Clinical trials: Non-Nutritive Sweetener
Overweight and Obesity
Metabolism Effects of Artificially Sweetened Beverages Restriction
The consumption of artificially sweetened beverages increases glucose and insulin concentrations in blood, body weight and waist circumference.
- Trial name
- NCT03679689
- Testing
- artificially sweetened beverages
- Where
- Mexico
- Volunteers
- 45 people
- Sponsor
- Monica Flores-Muñoz
Continuous Glucose Monitoring, Oral Glucose Tolerance
Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes
Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control.
- Conditions
- Continuous Glucose Monitoring, Oral Glucose Tolerance, Insulin Sensitivity, Inflammatory Markers
- Trial name
- NCT05337098
- Testing
- Non-Nutritive Sweetener Intake and impact on glucose homeostasis
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Virginia Polytechnic Institute and State University
Obesity, Diabetes Mellitus, Type 2
Enteroendocrine Hormonal Response After the Ingestion of Cola Beverages With Sucrose and Non-nutritive Sweeteners
Introduction: The consumption of non-nutritive sweeteners (NNS) has been increasing in recent years, as an alternative to replace sugars and reduce the additional intake of carbohydrates, with the idea of reducing the risk of…
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Metabolic Syndrome
- Trial name
- NCT05654285
- Testing
- Cola beverage with aspartame and acesulfame K, Cola beverage with sucrose and stevia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Type 1 Diabetes (T1D), Healthy Subjects
Effect of Artificial Sweetener (AFS) on Glucose Metabolism in Patients With Type 1 Diabetes (T1D)
The goal of this randomized crossover study is to test the prediction that consuming carbohydrates will affect insulin release differently depending on whether Non-Nutritive Sweeteners (NNSs) are consumed simultaneously.
- Trial name
- AFS_T1D (NCT06315725)
- Testing
- Sweet taste perception with/without sweet taste blockade
- Where
- Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Impaired Glucose Tolerance
Effects of Artificial Sweeteners on Gut Microbiota and Glucose Metabolism
The Objectives of this study is to determine the effect(s) of daily non-caloric artificial sweetener (NAS) consumption (sucralose or aspartame) on the composition of the bacteria and also to determine the changes in glucose…
- Trial name
- NCT02569762
- Testing
- Sucralose-Aspartame, Aspartame-Sucralose
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Inflamatory Bowel Disease, Crohn Disease (CD)
Non-nutritive Sweeteners in Inflammatory Bowel Disease
This study will focus on the commonly used non-nutritive sweetener (NNS) sucralose (2 sachets/day resulting in daily dose: sucralose 2.5mg/kg) and its role in changing the gut microbiota in humans with IBD, compared to healthy…
- Trial name
- NCT07769437
- Testing
- Sucralose (non-nutritive sweetener)
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Prediabetes
Glycemic Impact of NNS Via the Gut Microbiome
This pilot study will evaluate the feasibility and acceptability of a 30-day sucralose intervention among adults with prediabetes.
- Trial name
- NCT07868432
- Testing
- Sucralose
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tufts University
Obesity
Effects of Sweetness on Neurocognitive Responses, Glycemia and Food Intake
This study aims to examine potential differences in neurocognitive responses to food-related cues, physiological and appetite responses as well as subsequent energy intake following the consumption of preloads differing in…
- Trial name
- NCT03711084
- Testing
- Natural high potency sweetener from leaf extract, Glucose, Sucrose
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Obesity
The Sweet PEA Study: Effects of Diet During Pregnancy on Infant Growth and Development.
The purpose of the Sweet PEA Study is to determine whether diet during pregnancy has an effect on infant's growth, body composition, and brain development.
- Trial name
- NCT04674033
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Healthy Adult
SweetSpot - The Effect of Non-nutritive Sweeteners on Health
The aim of the study is to investigate the effect of non-nutritive sweeteners on glucose regulation. Secondary objectives are to investigate the effect of NNS on gut microbiome, gut hormone secretion, sweet taste sensitivity and…
- Trial name
- NCT07361406
- Testing
- Diet with non-nutritive sweeteners, Diet without non-nutritive sweeteners
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Diet, Healthy
Testing Non-nutritive Sweetener Labels in Chile
The goal of this experiment is to examine the effects of 2 types of non-nutritive sweetener (NNS) warning labels among a sample of Chilean parents.
- Trial name
- NCT06842693
- Testing
- Control, Chilean non-nutritive sweetener label, Colombian non-nutritive sweetener label
- Where
- United States
- Volunteers
- 3,916 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Diabetes Mellitus, Type 1
To Compare Influence of Breakfast With and Without Sweeteners on Postprandial Glycemic Response and Appetite-Satiety Sensation in Subjects With Type 1 Diabetes
Introduction: Type 1 diabetes is a chronic autoimmune disease with multifactorial etiology, resulting in partial or complete destruction of pancreatic β cells, leading to an absolute deficit of insulin and vital dependence on…
- Trial name
- T1D (NCT06201806)
- Testing
- Test food breakfast with NCS or witout NCS
- Where
- Chile
- Volunteers
- 32 people
- Sponsor
- University of Chile
Healthy Adult Participants
Effects of Coca-Cola Zero Sugar Consumption on Urinary Metabolites in Healthy Adults
Consumption of beverages containing non-nutritive sweeteners has increased worldwide, but limited information is available regarding the short-term urinary excretion of acesulfame potassium (Ace-K) and the acute metabolic…
- Trial name
- NCT07694401
- Testing
- Coca-Cola Zero Sugar, Still water
- Where
- Czechia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Czech University of Life Sciences Prague
Neuropsychology, Ingestive Behavior
Parsing the Impact of Calories Versus Sweet Taste on Beverage Brand Conditioning
The purpose of this study is to learn how the sweet taste and the calorie content of a beverage affect the way people respond to the brand logo printed on that beverage.
- Trial name
- PSK (NCT07883096)
- Testing
- 3-week daily beverage intervention
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Monell Chemical Senses Center
Glucose Intolerance, Obesity
Physiological Effects of Stevia Consumption in Humans
This study will evaluate whether long-term consumption of the low calorie sweetener stevia affects glucose tolerance in healthy participants.
- Trial name
- NCT03993418
- Testing
- stevia
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Diabetes Mellitus, Type 2
To Compare the Effects of Non-nutritive Sweeteners Intake in Subjects With T2DM
ABSTRACT Introduction: There is no current data about the effects of non-nutritive sweeteners (NNS) about important factors, such as the energy intake, appetite and its relationship in people with diabetes when tasting sweet.
- Trial name
- NCT03680482
- Testing
- Intervention ingest a 48 mg of sucralose, Intervention ingest a 96 mg of stevia
- Volunteers
- 17 people
- Sponsor
- University of Chile
Obesity
The Effects of Beverages on Food Liking
The use of non-nutritive sweeteners (NNS) in replacement of nutritive sweeteners (NS) could be a potential weight loss strategy as it may reduce energy intake.
- Trial name
- NCT03579043
- Testing
- Nutritive Sweetener, Non-Nutritive Sweetener, Carbonated Water
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Appetitive Behavior
Scot Sweet Study (Interaction of a Non-nutritive Sweetener With a High-fibre Weight Loss Diet)
The investigators present a weight loss diet intervention study, to be conducted as a within-subject design, with all food and beverages provided, to assess interaction of non-nutritive sweetener (sucralose) with a high-fibre…
- Trial name
- SSS (NCT05892003)
- Testing
- Phase 1 Control, Phase 2 High Fibre Weight Loss, Phase 3 High Fibre and Non-Nutritive Sweetener Weight Loss
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Insulin Sensitivity
Effect of Consumption of Non Caloric Sweeteners and Insulin Sensibility
This study will compare the effect of acute consumption of two carbonated drinks, sweetened with sugar or with non-caloric sweeteners, over the insulin response of healthy adults who normally consumed foods or drinks that contain…
- Trial name
- NCT02890108
- Testing
- Sugar sweetened beverages, Artificially sweetened beverages
- Where
- Chile
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Instituto de Nutrición y Tecnología de los Alimentos
Pre Diabetes
Cephalic Phase Responses to Nutritive and Non-Nutritive Sweeteners
This study will focus on changes in blood sugar in response to tasting different types of sweeteners using continuous glucose monitoring (CGM) technology.
- Trial name
- NCT06387316
- Testing
- No Oral Stimulation, Oral water stimulation, Oral Salt Stimulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Purdue University