Clinical trials: Nitrates
Stroke, CVA
Acute Effects of Beetroot Juice on Locomotor Economy and Capacity in Chronic Stroke
The purpose of this study is to investigate if a beetroot juice supplement can improve oxygen capacity during walking tasks at a submaximal and maximal effort in people greater than 6 months following stroke.
- Trial name
- NCT05720013
- Testing
- Beetroot Juice supplement
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Indiana University
Heavy Drinking
Study of Nitrate-Rich Juice on Cognitive Function in Heavy Alcohol Drinkers: a Two-Stage Adaptive Design Real-World Clinical Trial
It is known that alcohol consumption can lead to cognitive impairment and dysregulation of inflammatory responses. A preliminary randomized controlled trial conducted by our research team has suggested that nitrate may improve…
- Trial name
- NCT06777459
- Testing
- Nitrate-rich beetroot juice
- Volunteers
- 43 people
- Sponsor
- Peking University Sixth Hospital
High Intensity Intermittent Sports Performance
Nitrate for High Intensity Intermittent Exercise
The objective of the current study is to assess the effect of 6-day dietary nitrate ingestion on high intensity intermittent sports performance in recreational soccer players.
- Trial name
- NITR-ITE (NCT02436629)
- Testing
- Nitrate-rich concentrated beetroot juice, Nitrate-depleted concentrated red beetroot juice
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Cardiovascular Disease
Effects of Growth Hormone on the Nitric Oxide Pathway
The purpose of the study is to determine whether the treatment with growth hormone has an influence on the nitric oxide pathway in healthy males.
- Trial name
- NCT00470002
- Testing
- Somatropin
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Nitrate, Placebo - Control
Beetroot Juice and Neuromuscular Performance in Female Basketball Players
A randomized, double-blind, placebo-controlled study investigates the effects of 5 days of nitrate-rich beetroot juice supplementation (70 mL·day-¹; 6.4 mmol NO₃-·day-¹) on physical performance in female basketball players.
- Trial name
- BASKET_BEET (NCT07833579)
- Testing
- Beetroot juice supplementation
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
Aging, Aging Well
Adjuvant Nitrate to Boost Exercise-induced Health Benefits in Older Adults
Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments to compromise intrinsic capacity and healthspan.
- Conditions
- Aging, Aging Well, Healthy Aging
- Trial name
- BOOST-X (NCT07572266)
- Testing
- Nitrate enriched beetroot juice, Nitrate depleted beetroot juice, 12 week of combined exercise training
- Where
- United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Florida Institute for Human and Machine Cognition
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
Pilot Study of Nitrate-rich Beetroot Juice Supplementation in Patients With Idiopathic Pulmonary Fibrosis (IPF)
Idiopathic pulmonary fibrosis (IPF) is a type of scarring (fibrotic) lung disease. Reduced exercise capacity is a key symptom experienced by patients.
- Trial name
- BEET-IPF (NCT06488638)
- Testing
- nitrate-rich beetroot juice (70ml with approx. 400 mg nitrate) twice a day for 3 days
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Pulp Disease, Dental
Potassium Nitrate in Polycarboxylate as a Direct Pulp Capping
The study aimed to compare potassium nitrate in polycarboxylate cement to mineral trioxide aggregate as a direct pulp capping material of young permanent teeth in patients from 7 to 10 ears
- Trial name
- NCT05912907
- Testing
- potassium nitrate in polycarboxilate cement
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Minia University
Length of Hospital Stay
Preoperative Coadministration of Low-concentration Carbohydrate and Nitrates Loading vs Low- Concentration Carbohydrate Loading Alone in Patients Undergoing Open Gynecological Surgeries
Surgery is known to be associated with stress response affecting in a negative way the clinical outcome and patient experience. The stress response includes both sympathetic nervous system activation and systemic inflammatory…
- Trial name
- NCT04962776
- Testing
- Low-concentration carbohydrate and nitrates, Low-concentration carbohydrate
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Endothelial Dysfunction, High Blood Pressure
Inulin and Nitrate's Effects on Vascular Health and Gut Microbiome
Previous research has revealed that adults with pre-hypertensive and hypertensive blood pressure levels typically exhibit impaired vasodilation, which is a crucial aspect of blood vessel function, due to decreased nitric oxide…
- Conditions
- Endothelial Dysfunction, High Blood Pressure, Gut Microbiota Dysbiosis and Nutrition
- Trial name
- NCT06502535
- Testing
- Inulin, Potassium nitrate and inulin
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Exeter
Cardiovascular Diseases
Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina
The mainstay treatment for reducing the symptoms of angina and long-term risk of heart attacks in patients with heart disease is stent implantation in the diseased coronary artery.
- Trial name
- NITRATE-OCT (NCT02529189)
- Testing
- Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Queen Mary University of London
Peripheral Arterial Disease, Peripheral Vascular Diseases
The Effects of Oral Inorganic Nitrate Supplementation on Lower Limb Perfusion During Exercise in Patients With PAD
Peripheral arterial disease (PAD) is a highly prevalent and costly condition. Intermittent claudication (IC), defined as ischemic leg pain that occurs with walking, results in functional impairment, reduced daily physical…
- Trial name
- NCT05036213
- Testing
- BEET IT - Concentrate Beet root juice, BEET IT - Concentrate Beet root juice (nitrate depleted)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Virginia
Blood Plasma Nitrite
Nitrate and Power Output After Two Beetroot Juice Drinks
The main aim of this study is to determine and compare the optimal time to achieve peak concentration of blood plasma nitrite after ingestion of beetroot juice (BR) and isotonic beetroot juice (ISO-CB), respectively.
- Trial name
- NCT05452421
- Testing
- Isotonic carbohydrate beetroot juice drink, Beetroot juice drink
- Where
- Singapore
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Induction of Labor Affected Fetus / Newborn
Nitric Oxide Donor Isosorbide Mono Nitrate for Cervical Ripening in Induction of Labor
The study aims to evaluate and assess the effectiveness and safety of vaginal administration of isosorbide mono nitrate (IMN) to induce cervical ripening and shorten the interval time between induction and delivery in women…
- Trial name
- NCT03544606
- Testing
- isosorbide mononitrate
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- ahmed nagy shaker ramadan
Early Childhood Caries
The Caries-arresting Effect of Incorporating fTCP to NaF Varnish Applied Following AgNO3 in Preschool Children
The objective of this study is to compare the effectiveness of 25% AgNO3 solution plus 5% NaF varnish and 25% AgNO3 solution plus 5% NaF varnish with fTCP when applied semi-annually over 30 months in arresting dentine caries of…
- Trial name
- NCT03423797
- Testing
- 25% AgNO3 solution followed by 5% NaF, 25% AgNO3 solution followed by 5% NaF with fTCP
- Where
- China
- Volunteers
- 408 people
- Sponsor
- The University of Hong Kong
Hypertrophic Cardiomyopathy
Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy
The overall aim of this project is to establish potential benefits of a novel lifestyle (physical activity and dietary nitrate) and pharmacological (angiotensin receptor neprilysin inhibitor) interventions in patients with…
- Trial name
- SILICOFCM (NCT03832660)
- Testing
- Lifestyle, Sacubitril/Valsartan
- Where
- 5 sites in Germany, Italy and 2 more
- Volunteers
- 168 people
- Sponsor
- Newcastle University
HIV/AIDS
People Living With HIV/AIDS, Nitrate, Endotelial Function, Arterial Stiffness and Skeletal Muscle Oxygenation
Administration of antiretroviral therapy has brought benefits for infective human immunodeficiency virus-1 (HIV-1)-patients, reducing the number of AIDS-related morbidity and mortality.
- Trial name
- NCT03485248
- Testing
- Beetroot Juice
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Exercise Nutritional Physiology
Influence of Dietary Nitrate on Time Trial Performance in Swiss Paracycling Athletes
The aim of this study is to investigate wether beetroot juice or sodium nitrate enhances time trial performance in Swiss paracycling athletes compared to the ingestion of a placebo supplement.
- Trial name
- nitrate_TT (NCT02454049)
- Testing
- beetroot juice, sodium nitrate, water
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Malignant Breast Tissue Neoplasm
Is Dietary Nitrate Effective in Reducing Aerobic Glycolysis in Breast Cancer?
Breast cancer is the most prevalent cancer affecting women, with 1 in 8 women in the UK developing breast cancer in their life time.
- Trial name
- BEET (NCT03944226)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- University of Aberdeen
High Blood Pressure, Flow Mediated Dilation
Effect of Nitrate-rich Fruit and Vegetable Supplement on Blood Pressure
It is hypothesized that the daily supplementation of a nitrate-rich, two-ounce fruit and vegetable energy supplement (Isagenix International LLC) by healthy young adults with a would increase circulating nitrates and improve…
- Trial name
- NCT03486145
- Testing
- fruit and vegetable juice supplement
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Arizona State University