Clinical trials: Non-Cirrhotic Portal Hypertension
Cystic Fibrosis, Immunologic Deficiency Syndrome
Natural History of Noncirrhotic Portal Hypertension
Background: Noncirrhotic Portal Hypertension (NCPH) is caused by liver diseases that increase pressure in the blood vessels of the liver. It seems to start slowly and not have many warning signs.
- Conditions
- Cystic Fibrosis, Immunologic Deficiency Syndrome, Turner Syndrome, Congenital Hepatic Fibrosis
- Trial name
- NCT02417740
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Liver Cirrhosis, Portal Hypertension
Freiburg TIPS Registry
Patients with clinically significant portal hypertension allocated to implantation of a transjugular intrahepatic portosystemic shunt (TIPS) at the Department of Medicine II of the University Medical Center Freiburg, Germany will…
- Conditions
- Liver Cirrhosis, Portal Hypertension, Non-Cirrhotic Portal Hypertension, Budd Chiari Syndrome
- Trial name
- FRETIR (NCT05782556)
- Testing
- Implantation of a transjugular intrahepatic portosystemic shunt (TIPS)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Freiburg
Non-Cirrhotic Portal Hypertension, Common Variable Immunodeficiency
Prediction of Portal Hypertension in Patients With CVID (CVID-pHT)
Patients with CVID will be offered to participate in this observational trial during the routine annual visit in the outpatient clinic at the Center of chronic Immunodeficiency (CCI) of the University Medical Center Freiburg…
- Trial name
- CVID-pHT (NCT06145100)
- Testing
- Ultrasound including color doppler ultrasound
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- University Hospital Freiburg
Cirrhosis, Portal Hypertension
Hepatic Venous Pressure Gradient Versus Endoscopic Ultrasound-Guided Portal Pressure Gradient - Comparative Analysis (HEPCA)
The goal of this interventional trial is to compare in measuring of portal hypertension by HVPG and EUS-PPG in subject indicated to HVPG measurement.
- Conditions
- Cirrhosis, Portal Hypertension, EUS, Non-Cirrhotic Portal Hypertension
- Trial name
- HEPCA (NCT07424963)
- Testing
- Hepatic venous pressure gradient measurement, Endoscopic ultrasound-guided portal pressure gradient measurement
- Where
- 2 sites in Czechia
- Volunteers
- 40 people
- Sponsor
- Military University Hospital, Prague
Intrahepatic Non Cirrhotic Portal Hypertension
Apixaban for Intrahepatic Non Cirrhotic Portal Hypertension
Intrahepatic non-cirrhotic portal hypertension (INCPH) is a rare disease mostly affecting adults in their forties, characterized by portal hypertension related to alterations of intrahepatic microcirculation in the absence of…
- Trial name
- APIS (NCT04007289)
- Testing
- Apixaban
- Where
- France
- Volunteers
- 166 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-Cirrhotic Portal Hypertension, Porto-Sinusoidal Vascular Diseases
Non-invasive Tools for PSVD Diagnosis
Patients treated with platinum-based chemotherapy drugs have the probability of developing PSVD. The diagnosis of PSVD depends on liver biopsy.
- Trial name
- NCT06500403
- Testing
- liver and stiffness measurement
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Portal Hypertension, Budd-Chiari Syndrome
Clinical Diagnosis and Pathological Spectrum of Porto-sinusoidal Vascular Disease in India
There is a need to re-evaluate the patients classified as NCPH and determine whether the new histological classification proposed by the VALDIG applies to the Indian scenario.
- Conditions
- Portal Hypertension, Budd-Chiari Syndrome, Non-Cirrhotic Portal Hypertension, Porto-Sinusoidal Vascular Diseases
- Trial name
- PSVD-India (NCT06054451)
- Where
- India
- Volunteers
- 210 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Vascular Liver Disease, Portal Vein Thrombosis
Vienna Vascular Liver Disease Study
The aim of this Register Trial is to systematically study the epidemiology, risk factors, liver function as well prognosis of patients with vascular liver diseases.
- Conditions
- Vascular Liver Disease, Portal Vein Thrombosis, Budd-Chiari Syndrome, Non-Cirrhotic Portal Hypertension
- Trial name
- VALID (NCT03541057)
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University of Vienna
Portal Hypertension, Non-Cirrhotic Portal Hypertension
Hepatic Venous Pressure Gradient and Elastography in Porto-sinusoidal Vascular Disorder
Porto-sinusoidal vascular disorder (PSVD) is considered a rare cause of portal hypertension (PH), resulting from specific histological alterations that essentially affect the small portal branches and sinusoids, in the absence of…
- Conditions
- Portal Hypertension, Non-Cirrhotic Portal Hypertension, Non-Cirrhotic Portal Fibrosis, Regenerative Nodular Hyperplasia
- Trial name
- NCT05719857
- Testing
- Hepatic vein pressure gradient measurement, Ultrasound-guided percutaneous liver biopsy, Multiparametric Abdominal Magnetic Resonance with Elastography
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Liver Cirrhosis, Portal Hypertension
Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease
Prospective, observational study to define precipitants and predictors of development of Acute-on-Chronic Liver Failure (ACLF) after surgical interventions, allowing to develop a risk stratification for elective procedures in…
- Conditions
- Liver Cirrhosis, Portal Hypertension, Surgery, Acute-On-Chronic Liver Failure
- Trial name
- PERSEVERE (NCT04578301)
- Testing
- No Intervention
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bonn
Non Cirrhotic Portal Hypertension
Comparison of Endoscopic Variceal Ligation (EVL) With Propranolol in Non Cirrhotic Portal Hypertension (NCPH)
Background: Variceal bleeding is a major cause of morbidity and mortality in patients with Non Cirrhotic Portal Hypertension (NCPH).
- Trial name
- NCT01000779
- Testing
- Propranolol, multi band ligator for esophageal varices
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Govind Ballabh Pant Hospital