Clinical trials: Nitrates
Menopausal Hot Flashes
Flushing Reduction Associated With Nitrates
A randomized, double-blinded, placebo-controlled trial of uninterrupted transdermal nitrate therapy in 140 peri- or postmenopausal women who have frequent hot flashes.
- Trial name
- FRAN (NCT02714205)
- Testing
- transdermal nitroglycerin
- Where
- 2 sites in United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Alison Huang, MD
Molar Incisor Hypomineralisation
Effect of Nano Hydroxy Apatite Varnish and Potassium Nitrate Gel on the MIH-affected Permanent Teeth
This clinical study main goal is to investigate the effectiveness of nano hydroxy apatite crystal varnish and potassium nitrate gel as a non invasive approach in managing MIH-affected teeth.
- Trial name
- NCT06896565
- Testing
- nano hydroxy apatite varnish, Potassium Nitrate Gel, Varnishes, Fluoride
- Volunteers
- 48 people
- Sponsor
- Cairo University
Hypergranulation Tissue; Gastrostomy Tube Site
Silver Nitrate Application and Topical Corticosteroids for Hypergranulation Tissue
This protocol describes a randomized, two arm clinical trial comparing two topical treatments in patients with hypergranulation tissue at gastrostomy tube sites.
- Trial name
- NCT02398539
- Testing
- Silver Nitrate, Triamcinolone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Akron Children's Hospital
Heart Failure, Congestive Heart Failure
Vasodilator Therapy for Heart Failure and Preserved Ejection Fraction
The main objective is to test the effect of prolonged therapy (24 weeks) with isosorbide dinitrate ± hydralazine on arterial wave reflections (primary endpoint).
- Trial name
- NCT01516346
- Testing
- Isosorbide Dinitrate, Isosorbide Dinitrate + Hydralazine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Gingivitis, Cardiovascular Diseases
Dietary Nitrate Functional Gum Effect on Gingivitis and Heart Health
The purpose of this research is to determine the effects of a chewing gum containing dietary nitrate to gingival and heart health. Dietary nitrates are commonly found in leafy vegetables and beets.
- Conditions
- Gingivitis, Cardiovascular Diseases, Gingival Diseases, Gingival Bleeding
- Trial name
- NCT06029283
- Testing
- dietary nitrate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Maryland, Baltimore
Blood Pressure
Dietary Nitrate Intake in Vegetarians and Omnivores
Vegetarian diets are commonly associated with lower blood pressure levels. This has been related to greater consumption of inorganic nitrate, since vegetables are the main source of this anion.
- Trial name
- NO3 (NCT03871777)
- Testing
- Chlorhexidine mouthwash
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Gingivitis
Nitrate Consumption and Gingival Inflammation
The aim of this investigation is to evaluate the impact of the 14- day consumption of a nitrate-rich diet on the the extent of gingival inflammation in a cohort of periodontal aftercare patients.
- Trial name
- NITGIN14 (NCT05866341)
- Testing
- nitrate-rich lettuce juice, nitrate-depleted lettuce juice
- Volunteers
- 44 people
- Sponsor
- Wuerzburg University Hospital
Healthy Adults, Mechanical Ventilation Dependence
Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude
This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions.
- Conditions
- Healthy Adults, Mechanical Ventilation Dependence, Hypoxia, Exercise Training
- Trial name
- NCT07216755
- Testing
- Respiratory Muscle Training (RMT), Dietary Supplement: Beetroot Juice Concentrate
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Embry-Riddle Aeronautical University
Osteoporosis
Nitrates and Bone Turnover; Nitrates and Bone Turnover Bisphosphonate Sub-Study
Purpose: NABT: To compare five widely available nitrate formulations: (1) 15 of nitroglycerin (NTG) ointment, (2) 0.3 mg and (3) 0.6 mg of sublingual NTG, (4) 20 mg of isosorbide mononitrate (an oral tablet), and (5) 160 mg of…
- Trial name
- NABT;NABT-B (NCT01387672)
- Testing
- Nitrates (NABT Main trial)
- Where
- Canada
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy Individuals With no Periodontal Disease
The Effect of Nitrate Supplementation on Tongue Microbiome
The objective of this study is to investigate how the host environment influences microbiome structure. Specifically, the spatial organization of nitrate-metabolizing bacteria that will flourish in high and low salivary nitrate…
- Trial name
- NCT07865481
- Testing
- Nitrate-Supplemented Beet Juice, Nitrate-Depleted Beet Juice
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The Forsyth Institute
Heart Failure, Arrhythmia
Upregulating the Nitric Oxide Pathway To Restore Autonomic Phenotype (UNTRAP).
Autonomic nervous system dysfunction is known to be associated with an increased risk of heart rhythm abnormalities and sudden cardiac death (SCD) in patients with chronic heart failure - a condition affecting millions of people…
- Trial name
- UNTRAP (NCT03658174)
- Testing
- Nitrate-rich beetroot juice, Nitrate-free beetroot juice
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Leicester
Blood Pressure, Cognitive Change
Dietary Nitrate and Healthy Older Adults
This study investigates the influence of dietary nitrate supplementation on cardiovascular health and physical and cognitive performance in older adults.
- Conditions
- Blood Pressure, Cognitive Change, Functional Capacity, Brain Metabolism
- Trial name
- NCT03473678
- Testing
- Nitrate-rich beetroot juice, Nitrate-depleted beetroot juice
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Exeter
High Nitrate Dose, Moderate Nitrate Dose
The Effect of Beetroot Juice Supplementation Dose on Neuromuscular Performance During Resistance Exercise
Dietary nitrate supplementation, administered in the form of nitrate-rich beetroot juice, has been shown to improve exercise performance and may have more pronounced effects on exercise that requires high-power and high-velocity…
- Conditions
- High Nitrate Dose, Moderate Nitrate Dose, Low Nitrate Dose, Nitrate-depleted Dose
- Trial name
- NCT05957835
- Testing
- BR-HIGH, BR-MOD, BR-LOW
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pepperdine University
Hypertension, Blood Pressure, High
Dietary Nitrate on Blood Pressure and Cardiovascular Disease Risk Factors
The project aims to determine the effect of a high-nitrate dietary intervention on blood pressure and markers of vascular function compared to a low-nitrate intervention in people with elevated blood pressure.
- Trial name
- NCT03478631
- Testing
- High-nitrate dehydrated vegetable powder, Low-nitrate dehydrated vegetable powder
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Unity Health Toronto
Coronary Arteriosclerosis
Dietary Nitrate and Nitrite to Increase Nitric Oxide in Patients With Coronary Artery Disease
This study will determine whether dietary nitrates and nitrites can produce nitric oxide in the body and dilate blood vessels in patients with coronary artery disease.
- Trial name
- NCT00069654
- Testing
- Forearm blood flow study, Brachial artery reactivity study, Treadmill exercise test
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Bronchoscopic Lung Volume Reduction
Bronchoscopic Lung Volume Reduction in Management of Localized Emphysema
Emphysema is a progressive phenotype of chronic Obstructive Pulmonary Disease (COPD), poses a significant global health burden characterized by irreversible lung parenchymal destruction and airspace enlargement.
- Trial name
- NCT06629558
- Testing
- Silver Nitrate, Nano-silver nitrate, Bronchoscopic lung volume reduction
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University Hospital
Dentine Hypersensitivity
Efficacy of Miswak Extract Toothpaste as Compared Potassium Nitrate in The Management of Dentinal Hypersensitivity
The study will be a single-center, longitudinal, triple-masked (for participants, operators, and statistician), equal ratio, randomized non-crossover design.
- Trial name
- NCT04179994
- Testing
- Miswak extract-containing toothpaste, Potassium nitrates-containing toothpaste
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Saudi Arabia
Type 2 Diabetes
Nitrate Supplementation and Exercise Tolerance in Patients With Type 2 Diabetes
The purpose of this study is to use a randomized, double-blind, placebo controlled study design to comprehensively investigate the impact of 8-weeks of dietary nitrate supplementation on skeletal muscle blood flow, mitochondrial…
- Trial name
- NCT02804932
- Testing
- Super Beets
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Darren P Casey
Erectile Dysfunction
L-Arginine and Erectile Dysfunction
The purpose of the study is to determine whether the treatment with L-arginine leads to an improvement of erectile dysfunction in patients with erectile dysfunction.
- Trial name
- NCT00777075
- Testing
- L-arginine
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- Hannover Medical School
Pulmonary Hypertension, Chronic Obstructive Lung Disease
Pulmonary Hemodynamics in Patients With Severe Emphysema Pre and Post BLVR
This study is designed as a prospective study, with the primary endpoint being changes in pulmonary hemodynamic parameters after ELVR in patients with severe emphysema.
- Trial name
- NCT02778802
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University