Clinical trials: Non Cystic Fibrosis Bronchiectasis
Non-cystic Fibrosis Bronchiectasis, Pseudomonas Aeruginosa
Study to Evaluate the Safety, Phage Kinetics, and Efficacy of Inhaled AP-PA02 in Subjects With Non-Cystic Fibrosis Bronchiectasis and Chronic Pulmonary Pseudomonas Aeruginosa Infection
A phase 2, multi-center, double-blind, randomized, placebo-controlled study to evaluate the safety, phage kinetics, and efficacy of inhaled AP-PA02 administered in subjects with non-cystic fibrosis bronchiectasis and chronic…
- Conditions
- Non-cystic Fibrosis Bronchiectasis, Pseudomonas Aeruginosa, Lung Infection
- Trial name
- Tailwind (NCT05616221)
- Testing
- AP-PA02
- Where
- 23 sites in United States
- Volunteers
- 48 people
- Sponsor
- Armata Pharmaceuticals, Inc.
Adolescent Asthma
Study of RSS0343 Tablets in Patients With Non-cystic Fibrosis Bronchiectasis
Studies to evaluate the safety, tolerability, pharmacodynamics, and efficacy of RSS0343 tablets in patients with non-cystic fibrosis bronchiectasis
- Trial name
- NCT06775340
- Testing
- RSS0343 Tabella
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Non-cystic Fibrosis Bronchiectasis
A Translational Study for Phenotyping and Endotyping Chinese Patients With NCFBE
Non-cystic fibrosis bronchiectasis (NCFBE) is a chronic respiratory disease characterized by a clinical syndrome of chronic productive cough and recurrent respiratory infections in the presence of abnormal and permanent dilation…
- Trial name
- NCT07245407
- Testing
- Participant Follow-up
- Where
- 38 sites in China
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Non-cystic Fibrosis Bronchiectasis
A Study to Access Activity and Safety With SAR445399 Compared With Placebo in Participants Aged 18 to 80 Years of Age With Non-Cystic Fibrosis Bronchiectasis
This is a randomized, double-blind, placebo-controlled study to measure the reduction in mucus plug score at 24 weeks of treatment with SAR445399 compared with placebo in adult participants aged 18 to 80 years with non-cystic…
- Trial name
- NCT07547436
- Testing
- SAR445399
- Where
- 4 sites in United States
- Volunteers
- 70 people
- Sponsor
- Sanofi
Bronchiectasis Adult, Yoga
Effects of an Online Yoga Program on Exercise Capacity and Quality of Life in Bronchiectasis Patients
Bronchiectasis is a chronic lung disease characterized by persistent cough, sputum production, shortness of breath, and recurrent infections, which can reduce physical capacity and quality of life.
- Trial name
- YOGA-BR (NCT07540936)
- Testing
- Yoga Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Istanbul Medipol University Hospital
Chronic Suppurative Lung Disease, Protracted Bacterial Bronchitis
Digital Physiotherapy for Pediatric Chronic Suppurative Lung Diseases
This is a prospective, single-center, two-arm (1:1), assessor-blinded, randomized controlled clinical trial that will be conducted in collaboration with the outpatient clinic of the third Pediatric Pulmonology Unit, "Attikon"…
- Conditions
- Chronic Suppurative Lung Disease, Protracted Bacterial Bronchitis, Primary Ciliary Dyskinesia (PCD), Non Cystic Fibrosis Bronchiectasis
- Trial name
- NCT07376187
- Testing
- Videoconferencing (Vsee platform), Specially designed website (FysΑΩ)
- Where
- Greece
- Volunteers
- 32 people
- Sponsor
- University of Thessaly
Bronchiectasis
Role of Innate Immunity in Non-Cystic Fibrosis Bronchiectasis
The purpose of this study is to demonstrate that 1) the secretion of mucins, antimicrobial peptides and Toll-like receptors is altered in certain patients with non-CF bronchiectasis, which makes them more susceptible to be…
- Trial name
- NCT02163642
- Testing
- Cyranose® 320
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Non-CF Bronchiectasis
Inhaled Nebulized Tobramycin in Non-cystic Fibrosis Bronchiectasis
The purpose of this study is to evaluate the effect of tobramycin inhalation solution (TIS) once daily compared tot placebo in patients with non-CF bronchiectasis.
- Trial name
- BATTLE (NCT02657473)
- Testing
- tobramycin inhalation solution, Saline 0.9% inhalation solution
- Where
- 6 sites in Netherlands
- Volunteers
- 58 people
- Sponsor
- Medical Center Alkmaar
Non-cystic Fibrosis Bronchiectasis
Dose Range Finding, Efficacy, and Safety Study of Nebulized CSL787 in Adults With Non-cystic Fibrosis Bronchiectasis (NCFB)
This study is a proof-of-concept phase 2b, multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose selection study designed to explore the efficacy, safety, and tolerability of 2 active treatment regimens…
- Trial name
- NCT07048262
- Testing
- CSL787, Nebulizer
- Where
- 13 sites in Australia, Japan
- Volunteers
- 180 people
- Sponsor
- CSL Behring
Exacerbation Copd, Bronchiectasis
Efficacy of Roflumilast on Exacerbations in Patients With Non-cystic Fibrosis Bronchiectasis
Roflumilast compare with placebo for decrease infected exacerbation in non-cystic Bronchiectasis
- Conditions
- Exacerbation Copd, Bronchiectasis, Lung Function Decreased
- Trial name
- NCT04122547
- Testing
- Roflumilast
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Prince of Songkla University
Non Cystic Fibrosis Bronchiectasis
HFCWO in Children With Non-CF Bronchiectasis
the study will concentrate on the effect of High Frequency Chest Wall Oscillation compared to conventional pulmonary physiotherapy on children with non cystic fibrosis bronchiectasis
- Trial name
- NCT07722364
- Testing
- High Frequency Chest Wall Oscillation, conventional physiotherapy program directed towards improvement of pulmonary functions and quality of life.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sphinx university
Non-cystic Fibrosis Bronchiectasis
A Clinical Study of RSS0343 in Healthy Subjects
This is a phase I study to evaluate the safety, tolerability and pharmacokinetics of RSS0343 following multiple oral doses in healthy subjects, as well as its effects on the QT/QTc interval.
- Trial name
- NCT07289464
- Testing
- RSS0343 Tablets
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Reistone Biopharma Company Limited
Bronchiectasis, Bronchiectasis Adult
Compare Oral Itraconazole and Standard Care Versus Standard Care Alone in Patients With Non-cystic Fibrosis Related Bronchiectasis With Chronic Aspergillus Infection in Reducing Bronchiectasis Exacerbations
There is an intricate link between bronchiectasis and fungi. Patients with cystic fibrosis frequently manifest fungal sensitization and fungal colonization with Aspergillus fumigatus.6 Aspergillus species also has a…
- Trial name
- BAIT (NCT06160713)
- Testing
- Itraconazole 65 MG, Standard care
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
COPD, Respiratory Tract Infections
Targeted AntiBiotics for Chronic Pulmonary Diseases
This is a prospective, randomized multi-center trial investigating the impact of lower airway infection with P. aeruginosa in COPD patients. The aim of the study is to evaluate if targeted antibiotic therapy against P.
- Conditions
- COPD, Respiratory Tract Infections, Pseudomonas Aeruginosa, Bronchiectasis
- Trial name
- Target-ABC (NCT03262142)
- Testing
- Piperacillin/tazobactam, Ciprofloxacin
- Where
- Denmark
- Volunteers
- 51 people
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Bronchiectasis
The Effect of Theophylline in the Treatment of Bronchiectasis
Theophylline was well recommended in the treatment of chronic obstructive pulmonary disease (COPD) and asthma. However, there is no supporting evidence for their efficacy in the treatment of bronchiectasis.
- Trial name
- NCT01684683
- Testing
- Theophylline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Bronchiectasis, Non-Cystic Fibrosis
Long-Term Safety and Efficacy of Moxifloxacin in Bronchiectasis Patients
Bronchiectasis is a chronic respiratory disease characterized by recurrent infections, inflammation, and progressive lung damage.
- Trial name
- NCT07274020
- Testing
- Intermittent Moxifloxacin + Standard Care, Standard Care (in control arm)
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Assiut University
Severe Asthma, COPD
Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Muco-Obstructive Lung Disease
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with muco-obstructive pulmonary disease.
- Conditions
- Severe Asthma, COPD, Non-CF Bronchiectasis, Cystic Fibrosis (CF)
- Trial name
- NCT06985225
- Testing
- Hyperpolarized 129 Xenon
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Kansas Medical Center
Bronchiectasis
Is Regular Chest Physiotherapy an Effective Treatment in Severe, Non Cystic Fibrosis Bronchiectasis?
Bronchiectasis is a chronic chest condition which causes a persistent cough and frequent chest infections. One of the main forms of treatment is chest physiotherapy.
- Trial name
- NCT00816309
- Testing
- Acapella Physiotherapy
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Lothian
Non Cystic Fibrosis Bronchiectasis
Nutritional Status and Intake in Patients With Non-cystic Fibrosis Bronchiectasis (NCFB)
The aim of this study was to characterise nutritional status and dietary intake in a population of individuals living with bronchiectasis from a regional clinic.
- Trial name
- NCT06877091
- Where
- United Kingdom
- Volunteers
- 129 people
- Sponsor
- University of Leeds