Clinical trials: Nocebo Effect
Asthma
The Effect of Odors on Asthma Symptoms
An extended replication of Jaen \& Dalton (2014), the investigators aim to investigate the role of odors and associated trigger beliefs on symptom perception and airway inflammation in individuals with asthma
- Trial name
- NCT02624362
- Testing
- Therapeutic Suggestion, Asthmogenic Suggestion, Phenylethyl Alcohol odor
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pain
Neuromodulation of Lidocaine and Capsaicin Cream Effects on Pain Experience
The aim of this study is to use a brain stimulation tool called transcranial direct current stimulation (tDCS) to investigate the analgesic (reducing sensitivity to pain) effects of lidocaine cream and the hyperalgesic…
- Trial name
- NCT03102710
- Testing
- transcranial direct current stimulation (tDCS), Lidocaine cream, Capsaicin cream
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Communication Skills, Dental Care
Importance of the Type of Communication Used During Paraapical Anesthesia in Dentistry
Can we improve our communication to provide better care for our patients? In the healthcare field, the patient's experience is closely linked to pain management.
- Conditions
- Communication Skills, Dental Care, Hypnosis
- Trial name
- CADA (NCT06892184)
- Testing
- hypnotic communication, conventional communication
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Lower Back Pain, Healthy Control Subjects
Psychobiological Mechanisms of Placebo and Nocebo Effects in the Treatment of Chronic Back Pain
Placebo and nocebo responses have mainly been studied in healthy humans for pharmacological rather than psychological interventions.
- Trial name
- NCT02157389
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Side-Effect, Heart Failure
pErsonalised Nocebo Assessment of Beta-blockEr Symptoms in Heart Failure
Beta-blocker tablets are an effective treatment for heart failure that make people live longer and reduce the need to be admitted to hospital.
- Trial name
- ENABLE-HF (NCT07029906)
- Testing
- Bisoprolol 2.5 mg
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Imperial College London
Back Pain
Influence of Verbal Suggestion on the Therapeutic Effect of the Joint Manipulation
The aim of the study is to evaluate the influence of verbal suggestion on the therapeutic effect of the joint manipulation of the lumbar spine in patients with chronic non-specific low back pain in relation to the pain level…
- Trial name
- NCT06537739
- Testing
- Lumbar manipulation, Negative communication - nocebo, Neutral communication
- Where
- Poland
- Volunteers
- 64 people
- Sponsor
- John Paul II University in Biała Podlaska
Healthy Participants
The Influence of Doctor-patient Communication on Treatment Expectation, Placebo and Nocebo Response
The purpose of this study is to determine whether a patient-centered compared to doctor-centered communication style of a physician influences the treatment expectation and the placebo and nocebo response in healthy individuals.
- Trial name
- SENSE (NCT03949816)
- Testing
- medical consultation: different doctor-patient-centered style of communication, information letter / no medical consultation
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Communication, Chronic Pain
Physiotherapists' Placebo or Nocebo Communication Regarding VR in CMP
Rationale: Chronic musculoskeletal pain (CMP) is a common and disabling condition. Physiotherapy is the most frequently administered non-pharmacological treatment option for patients with CMP and recently virtual reality (VR) was…
- Trial name
- NCT06282757
- Testing
- Video nocebo communication
- Where
- Netherlands
- Volunteers
- 115 people
- Sponsor
- HAN University of Applied Sciences
Communication
Physiotherapists' Placebo or Nocebo Communication Regarding VR
Rationale: Chronic musculoskeletal pain (CMP) is a common and disabling condition. Physiotherapy is the most frequently administered nonpharmacological treatment option for patients with CMP and recently virtual reality (VR) was…
- Trial name
- NCT06307912
- Testing
- Video nocebo communication
- Where
- Netherlands
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- HAN University of Applied Sciences
Consent Forms, Osteoarthritis, Knee
Development, Piloting and Evaluation of an Evidence-based Informed Consent Form for Total Knee Arthroplasty
Every medical intervention requires informed consent. Informed consent may include comprehensible information about the necessity and kind of the intervention, material risks and consequences or alternative treatments.
- Conditions
- Consent Forms, Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
- Trial name
- EvAb-Pilot (NCT04669483)
- Testing
- evidence-based informed consent form
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- University of Witten/Herdecke
Attention Deficit Disorder, Attention Deficit Disorder (ADD)
The Primary Objective of This Study is to Determine Whether Positively Framed Information (PFI) on Side Effects, Compared to Negatively Framed and Extensive Information (NFI) Can Reduce the Number and Severity of Reported Adverse Events Caused by ADHD Medication in Children Aged 7 to 17 Years.
The goal of this randomized controlled care evaluation is to determine whether positively framed and concise information (PFI), compared to negatively framed and extensive information (NFI) about adverse events can reduce the…
- Conditions
- Attention Deficit Disorder, Attention Deficit Disorder (ADD), Attention Deficit Disorder with Hyperactivity, ADHD
- Trial name
- NOVA (NCT06797570)
- Testing
- Communication Strategy for Side Effect Counseling in ADHD Treatment
- Volunteers
- 130 people
- Sponsor
- St. Antonius Hospital
Nocebo Effect, Kinesiophobia
Effect of Anticipated Pain on Corticospinal Excitability
The purpose of this study is to investigate how the anticipation of pain, in the absence of real pain, affects the excitability of the corticospinal pathway.
- Trial name
- PACE (NCT07407595)
- Testing
- Pain Expectation Manipulation
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universite du Littoral Cote d'Opale
Placebo Effect, Nocebo Effect
Neurophysiological Mechanisms of Placebo and Nocebo Effects in Sports - a Protocol Paper
This clinical trial aims to investigate the neurophysiological mechanisms of placebo and nocebo effects on sports performance, using Electroencephalography (EEG) and isometric strength testing of the lower extremities.
- Trial name
- NCT06835777
- Testing
- Positive Expectation, Negative Expectation, Control
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Canterbury Christ Church University
Migraine, Nocebo Effects
Default Mode Network Connectivity and Nocebo Responses in Migraine: A Functional MRI Study
People with migraine sometimes experience symptoms because they expect a treatment to cause side effects. This is known as the "nocebo effect".
- Trial name
- Does not exist (NCT07720895)
- Testing
- intravenous saline infusion, Negative verbal suggestion, No intervention
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Ioanna Spanou
Obstructive Sleep Apnea
Nocebo Effect in OSA Patients With CPAP Treatment
This study is aimed to evaluate whether the information provided by health care professionals in the visits previous to start with CPAP treatment may influence the number of reported adverse effects and compliance in patients…
- Trial name
- NCT05284045
- Testing
- Detailed information
- Where
- Spain
- Volunteers
- 97 people
- Sponsor
- Hospital Clinic of Barcelona
Breast Cancer, Cognitive Symptoms
Breast Cancer Patients' Cognitive Symptoms After Information About Chemotherapy-Related Cognitive Symptoms
Previous cross-sectional studies have shown that informing cancer patients about potential chemotherapy-related cognitive symptoms may negatively affect perceived cognitive symptoms and verbal memory performance.
- Conditions
- Breast Cancer, Cognitive Symptoms, Cognitive Decline
- Trial name
- CONTEXT (NCT04813965)
- Testing
- Written information about potential chemotherapy-related cognitive symptoms without self-affirmation, Written information about potential chemotherapy-related cognitive symptoms with self-affirmation
- Volunteers
- 148 people
- Sponsor
- Radboud University Medical Center
ADHD
Nocebo Education to Reduce the Potential Unintended Harms of Mental Health Awareness
This project has two aims. First, the research team will confirm whether providing a mental health awareness workshop poses unintended harms by raising the rate of self-diagnosis (as opposed to a neutral workshop) and causing…
- Trial name
- NCT06638411
- Testing
- ADHD information workshop, ADHD information workshop with nocebo education, Sleep workshop
- Where
- Canada
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Female Breast Cancer
Side Effect Prevention Training (SEPT) for Nocebo Effects in Breast Cancer Patients
The purpose of this study is to evaluate a side effect prevention training (SEPT) that optimizes patients' response expectations before the start of adjuvant endocrine treatment (AET) to prevent nocebo side effects and enhance…
- Trial name
- NCT01741883
- Testing
- Side effect prevention training (SEPT), Attention Control group (ACG)
- Where
- Germany
- Volunteers
- 165 people
- Sponsor
- Philipps University Marburg
Hyperalgesia, Chronic Pain Syndrome
Pain-related Fear as a Facilitator of Nocebo Hyperalgesia
Nocebo hyperalgesia is characterized by adverse pain outcomes, induced by patients' expectations. In the lab, nocebo effects are commonly studied via classical conditioning, a method that employs pairings of neutral…
- Conditions
- Hyperalgesia, Chronic Pain Syndrome, Chronic Pain, Psychogenic, Fear of Pain
- Trial name
- LFS (NCT04197154)
- Testing
- Threat manipulation (control, no threat), Threat manipulation, Conditioning of moderate pain
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Nocebo Effect, Pain Anticipation
Muscular Synergies and Behavioral Adaptations of Gait in Pain Anticipation (SYAMAPP)
The purpose of this study is to determine whether the anticipation of pain influences gait control and psychophysiological responses in healthy individuals.
- Trial name
- SYAMAPP (NCT06929559)
- Testing
- Pain expectation conditioning, Comparator (Control Group), Intervention: Gait
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universite de Picardie Jules Verne