Clinical trials: Nitrates
Oral Health, Dietary Nitrate
Evaluating the Impact of Various Dietary Nitrate Supplements on Oral Health
This study aims to investigate the effects of different dietary nitrate supplements, versus placebo, on microbiological and immunological markers associated with oral health in people aged 18-65 years.
- Trial name
- NCT06956612
- Testing
- Juice (Active comparator), Crystals (Experimental)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shatha Alhulaefi
Dentin Sensitivity
Nano-hydroxyapatite With Potassium Nitrate in the Therapy of the Dental Sensitivity
The chief aim of this study is to evaluate the difference in tooth sensitivity after having used a gel containing nano - hydroxyapatite and potassium nitrate This randomized double-blind clinical study is designed to compare the…
- Trial name
- NCT02895321
- Testing
- Cavex Bite&White ExSense, Colgate, Protection Caries
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Università degli Studi di Sassari
Beetroot Juice, Placebo
Dose-Response Effects of Beetroot Juice on Neuromuscular Performance in the Bench Press
Beetroot juice is rich in dietary nitrate, a compound that may improve muscle function and exercise performance. However, the effects of different nitrate doses on upper-body strength and muscular endurance are lees explored.
- Trial name
- BEET_BP (NCT07911072)
- Testing
- Nitrate-Rich Beetroot Juice
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
Menopause
Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females
Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal…
- Trial name
- NCT06480695
- Testing
- Nitrate-Rich Beetroot Juice, High Intensity Exercise, Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Vulvovaginal Candidiasis
A Randomized Study Evaluating the Therapeutic Equivalence of Two Butoconazole Nitrate Vaginal Cream, 2% Formulations
This was a study that compared the efficacy and safety of a generic butoconazole nitrate vaginal cream, 2% to Gynazole-1 (butoconazole nitrate) Vaginal Cream, 2% in the treatment of vulvovaginal candidiasis caused by Candida…
- Trial name
- NCT01039584
- Testing
- Butoconazole Nitrate Vaginal Cream, Gynazole 1 vaginal cream
- Where
- United States
- Volunteers
- 611 people, healthy volunteers welcome
- Sponsor
- Padagis LLC
Hypercholesterolemia
Investigation of the Effect of Dietary Nitrate Treatment on Endothelial Function and Platelet Reactivity in Hypercholesterolemics.
Diets rich in fruit and vegetables reduce the risk of strokes and heart attacks, however the exact cause of this beneficial effect is uncertain.
- Trial name
- NCT01493752
- Testing
- beetroot juice
- Where
- United Kingdom
- Volunteers
- 69 people
- Sponsor
- Queen Mary University of London
Hypersensitivity Dentin
Effectiveness of the Use of Desensitizing Dentifrices Based on Nanocrystals of Hydroxyapatite / 5% Potassium Nitrate / 1450ppm Sodium Monofluorophosphate and Potassium Nitrate 5% / 1426ppm Sodium Floride in the Treatment of Dentine Hypersensitivity. Test Randomized Clinical
Background: Currently, periodontal treatment, both surgical and non-surgical, leaves sequelae in the vast majority of patients, dentine hypersensitivity (HSD) is one of the most important.
- Trial name
- NCT04156152
- Testing
- DEENSIBILIZING TOOTHPASTE BASED ON NANOCRISTALS OF HYDROXIAPATITA / 5% POTASSIC NITRATE / SODIUM MONOFluORPHOSPHATE 1450 PARTS PER MILLION, 5% POTASSIC NITRATE / SODIUM FLUORIDE 1426 PARTS PER MILLION TOOTHPASTE
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
Brain and Central Nervous System Tumors, Lymphoma
Gallium Nitrate in Treating Children With Brain Tumor, Neuroblastoma, Rhabdomyosarcoma, Non-Hodgkin's Lymphoma, or Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: : Phase I trial to study the effectiveness of gallium nitrate in young patients who have malignant…
- Conditions
- Brain and Central Nervous System Tumors, Lymphoma, Neuroblastoma, Sarcoma
- Trial name
- NCT00002543
- Testing
- gallium nitrate
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Medical College of Wisconsin
Aging
Nitrate and Exercise Performance in Middle to Older Aged Adults
Research with young healthy individuals has shown that beetroot juice beverages that contain large amounts of nitrate can improve exercise performance.
- Trial name
- NCT03371966
- Testing
- High Nitrate Beetroot Juice, Low Nitrate Beetroot Juice
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
ANOCA - Angina With Non-obstructive Coronary Arteries, INOCA (Ischemia With Non Obstructive Coronary Artery Disease)
Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing
This single-arm, multi-center, prospective study will assess the coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and determinants thereof (transit time, Pa, Pd) in patients before and after intracoronary…
- Trial name
- CRT-NITRO (NCT06896903)
- Testing
- Coronary reactivity testing with and without nitrates
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor Research Institute
Aging, Sarcopenia
Dietary Nitrate and Muscle Power With Aging
The purpose of this study is to see if drinking beetroot juice (BRJ) is beneficial for aging patients. We hope to determine the effect of BRJ on exercise performance.
- Trial name
- NCT03513302
- Testing
- nitrate
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Indiana University
Hypertension, CKD - Chronic Kidney Disease
The Effects of Dietary Nitrate in Patients With Hypertensive Kidney Injury
The study aims to study the effects of diatery nitrate in patients with hypertension and hypertensive kidney injury. The study is a randomized, placebo-controlled, double-blinded crossover trial.
- Trial name
- DINO-CKD (NCT07290842)
- Testing
- Beetroot Juice - Active
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Gødstrup Hospital
Dentin Sensitivity
Effect of Laser and Potassium Nitrate Application on the Sensitivity Control in Bleached Teeth
To investigate the effects of desensitizing agents on the dental bleaching process, testing the hypothesis that they may control dental sensitivity.
- Trial name
- NCT03434782
- Testing
- In-office dental bleaching, Low Level Laser Therapy, 5% potassium nitrate / 2% sodium fluoride gel
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Para
Vulvovaginal Candidiasis
Arasertaconazole Nitrate Pessaries - Dose Finding Study for the Vulvovaginal Candidiasis (VVC) Treatment
In order to find an optimal dose of arasertaconazole nitrate in the treatment of vulvovaginal candidiasis, a multicenter, randomized, double-blind, parallel, placebo-controlled study will be conducted to compare the therapeutic…
- Trial name
- NCT01144286
- Testing
- arasertaconazole nitrate
- Where
- Spain
- Volunteers
- 229 people
- Sponsor
- Ferrer Internacional S.A.
COPD
Nitrate, Chronic Obstructive Pulmonary Disease (COPD) and Exercise
Patients with moderate chronic obstructive pulmonary disease (COPD) typically have reduced exercise capacity. This is because their lungs are damaged and because of increased work of breathing.
- Trial name
- NCT01712386
- Testing
- Beetroot
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- NIHR Exeter Clinical Research Facility
Wound Healing, Granulation Tissue
Silver Nitrate vs. Triamcinolone for Treatment of Hypergranulation Tissue
This randomized controlled trial aims to compare the efficacy of silver nitrate, triamcinolone, and a successive use of both treatments in managing hypergranulation tissue in traumatic wounds.
- Trial name
- NCT06681194
- Testing
- Silver Nitrate, triamcinolone, Silver nitrate + triamcinolone
- Where
- United States
- Sponsor
- Francesco Egro
No Dental Disease, Non-smoking
Examination of the Distribution of Nitrate Reducing Bacteria in the Human Oral Cavity
Dietary nitrate have been shown to have health benefits including lowering blood pressure (Hobbs et al, 2012), improving endothelial function and inhibiting platelet aggregation in healthy humans (Lidder \& Webb, 2013).
- Trial name
- REBOC (NCT03068962)
- Testing
- beetroot Juice, Buxton water, antiseptic mouthwash then beetroot juice
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Reading
Sleep Apnea Syndromes
Sleep Apnea and Oxidative Stress and Nitric Oxide
Background: Previous studies present contradictory data concerning obstructive sleep apnea syndrome (OSAS), lipid oxidation and nitric oxide (NO) bioavailability.
- Trial name
- NCT00547937
- Testing
- nasal continuous positive airway pressure (CPAP) therapy
- Where
- Spain
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Blood Pressure
Effects of Dietary Nitrate and Vitamin C Co-supplementation on Blood Pressure and Endothelial Function in Overweight Individuals
The investigators have shown in two short-term studies in healthy, young participants that the combined supplementation of inorganic nitrate with vitamin C has beneficial effects on blood pressure and blood vessel wall stiffness.
- Trial name
- NCT07242066
- Testing
- Beetroot juice plus vitamin C tablet
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy Volunteers, Nitric Oxide
Evaluation of Adding Nitrate Into Foods for Regulating Nitric Oxide Bioavailability in Healthy Individuals
Inorganic nitrate, found in leafy green vegetables and beetroot, can help lower blood pressure and support heart health. Early experimental work has suggested that dietary nitrate supplementation, in the form of beetroot juice or…
- Conditions
- Healthy Volunteers, Nitric Oxide, Vascular Function
- Trial name
- NCT07172425
- Testing
- Inorganic potassium nitrate-fortified biscuits supplementation, Inorganic potassium nitrate-fortified cereal bar supplementation, Inorganic potassium nitrate-fortified porridge supplementation
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London