Clinical trials: Nocebo Effects
Pain, Nocebo Effect
Muscle Synergies in Pain and Pain Anticipation
This study investigates how the anticipation of pain affects muscle synergies. One group will be recruited who will first experience actual pain from capsaicin cream and are then presented with a harmless cream deceptively…
- Conditions
- Pain, Nocebo Effect, Pain Anticipation
- Trial name
- NCT07251387
- Testing
- Pain expectation conditioning, Gait assesment
- Where
- 2 sites in Canada, France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universite de Picardie Jules Verne
Orthopedic Surgery
The Impact of a Neutral Formulated and Designed Package Insert on Nocebo-effect.
Background The nocebo effect describes the association between the expectation of negative effects, (e.g. side effects) and the actual occurrence of negative effects.
- Trial name
- NEUPANO (NCT03428035)
- Testing
- Package Insert
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Witten/Herdecke
Pain, Itch
Topographical Distribution of Itch and Pain Receptors
The experiment consists of three experimental sessions conducted on three consecutive days. In all experimental sessions, the participant will fill in a series of questionnaires about how you perceive itch and pain, and about…
- Trial name
- NCT07122973
- Testing
- Histamine, Cowhage, Capsaicin 8% Patch
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Endometriosis, Expectations
The Role of Expectations on Complaints and Well-being After Endometriosis Surgery in Women
Endometriosis is a prevalent disease in women of procreative age. Most endometriosis patients are affected in their daily life by complaints such as chronic pelvic pain, dysmenorrhoea, infertility, or pain during sexual…
- Conditions
- Endometriosis, Expectations, Laparoscopy
- Trial name
- ROXWELL (NCT05019612)
- Testing
- Laparoscopy: A minimal invasive surgery
- Where
- Germany
- Volunteers
- 395 people
- Sponsor
- Helmut Schmidt University
Female Breast Cancer
Expectations and Side Effects of Endocrine Therapy in Women With Breast Cancer
The purpose of this study is to evaluate the role of patients' response expectations for nocebo side effects, quality of life and adherence during adjuvant endocrine treatment (AET).
- Trial name
- NCT02088710
- Testing
- Enhanced information about endocrine therapy
- Where
- Germany
- Volunteers
- 138 people
- Sponsor
- Philipps University Marburg
Communication
Placebo Versus Nocebo: Effects on Pain and Anxiety During Local Anaesthetic Infiltration in Parturient Undergoing Elective Caesarean Delivery
This randomized trial compared placebo and nocebo effect over anaesthetist-patient communication on pain and anxiety score during local anaesthetic (LA) skin infiltration in parturient undergoing caesarean delivery under regional…
- Trial name
- NCT04975659
- Where
- Malaysia
- Volunteers
- 76 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Adverse Effects, Cardiovascular Diseases
Self-Assessment Method for Statin Side-effects Or Nocebo
Front-line clinicians cannot currently test for an individual participant whether symptoms experienced are the pharmacological result of a statin or due to other phenomena.
- Conditions
- Adverse Effects, Cardiovascular Diseases, Hyperlipidemias
- Trial name
- SAMSON (NCT02668016)
- Testing
- Atorvastatin
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Imperial College London
Anesthesia
Poke and a Placebo
To discover if a positive description of the procedure for an epidural can reduce the overall pain score associated with the procedure.
- Trial name
- NCT04497220
- Testing
- Negative Connotation Langauge, Positive Connotation Language
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pain, Hyperalgesia
Reducing Nocebo Effects on Pressure Pain
Nocebo effects are known to adversely affect the experience of various physical symptoms, such as pain and itch. Nocebo effects can be induced by associative learning mechanisms of classical conditioning.
- Trial name
- NCT05284383
- Testing
- Closed-label nocebo conditioning, Closed-label counterconditioning, Open-label counterconditioning
- Where
- Netherlands
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Leiden University
Depressive Symptoms, Expectations
Disentangling Pharmacological and Expectation Effects in Antidepressant Discontinuation
Antidepressant medication is established as an evidence-based, guideline-recommended treatment for Major Depressive Disorders. In the past decades, prescriptions of antidepressant medication have markedly increased, with a…
- Conditions
- Depressive Symptoms, Expectations, Antidepressants
- Trial name
- PHEA (NCT05191277)
- Testing
- Treatment 'discontinuation of antidepressant medication', Treatment 'continuation of antidepressant medication', Expectation 'high'
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Nocebo Effect
Clinical Reporting to Alleviate the Nocebo Effect
Terminology in radiology reports may cause patients harm by anchoring to or justifying a particular diagnosis. This phenomenon is known as the nocebo effect.
- Trial name
- CRANE (NCT06103474)
- Testing
- Lumbar Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Alabama at Birmingham
Chronic Pain Syndrome, Chronic Pain, Psychogenic
Electrophysiological Correlates of Nocebo Effects on Pain
Pain is a nociceptive somatosensory process that can arise as a debilitating and chronic symptom in various diseases or following an injury.
- Conditions
- Chronic Pain Syndrome, Chronic Pain, Psychogenic, Chronic Pain, Hyperalgesia
- Trial name
- NCT04199858
- Testing
- Baseline pain stimulations, Conditioning, Evocation
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Depression
The Nocebo Effect: a Prospective Study of Informed Consent as a Factor in the Prevalence of SSRI's Side Effects
In this study we invetigate the influence of the nocebo effect (as part of obtaining informed consent) on the prevalence of side-effects.
- Trial name
- NCT01200615
- Testing
- Wording of the explenation on side-effects as part of the informed consent.
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Shalvata Mental Health Center
Dyslipidemia
Patient-engaged Development and Testing of Educational Content on Side Effects of Statins
The purpose of this study is to learn about people's experiences and perspectives on side effects of statins and to use this information to develop and test educational content to help people understand statin side effects when…
- Trial name
- NCT07094412
- Testing
- Educational content on statin side effects
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Weill Medical College of Cornell University
Attention Deficit Disorder With Hyperactivity, Placebo Effect
Attention and Pain in Children With and Without Attention Deficit and/or Hyperactivity Disorder
In Quebec, there has been an important increase of Attention Deficit Hyperactivity Disorder (ADHD) diagnosis since 2015. ADHD symptoms, related to behavioural and/or concentration difficulties, are very similar to other disorders…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Placebo Effect, Nocebo Effect, Pain
- Trial name
- ADE (NCT04766580)
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Low Back Pain
Contextual Effects on Inflammatory Biomarkers and Pain Relief After Spinal Joint Manipulation
The goal of this clinical trial is to learn whether contextual effects created by observational learning can change pain relief and inflammation-related biological responses after spinal joint manipulation in adults with chronic…
- Trial name
- CONTEXT-PAIN (NCT07507604)
- Testing
- Observational Learning, Spinal Joint Manipulation
- Where
- 2 sites in Poland
- Volunteers
- 72 people
- Sponsor
- John Paul II University in Biała Podlaska
ITCH
Mechanisms Underlying the Nocibo Effect of Contagious Itch. in Both Histaminergic and Nonhistaminergic Itch
The study consists of one experimental session of approximately 1½ hours. The participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as…
- Trial name
- NCT07255092
- Testing
- Histamine, Cowhage (Mucuna Pruriens)
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
ITCH
Mechanisms Underlying the Placebo Effect in Both Histaminergic and Non-histaminergic Itch
The study consists of one experimental session of approximately 1½ hours. The participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as…
- Trial name
- NCT07247695
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Plantar Fasciitis, Pain
Shock Wave Therapy: Do the External Appearance of the Device Influence Clinical Outcomes?
To check in patients suffering from chronic plantar fasciitis treated with shock wave therapy, if the outward appearance of the device affects clinical outcomes.
- Trial name
- NCT02608723
- Testing
- Standard shock waves device, Austere shock waves device, Sophisticated shock waves device
- Where
- Spain
- Volunteers
- 135 people
- Sponsor
- Asociacion Colaboracion Cochrane Iberoamericana
Low Back Pain, Musculoskeletal Injury
Does Self-efficacy Predict Outcomes Among U.S. Military Academy Cadets During Initial Entry Training?
Background: Lower back injuries are a common occurrence in athletes, sports programs, and in the military (Bengtsson, 2018; Lovalekar, 2021).
- Trial name
- NCT05453110
- Testing
- Deadlift Form Education
- Where
- United States
- Volunteers
- 903 people, healthy volunteers welcome
- Sponsor
- Keller Army Community Hospital