Clinical trials: Nociception Monitoring
Spine Surgery
Lidocaine Infusion With ANI Monitoring in Spine Surgery.
To evaluate the analgesic effect of intraoperative continuous lidocaine infusion (1.5 mg/kg/h (ideal body weight)) in combination of analgesia nociception index and depth of anesthesia monitors guided anesthetics adjustment on…
- Trial name
- NCT05103215
- Testing
- Lidocaine HCl 2%, Normal saline
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Target Controlled Infusion, Intracranial Neoplasm
Comparison of Opioid Consumption During TCI Guided by NOL Index or Standard Care Undergoing Intracranial Tumor Surgery
In this prospective, randomized controlled study, we hypothesized that nociception level index monitoring reduced opioid administration during surgery.
- Conditions
- Target Controlled Infusion, Intracranial Neoplasm, Opioid, Nociceptive Pain
- Trial name
- NOLopioid (NCT05732896)
- Testing
- Nociception Leve Indeks
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Turkish Society of Anesthesiology and Reanimation
Pain, Anesthesia
Impact of Intraoperative Non-invasive Analgesia Monitoring Using Nociception Level Index on Patient Management
This prospective randomised clinical trial aims to assess the impact of intraoperative nociception monitoring using NOL on anesthetic management during major abdominal surgery.
- Conditions
- Pain, Anesthesia, Perioperative Care
- Trial name
- NCT06804434
- Testing
- Lidocaine Intravenous Infusion, NOL
- Where
- Romania
- Volunteers
- 160 people
- Sponsor
- Osoian Cristiana
Anaesthesia, Anesthesia Depth Monitoring
Monitoring the Depth of Anesthesia and Nociception During the Induction of General Anesthesia in Pediatric Patients
Perioperative assessment of adequate depth of anesthesia and analgesia is currently a recommended part of routine anesthesia practice for all surgical procedures.
- Trial name
- ANIGAPP (NCT07245654)
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Nociceptive Pain, Surgical Procedure, Unspecified
Automatic Remifentanil Administration Guided by ANI During Propofol Anesthesia
Prospective Randomized Monocentric Clinical Trial during propofol anesthesia. The aim of the study is to test whether the use of a medical device designed to automatically administer remifentanil during surgery based on expert…
- Trial name
- ANI-LOOP (NCT03556696)
- Testing
- ANI-REMI-loop, remifentanil pK/pD target administration device, Remifentanil
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Lille
Postoperative Opioid-related Complications
Monitoring Nociception Using NoL Index to Reduce Opioid-Related Complications in Laparoscopic Abdominal Surgery
This study aims to determine if optimal intraoperative nociception monitoring using the NoL index can reduce postoperative complications related to opioid use in laparoscopic abdominal surgery.
- Trial name
- SIMONE (NCT06437743)
- Testing
- Nociception Level (NoL) Monitor
- Volunteers
- 282 people
- Sponsor
- Investigation Group Anesthesia, Resuscitation, And Perioperative Medicine of Aragon
Nociceptive Pain
Nociception and BIS Level Monitoring in COVID-19 Patients in the Intensive Care Unit
Pain (nociception), stress and discomfort are difficult to detect in sedated and intubated patients during mechanical ventilation.
- Trial name
- NEMO (NCT05579106)
- Testing
- Nociception Level Monitor (NOL) by Medasense Biometrics Ltd., Israel, Bispectral index (BIS), Questionnaire perception of the nurse on pain patient
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Leiden University Medical Center
Surgical Stress Response, Inflammation
CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy
This randomized controlled trial evaluates whether intraoperative guidance using the CoreSys monitor reduces the surgical stress response in patients undergoing elective open abdominal hysterectomy.
- Conditions
- Surgical Stress Response, Inflammation, Anesthesia, Perioperative Care
- Trial name
- CORESTRESS (NCT07571473)
- Testing
- propofol, CoreSys Monitor, Remifentanil (Target-Controlled Infusion)
- Where
- Argentina
- Volunteers
- 30 people
- Sponsor
- Hospital Provincial de Rosario
Pain, Postoperative, Analgesia
Prediction of Postoperative Pain by Nociception Monitoring
General anesthesia is a combination of hypnotic drugs and opioid analgesics. Modern general anesthesia aims to treat nociception induced by surgical stimulation while avoiding an overdose of opioid analgesics and reducing…
- Conditions
- Pain, Postoperative, Analgesia, Anesthesia Recovery Period, Opioid Use
- Trial name
- PredictPain (NCT05063227)
- Testing
- Observational: analgesia monitoring indices and changes in heart rate
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Elective Laparoscopic Cholecystectomy
"Impact of NOciception Level (NOL) Index Intraoperative Guidance of REmifentanil Administration on Opioid Consumption and QoR in Ambulatory Patients Undergoing LAparoscopic Cholecystectomy."
Background: Laparoscopic cholecystectomy is a common surgical procedure which constitutes the standard treatment for symptomatic gallbladder disease.
- Trial name
- NORELACs (NCT07810894)
- Testing
- Remifentanil titration based on Nociception Level Monitor, Remifetanil guided by vital parameters and clinical assessment
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Svendborg Hospital
Monitoring, Intraoperative
Effects of IV Administration of Ketamine on the Analgesia Nociception Index (ANI) Measured With the PhysioDoloris
This study evaluates effects of the analgesic ketamine on ANI measurements (Anti Nociceptive Index)
- Trial name
- NCT01717521
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Surgery, Pain
Clinical Validation of Medasense Pain Response Index (PRI)
In our previous study, NCT01631695, we proposed and clinically evaluated the Medasense pain response index, PRI, in anesthetized patients undergoing surgery. Note: the name PRI has been changed to NoL (Nociception Level) Index.
- Trial name
- NCT01762332
- Testing
- Base level of remifentanil effect side concentration: 2ng/ml, Base level of remifentanil effect side concentration: 4ng/ml, chronic beta-blocker treatment
- Where
- Israel
- Volunteers
- 82 people
- Sponsor
- Medasense Biometrics Ltd
Pain Monitoring, Pain Assessment
Intraoperative Analgesia Based on ANI
Osteoarthritis of the knee joint is common and total knee arthroplasty (TKA) is performed in patients with advanced joint degeneration, no response to conservative treatments, severe pain and joint instability.
- Conditions
- Pain Monitoring, Pain Assessment, Opioid Consumption
- Trial name
- NCT06236035
- Testing
- Analgesia nociception index
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Pain, Anesthesia
Analgesia-Nociception Index Guided Intraoperative Remifentanil Administration Versus Standard Practice:Evaluation of Perioperative Opioid Use
This study compares two groups of patients undergoing a gynecological surgey under general anesthesia: one group in which intraoperative analgesia is guided by the Analgesia-nociception index, and another group in which…
- Trial name
- MONIDOL-ANI (NCT03498820)
- Testing
- Analgesia Nociception Index, Remifentanil
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nociception, NOL Index
Nociception Monitoring During Cardiac Surgery
Cardiac surgery is frequently a source of acute or chronic pain. According to the International Association for the Study of Pain (IASP), nociception is defined as "the neural mechanisms of encoding and processing harmful…
- Conditions
- Nociception, NOL Index, Cardiac Surgery
- Trial name
- MoNOLcard (NCT06817005)
- Testing
- Intervention arm
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Depth of Anesthesia, Nociception
Anesthesia Induction Scheme for Painless Gastrointestinal Endoscopy Patients Based on Nociceptive Stimulation Monitoring
Nociception is the encoding and processing of noxious stimulation and is considered an objective indicator for monitoring pain. Currently, a new clinically-applied medical-engineering integrated monitoring device for noxious…
- Conditions
- Depth of Anesthesia, Nociception, Painless Gastrointestinal Endoscopy
- Trial name
- NCT06604156
- Testing
- EEG monitoring
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Min Su
ENT Disease
Analgesia Nociception Index Monitoring in Trigeminal Cardiac Reflex During Nasal Septoplasty
This study aims to evaluate the utility of Analgesia Nociception Index (ANI) monitoring as a predictive and preventive tool for TCR during septoplasty.
- Trial name
- ANI (NCT07435870)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Fayoum University Hospital
Hypovolemia, Somatic Pain
Influence of Variations of Systemic Venous Return on Analgesia Nociception Index (ANI) During General Anaesthesia
The purpose of this study is to determine whether the value of analgesia nociception index (ANI) is influenced by variations of systemic venous return (cardiac preload) under general anaesthesia.
- Trial name
- NCT02193412
- Testing
- noxious stimulus, change in operating table slope: head-down tilt position, change in operating table slope: head-up tilt position
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Pain, Stress
Evaluation Of The Analgesia Nociception Index vs. Surgical Pleth Index Under General And Regional Anaesthesia
There is a lack of sufficient analgesia monitoring apart from surrogate parameters. The analgesia nociception index (ANI) shall be evaluated under general and regional anaesthesia.
- Conditions
- Pain, Stress, Monitoring
- Trial name
- NCT02744573
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Intraoperative Neurophysiological Monitoring
Effect of Perioperative Factors on the Analgesia Nociception Index
The Analgesia Nociception Index (ANI) is a new unitless marker derived from Heart Rate Variability spectral analysis, ranging between 0 and 100 and expressing the parasympathetic tone.
- Trial name
- ANIFACT (NCT02305576)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen