Clinical trials: Non Invasive Positive Pressure Ventilation
Respiratory Distress Syndrome, Newborn, Bronchopulmonary Dysplasia
Work of Breathing During Non-invasive Ventilation in Premature Neonates
Background: Non-invasive forms of respiratory support have been developed to manage respiratory distress and failure in premature newborns without exposing them to the risks associated with invasive mechanical ventilation.
- Trial name
- NCT02788110
- Testing
- Noninvasive neurally adjusted ventilatory assist (NIV NAVA), Nasal intermittent positive pressure ventilation (NIPPV)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Acute Respiratory Failure, Exacerbation of COPD
Multicenter National Randomized Controlled Open Label Study Assessing Interest of Non Invasive Ventilation in out-of Hospital Setting During Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Patients. VeNIS BPCO
Goal of the study: To show that prehospital NPPV use for COPD decompensation, as compared to only standard medical treatment, might enable a decrease in intubation rate.
- Conditions
- Acute Respiratory Failure, Exacerbation of COPD, Non Invasive Positive Pressure Ventilation, Out of Hospital Setting
- Trial name
- VeNIS BPCO (NCT01626937)
- Testing
- Non invasive ventilation, conventional medical treatment
- Volunteers
- 398 people
- Sponsor
- Centre Hospitalier d'Agen
Cardiogenic Pulmonary Edema
Out-of-Hospital CPAP for Severe Cardiogenic Pulmonary Edema
In cardiogenic pulmonary edema, Continuous Positive Airway Pressure (CPAP) added to medical treatment improves outcome. The present study was designed to assess the benefit of CPAP as a first line treatment of cardiogenic…
- Trial name
- NCT00390442
- Testing
- continuous positive airway pressure
- Where
- France
- Sponsor
- Hopital Lariboisière
Respiratory Distress Syndrome in Premature Infant
Ventilator Weaning Outcome Between NIV-NAVA and Nasal CPAP (or IMV ) Modes in Premature Neonates
Premature neonates are prone to respiratory distress and need ventilator support because of the rapid breathing and large variations in respiratory patterns.
- Trial name
- NCT04118400
- Testing
- NIV-NAVA, Nasal CPAP or NIMV mode
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University Hospital
Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome (OHS)
Evaluation of Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive Ventilation
To evaluate the safety and effectiveness of the Automatic Expiratory Positive Airway Pressure (Auto-EPAP) feature versus manual expiratory positive airway pressure (EPAP) in the Vivo 45 LS Ventilator.
- Conditions
- Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome (OHS), Chronic Obstructive Pulmonary Disease (COPD), Neuromuscular Diseases (NMD)
- Trial name
- Vivo NOVA (NCT06560411)
- Testing
- Non-Invasive Ventilation
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Breas Medical, Inc.
Obstructive Sleep Apnea, Respiratory Failure
Healthcare Renunciation in Respiratory Chronic Disease and Treatment Compliance (OBSERVE)
Health care renunciation is a factor that can alter patients' health status and increase the costs of its support. To date, there is no national data on the renunciation of care.
- Trial name
- OBSERVE (NCT03591250)
- Where
- 3 sites in France
- Volunteers
- 1,083 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea
First Line Obstructive Sleep Apnea Treatment Study
The main objective is to evaluate the overall effectiveness of MAD therapy as a first line treatment, including both efficacy in terms of reduction in OSA severity as well as objective compliance, in patients recently diagnosed…
- Trial name
- FLOSAT (NCT05393531)
- Testing
- Mandibular advancement device (MAD), Continuous positive airway pressure (CPAP)
- Where
- Belgium
- Volunteers
- 136 people
- Sponsor
- University Hospital, Antwerp
Pediatric Asthma, Acute Asthma
Bilevel Positive Airway Pressure (BPAP) for Severe Asthma
The goal of this clinical trial is to assess the feasibility of early initiation of bilevel positive airway pressure (BPAP) in the emergency department (ED) for children with severe asthma exacerbations.
- Conditions
- Pediatric Asthma, Acute Asthma, BiPAP, Non-invasive Positive Pressure Ventilation
- Trial name
- NCT07582211
- Testing
- Bilevel positive airway pressure ventilation
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Columbia University
Acute Respiratory Distress Syndrome
Non-Invasive Positive Pressure Ventilation and Adult Respiratory Distress Syndrome (ARDS)
Background and objective: To determine the efficacy of non-invasive positive pressure ventilation (NPPV) and its effects upon intubation rate and mortality in ARDS.
- Trial name
- NPPV (NCT00644930)
- Testing
- the application of NPPV, invasive ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Eskisehir Osmangazi University
Cystic Fibrosis
The Addition of Non-Invasive Ventilation To Airway Clearance Techniques In Adults With Cystic Fibrosis
Cystic Fibrosis (CF) is a genetic disorder of altered ion transport across cell membranes which is characterised by the production of thickened bodily secretions, affecting the function of organs such as the pancreas and the…
- Trial name
- NIV (NCT01885650)
- Testing
- Airway Clearance Techniques
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Respiratory Insufficiency, Hypoxia
Prehospital CPAP vs. Usual Care for Acute Respiratory Failure
The purpose of this study is to evaluate the effectiveness of continuous positive airway pressure ventilation when applied by paramedics to individuals with severe breathing difficulties in the prehospital setting.
- Trial name
- NCT00405314
- Testing
- Continuous positive airway pressure ventilation mask
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Dalhousie University
Continuous Positive Airway Pressure, Noninvasive Ventilation
Effects of a Therapeutic Education Program on Treatment Adherence Among Patients Prescribed At-home CPAP or At-home NIV
The primary objective of this study is to study the effect of therapeutic education on patient adherence for at-home continuous positive airway pressure (CPAP) or at-home non-invasive ventilation.
- Trial name
- APARDetp (NCT03151317)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Montpellier
Respiratory Insufficiency
Comparison of Humidified High Flow Nasal Cannula to Nasal CPAP in Neonates
We hypothesize that the success rate for keeping babies extubated (without a breathing tube for assisted mechanical ventilation), defined as the proportion of infants remaining extubated for a minimum of 72 hours, will be…
- Trial name
- HHFNC (NCT00609882)
- Testing
- Nasal CPAP, Humidified High Flow Nasal Cannula (HHFNC)
- Where
- 9 sites in United States, China
- Volunteers
- 420 people
- Sponsor
- University of Utah
Respiratory Failure, Hypoxia
HVNI vs NIPPV in Type 2 Respiratory Failure
The purpose of this study is to determine if high velocity nasal insufflation (HVNI) is comparable to non-invasive positive pressure ventilation (NIPPV) in treatment of emergency patients with acute respiratory acidosis.
- Conditions
- Respiratory Failure, Hypoxia, Hypercapnia
- Trial name
- SHINE (NCT07065656)
- Testing
- Vapotherm high velocity therapy (HVT) 2.0 (Vapotherm, Inc, Exeter, NH), Respironics Vision V60
- Volunteers
- 84 people
- Sponsor
- National University Hospital, Singapore
Hypercapnic Respiratory Failure
High-flow Air Via Nasal Cannula vs Non-invasive Continuous Positive Airway Pressure for Hypercapnic Respiratory Failure
The study will be performed as a randomized controlled non-inferiority trial. HFA has been increasingly used in the last years to treat hypoxic respiratory failure (i.e.
- Trial name
- HIGHforHyper (NCT03944525)
- Testing
- High flow nasal cannula, Continuous positive airway pressure
- Where
- Austria
- Volunteers
- 62 people
- Sponsor
- Medical University of Vienna
COVID-19
Non Invasive Positive Pressure Ventilation to Minimize Aerosolization for COVID 19
Patients presenting to the emergency department, or needing hospitalization, for a variety of medical conditions often require non-invasive ventilation (breathing support).
- Trial name
- NCT04344925
- Testing
- Aerosol-reducing Mask, Standard Mask
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Acute Respiratory Failure
Efficacy and Safety of Dexmedetomidine During Non-Invasive Positive Pressure Ventilation
The purpose of the study is to determine the efficacy and safety of dexmedetomidine during Non-invasive positive pressure ventilation (NPPV) for patients with acute respiratory failure compared to standard analgesic/sedation…
- Trial name
- NCT00871624
- Testing
- Dexmedetomidine
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Tufts Medical Center
Respiratory Insufficiency, Chronic Obstructive Pulmonary Disease
Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure.
Non-invasive ventilation has become increasingly important in the management of patients with acute respiratory failure. One of its major goals is to prevent the need for invasive ventilation, which is associated with numerous…
- Conditions
- Respiratory Insufficiency, Chronic Obstructive Pulmonary Disease, Pneumonia, Pulmonary Edema
- Trial name
- NCT00331656
- Testing
- Non-invasive positive pressure mask ventilators, Extrathoracic biphasic cuirass ventilator (RTX, Hayek)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Respiratory Disease, Artificial Respiration
Non-invasive Assessment of Inspiratory Effort and Tidal Distension During Non-invasive Ventilation (INSPIRE)
The goal of this observational study is to evaluate whether the airway occlusion pressure recorded during a sudden end-expiratory breath-hold (ΔPocc) is correlated with esophageal swing in pressure and the reliability of P0.1…
- Trial name
- INSPIRE (NCT06344234)
- Testing
- End-inspiratory Maneuvers
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Bari
Tracheobronchomalacia
PEEP Mask for Tracheobronchomalacia-Induced Cough
This study aims to determine if an expiratory resistance device that delivers non-invasive positive expiratory pressure (nPEP) will reduce or stop coughing, reduce airway resistance and improve quality of life in patients with…
- Trial name
- NCT04169282
- Testing
- nPEP (non-invasive positive expiratory pressure) mask
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University