Clinical trials: Nocturnal Hypoglycemia
Type 1 Diabetes
Outpatient Reduction of Nocturnal Hypoglycemia by Using Predictive Algorithms and Pump Suspension in Children
The purpose of this study is to see whether low blood sugar at night can be reduced by using a system that turns off the insulin pump automatically.
- Trial name
- PSO4 (NCT01823341)
- Testing
- Pump suspension algorithm
- Where
- 3 sites in United States, Canada
- Volunteers
- 97 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus, Type 1, Adrenal Insufficiency
Hypoglycaemia (Low Blood Sugar) in Adults With Diabetes and Adrenal Failure
The purpose of this study is to measure how often low blood sugars occur in people who live with both adrenal insufficiency (AI) and diabetes and need to take insulin.
- Conditions
- Diabetes Mellitus, Type 1, Adrenal Insufficiency, Diabetes Mellitus Type 2 - Insulin-Treated
- Trial name
- HYPO-DIAD (NCT05806190)
- Testing
- Continuous Glucose Monitoring
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Imperial College Healthcare NHS Trust
Diabetes Mellitus, Type I
Effect of the Fat Content of the Bedtime Snack on Overnight Hypoglycemia
Low blood sugar at night (called nocturnal hypoglycemia), can often happen without symptoms and can last for a long time. Doctors often suggest that patients take a bedtime snack to try to prevent low blood sugar at night from…
- Trial name
- NCT00493935
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Jaeb Center for Health Research
Diabetes
Comparison of Insulin Glargine and NPH Insulin at Night and at Hypoglycemia in Type 2 Diabetes
Long-acting insulin injected at bedtime may cause hypoglycemia (low blood sugar) in the night in patients with diabetes. The aims of the study are 1) to compare the dynamic characteristics of long-acting insulin analog glargine…
- Trial name
- ClampHOE901 (NCT00468364)
- Testing
- insulin glargine, NPH insulin
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University of Giessen
Hypoglycemia
Effect of Hypoglycemia on Sleep
Growing evidence provided by many observational studies has established a strong link between decreased sleep duration and poor glucoregulation.
- Trial name
- NCT02687893
- Testing
- Aerobic Exercise, Resistance Exercise
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Hypoglycemia, Diabetes Mellitus, Type 1
A Pilot Study of Nocturnal Hypoglycemia Prevention in Type 1 Diabetes Using the Vigilant Diabetes Management Companion
A single center pilot study assessing the Vigilant Diabetes Management Companion for the prevention of recurrent nocturnal hypoglycemia in type I diabetes patients.
- Trial name
- NCT02906891
- Testing
- Vigilant Diabetes Management Application
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- InSpark Technologies, Inc.
Diabetes, Diabetes Mellitus, Type 2
A Trial to Investigate the Impact of Nocturnal Hypoglycaemia on Sleep in Subjects With Type 2 Diabetes
This trial is conducted in Europe. The aim of this trial is to investigate the impact of low blood sugar during the night on sleep in subjects with type 2 diabetes.
- Trial name
- NCT01780272
- Testing
- glucose clamp
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Outpatient Pump Shutoff Pilot Feasibility and Efficacy Study
The purpose of this study is to see whether low blood sugar at night can be reduced by using a system that turns off the insulin pump automatically.
- Trial name
- NCT01591681
- Testing
- Pump suspension
- Where
- 3 sites in United States, Canada
- Volunteers
- 49 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes Mellitus
Impact of Optimized Titration and Delivery of Bedtime Insulin on Prevention of Nocturnal Hypoglycemia
The purpose of this study is to determine whether or not bedtime snacks are necessary to prevent overnight low blood glucose reactions (nocturnal hypoglycemia) in adults with type 1 diabetes who are using intensive insulin…
- Trial name
- NCT00475345
- Testing
- Bedtime snacks
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- McGill University
Diabetes, Hypoglycemia
Investigating the Relationship Between Nocturnal Glucose Levels and Motion During Sleep
In this study the investigators will explore whether the motion during sleep of people with diabetes changes as a function of the blood glucose levels.
- Conditions
- Diabetes, Hypoglycemia, Hyperglycemia
- Trial name
- Moonwalk (NCT05609175)
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- University of Bern
Type 1 Diabetes
An Outpatient Pump Shutoff Pilot Feasibility and Safety Study
The purpose of this study is to evaluate an overnight system that will turn off the insulin pump automatically if the system predicts that a low blood sugar is likely.
- Trial name
- PSO1 (NCT01736930)
- Testing
- Pump suspension
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Jaeb Center for Health Research
Diabetes, Nocturnal Hypoglycemia
Adjusting Insulin Delivery to Activity
Increased daytime activity in children and adolescents with type I diabetes is known to be associated with overnight hypoglycemia.
- Trial name
- AIDA (NCT02299479)
- Testing
- Dexcom G4 Platinum CGM, Activity monitor
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Boston Children's Hospital
Type 1 Diabetes, Hypoglycemia
Late Night Snack and Insulin Glargine
Twenty patient with Type 1 diabetes, using insulin glargine as basal insulin, participated in a prospective, controlled crossover trial comparing blood glucose profiles over two 24 h periods with and without a late night snack (a…
- Trial name
- NCT02871180
- Testing
- Late night snack, No late night snack
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Diabeteszentrum Bad Lauterberg im Harz
Type 1 Diabetes
Comparison of an Artificial Pancreas Versus Threshold Low Glucose Suspend in Type 1 Diabetic Children
The objective of this study is to assess the efficacy of an Artificial Pancreas system which includes a Control-To-Range algorithm, versus standard Insulin Pump Therapy with Threshold Low glucose Suspend feature.
- Trial name
- SHAN (NCT02509429)
- Testing
- Insulin therapy (aspart, lispro ou glulisine) with Control-to-Range algorithm, Insulin therapy ((aspart, lispro ou glulisine) withThreshold Low Glucose Suspend
- Where
- 4 sites in France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes Mellitus With Hypoglycemia
A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes
The goal of this clinical trial is to learn about the effect of the study drug (ZT-01) on low blood sugar (hypoglycemia) in adults with type 1 diabetes (T1D) who have been having low blood sugars ("hypos") at night.
- Trial name
- ZONE (NCT05762107)
- Testing
- ZT-01, 7 mg, ZT-01, 15 mg, ZT-01, 22 mg
- Where
- 46 sites in United States, Canada
- Volunteers
- 186 people
- Sponsor
- Zucara Therapeutics Inc.
Diabetes Mellitus, Type 2
Effect of Insulin Glargine in Insulin Naïve Subjects With Type 2 Diabetes on Oral Hypoglycemic Agent(s)
The primary objective of this study is to compare the percentage of subjects who reach the target HbA1c level (< or = 7.0% at endpoint) and do not experience symptomatic nocturnal hypoglycemia during treatment with insulin…
- Trial name
- NCT00653341
- Testing
- insulin glargine, NPH human insulin
- Where
- 2 sites in United States, Canada
- Volunteers
- 764 people
- Sponsor
- Sanofi
Diabetes Mellitus, Hypoglycemia (Diabetic)
Continuous Bloodsugar Monitoring System With a Sensor Compared to Fingerstick Bloodsugar Monitoring
This clinical trial aims to compare a continuous glucose monitoring system with traditional fingerstick blood glucose monitoring.
- Conditions
- Diabetes Mellitus, Hypoglycemia (Diabetic), Hypoglycemia Night, Hyperglycemia
- Trial name
- GLUCOSENS (NCT06473480)
- Testing
- Abbott FreeStyle Libre System 2 Plus, Abbott Freestyle Libre Pro
- Where
- 2 sites in Denmark
- Volunteers
- 329 people
- Sponsor
- Odense University Hospital
Hypodlycemia
Early Detection of noctUrnal hypoglyCemiA in TypE 2 Diabetes Using Pulse Rate Variability Measured by a Smartwatch(EDUCATED-Smartwatch)
In patients with type 2 diabetes, it is necessary to identify and manage nocturnal hypoglycemia as early as possible, so as to reduce the damage caused by nocturnal hypoglycemia.We explore whether smartwatches can provide early…
- Trial name
- NCT05636007
- Testing
- Huawei Watch
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-sen University
Diabetes Mellitus Type 2
Risk of Nocturnal Hypoglycemia and Arrhythmias With Sitagliptin Versus Glimepiride in Patients With Type 2 Diabetes
This exploratory double blind randomized active controlled study is designed to assess the effects of a treatment with therapeutical dosage of sitagliptin versus therapeutical dosage of glimepiride as add on therapy in patients…
- Trial name
- NCT02373865
- Testing
- Sitagliptin, Glimepiride
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- GWT-TUD GmbH
Nocturnal Hypoglycemia, Type 1 Diabetes
Prevalence of Nocturnal Hypoglycemia in Children on a Type 1 Diabetes (TID) Insulin Regimen Using a Continuous Glucose Monitoring System (CGMS)
This study will help determine the frequency and magnitude of nocturnal hypoglycemia (low blood sugar at night during sleep), in children with type 1 diabetes who are on a standard insulin regimen, by using a Continuous Glucose…
- Trial name
- NCT00542334
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Eastern Ontario