Clinical trials: No Condition, Assessment of Healthy Volunteers
no Condition
Ascending Dose Tolerability Trial and PK Assessment in Healthy Volunteers After Single & Multiple Oral Intake of DF2755A
Primary objective: •To evaluate the tolerability and safety of ascending single doses of DF2755A in healthy adult male and female volunteers.
- Trial name
- NCT04803396
- Testing
- DF2755A
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Dompé Farmaceutici S.p.A
Gaucher Disease
Taste Evaluation of Different Liquid Formulations With Eliglustat
Primary Objective: The purpose of this study is to assess the palatability of eliglustat prototype liquid formulations in healthy subjects.
- Trial name
- NCT02422654
- Testing
- eliglustat
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Genzyme, a Sanofi Company
Healthy Volunteer
Assess Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban in Healthy Adult Participants
The primary objective of the study is to determine whether aspirin alone or aspirin combined with various doses of rivaroxaban causes subclinical GI blood loss as determined by the HemoQuant assay.
- Trial name
- NCT05546957
- Testing
- Aspirin, rivaroxaban low dose, rivaroxaban high dose
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Healthy
Nitrite Infusion in Healthy Volunteers
This study will determine the dose of sodium nitrite that can safely be used to prevent constriction, or tightening, of the arteries. Narrowed arteries in the brain can cause stroke.
- Trial name
- NCT00103025
- Testing
- Sodium Nitrite, Sodium Nitrite Injection
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy Volunteers (no Disease Condition Under Study)
A Phase 1, First-in-Human Trial of BLN-481in Healthy Adult Participants
This Phase 1 first-in-human study will evaluate BLN-481 in healthy adults. Participants will receive BLN-481 or placebo. Part 1 evaluates single ascending intravenous (IV) doses (SAD) and optional subcutaneous (SC) doses.
- Trial name
- NCT07903064
- Testing
- BLN-481
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Beeline Medicines Corporation
No Condition. Assessment of Healthy Volunteers.
The Pharmacokinetics and Potential Health Effects of Champagne Wine in Human Subjects
To assess whether acute, moderate Champagne wine consumption modulates endothelial function in healthy human volunteers. To establish the bioavailability of Champagne wine polyphenols and their metabolism.
- Trial name
- NCT00937313
- Testing
- Champagne wine intervention
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Reading
No Condition, Assessment of Healthy Volunteers
Usefulness of Intraosseous Anesthesia for Permanent Tooth Extraction Under GA in Pediatric Dental Treatment
The investigators are doing a study to see if a new way of giving local anesthesia during dental surgery can help children feel better after having a tooth removed under general anesthesia (when they are fully asleep).
- Trial name
- NCT07108439
- Testing
- Administration of intra-osseous local anesthesia before the extraction of a first permanent molar under general anesthesia
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Cytomegalovirus Infection, Healthy, no Evidence of Disease
Vaccine Therapy in Healthy Volunteers With or Without Previous Exposure to Cytomegalovirus
This phase I trial studies the side effects and the best dose of vaccine therapy in healthy volunteers with or without previous exposure to cytomegalovirus.
- Trial name
- NCT01941056
- Testing
- multi-CMV epitope modified vaccinia Ankara vaccine, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Colorectal Cancer, Healthy, no Evidence of Disease
Genetic Epidemiology Risk Assessment Program or Usual Care in Colorectal Cancer Screening for Healthy Participants
RATIONALE: The Genetic Epidemiology and Risk Assessment program may be more effective than usual care in increasing the number of healthy participants who regularly receive screening for colorectal cancer.
- Trial name
- NCT00478309
- Testing
- counseling intervention, educational intervention
- Where
- United States
- Volunteers
- 697 people, healthy volunteers welcome
- Sponsor
- Fox Chase Cancer Center
Healthy
Evaluate the Migration Potential of Xeomin® Compared to Two Other Botulinum Toxin Type A Products
Xeomin® is a Botulinum neurotoxin type A preparation free of complexing proteins, i.e. free of bacterial proteins other than the active toxin. Injected into the muscle, Xeomin® causes local weakening.
- Trial name
- NCT00515944
- Testing
- Botulinum neurotoxin type A, free of complexing proteins
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Merz Pharmaceuticals GmbH
No Disease, Mitochondria Health
Kaempferol Absorption and Pharmacokinetics Evaluation
This study is a multi-site clinical trial designed to evaluate how the body absorbs and processes Kaempferol, a naturally occurring compound found in many plant-based foods.
- Conditions
- No Disease, Mitochondria Health, Longevity, Pharmacokinetics and Biological Absorption of Kaempferol in Healthy Adult
- Trial name
- KAPE (NCT07322406)
- Testing
- Kaempferol
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy, Physiology
Assessment of the Changes in Cortical and Medullary Renal Blood Flow During Exercise in Healthy Subjects Using Contrast Enhanced Ultrasound
Renal parenchymal blood flow can be divided in cortical and medullary blood flow. Changes and factors affecting renal medullary blood flow have not been studied in detail previously as investigators/doctors did not have tools to…
- Trial name
- NCT02672722
- Testing
- Definity, Exercise, Kidney Ultrasound
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Virginia
No Condition, Assessment of Healthy Volunteers
Immunometabolism of Exercise
This study aims to examine the effects of acute aerobic exercise and cardiorespiratory fitness on cellular metabolism of CD8+ T cells and regulatory T cells (Tregs) found in the peripheral blood of humans.
- Trial name
- IMEX (NCT07188389)
- Testing
- Acute exercise-moderate intensity, Acute effects-heavy intensity
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Houston
Role of the Noradrenergic System in the Regulation of Learning Dynamics, No Disease or Condition is Being Studied
Role of the Noradrenergic System in the Regulation of Learning Dynamics: Evaluation of the Effect of a Low-dose Selective Noradrenaline Reuptake Inhibitor (NOISYXETINE)
Administration of low-dose selective noradrenaline reuptake inhibitor (sNRI) (e.g. atomoxetine) to healthy subjects is a validated model of increasing cortical noradrenaline levels which, combined with computational modelling of…
- Trial name
- NOISYXETINE (NCT07239791)
- Testing
- Atomoxetine
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne