Clinical trials: Nociception Monitoring
Nociceptive Pain, Anesthesia
Comparison of the Surgical Pleth Index and the Nociception Level Index in the Pediatric Population
This observational study aims to compare two nociception monitoring methods. The Nociception Level (NOL) index and the Surgical Pleth Index (SPI) in the pediatric population during general anesthesia.
- Conditions
- Nociceptive Pain, Anesthesia, Pediatric Anesthesia, Nociception Monitoring
- Trial name
- NOLvsSPI (NCT07084935)
- Testing
- Connecting all patients to the nociception level index(NOL) and the surgical pleth index (SPI), All patient will receive a tetanic stimuli (60mA, 100hz) of 5 seconds before start of incision
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Cardiac Surgery
Comparison of the Nociception Monitoring Devices During Cardiac Surgery.
The purpose of this study is to compare the values of Surgical Pleth Index (SPI) and Nociception Level Index (NOL) measured simultaneously during cardiac surgery.
- Trial name
- SYDNOS (NCT04712773)
- Testing
- PMD-200 monitor, Surgical Pleth Index monitor
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Kuopio University Hospital
Postoperative Pain, Lumbar Spine Surgery
Postoperative Pain Monitoring With ANI in Lumbar Spine Surgery
This study aims to compare two different pain management methods in patients undergoing elective lumbar spine surgery. Patients are randomly assigned to receive either an ultrasound-guided erector spinae plane block (ESPB) or…
- Trial name
- SPINE-ANI (NCT07455565)
- Testing
- Erector Spinae Plane Block, Intravenous Multimodal Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Akdeniz University Hospital
General Anesthesia
Analgesia Nociception Index Guided Remifentanil Administration During Propofol Anesthesia for Laparoscopic Surgery
The Physiodoloris (MetroDoloris, Lille, France) monitor, CE marqued, uses the ECG signal in order to compute the Analgesia Nociception Index (ANI) which has been shown to measure the relative parasympathetic tone, and hence to…
- Trial name
- AIVOC-ANI (NCT01893723)
- Testing
- ANI guided remifentanil, ANI blind arm
- Where
- 5 sites in Belgium, France
- Volunteers
- 37 people
- Sponsor
- University Hospital, Lille
Bradycardia
ANI Parasympathetic Monitoring in Neurosurgery
Surgery of large cerebellopontine angle (CPA) tumors (>2 x 2 cm diameter), with compression of the pons exposes the patient to inadvertent parasympathetic nerve stimulation (IPNS) leading to bradycardia and asystole.
- Trial name
- ANI (NCT03978819)
- Testing
- ANI
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Association de Developpement de la Neuroanesthesie Reanimation
Patients Undergoing Total Laparoscopic Hysterectomy
Effect of Intraoperative Nociception Control Based on Analgesia Nociception Index (ANI) Monitoring on Stress Response During Total Laparoscopic Hysterectomy
The "Analgesia Nociception Index" (ANI; MetroDoloris Medical Systems, Lille, France), derived from an electrocardiogram (ECG) trace, has been proposed as a noninvasive guide to analgesia.
- Trial name
- NCT04343638
- Testing
- conventional nociception control, ANI monitor guided nociception control
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Yonsei University
Pain Measurement
Intraoperative Nociception Monitoring with Medstorm, Medasense and Anspec-pro During Total Intravenous Anesthesia
The randomized controlled trial study aims to validate a new pain monitor during general anesthesia by comparing the new ANSPEC-PRO monitor (non-CE marked) with already CE-marked pain monitors (Medstorm and Medasense).
- Trial name
- NCT04986163
- Testing
- Non-invasive analgesia monitoring with ANSPEC-PRO monitor and MEDSTORM monitor, Non-invasive analgesia monitoring with ANSPEC-PRO monitor and MEDASENSE monitor, Non-invasive analgesia monitoring with MEDSTORM monitor and MEDASENSE monitor
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- University Hospital, Ghent
End of Life, Pain
Assessment of the Interest of ANI in the Non-communicating Patient in Palliative Care
Comfort evaluation is one of the major challenges in the palliative care setting, particularly when it comes to non-communicative patients.
- Conditions
- End of Life, Pain, Analgesia
- Trial name
- ANI-CARE (NCT05454202)
- Testing
- ANI
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Lille
Pain Relief
Nociception Monitoring During Epidural Analgesia
Introduction and aim: Nociception monitors have been used to assess pain management in anesthetized patients. The investigators set out to evaluate whether Nociception Level (NOL) monitor (PMD-200 monitor with NOL technology …
- Trial name
- NCT06456177
- Testing
- Assessment of nociception in obstetric patients during epidural analgesia
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Postoperative Delirium, Postoperative Agitation
Emergence Agitation in Paediatric Day Care Surgery
Emergence agitation is a significant and persistent challenge in paediatric anaesthesia, especially in children of preschool age.
- Conditions
- Postoperative Delirium, Postoperative Agitation, Anesthesia, Pain Monitoring
- Trial name
- NCT06571890
- Testing
- Narcotrend bispectral index anaesthesia monitor, Mdoloris Anaesthesia Nociception Monitor
- Where
- Denmark
- Volunteers
- 93 people
- Sponsor
- University of Southern Denmark
Anesthesia
Decision Support System for Anesthetists
The balanced anesthesia process contains three main parts: the control of hypnosis, analgesia, and neuromuscular blockade. For the induction phase, the anesthesiologist performs protocols based on prior planning specific to each…
- Trial name
- Serenity (NCT04079036)
- Where
- Brazil
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Pain, Postoperative, Opioid Use
Comparison of Postoperative Nociception Between NOL-guided and Standard Intraoperative Analgesia Based on Fentanyl
Pain is defined as an unpleasant sensory and emotional conscious experience, associated with actual or potential tissue damage. Nociception is the sympathetic response to noxious stimuli during unconsciousness.
- Conditions
- Pain, Postoperative, Opioid Use, Nociceptive Pain, Postoperative Pain
- Trial name
- NOLFentanyl (NCT03858621)
- Testing
- fentanyl NOL guided
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Victor Contreras, MSN
Nociception
Quantitative Consciousness Index Monitoring (qNOX) of Sedation During Endoscopy
Nociception is the encoding and processing of noxious stimulation and is considered an objective indicator for monitoring pain. Currently, a new clinically-applied medical-engineering integrated monitoring device for noxious…
- Trial name
- NCT06777589
- Testing
- Monitoring of anesthesia depth
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Min Su
Prostate Cancer, Pain Management
Effect of Rectus Block Timing on Opioid Use
The aim of this study is to observe the effect of administering local anesthetic to the abdominal wall at the beginning or end of surgery under general anesthesia on opioid consumption during surgery.
- Conditions
- Prostate Cancer, Pain Management, Nociception Level Index(NoL), Nociception Monitoring
- Trial name
- PROSTIMERSBOP (NCT07433140)
- Testing
- Early bilateral rectus sheat block, Late bilateral rectus sheat block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Koc University Hospital
Pain, Postoperative, Analgesia
Analgesia Nociception Index (ANI) in Intracranial Surgical Anesthesia
In our study, 75 patients aged 18-80 years, classified as ASA I-II risk groups, who underwent intracranial surgery performed by the Department of Neurosurgery at Trakya University Faculty of Medicine Hospital, were included.
- Conditions
- Pain, Postoperative, Analgesia, Supratentorial Brain Tumor, Infratentorial Neoplasms
- Trial name
- ANI (NCT06752824)
- Testing
- ANALGESIA NOCICEPTION INDEX MONITORING
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Trakya University
Spine Surgery, Pain After Surgery
Impact of NOL - Nociception Level Index Intraoperative Monitoring on Perioperative Outcomes in Spine Surgery - a Quality Improvement Pilot
The objective of this study is to evaluate the clinical impact of the NOL nociception level index monitoring on intraoperative and post operative patient outcomes and institutional metrics when used to guide intraoperative…
- Conditions
- Spine Surgery, Pain After Surgery, Anesthesia , Analgesia
- Trial name
- NCT07608276
- Testing
- NOL guided intraoperative analgesia
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Medasense Biometrics Ltd
Anesthesia
NoL Index Response to Stimulation in Anesthetized Children
The Nociception Level (NoL) is an index obtained via a non-invasive monitor, that is currently used to assess nociception in anesthetized adults. The NoL index varies from 0 to 100.
- Trial name
- STIMNOL (NCT05233449)
- Testing
- NoL monitor, Stimulation
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Opioid Use, Unspecified, Anesthesia
Impact of Administration of Esmolol on Nociception Level-guided Control of Nociception.
This study aims to evaluate esmolol's perfusion impact during induction and maintenance of general anesthesia, using Nociception-Level-guided control of nociception, in adult patients undergoing laparoscopic and lower abdominal…
- Conditions
- Opioid Use, Unspecified, Anesthesia, Nociceptive Pain
- Trial name
- ESMONOL (NCT06291363)
- Testing
- Esmolol Hydrochloride, Saline
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Analgesia
Nociception Level During Opioid-sparing Anaesthesia Versus Conventional Opioid-based Anaesthesia
The aim of this double blind, randomised controlled non-inferiority trial is to compare the antinociceptive efficiency of an opioid-sparing and a conventional opioid-based anaesthesia protocol with the help of the CEcertificated…
- Trial name
- NOL_Basel (NCT05485480)
- Testing
- conventional opioid-based group, opioid-sparing group
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University Hospital, Basel, Switzerland
Adult Patients Aged 19-64, Scheduled for Elective Arthroscopic Knee Surgery
Effect of Nociception Level Monitoring During Remimazolam-based Total Intravenous Anesthesia on Intraoperative Opioid Requirements and Postoperative Pain
This study aims to investigate whether the use of nociception monitoring during general anesthesia with remimazolam-based total intravenous anesthesia has an effect on intraoperative opioid requirements and postoperative pain.
- Trial name
- NCT05615441
- Testing
- Analgesia Nociception Index monitor, Standard monitoring
- Where
- South Korea
- Volunteers
- 54 people
- Sponsor
- Yonsei University