Clinical trials: Non Organic Psychosis
Schizophrenia
Tracking Outcomes in Psychosis
The investigators propose to study the brain processes that result in thought and language disorder and influence outcomes seen in patients with schizophrenia using a combination of brain scans and clinical assessments.
- Trial name
- TOPSY (NCT02882204)
- Where
- Canada
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Psychosis, Negative Symptoms With Primary Psychotic Disorder
Add-on MEmaNtine to Dopamine Modulation to Improve Negative Symptoms at First Psychosis
Antipsychotics affects the brain's dopamine system, and the drugs reduce delusions, hallucinations, and disorganized thinking, which are cardinal symptoms of psychotic disorders. However, negative symptoms e.g.
- Trial name
- AMEND (NCT04789915)
- Testing
- Memantine
- Where
- Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Bjorn H. Ebdrup
Schizophrenia, Schizotypal Disorder
Feasibility of a Novel Process-based Treatment for Patients With Psychosis
The purpose of this single-arm feasibility study is to develop and pilot test a novel process-based and modular group therapy approach for patients with acute psychotic symptoms in an inpatient setting.
- Conditions
- Schizophrenia, Schizotypal Disorder, Delusional Disorder, Brief Psychotic Disorder
- Trial name
- PROBAS (NCT04874974)
- Testing
- Metacognitive and Defusion Training
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Psychosis Associated With Alzheimer's Disease
An Open-Label Study of ML-007C-MA in Adults With Alzheimer's Disease Psychosis
ML-007C-MA-222 is a 52-week, flexible-dose, open-label extension study designed to evaluate the long-term safety, tolerability, and effectiveness of ML007C-MA in participants with ADP who have completed the antecedent study (ie…
- Trial name
- NCT07459660
- Testing
- ML-007C-MA
- Where
- 8 sites in United States, Bulgaria and 1 more
- Volunteers
- 210 people
- Sponsor
- MapLight Therapeutics
Schizophrenia and Disorders With Psychotic Features, Disorders
Investigator Initiated Study - Asenapine Early Psychosis
We propose a use of a unique facility, the databank at the CNDV, to examine the impact of switching subjects to asenapine in an open-label naturalistic setting.
- Trial name
- NCT01968161
- Testing
- Asenapine
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec
Clinical High Risk for Psychosis (CHR)
Interventions for Clinical High Risk Youth in Tunisia
Study participants will take part in one of the two types of treatments aimed at improving daily functioning as follows: either a Cognitive Training (CT) Program or an Enhanced - Treatment as Usual (E-TAU) Group.
- Trial name
- CHRTUNISIA (NCT06582901)
- Testing
- Cognitive training (CT) plus the neuropsychological educational approach to cognitive remediation (NEAR) model and an Enhanced - Treatment as Usual (E-TAU), Enhanced - Treatment as Usual
- Where
- Tunisia
- Volunteers
- 54 people
- Sponsor
- University of California, Los Angeles
Schizophrenia, Affective Disorders, Psychotic
Self-Management and Recovery Technology Psychosocial Intervention Trial
This project is a component of a broader research program referred to as "Self-Management and Recovery Technology (SMART): Use of online technology to promote self-management and recovery in people with psychosis", which has been…
- Conditions
- Schizophrenia, Affective Disorders, Psychotic, Psychotic Disorders
- Trial name
- SMARTTherapy (NCT02474524)
- Testing
- Health intervention, Social intervention
- Where
- 10 sites in Australia
- Volunteers
- 148 people
- Sponsor
- Swinburne University of Technology
Mental Health
Patient Generated Goals in Mental Health: Better Outcomes?
Researchers believe that clinical care can be improved by engaging patients and families directly in planning the care process. Engagement efforts have included asking patients/families to provide information about whether they…
- Trial name
- NCT03527914
- Testing
- Goal Based Outcomes, Treatment as Usual
- Where
- Canada
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Schizophrenia, Psychotic Disorders
Bergen Psychosis Project 2 - The Best Intro Study
In the Bergen Psychosis Project 2 the antipsychotic drugs aripiprazole, amisulpride, and olanzapine will be compared head-to-head in patients with schizophrenia and related psychoses and followed for 12 months.
- Trial name
- BP2 (NCT01446328)
- Testing
- Amisulpride, Aripiprazole, Olanzapine
- Where
- 4 sites in Austria, Norway
- Volunteers
- 151 people
- Sponsor
- Haukeland University Hospital
Schizophrenia Disorders, Schizoaffective Disorder
Randomized Clinical Trial of iTEST: A Blended Intervention Targeting Introspective Accuracy
The purpose of this study is to evaluate the effectiveness of a psychosocial intervention called iTEST for people with psychotic disorders that targets introspective accuracy, or the ability to accurately gauge ones abilities.
- Conditions
- Schizophrenia Disorders, Schizoaffective Disorder, Psychotic Disorder
- Trial name
- iTEST R33 (NCT07098169)
- Testing
- iTEST, Active Control
- Where
- 3 sites in United States
- Volunteers
- 201 people
- Sponsor
- University of California, San Diego
First Episode Psychosis (FEP)
Digital Heart Rate Variability Biofeedback Intervention for First Episode Psychosis
The objective of the current study is to assess the impact of a five-week digital heart rate variability biofeedback (HRV-B) intervention or music listening on the well-being of first episode psychosis patients.
- Trial name
- NCT07628699
- Testing
- Heart Rate Variability Biofeedback, Music Listening
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- The University of Hong Kong
Psychosis, Aggression
Haloperidol vs. Risperidone in the Treatment of Aggression in Psychotic Inmates
This study examines the efficacy of haldol versus risperdal in the treatment of aggression in psychotic prison inmates. It is hypothsized that risperdal will be more effective in decreasing aggression than haldol.
- Trial name
- NCT00203775
- Testing
- risperidone
- Where
- United States
- Sponsor
- University of Connecticut
Alzheimer Disease
Home-based Transcranial Direct Current Stimulation (tDCS) for Behavioral Symptoms in Alzheimer's Disease and Related Dementias (ADRD)
The purpose of this study is to assess acceptability, and safety of providing tDCS to ADRD patients with behavioral symptoms and to assess the efficacy of tDCS for ADRD-related symptoms, mainly behavioral symptoms.
- Trial name
- NCT05478681
- Testing
- active tDCS
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas Health Science Center, Houston
Psychosis, Schizoaffective Disorder
OnTrack>An Online Role-Playing Game: A Small Business Innovation Research (SBIR) Grant
Our team will develop a prototype game (OnTrack>The Game) in which users play the role of a person who has experienced First Episode Psychosis and move through animated role-playing scenarios, learning practical tips for engaging…
- Conditions
- Psychosis, Schizoaffective Disorder, Schizophrenia
- Trial name
- NCT02415764
- Testing
- Behavioral/Attitudinal OnTrack Role-Playing Game
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Center for Social Innovation, Massachusetts
Ultra High Risk for Psychosis
Placebo-controlled Trial in Subjects at Ultra-high Risk for Psychosis With Omega-3 Fatty Acids in Europe
The purpose of this study is to determine whether omega-3 fatty acids are effective in the prevention of psychosis in individuals at ultra-high risk for psychosis.
- Trial name
- PURPOSE (NCT02597439)
- Testing
- Omega-3 fatty acids
- Where
- 14 sites in Austria, Germany and 7 more
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Rene Kahn
Psychotic Disorders, Schizophrenia and Related Disorders
EEG Outcomes From Cognitive Behavioural Therapy for Psychosis
Despite overwhelming evidence for neurocognitive and neurophysiological factors involved in the etiology of psychosis, these factors have never been examined as mechanisms of improvement from CBTp.
- Trial name
- EPIC (NCT05703698)
- Testing
- Cognitive Behavioural Therapy for Psychosis
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Toronto
Psychotic Disorders, Schizophrenia
Development and Pilot Evaluation of Modified Cognitive Behavioural Therapy for Adolescents With Early Onset Psychosis
In the last decade cognitive behavioural therapy (CBT) approaches for patients with schizophrenia have been developed, which where especially designed to reduce severity of positive symptoms, readmission rates, treatment…
- Conditions
- Psychotic Disorders, Schizophrenia, Schizoaffective Disorder, Delusional Disorder
- Trial name
- mCBT (NCT00465920)
- Testing
- modified cognitive behavioural therapy (mCBT)
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- University of Cologne
Obsessive-Compulsive Disorder (OCD), Schizophrenia and Schizophrenia Spectrum Psychosis
Obsessive-Compulsive Disorder: Insight, Trauma, and Links to Schizophrenia Spectrum Disorders
This study aims to better understand Obsessive-Compulsive Disorder (OCD) by examining the types and patterns of OCD symptom presentation. The investigators seek to determine how these symptoms impact overall daily functioning.
- Trial name
- NCT07092826
- Testing
- Psychopathological assessment and non-invasive multisensory stimulation
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Matteo Tonna
Schizophrenia; Psychosis, Nurse's Role
Effect of Applying Cognitive Defusion Techniques on Mindful Awareness, Cognitive Fusion and Believability of Delusions Among Clients With Schizophrenia
Schizophrenia causes hallucinations, delusions, and disorganized thinking, resulting in decreased functioning and lifelong therapy.Delusion believability is the degree of belief in the truth of one's subjective experiences as…
- Conditions
- Schizophrenia; Psychosis, Nurse's Role, Delusions
- Trial name
- NCT05759091
- Testing
- cognitive defusion techniques
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Alexandria University
Cannabis Use Disorder
Pilot Testing the Check Up
We propose to pilot test an adapted version of the Teen Marijuana Check Up (TMCU) for persistent cannabis users with first episode psychosis (FEP) in Coordinated Specialty Care (CSC).
- Trial name
- NCT04624074
- Testing
- Teen Marijuana Check Up
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Maryland, Baltimore
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