Clinical trials: Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
Coronary Artery Disease, Acute Myocardial Infarction
Beta Blocker De-prescription Following Coronary Artery Bypass Graft Surgery (BEEFBURGER Trial).
Beta-blockers have the greatest cardiovascular impact in patients with reduced heart function/heart failure and in reducing the peri-operative risk of atrial fibrillation.
- Conditions
- Coronary Artery Disease, Acute Myocardial Infarction, Coronary Artery Stenosis, ST Elevation Myocardial Infarction
- Trial name
- BEEFBURGER (NCT04788186)
- Testing
- De-prescribe beta blocker therapy
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Saskatchewan
Stable Angina, Unstable Angina
Optical Coherence Tomography Comparison of Neointimal Coverage Between CRE8 DES and BMS
The purpose of the study is to demonstrate the non-inferiority of Cre8 (CID) Drug Eluting Stent, studied 3 months after implant, compared to Vision/Multilink8 Bare Metal Stent (Abbott) studied at 1 month, in terms of neointimal…
- Conditions
- Stable Angina, Unstable Angina, NSTEMI
- Trial name
- DEMONSTRATE (NCT01543373)
- Testing
- Amphilimus Eluting Stent, Bare Metal Stent
- Where
- 6 sites in Italy, Netherlands
- Volunteers
- 38 people
- Sponsor
- CID - Carbostent & Implantable Devices
Non ST Segment Elevation Acute Coronary Syndrome, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
Prasugrel Or Ticagrelor De-escalation in NSTE-ACS
The PROTEUS study is a randomized, cross-over, open-label, pharmacodynamic trial designed to compare the antiplatelet effect of reduced maintenance doses of prasugrel and ticagrelor in stable patients who recently had…
- Conditions
- Non ST Segment Elevation Acute Coronary Syndrome, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), Unstable Angina
- Trial name
- PROTEUS (NCT05779059)
- Testing
- De-escalation to ticagrelor 60 mg at day 30, De-escalation to prasugrel 5 mg at day 30, Switch to ticagrelor 60 mg at day 45
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Coronary Artery Disease, Stable Angina
Comparison of Drug Eluting Balloon and Drug Eluting Stent
The purpose of this study is to evaluate the safety and efficacy of Drug-Eluting Balloon first and then bare metal stent compared with drug-eluting stent for treatment of de novo lesions (DEB first).
- Conditions
- Coronary Artery Disease, Stable Angina, Unstable Angina, NSTEMI
- Trial name
- DEBfirst (NCT01539603)
- Testing
- Drug eluting balloon + Bare metal stent, drug eluting stent (Zotarolimus-eluting stent)
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Seoul National University Bundang Hospital
Acute Coronary Syndrome, STEMI
EKG Criteria and Identification of Acute Coronary Occlusion
The objective of this research study is to test the accuracy of preexisting criteria versus expert interpretation for the diagnosis of acute coronary occlusion (major heart attack due to a completely blocked blood vessel).
- Conditions
- Acute Coronary Syndrome, STEMI, STEMI - ST Elevation Myocardial Infarction, Acute Coronary Artery Thrombosis (Diagnosis)
- Trial name
- NCT03863327
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Stony Brook University
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Romania Satellite Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES).
- Trial name
- NCT01593059
- Where
- 4 sites in Romania
- Volunteers
- 13 people
- Sponsor
- Biotronik Vertriebs-GmbH
Myocardial Infarction, Angioplasty
Intracoronary Bolus Only Compared With Intravenous Bolus and 12-hours Infusion of Abciximab in Non-ST Elevation Myocardial Infarction.
Intracoronary bolus Abciximab single is non-inferior to intravenous and continuous 12- hours infusion in the size reduction of infarction on cardiac magnetic resonance in Non-ST elevation Myocardial infarction.
- Trial name
- NCT01080638
- Testing
- glycoprotein IIb/IIIa inhibitor (abciximab)
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital
Myocardial Infarction
Is the Current Threshold for Diagnosis of "Abnormality", Including Non ST Elevation Myocardial Infarction, Using Raised Highly Sensitive Troponin Appropriate for a Hospital Population? The CHARIOT Study
Currently when defining the upper limit of normal (ULN) or 99th percentile of a troponin assay manufacturer's use a healthy population traditionally aged 18-40.
- Trial name
- CHARIOT (NCT03047785)
- Where
- United Kingdom
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Cardiac Disease
Triple Antithrombotic Therapy in Cardiac Patients Requiring Revascularization
Aim(s)/Objective(s) To evaluate the safety and efficacy of triple antithrombotic therapy in patients taking DAPT of aspirin and a P2Y12 inhibitor in addition to either a NOAC or warfarin for the prevention of thromboembolic or…
- Trial name
- NCT03889574
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Methodist Health System
Coronary Artery Diseases
BIOTRONIK - BIOFLOW-III Registry French Satellite
For the majority of Coronary Artery Disease (CAD) treatment with Percutaneous Transluminal Coronary Angioplasty (PTCA) provides high initial procedure success.
- Trial name
- NCT02273648
- Testing
- Drug Eluting Stent (DES)
- Where
- 50 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Biotronik France
Acute Myocardial Infarction
Impact of OCT on Outcomes in AMI
This protocol describes a retrospective, single-center study intended to test the impact of optical coherence tomography(OCT) on long term clincical outcomes in patients with acute myocardial infarction(AMI).
- Trial name
- NCT05266547
- Testing
- OCT guided coronary intervention
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Beijing Luhe Hospital
Multivessel Coronary Artery Disease, Vessel Disease
Functional Testing Underlying Coronary Revascularisation
The objective of this trial is to compare the clinical outcomes and cost-effectiveness of 2 therapeutic strategies, one based on coronary angiography guidance and the other based on coronary angiography with fractional flow…
- Conditions
- Multivessel Coronary Artery Disease, Vessel Disease, Stable Angina, Unstable Angina or Stabilized Non-ST Elevated Myocardial Infarction
- Trial name
- FUTURE (NCT01881555)
- Testing
- invasive coronary angiography, Functional testing by fractional flow reserve measurement
- Where
- France
- Volunteers
- 941 people
- Sponsor
- Hospices Civils de Lyon
Ischemic Heart Disease, Angina, Stable
Post-Revascularization Optimization and PHysiological Evaluation of intermediaTe Lesions
PROPHET-FFR is a single center ambispective registry aiming to explore the impact of post-revascularization functional assessment on later outcomes.
- Conditions
- Ischemic Heart Disease, Angina, Stable, Non ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction
- Trial name
- PROPHET-FFR (NCT05056662)
- Testing
- Invasive functional evaluation with either Pd/Pa, FFR, iFR or contrast FFR
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Catholic University of the Sacred Heart
Acute Coronary Syndrome, Depression
MBCT Delivered Via Group Videoconferencing for ACS Patients With Elevated Depression Symptoms
The objective of this study is to identify Acute Coronary Syndromes (ACS) patients' specific needs and preferences for depression treatment via in-person or virtual individual interviews to (a) guide MBCT adaptation; and identify…
- Conditions
- Acute Coronary Syndrome, Depression, Myocardial Infarction, Unstable Angina
- Trial name
- NCT03878160
- Testing
- Individual Interview
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Non-ST Elevation Myocardial Infarction, Acute Coronary Syndrome
Cardiac MRI Prior to Invasive Coronary Angiography in Patients With Suspected Non-ST-Elevation Myocardial Infarction
Patients with a suspected myocardial infarction are subdivided into ST-elevation and non-ST-elevation myocardial infarctions (STEMI and NSTEMI, respectively) using ECG.
- Trial name
- KaPSICA-CMR (NCT06566625)
- Testing
- Cardiac MRI (CMR) examination
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Myocardial Infarction (MI), Dyslipidemias
Germany on Target Registry
Germany on Target Registry (DaZiR) is a prospective, Germany-wide patient registry designed to assess lipid management and low-density lipoprotein cholesterol ( LDL-C) target attainment in adults following acute myocardial…
- Trial name
- DaZiR (NCT07835282)
- Testing
- No study-assigned intervention
- Volunteers
- 10,000 people
- Sponsor
- Deutsche Gesellschaft für Lipidologie e. V. (DGFL) - Lipid-Liga
STEMI, Covid19
Evaluation of the Effect of Long-term Lipid-lowering Therapy in STEMI Patients With Coronavirus Infection COVID-19
It is planned to include 200 patients hospitalized with primary myocardial infarction with and without ST segment elevation (STEMI or NSTEMI) in combination with COVID-19 within the first 15 days from the disease onset.
- Conditions
- STEMI, Covid19, NSTEMI
- Trial name
- CONTRAST-3 (NCT04900155)
- Testing
- Atorvastatin 80mg, Atorvastatin-Ezetimibe
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Penza State University
Cardiac Rehabilitation
The Use of Contextualised Body Data in Cardiac Rehabilitation (CR)
KiCS1 study : Digital health for current hospital- based Cardiac rehabilitation programmes to increase effectiveness and patient outcomes.
- Trial name
- KiCS1 (NCT05492526)
- Testing
- Ki Monitor without feedback, Ki monitor with contextualised data feedback
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Coronary Heart Disease
After Eighty Study
The rationale of the present clinical trial is to study whether an invasive strategy in clinical stable patients over 80 years with NSTEMI/UAP may improve rates of death, reinfarction, stroke, need of urgent revascularisation…
- Trial name
- NCT01255540
- Where
- Norway
- Volunteers
- 492 people
- Sponsor
- Oslo University Hospital
ACS (Acute Coronary Syndrome), Myocardial Infarction (MI)
TIRANA-ACS: A Prospective Registry Study for the Targeted Investigation of Residual Inflammation After Non-ST/ ST Elevation Acute Coronary Syndrome
This prospective observational study aims to evaluate the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) as a predictor of mortality in patients following an episode of Acute Coronary Syndrome (ACS).
- Conditions
- ACS (Acute Coronary Syndrome), Myocardial Infarction (MI), Myocardial Inflammation, Inflammation Biomarkers
- Trial name
- TIRANA (ACS) (NCT07026708)
- Where
- Albania
- Volunteers
- 1,600 people
- Sponsor
- University Hospital Centre Mother Teresa