Clinical trials: Nociception
Pain, Postoperative, Nociceptive Pain
Intraoperative Nociception and Postoperative Pain
If the individual patient's pain is assessed and the amount of analgesic needed after surgery is predicted, appropriate injection of pain control and excessive injection of narcotic analgesic can be prevented.
- Conditions
- Pain, Postoperative, Nociceptive Pain, Analgesics
- Trial name
- NCT03761433
- Testing
- SPI group
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Samsung Medical Center
Cesarean Section, Postoperative Pain After Cesarean Section
Nociception Level Index Monitoring During Cesarean Section
This prospective randomized controlled trial evaluated the effect of nociception level (NOL) index-guided intraoperative analgesia on postoperative pain management in patients undergoing elective cesarean section under general…
- Conditions
- Cesarean Section, Postoperative Pain After Cesarean Section, Pain Management
- Trial name
- NOL-CS (NCT07720440)
- Testing
- Nociception Level Index Monitoring, Standard Intraoperative Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istinye University
Median Sternotomy, Pain Management
Effect of Parasternal Plane Block on Intraoperative Nociception
Effective pain control during pediatric cardiac surgery remains a major clinical challenge, particularly in procedures involving median sternotomy, which is associated with intense nociceptive stimulation.
- Trial name
- NCT07354750
- Testing
- Parasternal Plane Block, Group without peripheral nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Intraoperative Neurophysiological Monitoring
Effect of Perioperative Factors on the Analgesia Nociception Index
The Analgesia Nociception Index (ANI) is a new unitless marker derived from Heart Rate Variability spectral analysis, ranging between 0 and 100 and expressing the parasympathetic tone.
- Trial name
- ANIFACT (NCT02305576)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen
No Disease or Condition is Being Studied
ANI-Guided Fentanyl Infusion During Living Donor Liver Resections
Thу goal of this study was to learn whether intraoperative analgesia nociception monitoring (ANI) could be beneficial during intraoperative monitoring for patients undergoing living donor liver resections.
- Trial name
- NCT06619977
- Testing
- Analgesia nociception monitoring (ANI)
- Where
- Ukraine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bogomolets National Medical University
Pain
The Medasense Study
Despite various efforts there is still the need for adequate monitoring of pain and nociception during anesthesia. In a previous protocol the investigators measured pain responses during anesthesia based on single end-points, eg…
- Trial name
- NCT01912118
- Testing
- Propofol, Remifentanil
- Where
- Netherlands
- Volunteers
- 96 people
- Sponsor
- Leiden University Medical Center
Pain, Postoperative, Analgesia
Analgesia Nociception Index (ANI) in Intracranial Surgical Anesthesia
In our study, 75 patients aged 18-80 years, classified as ASA I-II risk groups, who underwent intracranial surgery performed by the Department of Neurosurgery at Trakya University Faculty of Medicine Hospital, were included.
- Conditions
- Pain, Postoperative, Analgesia, Supratentorial Brain Tumor, Infratentorial Neoplasms
- Trial name
- ANI (NCT06752824)
- Testing
- ANALGESIA NOCICEPTION INDEX MONITORING
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Trakya University
Target Controlled Infusion, Intracranial Neoplasm
Comparison of Opioid Consumption During TCI Guided by NOL Index or Standard Care Undergoing Intracranial Tumor Surgery
In this prospective, randomized controlled study, we hypothesized that nociception level index monitoring reduced opioid administration during surgery.
- Conditions
- Target Controlled Infusion, Intracranial Neoplasm, Opioid, Nociceptive Pain
- Trial name
- NOLopioid (NCT05732896)
- Testing
- Nociception Leve Indeks
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Turkish Society of Anesthesiology and Reanimation
Orthopedic Disorder
Pupilometric Evaluation of Patients Under Procedural Sedation With Propofol
Procedural sedation involves the administration of sedative medications that allow patients to tolerate painful procedures. Procedural sedation has been formally recommended by experts from the French Society of Emergency…
- Trial name
- ALGISAP 2023 (NCT05750485)
- Testing
- Pupilometric evaluation
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Gastrointestinal Disorders, Functional
Web-based Management of Pediatric Functional Abdominal Pain
Functional abdominal pain (FAP), a pediatric pain condition without significant organic pathology, is a precursor to chronic pain and high healthcare utilization in young adulthood.
- Trial name
- NCT02327377
- Testing
- Online Cognitive Behavior Therapy, Online Education
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- Vanderbilt University Medical Center
Pain, Procedural
ANI and Remifentanil in Skull Pin Fixation.
Forty patients were enrolled, and all patients used total intravenous anesthesia (remifentanil-propofol based total intravenous analgesia) as anesthesia induction and maintenance.
- Trial name
- NCT05125328
- Testing
- Remifentanil
- Where
- Taiwan
- Volunteers
- 27 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Intellectual Disability
Characterization of Nociception Phenotype in Individuals With Intellectual Disability
Background: People with intellectual disability (ID) often have physical disabilities as well. These physical problems can affect their bones, muscles, nerves, and gastrointestinal tracts. All of these issues can also cause pain.
- Trial name
- NCT05473429
- Testing
- TSA2 Thermosensory Stimulator
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Nociceptive Pain
Nociception and BIS Level Monitoring in COVID-19 Patients in the Intensive Care Unit
Pain (nociception), stress and discomfort are difficult to detect in sedated and intubated patients during mechanical ventilation.
- Trial name
- NEMO (NCT05579106)
- Testing
- Nociception Level Monitor (NOL) by Medasense Biometrics Ltd., Israel, Bispectral index (BIS), Questionnaire perception of the nurse on pain patient
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Leiden University Medical Center
Surgery, Pain
Clinical Validation of Medasense Pain Response Index (PRI)
In our previous study, NCT01631695, we proposed and clinically evaluated the Medasense pain response index, PRI, in anesthetized patients undergoing surgery. Note: the name PRI has been changed to NoL (Nociception Level) Index.
- Trial name
- NCT01762332
- Testing
- Base level of remifentanil effect side concentration: 2ng/ml, Base level of remifentanil effect side concentration: 4ng/ml, chronic beta-blocker treatment
- Where
- Israel
- Volunteers
- 82 people
- Sponsor
- Medasense Biometrics Ltd
Chronic Knee Pain, Obesity, Morbid
Photobiomodulation in Chronic Knee Pain in Patients Who Are in PreRehabilitation for Bariatric Surgery
Chronic pain is a global public health problem, which intensifies even more in the obese population, reaching about 33% of these patients.
- Trial name
- NCT05816798
- Testing
- Photobiomodulation, Standard Physiotherapy Tretament
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- University of Nove de Julho
Postoperative Opioid-related Complications
Monitoring Nociception Using NoL Index to Reduce Opioid-Related Complications in Laparoscopic Abdominal Surgery
This study aims to determine if optimal intraoperative nociception monitoring using the NoL index can reduce postoperative complications related to opioid use in laparoscopic abdominal surgery.
- Trial name
- SIMONE (NCT06437743)
- Testing
- Nociception Level (NoL) Monitor
- Volunteers
- 282 people
- Sponsor
- Investigation Group Anesthesia, Resuscitation, And Perioperative Medicine of Aragon
Immediate Severe Postoperative Pain, Perioperative Hemodynamic
GOAL-Directed ANalgesia (GOALDAN)
The primary purpose of GOALDAN study is to demonstrate the superiority of a targeted perioperative analgesic strategy by the ANI over the usual practice on the incidence of immediate postoperative pain.
- Trial name
- GOALDAN (NCT03618082)
- Testing
- Anesthesic agent guided by ANI (Interventional Group), Administration of the lowest effective concentration of desflurane (Interventional Group)
- Where
- France
- Volunteers
- 380 people
- Sponsor
- University Hospital, Clermont-Ferrand
MeSH C23.300.707.374.875, MeSH E01.370.388.250.520
Comparing Two Nerve Block Methods for Pain Relief in Laparoscopic Hernia Surgery
After inguinal hernia repair, patients having chronic pain approximately 20 percent. If patients don't have postoperatively acute pain, they will tend to have less chronic pain.
- Conditions
- MeSH C23.300.707.374.875, MeSH E01.370.388.250.520, MeSH E03.155.086.711, MeSH C23.550.767.700
- Trial name
- NCT07676123
- Testing
- Anterior Quadratus Lumborum Block, Ilioinguinal-Iliohypogastric Block
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Ankara University
Pain, Acute, Anesthesia
Pupillary Dilation Reflex Assessment for Intraoperative Analgesic Titration.
In this double blinded randomized controlled study, the pupillary dilation reflex is used for as a nociceptive indicator for opioid administration during elective surgery under general anesthesia.
- Trial name
- PUP-AIT (NCT03248908)
- Testing
- Pupillary dilation reflex, Standard of care
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- University Hospital, Antwerp
Analgesia
Correlation Between qNOX and Analgesia Nociception Index (ANI) Values During General Anesthesia
qNOX and ANI are two indexes evaluting the analgesia conduction during general anesthesia. No trials have compared them, so with this trial authors want to explore the correlations between them.
- Trial name
- ANI (NCT06351072)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Padova