Clinical trials: Non Infectious Uveitis
Uveitis, Posterior, Uveitis, Intermediate
A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis
The objective of this study is to evaluate the safety and efficacy of LX211 as therapy in subjects with clinically quiescent non-infectious uveitis
- Conditions
- Uveitis, Posterior, Uveitis, Intermediate, Panuveitis
- Trial name
- LUMINATE (NCT00404742)
- Testing
- LX211
- Where
- 41 sites in United States, Austria and 5 more
- Volunteers
- 232 people
- Sponsor
- Lux Biosciences, Inc.
Uveitis
Infectious Causes of Uveitis
Uveitis is an inflammatory disease of one or both eyes. Uveitis will in severe cases lead to permanent loss of vision/blindness on the affected eye.
- Trial name
- NCT00676624
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Statens Serum Institut
Uveitis, Cystoid Macular Edema
Pegaptanib Therapy in Non-Infectious Uveitic Cystoid Macular Edema
According to a recent estimate more than 280,000 people in the United States are affected by uveitis each year. This report, also estimated that uveitis is the reason for 30,000 new cases of blindness/year and up to 10 percent of…
- Trial name
- NCT00790803
- Testing
- Pegaptanib
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Wake Forest University
Uveitis, Posterior, Uveitis, Intermediate
Ozurdex Monotherapy Trial
This study will investigate the efficacy and safety of OZURDEX® (dexamethasone intravitreal implants; DEX, Allergan, Inc. Irvine, CA) as monotherapy for the treatment of non-infectious intermediate-, posterior- or panuveitis.
- Conditions
- Uveitis, Posterior, Uveitis, Intermediate, Panuveitis
- Trial name
- OM (NCT05101928)
- Testing
- Ozurdex 0.7mg Ophthalmic Implant, Prednisone
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Non-Infectious Anterior Uveitis
Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis
The purpose of this study is to determine the efficacy, safety, and tolerability of dexamethasone sodium phosphate Visulex (DSP-Visulex) after repeated-dose administration in patients with acute anterior uveitis.
- Trial name
- NCT02309385
- Testing
- 8% Dexamethasone Sodium Phosphate - Visulex, 15% Dexamethasone Sodium Phosphate - Visulex, Prednisolone Acetate (1%) Eye Drops
- Where
- 6 sites in United States
- Volunteers
- 44 people
- Sponsor
- Aciont Inc
Non-Infectious Uveitis of the Posterior Segment of the Eye
A Phase IIIb, Multinational, Multicenter, Open-Label Extension Study Assessing the Long-Term Safety of PRN Intravitreal Injections of DE-109 in Subjects With Non-Infectious Uveitis of the Posterior Segment of the Eye Who Have Participated in the SAKURA Development Program
The objective of this extension study is to evaluate the long-term safety of treatment with DE-109 (440 μg) in subjects with non-infectious uveitis of the posterior segment of the eye who have participated in the SAKURA…
- Trial name
- SPRING (NCT02251938)
- Testing
- DE-109 440 μg
- Where
- 25 sites in United States, Austria and 4 more
- Volunteers
- 60 people
- Sponsor
- Santen Inc.
Non-infectious Intermediate, Posterior and Panuveitis
Post-marketing Surveillance Study of Adalimumab (Humira®) for Non-infectious Intermediate, Posterior, or Panuveitis Patients
The objective of this study is to evaluate the safety and effectiveness of Humira® (Adalimumab) for the treatment of non-infectious intermediate, posterior, or panuveitis patients under a routine treatment practice.
- Trial name
- NCT03339102
- Where
- 17 sites in South Korea
- Volunteers
- 158 people
- Sponsor
- AbbVie
Uveitis, Posterior
Fluocinolone Acetonide Intravitreal Implant 0.18 mg in the Treatment of Chronic Non-Infectious Posterior Segment Uveitis
A study to evaluate the safety and efficacy of YUTIQ® 0.18 mg intravitreal implant for the management of chronic non-infectious posterior segment uveitis (intraocular inflammation) that has responded to previous steroid therapy.
- Trial name
- NCT05322070
- Testing
- Fluocinolone Acetonide Intravitreal Implant 0.18 mg
- Where
- 23 sites in United States
- Volunteers
- 125 people
- Sponsor
- Alimera Sciences
Non-infectious Uveitis
Safety and Efficacy of AIN457 in Noninfectious Uveitis
This study was performed to evaluate the efficacy and safety of AIN457 for patients with active uveitis that requires systemic immunosuppression.
- Trial name
- NCT00685399
- Testing
- AIN457, AIN 457
- Where
- 23 sites in United States, Germany
- Volunteers
- 76 people
- Sponsor
- Novartis Pharmaceuticals
Non Infectious Uveitis
Treatment FOr Corticosteroid Dependent UveitiS
FOCUS is the first prospective randomized study comparing standard of care (mycophenolate mofetil) to adalimumab in recently active non infectious uveitis (NIU) with steroid dependency.
- Trial name
- FOCUS (NCT06258915)
- Testing
- Adalimumab, Mycophenolate Mofetil
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Uveitis, Non-Infectious Uveitis
Intravitreal Adalimumab Versus Subcutaneous Adalimumab in Non-infectious Uveitis
The objective of this study is to compare and evaluate the efficacy of subcutaneous (40mg) adalimumab biweekly injections to intravitreal adalimumab (1.5 mg/ 0.03 mL) administration, given at zero, 2 weeks then every four weeks…
- Trial name
- IVAS (NCT02706704)
- Testing
- Adalimumab
- Where
- Lebanon
- Volunteers
- 32 people
- Sponsor
- American University of Beirut Medical Center
Non-infectious Uveitis Affecting the Posterior Segment of the Eye
Open Label Trial Studying the Safety and Effectiveness of ILUVIEN® (190μg) in Children and Adolescents, Who Have Recurrent Non-infectious Uveitis Affecting the Posterior Segment of the Eye.
The main aim is to test how safe and effective the medicine ILUVIEN® (190μg) is for children and adolescents, who have non-infectious uveitis that keeps coming back and affects the back of the eye.
- Trial name
- NCT06539481
- Testing
- fluocinolone acetonide 190 micrograms
- Where
- 6 sites in Germany, Spain and 1 more
- Volunteers
- 25 people
- Sponsor
- Alimera Sciences
Anterior Uveitis
Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis
The purpose of this study is to evaluate the safety and efficacy of ocular iontophoresis with dexamethasone phosphate ophthalmic solution EGP-437 using the EyeGate® II Drug Delivery System (EGDS) compared to prednisolone acetate…
- Trial name
- NCT01505088
- Testing
- 40 mg/mL Dexamethasone phosphate ophthalmic solution, Prednisolone Acetate (1%) Eyedrops, 100 mM sodium citrate buffer solution
- Where
- 39 sites in United States
- Volunteers
- 193 people
- Sponsor
- Eyegate Pharmaceuticals, Inc.
Uveitis, Macular Edema
Efalizumab to Treat Uveitis
This study examined the safety and potential efficacy of the monoclonal antibody efalizumab (Raptiva) for treating sight-threatening uveitis (eye inflammation).
- Trial name
- NCT00280826
- Testing
- Efalizumab
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Eye Institute (NEI)
Uveitis
Abatacept in the Treatment of Uveitis
The purpose of this study is to assess the safety and efficacy of abatacept in the treatment of uveitis.
- Trial name
- NCT01279954
- Testing
- Abatacept
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Non-infectious Anterior Uveitis
SOLACE Trial - A Phase 3 Trial in Subjects With Non-infectious Anterior-uveitis.
A Phase 3, randomized, double-masked, vehicle-controlled trial to evaluate the safety and efficacy of ADX-102 ophthalmic solution in Subjects with non-infectious anterior-uveitis.
- Trial name
- NCT03131154
- Testing
- ADX-102 Ophthalmic Solution (0.5%), Vehicle of ADX-102 Ophthalmic Solution
- Where
- 27 sites in United States
- Volunteers
- 123 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Uveitis
Optiquel® as Corticosteroid-sparing Therapy for Chronic Noninfectious Uveitis
Background: Uveitis is a serious inflammatory condition in which the body's immune system attacks parts of the eye, often causing vision loss.
- Trial name
- NCT01195948
- Testing
- B27PD
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- National Eye Institute (NEI)
Non-Infectious Uveitis
Utilization and Safety of the Mk II Inserter and the Safety of the FAI Insert in Non-Infectious Uveitis
This trial is a 12 month, Phase 3, multi-center, randomized, single-masked (subject), controlled study designed to evaluate the utilization and safety of the Mk II inserter and the safety of the FAI insert, in subjects with…
- Trial name
- MkII (NCT02748512)
- Testing
- FAI Insert administered using the Mk II inserter, FAI Insert administered using the Mk I inserter
- Where
- 6 sites in United States
- Volunteers
- 26 people
- Sponsor
- EyePoint Pharmaceuticals, Inc.
Uveitis, Uveitis, Posterior
MAGNOLIA: Extension Study of Patients With Non-infectious Uveitis Who Participated in CLS1001-301
This study is a non-interventional, observational extension of the Parent study, CLS1001-301 (NCT02595398). The purpose of this study is to characterize the continued clinical benefit(s) regarding safety and efficacy of…
- Conditions
- Uveitis, Uveitis, Posterior, Uveitis, Anterior, Uveitis, Intermediate
- Trial name
- NCT02952001
- Testing
- 4 mg CLS-TA Suprachoriodal Injection
- Where
- 16 sites in United States, India
- Volunteers
- 33 people
- Sponsor
- Clearside Biomedical, Inc.
Uveitis Posterior Non-Infectious, Uveitis, Intermediate
POC Study to Evaluate the Efficacy and Safety of ESK-001 in Patients With Active Intermediate, Posterior, or Pan NIU
This is a multi-center, randomized, double-masked, proof-of-concept study in patients with Active Noninfectious Intermediate, Posterior, or Panuveitis.
- Conditions
- Uveitis Posterior Non-Infectious, Uveitis, Intermediate, Noninfectious Panuveitis
- Trial name
- OPTYK-1 (NCT05953688)
- Testing
- ESK-001
- Where
- 17 sites in United States
- Volunteers
- 36 people
- Sponsor
- Alumis Inc