Clinical trials: Non Organic Psychosis
Schizophrenia, Schizoaffective Disorder
Interventions to Improve Functional Outcome and Persistent Symptoms in Schizophrenia
Many individuals with schizophrenia continue to hear voices, have false beliefs, and problems with attention, memory planning and everyday functioning even with medication treatment.
- Trial name
- Mcog (NCT01915017)
- Testing
- Cognitive Behavior Therapy for Psychosis, Cognitive Adaptation Training, Multi-modal Cognitive Therapy
- Volunteers
- 178 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Cannabis, Ketamine
THC and Ketamine Effects in Humans: Relation to Neural Oscillations and Psychosis
The aim of the research protocol is to evaluate cannabinoid-glutamate interactions in humans. As part of this aim the investigators will assess the safety and tolerability of the combination of NMDA antagonist, ketamine, and the…
- Trial name
- NCT04199468
- Testing
- Active Delta-9-THC, Active Ketamine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Yale University
Cannabis Use Disorder
Pilot Testing the Check Up
We propose to pilot test an adapted version of the Teen Marijuana Check Up (TMCU) for persistent cannabis users with first episode psychosis (FEP) in Coordinated Specialty Care (CSC).
- Trial name
- NCT04624074
- Testing
- Teen Marijuana Check Up
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Maryland, Baltimore
Psychotic Disorders
Motivational Intervention for Physical Activity in Psychosis
The purpose of this study is to determine whether motivational intervention is effective in promoting exercise habit in patients with psychosis.
- Trial name
- NCT02648321
- Testing
- Motivational Interviewing, Health Education
- Where
- China
- Volunteers
- 82 people
- Sponsor
- The University of Hong Kong
Schizophrenias, Psychoses
Sarcosine Preventive Therapy for Individuals At High Risk for Schizophrenia
The purpose of this study is to determine whether preventative treatment with sarcosine can reduce symptoms and delay/avoid disease progression in individuals defined as being in a prodromal stage of schizophrenia.
- Conditions
- Schizophrenias, Psychoses, Psychotic Disorders, Schizophrenic Disorders
- Trial name
- NCT00276263
- Testing
- Sarcosine (N-methylglycine)
- Where
- 2 sites in Israel
- Sponsor
- Herzog Hospital
Engagement, Patient, First Episode Psychosis
Optimizing Engagement in Services for First-Episode Psychosis
This study will compare a 12-session behavioral activation (BA) intervention modified for first-episode psychosis (FEP) to usual community mental health care (i.e., treatment-as-usual; TAU) delivered over 6 months with a sample…
- Trial name
- NCT05310838
- Testing
- Behavioral Activation for First Episode Psychosis, Treatment As Usual
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- California State University, San Bernardino
Psychosis
Learning Through Play Plus for Psychosis
Evidence reports that parents with schizophrenia are particularly vulnerable to parenting difficulties and also experience problems in sensitively interacting with their children.
- Trial name
- NCT06301347
- Testing
- Learning through Play Plus
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Pakistan Institute of Living and Learning
Serious Mental Illness
Piloting and Evaluation of a Group Intervention for People With Psychosis Designed to Boost Access and Usage of ICT
Participants will be given access to a tablet. With this technology, participants will be invited to set personal goals related to using this technology to foster social connection and community participation.
- Trial name
- NCT07025499
- Testing
- Group ICT Intervention
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- McMaster University
Clinical High-Risk, Psychological
Skills Group for Youth at Clinical High-Risk for Psychosis
This study is intended to test the feasibility of an integrated cognitive behavioral therapy (CBT) and dialectical behavioral therapy (DBT) skills group for adolescents and young adults at clinical high-risk (CHR) for psychosis.
- Trial name
- NCT05398120
- Testing
- Skills Group
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Auditory Verbal Hallucinations, Schizophrenia
Theta-Burst Transcranial Magnetic Stimulation for Treatment-Resistant Auditory Hallucinations
The goal of this clinical trial is to learn whether theta-burst transcranial magnetic stimulation (TBS), a non-invasive brain stimulation technique, can help reduce persistent auditory verbal hallucinations (hearing voices) in…
- Conditions
- Auditory Verbal Hallucinations, Schizophrenia, Schizoaffective Disorder, Psychotic Disorders
- Trial name
- NCT07902518
- Testing
- Theta-Burst Transcranial Magnetic Stimulation (TBS)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Schizophrenia; Psychosis, First Episode Psychosis
Repetitive Transcranial Magnetic Stimulation in Early Psychosis and The Functional Connectivity Biotypes
The present study plans to explore different cortical targets of repetitive transcranial magnetic stimulation (rTMS) for populations at the early phase of psychosis, including those at clinical high risk of psychosis and in the…
- Conditions
- Schizophrenia; Psychosis, First Episode Psychosis, Clinical High Risk
- Trial name
- NCT04853485
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- 6 sites in China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Schizophrenia, Schizophreniform
Transcranial Direct Current Stimulation for Hallucinations in First-Episode Schizophrenia
The purpose of this study is to test the efficacy of transcranial direct current stimulation (tDCS) for the treatment of auditory hallucinations in patients currently on risperidone treatment who are experiencing recent onset…
- Conditions
- Schizophrenia, Schizophreniform, Schizoaffective Disorder, Psychosis Not Otherwise Specified (NOS)
- Trial name
- NCT02661347
- Testing
- Risperidone, tDCS
- Where
- United States
- Sponsor
- Northwell Health
Ketamine Abuse, Psychotic Disorders
Substance Misuse To Psychosis for Ketamine (SToP-K)
Evidence suggests that repeated or chronic ketamine use, as compared to acute ketamine users, posed a higher clinical risk of developing psychotic disorders, potentially related to the underlying chronic N-methyl-D-aspartate…
- Conditions
- Ketamine Abuse, Psychotic Disorders, Substance Use Disorders, Schizophrenia
- Trial name
- NCT03485339
- Testing
- genome testing
- Where
- 2 sites in Hong Kong
- Volunteers
- 162 people
- Sponsor
- The University of Hong Kong
Psychotic Disorders
Effects of a Peer-facilitated, Recovery-focused Self-illness Management Program for First-episode Psychosis
Psychosis is a major disabling and disruptive mental illness characterized by a wide variety of disturbances in cognition and emotions, resulting in poor psychosocial functioning and frequent relapses.
- Trial name
- Peer-RESIM (NCT06487195)
- Testing
- Peer-facilitated, Recovery-based Self-illness-management programme, Psycho-education group, Treatment-as-usual only
- Where
- Hong Kong
- Volunteers
- 198 people
- Sponsor
- Chinese University of Hong Kong
Psychosis Associated With Alzheimer's Disease
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)
This is a Phase 3, randomized, double-blind, placebo-controlled, parallel group study to evaluate the safety and efficacy of KarXT in male and female subjects who are aged 55 to 90 years and have mild to severe Alzheimer's…
- Trial name
- NCT06126224
- Testing
- KarXT
- Where
- 157 sites in United States, Belgium and 12 more
- Volunteers
- 500 people
- Sponsor
- Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Schizophrenia, Affective Disorders, Psychotic
Self-Management and Recovery Technology Psychosocial Intervention Trial
This project is a component of a broader research program referred to as "Self-Management and Recovery Technology (SMART): Use of online technology to promote self-management and recovery in people with psychosis", which has been…
- Conditions
- Schizophrenia, Affective Disorders, Psychotic, Psychotic Disorders
- Trial name
- SMARTTherapy (NCT02474524)
- Testing
- Health intervention, Social intervention
- Where
- 10 sites in Australia
- Volunteers
- 148 people
- Sponsor
- Swinburne University of Technology
Schizophrenia, Schizoaffective Disorder
Recovery From Psychosis in Schizophrenia - The Impact of Cognitive-Behavioral Therapy
This study examines the impact of Cognitive-Behavior Therapy (CBT) on symptoms, physiological arousal, stressors, and the ways to deal with them in individuals with schizophrenia and related disorders.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- NCT00791440
- Testing
- Cognitive-Behavior Therapy, Standard Psychiatric Treatment
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- New York State Psychiatric Institute
Insomnia, Psychosis
CBT-I for Psychosis: Guidelines, Preliminary Efficacy, and Functional Outcomes
The goal of this project is to develop guidelines for the clinical tailoring of Cognitive Behavioral Therapy for Insomnia (CBT-I) for Veterans with psychotic disorders and insomnia, and to test the acceptability, feasibility, and…
- Trial name
- CBT-I (NCT02535923)
- Testing
- Cognitive Behavioral Therapy-Insomnia, Health and Wellness
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- VA Office of Research and Development
Psychotic Disorders
A Study of Taurine in Patients With First-episode Psychosis Receiving Antipsychotic Treatment
The purpose of this study is to determine whether Taurine 4g is effective with antipsychotic medication in the treatment of First Episode Psychosis.Taurine may have an effect on cognition and symptoms.
- Trial name
- NCT00420823
- Testing
- Taurine 4g
- Where
- 2 sites in Australia
- Volunteers
- 121 people
- Sponsor
- Melbourne Health
Psychoses
Brain Cell Injury in Patients With A First Episode of Psychosis
Patients experiencing a first episode of psychosis may have brain cell damage due to a chemical process called oxidation. This study will compare patients with psychosis to healthy volunteers to determine if there are differences…
- Trial name
- NCT00070889
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
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