Clinical trials: Non-Nutritive Sweetener
Healthy Volunteers - Male and Female
Resting-state Imaging and Chronic Consumption of Non-Nutritive SweetenerS
Non-nutritive sweeteners are used as a substitute for simple sugars to improve the palatability of food products without increasing their sugar and calorie content.
- Trial name
- RNSS (NCT07183254)
- Testing
- administration of questionnaires, carrying out a MRI scan, Can distribution visit for subjects in the "non/low" sweetener consumption group
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Obesity, Diabetes Mellitus, Type 2
Enteroendocrine Hormonal Response After the Ingestion of Cola Beverages With Sucrose and Non-nutritive Sweeteners
Introduction: The consumption of non-nutritive sweeteners (NNS) has been increasing in recent years, as an alternative to replace sugars and reduce the additional intake of carbohydrates, with the idea of reducing the risk of…
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Metabolic Syndrome
- Trial name
- NCT05654285
- Testing
- Cola beverage with aspartame and acesulfame K, Cola beverage with sucrose and stevia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Pre Diabetes
Cephalic Phase Responses to Nutritive and Non-Nutritive Sweeteners
This study will focus on changes in blood sugar in response to tasting different types of sweeteners using continuous glucose monitoring (CGM) technology.
- Trial name
- NCT06387316
- Testing
- No Oral Stimulation, Oral water stimulation, Oral Salt Stimulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Purdue University
Healthy Adult Participants
Effects of Coca-Cola Zero Sugar Consumption on Urinary Metabolites in Healthy Adults
Consumption of beverages containing non-nutritive sweeteners has increased worldwide, but limited information is available regarding the short-term urinary excretion of acesulfame potassium (Ace-K) and the acute metabolic…
- Trial name
- NCT07694401
- Testing
- Coca-Cola Zero Sugar, Still water
- Where
- Czechia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Czech University of Life Sciences Prague
Healthy, Overweight and Obesity
Strategies To OPpose Sugars With Non-nutritive Sweeteners Or Water (STOP Sugars NOW) Trial
Health authorities recommend a reduction in added sugars from sugar-sweetened beverages (SSBs) due to risk of obesity and diabetes. As a sugar-reduction strategy, finding the ideal SSB replacement is of the utmost importance.
- Conditions
- Healthy, Overweight and Obesity, Metabolic Syndrome, PreDiabetes
- Trial name
- NCT03543644
- Testing
- Sugar-sweetened beverage (SSB), Non-nutritive sweetened beverages (NSB), Water
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Gestational Diabetes Mellitus in Pregnancy, Glucose Intolerance During Pregnancy
Effects of a Non-nutritive Sweetener Reduction Intervention in Pregnancy and Lactation on Maternal and Infant Outcomes
The effects of consuming non-nutritive sweeteners (NNS) during pregnancy and lactation on infant obesity and cardiometabolic disease risk are not well understood.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Glucose Intolerance During Pregnancy, Non-nutritive Sweeteners Consumption in Pregnancy and/or Lactation
- Trial name
- NCT06548828
- Testing
- NNS Restriction Intervention, Control Intervention
- Where
- United States
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- George Washington University
Non Nutritive Sweeteners Consumption
Effect of Non-nutritive Sweeteners on Vascular Function in Humans
In recent decades, low-to-null caloric, non-nutritive sweeteners (NNS) have been increasingly used, replacing and offering an alternative to food and beverages sweetened by high-energy, added sugars.
- Trial name
- SOSweet (NCT05099393)
- Testing
- Non Nutritive Sweeteners
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Obesity
The Sweet PEA Study: Effects of Diet During Pregnancy on Infant Growth and Development.
The purpose of the Sweet PEA Study is to determine whether diet during pregnancy has an effect on infant's growth, body composition, and brain development.
- Trial name
- NCT04674033
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Postprandial Glucose, Glucose Levels
Ultra-processed Food-reducing Intervention and Continuous Glucose Monitoring
The goal of this trial is to investigate whether reduction in ultra-processed food intake through dietary counseling and education can improve postprandial glucose responses and glycemic variability compared with a usual diet in…
- Conditions
- Postprandial Glucose, Glucose Levels, Hyperglycemias
- Trial name
- ULTRA-CGM (NCT07175701)
- Testing
- 40-minute one-on-one dietary counseling and nutrition education aimed at reducing ultra-processed food consumption, Standard dietary counseling and nutrition education based on national guidelines
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Korea University
Inflamatory Bowel Disease, Crohn Disease (CD)
Non-nutritive Sweeteners in Inflammatory Bowel Disease
This study will focus on the commonly used non-nutritive sweetener (NNS) sucralose (2 sachets/day resulting in daily dose: sucralose 2.5mg/kg) and its role in changing the gut microbiota in humans with IBD, compared to healthy…
- Trial name
- NCT07769437
- Testing
- Sucralose (non-nutritive sweetener)
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Appetitive Behavior
Scot Sweet Study (Interaction of a Non-nutritive Sweetener With a High-fibre Weight Loss Diet)
The investigators present a weight loss diet intervention study, to be conducted as a within-subject design, with all food and beverages provided, to assess interaction of non-nutritive sweetener (sucralose) with a high-fibre…
- Trial name
- SSS (NCT05892003)
- Testing
- Phase 1 Control, Phase 2 High Fibre Weight Loss, Phase 3 High Fibre and Non-Nutritive Sweetener Weight Loss
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Glucose Intolerance, Glucose and Insulin Response
Sucralose and Glucose Metabolism in Young Healthy Adults
This study aimed to investigate the effects of a three-week consumption of sucralose-sweetened beverages (low-calorie sweetener) on postprandial glycemic responses in healthy adults, compared with sugar-sweetened beverages under…
- Conditions
- Glucose Intolerance, Glucose and Insulin Response, Glucose Homeostasis, Low-grade Inflammation
- Trial name
- NARELO (NCT07194772)
- Testing
- Low-calorie sweeteners (LCS), Refined sugars (SSB), Natural sugars (FJ)
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Obesity
Metabolic Effects of Non-nutritive Sweeteners
The purpose of this research study is to examine whether sugar-replacement sweeteners that are currently on the market (ex. Sucralose, which is in Splenda) change how well the body works to control blood sugar.
- Trial name
- NNS (NCT02413424)
- Testing
- Sucralose, Water, glucose load
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Pregnancy Related, Diabetes
Transport of Artificial Sweeteners During Pregnancy
With obesity on the rise worldwide more and more young women are also affected, leading to a higher prevalence of obese pregnant women and pregnant women with diabetes.
- Conditions
- Pregnancy Related, Diabetes, IUGR
- Trial name
- NCT03954418
- Testing
- Acesulfame K, cyclamate, saccharine, aspartame
- Where
- Denmark
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Insulin Sensitivity
Effect of Consumption of Non Caloric Sweeteners and Insulin Sensibility
This study will compare the effect of acute consumption of two carbonated drinks, sweetened with sugar or with non-caloric sweeteners, over the insulin response of healthy adults who normally consumed foods or drinks that contain…
- Trial name
- NCT02890108
- Testing
- Sugar sweetened beverages, Artificially sweetened beverages
- Where
- Chile
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Instituto de Nutrición y Tecnología de los Alimentos
Diet Habit
The Validation of Various Dietary Assessment Methodologies
The purpose of the study is see how well two dietary intake questionnaires, blood values, and urine samples can estimate what participants are eating and drinking.
- Trial name
- NCT03364452
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Obesity
Sugar-replacement Sweeteners, and Blood Sugar Control
Several sugar-replacement sweeteners are currently on the market, including saccharine (ex. Sweet'N Low), aspartame (ex. Equal), and sucralose (ex. Splenda).
- Trial name
- SIR (NCT01128829)
- Testing
- Water, Sucralose
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Breastfeeding, Diabetes Mellitus
Artificial Sweeteners in Breast Milk
This study will investigate how some artificial sweeteners (AS) cross from blood to breastmilk in breastfeeding women after oral intake.
- Conditions
- Breastfeeding, Diabetes Mellitus, Overweight
- Trial name
- NCT04578431
- Testing
- Artificial sweeteners (acesulfame-potassium, sucralose, saccharine, cyclamate)
- Where
- Denmark
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy Population, Glucose Tolerance
Effects of Low/No Calorie Sweeteners on Glucose Tolerance
This study aims to determine the effects of chronic exposure to some low/no calorie sweeteners (LNCS) on glucose tolerance and glucagon like peptide 1 (GLP-1) release in healthy individuals.
- Trial name
- NCT04904133
- Testing
- Low/No Calorie Sweeteners
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Glucose Intolerance, Obesity
Physiological Effects of Stevia Consumption in Humans
This study will evaluate whether long-term consumption of the low calorie sweetener stevia affects glucose tolerance in healthy participants.
- Trial name
- NCT03993418
- Testing
- stevia
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manchester