
- Preventive Intervention, Survey Administration
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco Use Disorder
Combining a Smoke Ending Aid With Behavioral Treatment - 1
The purpose of this study is to combine a smoke ending aid with behavioral treatment.
- Trial name
- NCT00006151
- Testing
- Behavioral Therapy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peter Gariti
Smoking, Tobacco Use
CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches
This is a two-site, open-label, randomized, 6-way cross-over study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics [PD]) and plasma nicotine uptake…
- Conditions
- Smoking, Tobacco Use, Tobacco Smoking
- Trial name
- NCT05294497
- Testing
- Product A, Product B, Product C
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Tobacco Use Disorder
Examining the Effectiveness of the Nicotine Patch in Male and Female Smokers - 2
Treatment studies have demonstrated that current smoking cessation techniques are less effective for women. The purpose of this study is to determine the role that gender plays on the effectiveness of nicotine replacement…
- Trial name
- NCT00135746
- Testing
- nicotine transdermal system
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking
Cue Reactivity in Virtual Reality: The Role of Context
The objectives of this proposal are to examine the role of context in a virtual reality (VR) environment and to explore the extent to which cues (i.e., contextual cues or explicit smoking cues) influence craving and physiological…
- Trial name
- NCT00862927
- Testing
- Breath Sample, Saliva Sample, Questionnaire
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Tobacco Use
E-Cigarette and Cigarette Nicotine Delivery and Abuse Liability in Cigarette Smokers and Dual Users
The FDA has shown clear interest in strategies that will reduce the public health burden of tobacco use. One proposed strategy includes banning the sale of fully nicotinized cigarettes and only allowing VLNCs (Very Low Nicotine…
- Trial name
- NCT03943706
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cigarette Smoking-Related Carcinoma
Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia
This clinical trial compares the use of oral nicotine pouches to nicotine replacement therapy, consisting of nicotine patches and lozenges, to reduce cigarette use in smokers living in rural Appalachia.
- Trial name
- ARISE (NCT06763536)
- Testing
- Carbon Monoxide Measurement, Nicotine Lozenge, Oral Nicotine Pouch
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Healthy
Melanin and Dermal Uptake of Thirdhand Cigarette Smoke
This is a pilot study of the effects of dermal melanin on dermal uptake and retention of nicotine. The initial hypothesis is that higher levels of dermal melanin will correlate with lower uptake and longer retention of nicotine…
- Trial name
- THS05 (NCT06020248)
- Testing
- Wear clothing that has been exposed to cigarette smoke for 3 hours.
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use Disorder, Nicotine Dependence
Novel Determinants and Measures of Smokeless Tobacco Use: Study 2
The research project will determine the level of nicotine in ST products that will lead to the greatest reduction in toxicant exposure
- Trial name
- NCT01067599
- Testing
- Low nicotine, Medium nicotine, High nicotine
- Where
- 2 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Healthy Lifetime Non-smokers
Evaluation of Acute and Subacute Effects of Nicotine Free Electronic Cigarette(NCFE) Vapors
This aim will examine the acute and subacute exposures to electronic cigarette (EC) vapor generated from e-liquids without nicotine (NFEC) on life-time non smokers subjects by measuring changes in nasal ion transport and TGF-β…
- Trial name
- NCT02585791
- Testing
- Propylene Glycol, vegetable glycerin, PG+VG
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Miami
Depressive Symptoms, Allostatic Load
Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.
American youth and young adults face persistent and chronic stressors, which have contributed to a mental health crisis in the United States.
- Conditions
- Depressive Symptoms, Allostatic Load, Metabolic Syndrome
- Trial name
- R&T (NCT07554326)
- Testing
- Rise Together: Community Engagement Intervention, Adulting 101: Life Skills
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Tobacco Use
Jail-Based Use of Smoking Cessation Treatment Study
Smoking rates remain above 60% for individuals involved in the criminal justice system and contribute to elevated mortality rates in this population.
- Trial name
- JUST (NCT03799315)
- Testing
- Nicotine Replacement Therapy, Counseling
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Hennepin Healthcare Research Institute
Tobacco Use Disorder
Comparison Across Treatment Conditions to Reduce Smokeless Tobacco Use
Smokeless tobacco (ST), which includes both chewing tobacco and snuff, has health risks associated with its use. While treatment programs that focus on stopping tobacco use may be effective, past research has shown that…
- Trial name
- NCT00218296
- Testing
- Usual Care Group, Reduction Group
- Where
- United States
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smoking
E-cigarette vs. Nicotine Inhaler Comparisons
The goal of this study is to get information from current smokers about how they feel towards both the electronic cigarette (e-cigarette) and the nicotine oral inhaler.
- Trial name
- NCT02294617
- Testing
- Electronic Cigarette, Nicotrol Inhaler
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey