Clinical trials: Noise-Induced Hearing Loss
Hearing Loss, Sensorineural Hearing Loss
Study to Determine the Safety, Tolerability, and Pharmacokinetic Profile of HPN-07 and HPN-07 Plus NAC
This study is a single-center, randomized, placebo-controlled, double-blind, single ascending dose escalation study to determine the safety, tolerability, and PK profile of oral administration of HPN-07 in single doses to…
- Conditions
- Hearing Loss, Sensorineural Hearing Loss, Noise-Induced Hearing Loss
- Trial name
- NCT02259595
- Testing
- HPN-07, NAC
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Otologic Pharmaceutics, Inc.
Tinnitus
The Effect of Gabapentin on the Sensation and Impact of Tinnitus
This study evaluated the effectiveness of gabapentin in treating tinnitus in two populations: Tinnitus with associated acoustic trauma and tinnitus without associated acoustic trauma.
- Trial name
- NCT00257270
- Testing
- gabapentin
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tinnitus Research Consortium
Noise-induced Hearing Loss
Phase 3 Clinical Trial: D-methionine to Reduce Noise-Induced Hearing Loss (NIHL)
This prospective study is a randomized, double-blind, placebo-controlled Phase 3 clinical trial of oral D-methionine (D-met) to reduce noise-induced hearing loss (NIHL) and tinnitus.
- Trial name
- NCT02903355
- Testing
- D-methionine
- Where
- United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Southern Illinois University
Noise-induced Hearing Loss
Prevention of Noise-induced Hearing Loss
Noise-induced hearing loss affects an estimated 5% of the worldwide population, with 30-40 million Americans exposed to hazardous sound or noise levels regularly.
- Trial name
- NCT02049073
- Testing
- Zonisamide, Methylprednisolone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Noise-induced Tinnitus, Noise-induced Hearing Loss
Prevention of Noise-induced Damage by Use of Antioxidants
The current study is a dubble-blinde placebo-controlled cross-over study verifying the preventive effect of antioxidants on noise-induced hearing loss (NIHL) and noise-induced tinnitus (NIT).
- Trial name
- NCT01727492
- Testing
- Antioxidantia
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Hearing Loss, Noise-Induced
Noise Exposure and Near-Infrared Light
The primary objective of this work is to determine the effect noise has on the auditory system (both auditory health and performance) and also the degree to which the effect of pre-noise therapy such as Near Infrared (NIR) light…
- Trial name
- NCT03834714
- Testing
- Near Infrared Light, Noise Stimulus
- Where
- 3 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Miami
Hearing Loss, Noise-Induced
Noise-Induced Hearing Loss-Acute Exposure Treatment
The purpose of this study is to assess the safety and efficacy of zonisamide for the treatment of noise-induced hearing loss in adults.
- Trial name
- PINIHL-AET (NCT04768569)
- Testing
- Zonisamide 100Mg Cap
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Hearing Loss, Noise-Induced
Risk Factors for Hearing Loss as a Result of Exposure to Noise During Military Training in the IDF
As part of the proposed work, the investigators would like to examine whether there is a need to use a training video to train IDF combat soldiers to improve the use of ear plugs and to prevent hearing loss from exposure to…
- Trial name
- NCT03314116
- Testing
- Guidance on auditory protection
- Where
- Israel
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Noise-Induced Hearing Loss
Micronutrients to Prevent Noise-induced Hearing Loss
Noise-induced hearing loss (NIHL) is a significant clinical, social, and economic issue. Studies in animals have allowed us to identify mechanisms contributing to NIHL, including direct mechanical trauma, free radicals formed in…
- Trial name
- NCT00808470
- Testing
- beta-carotene, vitamins C and E, magnesium
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Hearing Loss, Hearing Loss, Noise-Induced
Understanding the Consequences of Recreational Noise Exposure
The aim of this study is to determine whether measures derived from Magnetic Resonance Imaging (MRI) scans, and clinical and behavioural measures of hearing loss, in the peripheral and central auditory system (ranging from the…
- Trial name
- NCT05076344
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Noise-induced Hearing Loss and Tinnitus
TUNE! Teaching the UK About Noise Exposure: A Pilot Study
In 1986 The Medical Research Council estimated that 4 million UK adolescents were at risk of hearing damage from over-exposure to loud music from personal audio players (PAPs), gigs, clubs, pubs and festivals.
- Trial name
- gildeaf1 (NCT00916305)
- Testing
- Modified Audio video, Unmodified audio video
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Acoustic Trauma
Study of Diagnostic Biomarkers of Acute Acoustic Trauma
Every year, more than two thousand acute acoustic trauma occur in France, equally between the military and the civilian environment.
- Trial name
- BIOTSA (NCT04832230)
- Testing
- Hearing test, Questionnaire about previous noise exposure, Otoacoustic emission measurement
- Where
- 14 sites in France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Hearing Loss
Three-dimensional Perception of Sounds in Military with Acoustic Trauma
Spatial hearing capacities of soldiers with acoustic trauma are evaluated in ENT consultations with routine tests (i.e. tonal audiometry, voice audiometry).
- Trial name
- SPHEAR (NCT05468567)
- Testing
- SPHERE protocol : Spatial hearing performances test, French Matrix Test : audiology test of speech in noise perception, SSQ15 questionnaire of life : (The Speech, Spatial and Other Qualities of Hearing Scale)
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Tinnitus
Incidence of Tinnitus Amongst Teenagers and Young Adults mp3 Users
The aim of this study is to compare the incidence of tinnitus between mp3 users and non-users, aged between 15 and 30 years old. 100 patients will be recruited in Valença secondary schools.
- Trial name
- NCT01187251
- Where
- 2 sites in Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Faculdade de Medicina de Valenca
Hearing Loss, Noise-Induced, Tinnitus, Noise Induced
Improvement of Tinnitus After Oral Zinc on Patients With Noise-induced Hearing Loss
Twenty patients with tinnitus and a typical noise-induced hearing loss (NIHL) audiogram were included. Each subject underwent an otoscopic examination, distortion product otoacoustic emissions, tinnitus-match testing, Tinnitus…
- Conditions
- Hearing Loss, Noise-Induced, Tinnitus, Noise Induced, Zinc Deficiency
- Trial name
- NCT02951715
- Testing
- zinc gluconate
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Noise Induced Hearing Loss
A Phase 2b Study of SPI-1005 to Prevent Acute Noise Induced Hearing Loss
SPI-1005 is a novel oral drug that contains a glutathione peroxidase mimetic (ebselen) that will be tested in subjects with a history of NIHL at risk for additional NIHL.
- Trial name
- PANIHL (NCT02779192)
- Testing
- SPI-1005 200mg, SPI-1005 400mg
- Where
- 5 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sound Pharmaceuticals, Incorporated
Hearing Loss, Noise-Induced
Hearing Loss Prevention for Veterans
Hearing loss is the most prevalent service-connected disability in the VA. It causes communication difficulties, which contribute to isolation, frustration and depression.
- Trial name
- HLPP (NCT01038336)
- Testing
- Multimedia Hearing Loss Prevention Program, Hearing Conservation Brochure
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Hearing Loss, Sensorineural
Early Detection of Noise-Induced Hearing Loss
This study measures sounds produced by the sensory receptors of the inner ear called hair cells. These sounds are called otoacoustic emissions and one special case the investigators are studying are called distortion product…
- Trial name
- NCT01022710
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Hearing Loss
Antioxidation Medication for Noise-induced Hearing Loss
This study will examine whether oral intake of 1200mg N-Acetylcysteine/day will prevent temporary threshold shift in hearing among workers exposed to noise
- Trial name
- NCT00552786
- Testing
- N-acetylcysteine (NAC), glucose
- Where
- Taiwan
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Noise Exposure, Noise-induced Hearing Loss
Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss
The goal of this interventional clinical study is to investigate the use of mild therapeutic hypothermia devices for preservation of sensory structures in the cochlea after noise exposure. The main aims of the study are: 1.
- Conditions
- Noise Exposure, Noise-induced Hearing Loss, Noise; Adverse Effect, Mild Therapeutic Hypothermia
- Trial name
- NCT06729632
- Testing
- Cold pack-delivered mild therapeutic hypothermia
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Restorear Devices LLC