Clinical trials: Non Organic Psychosis
Schizophrenia, Psychosis
Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry
This study is a multi-site study examining the use of Quetiapine XR for psychotic aggression in an acute psychiatric setting. The study aims to demonstrate that management with Quetiapine XR significantly reduces aggressive…
- Trial name
- NCT00986167
- Testing
- Quetiapine XR
- Where
- 2 sites in Australia
- Volunteers
- 72 people
- Sponsor
- Bayside Health
Schizophreniform Disorder, Schizoaffective Disorder
Open-label Ziprasidone Study for Psychosis Treatment in Adolescents
This open-label study will assess the medication Geodon® (Ziprasidone) in pediatric patients, aged 13-17, diagnosed with psychotic disorder.
- Conditions
- Schizophreniform Disorder, Schizoaffective Disorder, Psychosis, Depressive Disorder, Major
- Trial name
- NCT00421954
- Testing
- Ziprasidone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Psychosis, Substance Abuse
Clinical Intervention Psychosis and Addiction
The purpose of this study is to evaluate an integrative therapeutic concept for schizophrenic patients with comorbid substance use disorder.
- Trial name
- KLIPS (NCT01411566)
- Testing
- Skills trainig for patients with dual diagnosis, regular treatment
- Where
- Germany
- Volunteers
- 122 people
- Sponsor
- University of Cologne
Alzheimer's Disease Psychosis
A Study of the Safety and Efficacy of Pimavanserin in Patients With Alzheimer's Disease Psychosis
This study will evaluate the safety and efficacy of pimavanserin 40 mg compared to placebo in patients with Alzheimer's disease psychosis.
- Trial name
- NCT02035553
- Testing
- Pimavanserin tartrate
- Where
- United Kingdom
- Volunteers
- 181 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Affective Psychosis, Bipolar, Bipolar Disorder
A Study to Evaluate the Efficacy and Safety of Adjustable Doses of Extended-release (ER) Paliperidone Compared With Placebo, in Combination With Lithium or Valproate, to Treat Manic and Mixed Episodes in Patients With Bipolar I Disorder
The purpose of this study is to evaluate the effectiveness and safety over a 6-week period of paliperidone ER compared with placebo in treating subjects with Bipolar I Disorder who are experiencing a manic or mixed episode while…
- Conditions
- Affective Psychosis, Bipolar, Bipolar Disorder, Mania
- Trial name
- NCT00309686
- Testing
- Paliperidone ER
- Volunteers
- 300 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Schizophrenia
Antipsychotic and Motor Effects of ACP-103 When Administered in Combination With Haloperidol and Risperidone
The primary purpose of this study is to determine whether a combination of ACP-103 (the study medication) with either haloperidol or risperidone will show antipsychotic efficacy and that it is safe and well tolerated.
- Trial name
- NCT00361166
- Testing
- ACP-103
- Where
- 17 sites in United States, Brazil
- Volunteers
- 400 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Delirium, Critical Illness
Haloperidol for Delirium in Adult Critically Ill Patients
The EuRIDICE trial will study whether haloperidol as a first line treatment for ICU delirium reduces delirium duration (and severity).
- Conditions
- Delirium, Critical Illness, Intensive Care Psychosis, Cognitive Impairment
- Trial name
- EuRIDICE (NCT03628391)
- Testing
- Haloperidol
- Where
- 8 sites in Netherlands
- Volunteers
- 142 people
- Sponsor
- Erasmus Medical Center
Psychosis
CLinical Utility of Early Intervention Including the 5-Step Precision Medicine (5SPM) Method in First-episode Psychosis: The CLUMP Project
CLUMP is a project of translational research that intends to bridge the gap between what we already know about pharmacogenetics of antipsychotic drugs and what we still do to treat patients with first-episode psychosis (FEP).
- Trial name
- CLUMP (NCT06453174)
- Testing
- Adherence to the first prescribed antipsychotic medication
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Psychosis, Schizophrenia
Risperidone LA Heathcare Resource Study
The primary objective of this pilot study is to evaluate the impact of switching 30 subjects from an existing antipsychotic to risperidone long acting on healthcare resource utilization.
- Trial name
- NCT00272597
- Testing
- Risperidone
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Psychosis, Suicide
Youth Nominated Support Team
This study aims to adapt the current Youth-Nominated Support Team (YST) manual used to treat suicide risk for people at clinical high risk for psychosis.
- Conditions
- Psychosis, Suicide, Health Care Utilization, Family Members
- Trial name
- YST (NCT05558332)
- Testing
- Youth-Nominated Support Teams for CHR
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, Irvine
First-Episode Psychosis, Bipolar Disorder
Comparison of Aripiprazole Versus Risperidone on Brain Morphology Using MRI
Significant changes in brain morphology are observed in people with first-episode psychosis. Studies have shown that total brain volume and particular brain structures are decreased in people with psychosis disorders.
- Trial name
- CARB (NCT02334904)
- Testing
- Aripiprazole, Risperidone
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Psychosis, Psychotic Disorders
Acceptability, Feasibility and Preliminary Outcomes of the Kiso Mind App for Outpatients With Schizophrenia Spectrum Disorders
The Kiso pilot study is a randomized controlled trial to test the acceptability and feasibility of a novel digital intervention, namely the Kiso Mind smartphone app. A parallel-group design is utilized.
- Conditions
- Psychosis, Psychotic Disorders, Primary Psychotic Disorders, Schizophrenia Spectrum Disorders
- Trial name
- KISO (NCT07395206)
- Testing
- Digital: Kiso Mind App
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Psychosis
Learning Through Play Plus for Psychosis
Evidence reports that parents with schizophrenia are particularly vulnerable to parenting difficulties and also experience problems in sensitively interacting with their children.
- Trial name
- NCT06301347
- Testing
- Learning through Play Plus
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Pakistan Institute of Living and Learning
Schizophrenia
Diabetes in Neuropsychiatric Disorders
The purpose of this study was to describe metabolic changes in the first 16 weeks of anti-psychotic treatment in previously drug-naïve patients with psychosis.
- Trial name
- NCT00446992
- Testing
- Olanzapine
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Schizophrenia, Psychosis
RCT Examining the Effectiveness of Digital Picture Frame Use in Inpatient Setting
This study will be a randomized controlled trial that investigates the effectiveness of digital picture frames (DPF) installed in inpatient rooms on long stay inpatient wards servicing schizophrenia clients at CAMH.
- Conditions
- Schizophrenia, Psychosis, Psychosis NOS
- Trial name
- NCT02950571
- Testing
- Digital Picture Frame, Standard Care
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Centre for Addiction and Mental Health
Epilepsy With Partial Onset Seizures With or Without Secondary Generalization, Psychoses
Epileptic Psychoses and Their Link With Ictal Emotions and Consciousness
Background : Psychiatric comorbidities are common in epilepsy, affecting 50 to 70% of patients, especially when the epilepsy is focal and drug-resistant.
- Conditions
- Epilepsy With Partial Onset Seizures With or Without Secondary Generalization, Psychoses, Epilepsy, Generalized
- Trial name
- ASPAIC (NCT06960811)
- Where
- France
- Volunteers
- 117 people
- Sponsor
- Central Hospital, Nancy, France
Schizophrenia and Related Disorders, Psychosis
Ketosis Impact on Signs & Symptoms of Schizophrenia and Bipolar disorderS
The goal of this clinical trial is to learn if a ketone drink can improve signs and symptoms of patients with a schizophrenia-spectrum disorder (SSD), or a bipolar-spectrum disorder (BD).
- Conditions
- Schizophrenia and Related Disorders, Psychosis, Bipolar and Related Disorders, Manic Episode
- Trial name
- KISSeS (NCT06426134)
- Testing
- (R)-3-hydroxybutyl (R)-3-hydroxybutyrate), Maltodextrin, Fructose, Pectin, Sodium alginate, Sodium chloride
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Psychosis
Determining the Role of Social Reward Learning in Social Anhedonia
This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels.
- Trial name
- SAMI (NCT05617898)
- Testing
- Motivational Interviewing, Nutrition Didactic Training
- Where
- 2 sites in United States
- Volunteers
- 152 people
- Sponsor
- University of Alabama at Birmingham
Verbal Auditory Hallucination, Psychotic Disorders
RELATE - Efficacy and Feasibility of a Cognitive Behavioural Module for Distressing Auditory Verbal Hallucinations
Auditory hallucinations (AH) are associated with distress and reduced functioning. Psychological interventions show some promising effects on psychopathology but have been less successful in reducing AH related distress, which…
- Conditions
- Verbal Auditory Hallucination, Psychotic Disorders, Psychosis, Schizophrenia
- Trial name
- RELATE (NCT04578314)
- Testing
- Relating Therapy, Treatment as usual
- Where
- 5 sites in Germany
- Volunteers
- 85 people
- Sponsor
- University of Hamburg-Eppendorf
Schizophrenia
Evaluation of the Antipsychotic Efficacy of Cannabidiol in Acute Schizophrenic Psychosis
A controlled, randomized study on the treatment of schizophrenic psychosis with cannabidiol, a phytocannabinoid is performed. This approach is based upon recent findings indicating that the human endogenous cannabinoid system is…
- Trial name
- CBD-CT1 (NCT00628290)
- Testing
- Cannabidiol, Amisulpride
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- University of Cologne
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