Clinical trials: Nitrate Supplementation
Hypertension in Pregnancy, Hypertension
Inorganic Nitrate Supplementation in Chronic Hypertensive Pregnancies
High blood pressure during pregnancy poses significant risks to both the mother and baby. A combination of factors, including advancing maternal age, rising obesity rates, and metabolic health issues, have amplified the…
- Conditions
- Hypertension in Pregnancy, Hypertension, Pregnancy
- Trial name
- NIT_CH (NCT06105775)
- Testing
- Inorganic Nitrate Capsule
- Where
- Brazil
- Volunteers
- 144 people
- Sponsor
- University of Sao Paulo
Type 2 Diabetes
The Effect of Dietary Nitrate Supplementation on Ability of Individuals With Type 2 Diabetes to Perform Exercise
The investigators are conducting a research study to see if increasing the amount of nitrate (a substance found in large quantities in certain vegetables) in the diet can increase the ability of individuals with Type 2 diabetes…
- Trial name
- Ex nit as (NCT02206074)
- Testing
- Beetroot
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- University of Exeter
Blood Pressure
Effect of High Nitrate Vegetable Juice Supplementation on Plasma Nitrate and Blood Pressure in Healthy Adults
Aims: The aim of this study is to carry out a randomised crossover intervention study examining the effect of two different high nitrate vegetable juices on plasma nitrate levels and blood pressure (BP) in healthy adults.
- Trial name
- NIVJUS (NCT04736784)
- Testing
- Food-based - beetroot juice, Food-based - leafy green vegetable juice
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Type 2 Diabetes
Nitrate Supplementation and Exercise Tolerance in Patients With Type 2 Diabetes
The purpose of this study is to use a randomized, double-blind, placebo controlled study design to comprehensively investigate the impact of 8-weeks of dietary nitrate supplementation on skeletal muscle blood flow, mitochondrial…
- Trial name
- NCT02804932
- Testing
- Super Beets
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Darren P Casey
Raynaud Phenomenon
Beet the Cold: The Effect of Inorganic Nitrate Supplementation in Individuals With Raynaud's Phenomenon
Individuals with Raynaud's phenomenon often experience episodes of reduced blood flow to their fingers and toes during times of stress or cold exposure, causing significant discomfort and pain.
- Trial name
- NCT03129178
- Testing
- Concentrated beetroot juice
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University of Portsmouth
Alzheimer's Disease
An Investigation Into the Feasibility of Beetroot Juice Supplementation in People Living With Alzheimer's Disease.
The goal of this clinical trial is to learn if taking a beetroot juice supplement will work in people living with Alzheimer's disease.
- Trial name
- OMNI (NCT07258004)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of the West of Scotland
Nitrate, Caffeine
The Effects of Nitrate, Caffeine, and Cold Exposure on Cardiovascular Function.
Dietary inorganic nitrate supplementation may have positive implications on cardiovascular function. The aim of this project is to determine if nitrate supplementation can attenuate the effects that caffeine and cold exposure…
- Conditions
- Nitrate, Caffeine, Cold Exposure
- Trial name
- NCT06602921
- Testing
- TruBeet inorganic beetroot juice, Caffeine, Cold pressor test
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Supplementation
Effects of Nitrates and Citrulline Malate on Performance in Professional Professional Soccer
Randomized, single-center, parallel, team-stratified, stratified experimental study to evaluate the efficacy of a high sports supplement in improving high-intensity intermittent exercise performance in professional female soccer…
- Trial name
- NiCiFut (NCT05525871)
- Testing
- Nitrates and Citrulline Malate, Control product
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Hypertension, Hypertension (HTN)
Effects of Beetroot Extract on Blood Pressure and Exercise in Hypertensive Older Women
The goal of this clinical trial is to learn about the acute effects of beetroot extract in older women with high blood pressure.
- Trial name
- NCT07444138
- Testing
- Beetroot Extract (Nitrate-rich), Exercise, Rest (Control Condition)
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- São Paulo State University
Dietary Supplements, Healthy
Nitrate Supplementation on Motor Unit Activity
This study aimed to assess if nitrate supplementation influence motor unit (MU) activity following a sustained ischemic contraction and whether this is affected by blood flow restriction (BFR) during the recovery period.
- Trial name
- NCT05993715
- Testing
- Nitrate supplementation
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Exercise Performance
The Impact of Acute (2 h) and Short-term (4 Days) Nitrate Supplementation in the Form of Red Beet Root Juice on Intense Intermittent Exercise Performance.
Both acute ingestion (1-3 h) and chronic supplementation (3-30 days) with dietary nitrate has been shown to increase nitric oxide activity and, in some studies, to improve exercise economy, exercise tolerance, and endurance…
- Trial name
- NCT03616093
- Testing
- Test Beet Shot
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Healthy Adults
Effect of Acute Nitrate Supplementation on Vascular Function in Hispanic, Black and White Population
The purpose of the study is to assess vascular function in African Americans, Hispanic and Caucasian Americans to better understand racial differences in cardiovascular health.
- Trial name
- NCT05188079
- Testing
- Beetroot juice
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Dietary Habits, Nitrates
Effects of Beet Juice and Diet in Female Rowers
The purpose of this study is to determine the effects of nitrate-rich beetroot juice supplementation on exercise performance in female rowers when accounting for habitual vegetable nitrate consumption.
- Conditions
- Dietary Habits, Nitrates, Exercise
- Trial name
- NCT06045845
- Testing
- Beet Juice
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Nitric Oxide, Insulin Sensitivity
Nutritional Supplementation and Insulin Sensitivity
Type 2 diabetes mellitus (T2DM) is a progressive disease and early intervention and prevention strategies are therefore very important. An important early hallmark in the development of T2DM is insulin resistance.
- Conditions
- Nitric Oxide, Insulin Sensitivity, Vascular Function, L-arginine
- Trial name
- NCT04239482
- Testing
- L-arginine + Nitrate / Nitrite
- Where
- Netherlands
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Peripheral Arterial Disease, Peripheral Vascular Diseases
The Effects of Oral Inorganic Nitrate Supplementation on Lower Limb Perfusion During Exercise in Patients With PAD
Peripheral arterial disease (PAD) is a highly prevalent and costly condition. Intermittent claudication (IC), defined as ischemic leg pain that occurs with walking, results in functional impairment, reduced daily physical…
- Trial name
- NCT05036213
- Testing
- BEET IT - Concentrate Beet root juice, BEET IT - Concentrate Beet root juice (nitrate depleted)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Virginia
Dietary Supplements: Beetroot Juice Acute Supplementation, Dietary Supplement: Placebo Acute Supplementation
Acute Effects of Beetroot Juice Ingestion on Cognitive Function and Neuromuscular Performance in Elite Female Taekwondo Athletes
Beetroot juice is a good source of nitrate (NO3-), which is a precursor of nitric oxide (NO) through the NO3- to nitrite (NO2-) to NO pathway (Lundberg et al., 2008).
- Trial name
- BEET_TAEKWONDO (NCT06675305)
- Testing
- Beetroot juice (James White, UK)
- Where
- Spain
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
Early Menopause, Menopause
Influence of Early Menopause on Sympathetic Activation and Cardiovascular Function in Older Women
Women who enter menopause early are at a greater risk for developing cardiovascular disease later in life as compared to women with normal onset of menopause.
- Trial name
- NCT03692572
- Testing
- Nitrate supplementation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Aging
Nitrate and Exercise Performance in Middle to Older Aged Adults
Research with young healthy individuals has shown that beetroot juice beverages that contain large amounts of nitrate can improve exercise performance.
- Trial name
- NCT03371966
- Testing
- High Nitrate Beetroot Juice, Low Nitrate Beetroot Juice
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Postmenopausal Women
Effect of Beetroot Juice on Blood Pressure Regulation in Post Menopausal Women
In this study the investigators will test the hypothesis that acute consumption of inorganic nitrate (supplied in concentrated beetroot juice) reduces artery stiffness and resting blood pressure, and lessens the rise in blood…
- Trial name
- NCT03380000
- Testing
- Beetroot juice
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Diseases in Old Age
Efficacy Long-term Dietary Nitrate Consumption to Plasma Nitrite Conversion
The objective of this study was to determine the chronic effects of beetroot juice supplementation on the acute (90-minute post nitrate consumption) efficacy of converting dietary nitrate to plasma nitrate and plasma nitrite in…
- Trial name
- NCT05380167
- Testing
- BRJ Nitrate
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Wake Forest University