Clinical trials: Nicotine Dependence
Tobacco Use, Cigarette Smoking
Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures
Characterize effects of relighting on smoke toxicant deliveries and subjective smoking measures. This will be a within-subject comparison in a single experimental group of 30 smokers who report engaging in relighting behaviors.
- Conditions
- Tobacco Use, Cigarette Smoking, Nicotine Dependence
- Trial name
- NCT06295757
- Testing
- Cigarettes
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Nicotine Dependence
Trial on the Effectiveness of Mindfulness Training for Smokers
The Mindfulness Training for Smokers study follows a randomized controlled design with 240 total participants. Both the study group and the control group will be enrolled in the Wisconsin Tobacco Quit Line and will receive four…
- Trial name
- MTS (NCT01093599)
- Testing
- Quit Line plus MTS, Quit Line Only
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- University of Wisconsin, Madison
Tobacco Dependence, Schizophrenia
The Pharmacogenetic Study , Readiness to Change, and Pharmacological Intervention for Smoking Cessation in Schizophrenia
Cigarette smoking represents a major health problem for patients suffering from schizophrenia. Compared to the general population, schizophrenic patients are significantly more likely to be addicted to nicotine.
- Trial name
- PSIAARP (NCT00495352)
- Testing
- Hihg-doseNRT, Low-dose NRT, bupropion
- Where
- Taiwan
- Volunteers
- 360 people
- Sponsor
- Yu-Li Hospital
Nicotine Dependence, Cigarettes
The Role of Nicotine Dose and Route of Delivery in Affecting Adoption of E-cigarettes and Reducing Exposure to Toxic Combustion Products
This study plans to investigate whether using electronic cigarettes (e-cigarettes) or skin patches containing nicotine affects switching from smoking conventional combustible (burning) cigarettes.
- Trial name
- ENDS-Switch (NCT03492463)
- Testing
- Nicotine patch, E-cigarettes, Non-nicotine e-cigarettes
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Duke University
Breast Cancer, Smoking
Brief Smoking Intervention for Women Undergoing Breast Cancer Surgery
The primary purpose of this study is to examine the effect of a brief preoperative smoking intervention on postoperative complications in women undergoing breast cancer surgery.
- Trial name
- NCT00299117
- Testing
- Brief preoperative smoking intervention
- Where
- 3 sites in Denmark
- Volunteers
- 130 people
- Sponsor
- Herlev Hospital
Smoking, Smoking Cessation
Treating Caregivers Who Smoke at AFCH
The purpose of this research study is to 1) see if a smoking cessation program is something that caregivers will use while their child is hospitalized, 2) see if caregivers think this program is something we should institute…
- Trial name
- NCT06051474
- Testing
- Nicotine Replacement Product
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Diabetes Mellitus, Type 2, Nicotine Dependence, Cigarettes
Effect of Glucagon-like Peptide-1 (GLP-1) Receptor Agonist Stimulation on Smoking Consumption in Type 2 Diabetes Patients
Diabetes has become an increasingly serious global health issue. In 2024, approximately 537 million adults were living with diabetes, and this number is projected to rise to 783 million by 2045, representing a 46% increase.
- Trial name
- NCT06924697
- Testing
- Application of GLP-1RAs drugs, DPP-4i group
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai East Hospital
Nicotine Dependence
Glucocorticoid Antagonist Treatment for Tobacco Use Disorder
The purpose of this protocol is to examine whether mifepristone, a medication with glucocorticoid receptor antagonist activity, may be a potential treatment for Tobacco Use Disorder (TUD).
- Trial name
- NCT03248713
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Nicotine Dependence
Nicotinic Modulation of the Default Network of Resting Brain Function
Background: A brain circuit called the default network is the brain circuit that is active when the brain is at rest; that is, when individuals are not concentrating on specific tasks.
- Trial name
- NCT01240616
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence, Cigarettes
Online Lapse Management Intervention
The purpose of the trial is to test the adjunctive effect of adding a lapse management system to a best practices web- and mobile smoking cessation program.
- Trial name
- NCT03191825
- Testing
- Endre: a digital smoking cessation counsellor, Lapse management system triggered from web-page, Lapse management system triggered by SMS-textmessage
- Where
- 2 sites in Czechia, Norway
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Nicotine Dependence
Effects of Varenicline on Brain Activity During Nicotine Abstinence
This project aims to define mechanisms through which varenicline might be an effective smoking cessation medication.
- Trial name
- NCT00602927
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Smoking, Smoking Cessation
Implementation Science to Reduce the Disparity in Tobacco Treatment Among Individuals With Serious Mental Illness
This is a pilot trial to examine the feasibility and preliminary effect of a multilevel intervention 'Nudges to Quit' on smoking cessation in patients with serious mental illness who smoke in a community mental health center…
- Conditions
- Smoking, Smoking Cessation, Tobacco Use Cessation
- Trial name
- ISRAISE (NCT05952401)
- Testing
- Usual Care, "Nudges"
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Washington University School of Medicine
Bipolar Disorder
A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder
The purpose of this pilot study is to determine the safety and potential efficacy of sustained-release bupropion (Zyban®) for the treatment of nicotine dependence in patients with bipolar affective illness.
- Trial name
- NCT00593099
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking, Smoking Cessation
Evaluation of Treatments to Improve Smoking Cessation Medication Adherence
Many smokers fail to take their smoking cessation medication as recommended. This research is designed to identify treatments that improve the use of cessation medications and to determine whether an increase in medication use…
- Conditions
- Smoking, Smoking Cessation, Adherence, Nicotine Dependence
- Trial name
- Adherence (NCT01120704)
- Testing
- Short Term Combination Nicotine Replacement Therapy (patch + gum), Long Term Combination Nicotine Replacement Therapy (patch + gum), Intensive Maintenance Counseling
- Where
- United States
- Volunteers
- 544 people
- Sponsor
- University of Wisconsin, Madison
Second Hand Tobacco Smoke, Nicotine Dependence
Kids Safe and Smokefree (KiSS)
The study's primary aim is to test the hypothesis that an intervention integrating pediatric clinic-level quality improvement with home-level behavioral counseling (CQI+BC) will result in greater reductions in child cotinine (a…
- Trial name
- KiSS (NCT01745393)
- Testing
- Clinic Quality Improvement + Behavioral Counseling, Clinic Quality Improvement + Attention Control
- Where
- 4 sites in United States
- Volunteers
- 327 people
- Sponsor
- Temple University
Nicotine Addiction
Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids
The goal of this observational study is to learn if electronic cigarette users who currently choose to use lower nicotine eliquids have reduced harm compared those who choose higher nicotine eliquids.
- Trial name
- NCT06619964
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rochester Institute of Technology
Nicotine Dependence
Pharmacokinetics and Pharmacodynamics of Different Nicotine Salt Concentration Vape System Pods and Free-base Nicotine
Comparison of the pharmacokinetics and pharmacodynamics of two different nicotine salt concentrations and free-base nicotine using an open vape pod system
- Trial name
- NCT04170907
- Testing
- standardized vaping protocol
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Schizophrenia, Nicotine Dependence
Network-Targeted Neuromodulation for Nicotine Dependence in Schizophrenia
The goal of this clinical trial is to compare two active types of transcranial magnetic stimulation in two nicotine-using populations: nicotine-using people with psychosis and nicotine-using people without a diagnosis of a…
- Trial name
- NCT06389266
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Tobacco Dependence
Bioequivalence Between Two Oral Nicotine Sublingual Tablets, 2 mg and 4 mg
The purpose of this study is to assess the bioequivalence between two oral nicotine sublingual tablets, 2 mg and 4 mg.
- Trial name
- NCT01238627
- Testing
- Nicotine Sublingual Tablet Mint (NSTM), Marketed Nicotine Tablet
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- McNeil AB
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders
While the prevalence of smoking in the United States general population has declined over the past 50 years, there has been little to no decline among people with mental health conditions.
- Trial name
- NCT04090879
- Testing
- Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Brown University