Clinical trials: Nitrous Oxide
Complex Regional Pain Syndrome
Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome
Patients will then be randomized via a web-based randomization system Redcap Allocation will be stratified based on the presence of a pre-existing spinal cord stimulator to either the nitrous oxide study group or the oxygen…
- Trial name
- NCT03879538
- Testing
- Nitrous Oxide, Oxygen
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- The Cleveland Clinic
Oral Lichen Planus, Oral Cancer
Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions
investigating the level of malondialdehyde (MDA) \& nitric oxide (NO) in saliva in oral premalignant and malignant lesions in order to determine their diagnostic value for the malignant and potentially malignant lesions.
- Conditions
- Oral Lichen Planus, Oral Cancer, Leukoplakia, Oral Keratoses
- Trial name
- NCT04267419
- Testing
- salivary biomarker
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Burns, Pain, Acute
A Pilot Trial of Disposable Nitrous Oxide Canisters in Providing Pain Control During Burn Dressing Changes
Improvements in burn care have resulted in increased survival. Despite these improved outcomes one of the leading challenges of burn care remains providing adequate analgesia during routine wound care and dressing changes.
- Trial name
- NCT03695887
- Testing
- Nitrous Oxide Inhalant Product
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Prospective Study , Questionaires, Outcomes
Prospective Study To Assess The Outcomes Of Nitrous Oxide Cryoablation For Treatment Of Duodenal Adenomas In Patients With Hereditary Conditions Such As FAP, HNPCC
To learn how well nitrous oxide cryoballoon ablation, a procedure that uses extreme cold to destroy abnormal tissue, works in treating flat duodenal adenomas (abnormal growths in the small intestine) in people with FAP or Lynch…
- Conditions
- Prospective Study , Questionaires, Outcomes, Nitrous Oxide, Cryoablation
- Trial name
- NCT07859514
- Testing
- Esophagogastroduodenoscopy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Sickle Cell Disease
Prevalence of Problematic Use of Equimolar Mixture of Oxygen and Nitrous Oxide and Analgesics in the Sickle-cell Disease
The use of analgesics can lead to cases of drug abuse and dependence. It can also cause pseudo-addiction in patients suffering from pain.
- Trial name
- PHEDRE (NCT02580565)
- Testing
- telephone interview
- Where
- France
- Volunteers
- 1,004 people
- Sponsor
- Nantes University Hospital
Dental Carie; Orthodontics
Adverse Event Risk Assessment in the Use of Nitrous Oxide for Pediatric Dental Patients
The objective was to assess adverse event risk in the use of Nitrous Oxide for Pediatric Dental Patients. The investigators performed a multicenter observational study.
- Trial name
- NCT02909816
- Where
- France
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intoxication by Drug
Concentrations of Nitrous Oxide in Blood, Exhaled Air and Urine After Various Types of Exposure.
The study examines the concentrations of nitrous oxide that are achieved in blood, exhaled air, and urine after three different exposures to nitrous oxide: inhalation of three or four cartridges of nitrous oxide released in a car…
- Trial name
- NCT07690358
- Testing
- Nitrous Oxide 99 %, Nitrous Oxide + Oxygen Gas
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Anesthesia, Delirium, Dementia, Amnestic, Cognitive Disorders
International Substudy Enigma2 on Postoperative Cognitive Disorders
The study is a substudy of the Enigma2 trial (NCT00430989) which aims at investigating the effectiveness and safety of nitrous oxide (N2O) in anaesthesia.The substudy focus is on postoperative cognitive disorders.
- Trial name
- ISEP (NCT02489097)
- Testing
- Nitrous Oxide
- Where
- 2 sites in China, Switzerland
- Volunteers
- 140 people
- Sponsor
- University Hospital, Geneva
Global Warming Effect of Nitrous Oxide
Global Warming Impact of Nitrous Oxide
Environmental hazards of human activity are a topic of present day world, global warming being one of the leading concerns. Gases that contribute to this are greenhouse gases.
- Trial name
- NCT05430750
- Testing
- Nitrous oxide, Sevoflurane
- Where
- India
- Volunteers
- 102 people
- Sponsor
- Sir Ganga Ram Hospital
Cerebral Palsy
Conscious Sedation With Nitrous Oxide in Control of Stress During Dental Care for Individuals With Cerebral Palsy
Cerebral Palsy induces oral alterations that impact on oral health, requiring dental treatment. The objective of this study was to evaluate the use of conscious sedation with nitrous oxide (N2O) in the control of stress during…
- Trial name
- NCT02322983
- Testing
- Control of Stress
- Where
- Brazil
- Volunteers
- 77 people
- Sponsor
- Universidade Cruzeiro do Sul
Lacerations, Abscess
Effectiveness of Nitrous Oxide in the ED
This will be a randomized control trial. All patients for whom an emergency provider determines that abscess drainage or laceration repair are necessary will be considered for enrollment.
- Trial name
- NCT02703233
- Testing
- Nitrous Oxide, Oxygen
- Volunteers
- healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Injection Site Vesicles
The Interest of the Nitrous Oxide During Intravesical Injection of Botulinum Toxin A
Second line treatment for detrusor hyperreflexia is the intravesical BTX-A injections. First 300 units Botox are diluted with 30 ml of preservative-free saline.
- Trial name
- PROTOTOX (NCT00948103)
- Testing
- Nitrous Oxide, Oxygen
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Opioid-Related Disorders, Substance-Related Disorders
Subjective Effects of Nitrous Oxide in Dental Patients - 17
The purpose of this study was to characterize mood changes during nitrous oxide inhalation in patients with different levels of preoperative dental anxiety.
- Trial name
- NCT00000265
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Nitrous Oxide Poisoning
Effects of Low Concentrations of Nitrous Oxide
The aim of the study is to test the effects of low concentrations of nitrous oxide on cognitive functions and reaction time in human.
- Trial name
- NCT04050267
- Testing
- Nitrous Oxide
- Where
- Czechia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Lumbar Puncture
Impact of 50% Nitrous Oxide Inhalation on Pain and Anxiety Induced by Lumbar Puncture: a Double-blind Randomized Controlled Trial
This study is designed to evaluate the analgesic effect of nitrous oxide (N2O) on the pain induced during lumbar puncture.
- Trial name
- NCT02243826
- Testing
- 50:50 mixture of nitrous oxide/oxygen
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Clermont-Ferrand
Leukemia, Non Hodgkin Lymphoma
Evaluation of the Analgesy With Emla and/or Nitrous Oxide in Pediatric Patients for Lumbar Puncture
In this randomised controlled study the investigators intended to compare the analgesic effects of EMLA and\or nitrous oxide in children submitted to lumbar puncture.
- Trial name
- NCT00808171
- Testing
- Livopan, EMLA
- Where
- Brazil
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Contraception, Inhalation of Nitrous Oxide
Nitrous Oxide for Pain Management During In-office Transcervical Sterilization
This is a randomized, double blind study that aims to measure the difference in maximum pain experienced during in-office transcervical sterilization (Essure®) for women receiving either inhaled nitrous oxide or standard oral…
- Trial name
- NEST (NCT02312739)
- Testing
- In-office Transcervical Sterilization (Essure®), Standard Oral pain medications, Intramuscular Ketorolac
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Mild to Moderate Dehydration
Nitrous Oxide for Analgesia During Nasogastric Tube Placement in Young Children
Since nitrous oxide/oxygen mixture is effective to reduce pain and anxiety induced by various painful procedures in children, the investigators hypothesized that its inhalation would reduce pain during nasogastric tube placement…
- Trial name
- SONGER (NCT04008628)
- Testing
- Nitrous Oxide
- Where
- 4 sites in France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alcohol-Related Disorders, Opioid-Related Disorders
Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide - 13
The purpose of this study is to evaluate the effects of alcohol history on the subjective and reinforcing effects of sevoflurane and nitrous oxide in healthy volunteers.
- Conditions
- Alcohol-Related Disorders, Opioid-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00000261
- Testing
- 30% Nitrous oxide, 0.2% sevoflurane, 0.4% sevoflurane
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Chicago
Low Back Pain, Radiating Pain
Effect of Nitrous Oxide in Treating Neuropathic Pain: A Study in Chronic Low Back Pain Patients
Epidural injection will be completed under fluoroscopy and all patients will receive 1-4 mg of Midazolam for relaxation before procedure and, if needed, 50-100 mcg of Fentanyl intravenous (IV).
- Trial name
- NCT01172600
- Testing
- Entonox, Oxygen
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- The Cleveland Clinic