Clinical trials: Non Invasive Ventilation
Airway Disease
Airway Pressure and Lumen Changes During NIV With Flexible Bronchoscopy
Introduction: The non-invasive ventilation (NIV) of continuous nasopharyngeal O2 with intermittent close/open nose and abdomen compression (PO2-NC-AC) can provide effective oxygenation, ventilation and circulation.
- Trial name
- NCT03666403
- Testing
- NIV rate: 0/min, NIV rate: 10-20/min, NIV rate: 5-10/min
- Where
- 2 sites in Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
CO2 Clearance, Mask Comfort
Noninvasive Ventilation Masks Carbon Dioxide Clearance in Normal Volunteers
This study will be a randomized crossover trial that will be conducted at Rush University. The study will be conducted with 20 healthy volunteers who will be placed on ICU ventilator operating in the NIPPV mode.
- Conditions
- CO2 Clearance, Mask Comfort, Rebreathing Exhaled Gas
- Trial name
- NCT03882723
- Testing
- Evaluated 4 masks used for NIV with mechanical ventilators
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Non-invasive Ventilation, High-frequency Ventilation
MRI of the Chest Under High Frequency Ventilation
The purpose of the study is to evaluate the benefit on image quality of MRI of the chest performed under high frequency non-invasive ventilation.
- Conditions
- Non-invasive Ventilation, High-frequency Ventilation, Healthy Volunteer
- Trial name
- NCT02973373
- Testing
- MRI with High-frequency non-invasive ventilation, MRI without High-frequency non-invasive ventilation
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Blood Oxygen Desaturations, Sleep-Disordered Breathing
Assessment of the Accuracy of the Non-invasive Wireless Armband Gabi Baby Band for Continuous Vital Parameters Monitoring in Infants and Young Children
During a polysomnography test (PSG) previously prescribed by a physician, the patient also wears the Gaby Baby Band (GBB) during an entire night of sleep.
- Trial name
- WAGSC1 (NCT04886583)
- Testing
- Gabi Baby Band
- Where
- 3 sites in Belgium
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Gabi SmartCare
Healthy
Comparison of Preoxygenation Techniques in Healthy Volunteers With Monitoring of End-tidal Oxygen Fraction (FeO₂) and Oxygen Reserve Index (ORI)
The objective of this physiological study is to compare two preoxygenation techniques (non-invasive ventilation combined with high-flow nasal oxygen versus non-invasive ventilation alone) by monitoring end-tidal oxygen fraction…
- Trial name
- OXYGAME1 (NCT07334041)
- Testing
- Preoxygenation with VNI + OHD, Preoxygenation with VNI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Sleep-Wake Disorders, Healthy
Validation of Non-invasive Miniature Optical Sensors for Scoring Sleep Stages
Validation of two devices with optical sensor in healthy participants and patients with sleep wake disorders.
- Trial name
- NCT03823105
- Testing
- OHR Tracker and PulseWatch
- Where
- Switzerland
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Transient Tachypnea of the Newborn
PATET Ratio to Rule Out Transient Tachypnea of the Newborn
This study aims to find out whether diagnosis of Transient Tachypnea of the Newborn(TTN) can be predicted via evaluating pulmonary artery Doppler indices.
- Trial name
- PATET (NCT02965365)
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
Coronary Artery Disease
Impact of Breathing Maneuvers on the Oxygenation Supply of the Heart Assessed With MRI in Patients With Coronary Artery Disease
Patients with an impaired blood supply of the heart routinely receive oxygen in order to improve or preserve the oxygen supply of the heart muscle in acute cardiac care.
- Trial name
- CADOS-CMR (NCT02233634)
- Testing
- Oxygen, Hyperventilation Breath-hold (HVBH), HVBH with Oxygen
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Neuromuscular Diseases, Neurologic Disorder
Multisystem and Autonomic Complications of NMD on Long-term NIV
This exploratory observational study evaluates autonomic function using measures including heart rate variability in adults with childhood-onset neuromuscular and neurological disorders (NMD) who use non-invasive ventilation…
- Trial name
- NCT04100993
- Testing
- No intervention used
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Healthy Adult, Cardiac Output
Effect of Systematic and Sequential Leg Elevation on Cardiac Output in Healthy Volunteers
Passive leg raising (PLR) transiently increases venous return and cardiac preload and is commonly used to predict fluid responsiveness in critically ill patients.
- Conditions
- Healthy Adult, Cardiac Output, Hemodynamic, Passive Leg Raising
- Trial name
- SYSLE-1 (NCT07860515)
- Testing
- Passive Leg Raising, Non-Invasive Ventilation
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Non-invasive Ventilation
VENTILATION DURING SPACEFLIGHT (PHASE 2)
Space flights expose astronauts to medical risks, particularly respiratory risks, which are exacerbated in microgravity. Devices such as standard oxygen therapy and non-invasive ventilation (NIV) are used, but their performance…
- Trial name
- VESPA-2 (NCT07435389)
- Testing
- non-invasive oxygenation strategies
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Normal Subjects
Radioaerossol Pulmonary Deposition Using Mesh in Normal Subjects
In vivo deposition studies of aerosol administration during noninvasive ventilation are scarce in the current literature. We assessed 10 normal subjects in a crossover study evaluated by pulmonary scintigraphy aiming to compare…
- Trial name
- NCT01889524
- Testing
- Mesh nebulizer, Jet nebulizer, Noninvasive ventilation-NIV
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Chronic Obstructive Pulmonary Disease Exacerbation
Evaluation of Oxygen Delivery Methods in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
To examine the effects of oxygen therapy methods applied as indicated in COPD acute exacerbations on blood gas results and spirometric measurements.
- Trial name
- NCT06561464
- Testing
- EzPAP®, Non-invasive mechanical ventilation (NIMV)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Apnea, Hypoxia
Effects of Automated Adjustment of Inspired Oxygen With Combined Adaptive Mechanical Backup Ventilation as Compared to Automated Oxygen Adjustment Alone in Preterm Infants With Intermittent Hypoxemic Events During Non-invasive Ventilatory Support
In this 2-phase cross-over study the investigators test the hypothesis that automated adjustment of the inspired oxygen with the combined use of synchronized noninvasive SpO2-sensitive and apnea-sensitive backup-ventilation…
- Trial name
- NCT02774408
- Testing
- Saturation sensitive backup ventilation
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Healthy Volunteers, Noninvasive Ventilation
The Effect of Mask Design on Transcutaneous Carbon Dioxide in Healthy Volunteers: A Pilot Clinical Investigation
The goal of this randomized cross-over study is to investigate whether the design of non-invasive ventilation (NIV) mask impacts transcutaneous CO2 in healthy volunteers on NIV therapy.
- Trial name
- NCT06670482
- Testing
- Non-invasive ventilation (NIV)
- Where
- New Zealand
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fisher and Paykel Healthcare
Chest Trauma
Sedation for Non-invasive Ventilation in Blunt Chest Trauma
Effectiveness of sedation using dexmedetomidine and ketamine to facilitate non-invasive ventilation sessions which improve overall outcome after blunt chest trauma
- Trial name
- NCT05175781
- Testing
- Dexmedetomidine Hydrochloride, Ketamine Hydrochloride
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Mechanical Ventilation Complication, Respiratory Distress Syndrome in Premature Infant
Effect of Implementing Evidence Based Practices on Prevention of Associated Nasal Pressure Injuries Among Preterm Neonates With Non-Invasive Respiratory Support
This study aims to evaluate the effect of implementing evidence based practices on prevention of associated nasal pressure injuries among preterm neonates with non invasive respiratory support
- Trial name
- NCT06642285
- Testing
- Non Invasive Respiratory Support bundle
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Preterm Infant
Effects of Two Modalities of Non-invasive Ventilation After Extubation in Very Low Birth Weight Neonates
The objective of this study is to evaluate the effects of continuous positive airway pressure and nasal intermittent positive pressure ventilation on breathing pattern variables of very low birth weight neonates immediately after…
- Trial name
- NCT03551314
- Testing
- Nasal Intermittent Positive Pressure, Continuous Positive Airway Pressure
- Where
- 2 sites in Brazil
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Respiratory Diseases, Lung Diseases
In Vitro Assessment of a Breath-synchronized Vibrating Mesh Nebulizer During Non Invasive Ventilation
Using an adult lung bench model of non invasive ventilation, the aim of the study is to compare an experimental system of breath-synchronized vibrating mesh nebulizer to a conventional vibrating mesh nebulizer during non invasive…
- Conditions
- Respiratory Diseases, Lung Diseases, Cystic Fibrosis, COPD
- Trial name
- Synchro-Neb (NCT02084043)
- Testing
- Nebulization of Amikacin during NIV (RR: 15 cycles/minute), Nebulization of Amikacin during NIV (RR: 25 cycles/minute)
- Where
- Belgium
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University Hospital St Luc, Brussels
Respiratory Insufficiency
Effect of Non-invasive Ventilation (NIV) on Cerebral Oxygenation
SUMMARY AND AIM Background: The proper management of brain oxygenation is an essential component of all anaesthesiologic procedures.
- Trial name
- NCT02454582
- Testing
- Somanetics INVOS Cerebral Oxymeter 5100C
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ass.-Prof. PD Dr. Klaus Ulrich Klein