Clinical trials: Nitrates
Diaper Rash
Prospective Two-Year Study to Assess Miconazole Nitrate Resistance in Neonates and Infants
The purpose of this study is to determine whether repeated use of 0.25% miconazole nitrate ointment in newborns and infants with a yeast infection in the diaper area causes the yeast to become resistant to the drug.
- Trial name
- NCT00702507
- Testing
- 0.25 % Miconazole Nitrate Ointment
- Where
- 8 sites in United States, Dominican Republic and 2 more
- Volunteers
- 200 people
- Sponsor
- Stiefel, a GSK Company
Asthma
The Effects of NOx and Conjugated Linoleic Acid on Asthmatics
This study will examine the hypothesis that in obese asthmatics; treatment with NOx + CLA is well tolerated, safe and will increase eNO while reducing airway oxidative stress.
- Trial name
- NICLA (NCT02433977)
- Testing
- Conjugated Linolenic Acid, Sodium Nitrite, Sodium Nitrate
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Gladwin, Mark, MD
Peripheral Arterial Disease
Effect of Beetroot Juice on Coronary Blood Flow and Walking Performance in PAD
In this study the investigators will test the hypothesis that short-term consumption of inorganic nitrate (supplied in concentrated beetroot juice) enhances coronary blood flow responses, large artery hemodynamics, and leg…
- Trial name
- HeartBeet (NCT02553733)
- Testing
- Beetroot juice
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- David N. Proctor, PhD
Acute Coronary Syndromes
Nitrate - Clopidogrel - Acute Coronary Syndrome
This study aims to investigate whether intravenous nitrate given during non-ST-elevation myocardial infarction (non-STEMI) affects the platelet inhibition of clopidogrel.
- Trial name
- NCT06878638
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Bursa Postgraduate Hospital
Exercise Performance
The Impact of Acute (2 h) and Short-term (4 Days) Nitrate Supplementation in the Form of Red Beet Root Juice on Intense Intermittent Exercise Performance.
Both acute ingestion (1-3 h) and chronic supplementation (3-30 days) with dietary nitrate has been shown to increase nitric oxide activity and, in some studies, to improve exercise economy, exercise tolerance, and endurance…
- Trial name
- NCT03616093
- Testing
- Test Beet Shot
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Oral Dysbiosis
Effects of a Composition on the Oral Microbiome, pH, Nitrite/Nitrate Ratio, Elastases and Inflammation in Oral Dysbiosis
Dysbiosis is a condition in which the normal function of an ecological net is altered. In dysbiosis a state of inflammation, a loss of hydration, a change in pH, a loss of the barrier function are all allies of key pathogens that…
- Trial name
- NCT05463484
- Testing
- Test composition Saliactive® (olive product, betaine and xylitol), Control
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Mucosa Innovations, S.L.
Time-trial Performance, Submaximal Exercise Performance
Nitrate Supplementation; Duration
The main aim of the current study will be to find the optimal duration of supplementation to enhance sports performance.
- Conditions
- Time-trial Performance, Submaximal Exercise Performance, Nitrite, Nitrate
- Trial name
- NO-how (NCT02115893)
- Testing
- Sodium Nitrate, Sodium Chloride
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Exercise Physiology, Sports Nutrition
Effects of Acute Beetroot Juice on Aerobic Performance and Muscle Oxygenation in Amateur Female Soccer Players
Effects of Acute Beetroot Juice on Aerobic Performance and Muscle Oxygenation in Amateur Female Soccer Players
- Conditions
- Exercise Physiology, Sports Nutrition, Cardiorespiratory Fitness
- Trial name
- NCT07840014
- Testing
- Nitrate-rich beetroot juice
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Sakarya Applied Sciences University
Raynaud Phenomenon
Beet the Cold: The Effect of Inorganic Nitrate Supplementation in Individuals With Raynaud's Phenomenon
Individuals with Raynaud's phenomenon often experience episodes of reduced blood flow to their fingers and toes during times of stress or cold exposure, causing significant discomfort and pain.
- Trial name
- NCT03129178
- Testing
- Concentrated beetroot juice
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University of Portsmouth
Contrast Induced Nephropathy
Contrast Nephropathy and Nitrates
Contrast-induced nephropathy (CIN) is a complication of percutaneous coronary angiography that occurs in about 10 to 20% of patients exposed to contrast media.
- Trial name
- CoNaN (NCT01999517)
- Testing
- Intravenous Nitroglycerin, IV Fluids
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Mt. Sinai Medical Center, Miami
Muscle Protein Synthesis
Impact of Nitrate Ingestion on Protein Synthesis
A diet rich in leafy green vegetables has been shown to reduce the risk of developing chronic metabolic disease. The health benefits from these particular vegetables may be attributed to their high nitrate content.
- Trial name
- PRO-Nitrate (NCT01473576)
- Testing
- Nitrate, Sodium chloride
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht University Medical Center
Chronic Obstructive Pulmonary Disease
Dietary Nitrate in COPD
The acute consumption of dietary nitrate has been shown to improve exercise capacity in athletes, healthy adults and subjects with peripheral vascular disease.
- Trial name
- CHB-BRJ-COPD (NCT02148289)
- Testing
- Nitrate rich beverage, Nitrate free beverage
- Volunteers
- 12 people
- Sponsor
- Royal College of Surgeons, Ireland
Heart Failure, Heart Failure, Systolic
Effect of Dietary Nitrate Ingestion in Heart Failure
This study evaluates the addition of inorganic dietary nitrate to the optimal treatment of patients diagnosed with heart failure with reduced ejection fraction.
- Trial name
- DiNOmo-HF (NCT03511248)
- Testing
- Nitrate-rich Beetroot Juice, Nitrate-deplete Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- Queen Mary University of London
Health Risk Behaviors
Nitrate INFORMER Vegetable Study
Nitrate is a controversial component of vegetables, meat, and drinking water. The now well-established benefits of nitrate, through the enterosalivary nitrate-nitrite-nitric oxide (NO) pathway, on cardiovascular risk factors and…
- Trial name
- NCT05886023
- Testing
- High nitrate vegetables, Low nitrate vegetables
- Where
- Australia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Edith Cowan University
Kidney Injury, Acute
Inorganic Nitrate (NaNO3) Prevention of Contrast-Associated Acute Kidney Injury
This pilot study is designed to test the logistics and recruitment of a trial testing the benefit of sodium nitrate in the prevention of contrast-associated kidney injury in a group of patients at high-risk.
- Trial name
- NCT07016074
- Testing
- Sodium Nitrate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Nutrition, Physical Performance
The Effects of Nitrate Supplementation on Elite Runners
This study analyzed the effects of 15 days of beetroot juice supplementation on different performance measures in elite Spanish distance runners
- Conditions
- Nutrition, Physical Performance, Sport Physiology, Nitrates
- Trial name
- NCT03449992
- Testing
- nitrate-rich beetroot juice
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Hypertension
Investigation of Dietary Nitrate Effects in Hypertension-induced Target Organ Damage
This study aims to determine whether dietary inorganic nitrate (in beetroot juice) is able to reduce overall thickening of the heart (left ventricular hypertrophy or LVH) and stiffness of the arteries when given to patients with…
- Trial name
- NITRATE-TOD (NCT03088514)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 149 people
- Sponsor
- Queen Mary University of London
Nitrates, Hockey
Beetroot Juice Ingestion Effects on Field Hockey Performance.
Scientific evidence supports that only a few dietary supplements have reported good evidence for improving sports performance, between we can mention beetroot juice supplementation with doses > 5 mmol of NO3-.
- Trial name
- BEETHOCKEY (NCT05209139)
- Testing
- Beetroot juice
- Where
- Spain
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Stroke, Ischemic Stroke
Dietary Nitrate Supplements and Ischemic Stroke Recovery
This is a double-blind, randomized, placebo-controlled, pilot study. Participants will be randomized to receive either beetroot juice or a beetroot juice placebo, as a dietary supplement, for 30 days.
- Conditions
- Stroke, Ischemic Stroke, Cerebrovascular Accident
- Trial name
- NCT02838901
- Testing
- Beet it Beetroot juice
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Wake Forest University Health Sciences
Performance
Dietary Nitrate Supplementation and Crossfit Athletes
In the past, dietary nitrate supplementation has been shown to have clinical benefits in the treatment of cardiovascular issues.
- Trial name
- NCT02162927
- Testing
- Dietary Nitrate
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Florida State University