Clinical trials: Nitrate Supplementation
Type 2 Diabetes Mellitus
Nitrate and Exercise-induced Cardiac Troponin T in Type 2 Diabetes
Blood cardiac troponin T (cTnT) concentration is a widely used marker of acute cardiac injury. Previous research has shown that type 2 diabetic patients may experience large increments in cTnT levels over the subsequent hours…
- Trial name
- NO troponin (NCT01714674)
- Testing
- Dietary nitrate beverage, NaCl beverage
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht University Medical Center
Healthy Adults
Acute Effects of Beetroot Juice on Isometric Knee Extension Strength, Explosive Strength and Local Muscular Endurance
This is a double-blind placebo-controlled cross-over trial that aims to determine the acute effect of beetroot juice ingestion on isometric knee extension strength, explosive strength and local muscular endurance.
- Trial name
- NCT05567926
- Testing
- Beetroot juice concentrate (140 ml)
- Where
- Slovenia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Primorska
High Intensity Intermittent Sports Performance
Nitrate for High Intensity Intermittent Exercise
The objective of the current study is to assess the effect of 6-day dietary nitrate ingestion on high intensity intermittent sports performance in recreational soccer players.
- Trial name
- NITR-ITE (NCT02436629)
- Testing
- Nitrate-rich concentrated beetroot juice, Nitrate-depleted concentrated red beetroot juice
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Aging
Dietary Nitrate and Physiological Aging
The main purpose/s of this study is to examine the effects of 4 weeks of dietary nitrate supplementation on peripheral chemoreceptor sensitivity, spontaneous baroreflex sensitivity, and blood pressure responsiveness to a variety…
- Trial name
- NCT02593305
- Testing
- Super Beets
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Darren P Casey
Aging, Arterial Stiffness
Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study
This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults.
- Conditions
- Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension
- Trial name
- INCA (NCT03617302)
- Testing
- Experimental: Nitrate-containing
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce, PhD
Hypoxia
Exercise in Hypoxia and Nitrate Supplementation in Athletes: is the Whole Greater Than the Sum of Its Parts?
Determine the combined effect of training in hypoxia and nitrate supplementation on the performance and health of athletes at sea-level and altitude conditions.
- Trial name
- NCT06727656
- Testing
- Nitrate + Hypoxia, Control
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Trás-os-Montes and Alto Douro
COPD
Nitrate, Chronic Obstructive Pulmonary Disease (COPD) and Exercise
Patients with moderate chronic obstructive pulmonary disease (COPD) typically have reduced exercise capacity. This is because their lungs are damaged and because of increased work of breathing.
- Trial name
- NCT01712386
- Testing
- Beetroot
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- NIHR Exeter Clinical Research Facility
Heart Failure, Arrhythmia
Upregulating the Nitric Oxide Pathway To Restore Autonomic Phenotype (UNTRAP).
Autonomic nervous system dysfunction is known to be associated with an increased risk of heart rhythm abnormalities and sudden cardiac death (SCD) in patients with chronic heart failure - a condition affecting millions of people…
- Trial name
- UNTRAP (NCT03658174)
- Testing
- Nitrate-rich beetroot juice, Nitrate-free beetroot juice
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Leicester
Heart Failure With Reduced Ejection Fraction
Neuromuscular Fatigability in Individuals With Heart Failure
Brief summary The aims of this project are to 1) characterise muscle fatigue in individuals with chronic heart failure during exercise involving a smaller and larger muscle mass (Part I), 2) to determine the effect of nitrate…
- Trial name
- NCT06551012
- Testing
- Nitrate-rich beetroot juice, Beetroot juice with nitrate extracted
- Volunteers
- 28 people
- Sponsor
- Newcastle University
Time-trial Performance, Submaximal Exercise Performance
Nitrate Supplementation; Duration
The main aim of the current study will be to find the optimal duration of supplementation to enhance sports performance.
- Conditions
- Time-trial Performance, Submaximal Exercise Performance, Nitrite, Nitrate
- Trial name
- NO-how (NCT02115893)
- Testing
- Sodium Nitrate, Sodium Chloride
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Heart Failure, Systolic
Effects of Dietary Nitrate Supplementation on Cardiorespiratory Control in Chronic Heart Failure
The main purpose of this study is to determine whether dietary nitrate supplementation via concentrated beetroot juice improves central and peripheral cardiovascular control and physical capacity in patients with systolic heart…
- Trial name
- NCT02401126
- Testing
- Nitrate supplementation
- Volunteers
- 13 people
- Sponsor
- Queen's University
Airway Disease
Nitrate Supplementation During Final Examination Stress
The purpose of the present study is to explore the effects of a dietary nitrate supplement on immunity, mood, cardiovascular activity, and lung function during and following final exam stress in both healthy and asthmatic…
- Trial name
- NCT03159273
- Testing
- Beetroot Juice Group
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Southern Methodist University
Long COVID, Cardiorespiratory Fitness
Nitrite Supplementation in Long COVID Patients
Potential benefits of a nitrate-rich juice supplement to improve skeletal muscle function and associated physical capacity will be studied in patients with Long COVID.
- Trial name
- NCT05618574
- Testing
- 140 ml per day of Beet-It nitrate beverage (James White Drinks Ltd., Ipswich, UK)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
Pilot Study of Nitrate-rich Beetroot Juice Supplementation in Patients With Idiopathic Pulmonary Fibrosis (IPF)
Idiopathic pulmonary fibrosis (IPF) is a type of scarring (fibrotic) lung disease. Reduced exercise capacity is a key symptom experienced by patients.
- Trial name
- BEET-IPF (NCT06488638)
- Testing
- nitrate-rich beetroot juice (70ml with approx. 400 mg nitrate) twice a day for 3 days
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Type 2 Diabetes
Taurine and Nitrate Supplementation on Thermoregulatory in T2DM
Anthropogenic warming is increasing the frequency and intensity of extreme heat events. Elevated temperatures raise the risk of mortality and hospital admissions, particularly among people with chronic illnesses such as type 2…
- Trial name
- NCT07656051
- Testing
- taurine, Beetroot and taurine
- Volunteers
- 18 people
- Sponsor
- University of Portsmouth
High Nitrate Dose, Moderate Nitrate Dose
The Effect of Beetroot Juice Supplementation Dose on Neuromuscular Performance During Resistance Exercise
Dietary nitrate supplementation, administered in the form of nitrate-rich beetroot juice, has been shown to improve exercise performance and may have more pronounced effects on exercise that requires high-power and high-velocity…
- Conditions
- High Nitrate Dose, Moderate Nitrate Dose, Low Nitrate Dose, Nitrate-depleted Dose
- Trial name
- NCT05957835
- Testing
- BR-HIGH, BR-MOD, BR-LOW
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pepperdine University
Nitrate, Placebo - Control
Beetroot Juice and Neuromuscular Performance in Female Basketball Players
A randomized, double-blind, placebo-controlled study investigates the effects of 5 days of nitrate-rich beetroot juice supplementation (70 mL·day-¹; 6.4 mmol NO₃-·day-¹) on physical performance in female basketball players.
- Trial name
- BASKET_BEET (NCT07833579)
- Testing
- Beetroot juice supplementation
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
Nutrition, Physical Performance
The Effects of Nitrate Supplementation on Elite Runners
This study analyzed the effects of 15 days of beetroot juice supplementation on different performance measures in elite Spanish distance runners
- Conditions
- Nutrition, Physical Performance, Sport Physiology, Nitrates
- Trial name
- NCT03449992
- Testing
- nitrate-rich beetroot juice
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Metabolic Syndrome
Nitrate Supplementation and Cerebrovascular and Cognitive Function in Metabolic Syndrome
The purpose of this study is to determine if beetroot juice consumption can improve cognitive performance and brain vascular function in individuals with metabolic syndrome
- Trial name
- NCT05532423
- Testing
- Beetroot Juice - Active
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Penn State University
Colorectal Cancer
Does Dietary Nitrate Supplementation Improve Aerobic Performance
The purpose of this study is to determine whether dietary nitrate supplementation improves performance in cardiopulmonary exercise testing (CPET).
- Trial name
- NCT02319356
- Testing
- Beetroot juice
- Volunteers
- 70 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust