Clinical trials: Non-fluent Aphasia
Stroke, Aphasia
Effects of rTMS Based on Neural Activation in Language Performance in Stroke Patients With Non-fluent Aphasia
The aim of this study is to assess the safety and clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) based on hemodynamic brain activity pattern with functional near infrared spectroscopy (fNIRS) in early…
- Trial name
- NCT02591719
- Testing
- MagPro magnetic stimulator (HF rTMS), MagPro magnetic stimulator (LF rTMS)
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Seoul National University Bundang Hospital
Stroke
Effects of Cerebrolysin on Language Ability in Non-fluent Aphasia Patients After Stroke: A Randomized, Placebo-controlled, Double-blinded, Single Center Study
" This study aims to measure changes in language ability after adding cerebrolysin to standard treatment for non-fluent aphasia patients with post-stroke language impairment.
- Trial name
- NCT06897176
- Testing
- Cerebrolyisin
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Primary Progressive Aphasia, Nonfluent Progressive Aphasia
Language Treatment for Progressive Aphasia
Progressive aphasia is characterized by a steady and progressive loss of language skills in the presence of relatively preserved memory, attention, and thinking.
- Conditions
- Primary Progressive Aphasia, Nonfluent Progressive Aphasia, Semantic Dementia
- Trial name
- NCT00957710
- Testing
- Errorless learning
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Baycrest
Primary Progressive Nonfluent Aphasia
Transcranial Magnetic Stimulation in Nonfluent/Agrammatic Variant Primary Progressive Aphasia
Nonfluent/agrammatic variant primary progressive aphasia (nf/avPPA) is a fatal neurodegenerative disease that begins with isolated language deficits. There is currently no cure or treatment for this disease.
- Trial name
- NCT03153540
- Testing
- Active iTBS
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of British Columbia
PPA, Non-fluent Aphasia
Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech
The study is designed to determine the relationship between structural and functional changes in the brain on imaging and progression of speech and language, neurological and neuropsychological features in patients with…
- Conditions
- PPA, Non-fluent Aphasia, Apraxia of Speech, Primary Progressive Non-fluent Aphasia
- Trial name
- NCT01818661
- Testing
- AV-1451
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Stroke, Ischemic, Aphasia Non Fluent
Effects of Neuronavigated Theta Burst Stimulation in Therapy of Post-stroke Aphasia
Aphasia is an impairment in the ability to express and/or understand language, commonly observed after stroke to the language dominant (left) hemisphere.
- Trial name
- NCT05303649
- Testing
- Noninvasive transcranial brain stimulation: excitatory iTBS, Noninvasive transcranial brain stimulation: inhibitory cTBS, Individual speech-language therapy (SLT)
- Where
- Poland
- Volunteers
- 45 people
- Sponsor
- Institute of Psychiatry and Neurology, Warsaw
Primary Progressive Aphasia(PPA)
Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia
This is a monocenter randomized controlled clinical trial with cross-over arm - assessor blinded. The aims is investigating the effects of the speech language therapy (SLT) alone vs SLT + non-invasive brain stimulation (STIM)…
- Trial name
- NCT06921265
- Testing
- Training with Speech Language Therapy, Standard rTMS, Targeted rTMS
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Primary Progressive Aphasia, Frontotemporal Dementia
Communication Bridge Speech Therapy Research Study
This is a study on Internet-based video-practice speech and language therapy for persons with primary progressive aphasia (PPA), behavioral-variant frontotemporal dementia (bvFTD), or related conditions.
- Trial name
- CB (NCT02439853)
- Testing
- Monthly Check-in Session
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Chicago
Predicted Tauopathies, Including, Progressive Supranuclear Palsy
Davunetide (AL-108) in Predicted Tauopathies - Pilot Study
The primary objective of the study is to obtain preliminary safety and tolerability data with davunetide (NAP, AL-108) in patients with a tauopathy (frontotemporal lobar degeneration [FTLD] with predicted tau pathology…
- Conditions
- Predicted Tauopathies, Including, Progressive Supranuclear Palsy, Frontotemporal Dementia With Parkinsonism Linked to Chromosome 17, Corticobasal Degeneration Syndrome
- Trial name
- NCT01056965
- Testing
- davunetide (AL-108, NAP)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Aphasia, Broca, Aphasia, Wernicke
Remote Neurobased Approach to Aphasia Therapy
The purpose of this study is the development and validation of an evidence-based mobile application, based on the core premises of Intensive Language-Action Therapy (ILAT) for aphasia, for the training and improvement of chronic…
- Conditions
- Aphasia, Broca, Aphasia, Wernicke, Aphasia, Fluent, Aphasia, Nonfluent
- Trial name
- RNAAT (NCT05274360)
- Testing
- Mobile evidence-based aphasia therapy, Conventional aphasia rehabilitation
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Institute for Bioengineering of Catalonia
Aphasia, Aphasia Following Cerebral Infarction
Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST)
The goal of this clinical trial is to compare the effectiveness of traditional Semantic Feature Analysis (SFA) treatment to a modified SFA protocol that includes Metacognitive Strategy Training (SFA+MST) for adults with acquired…
- Conditions
- Aphasia, Aphasia Following Cerebral Infarction, Aphasia, Acquired, Aphasia, Rehabilitation
- Trial name
- NCT07036406
- Testing
- Semantic Feature Analysis (traditional), Semantic Feature Analysis + Metacognitive Strategy Training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Teachers College, Columbia University
Primary Progressive Aphasia
Effects of tDCS on Apraxia of Speech in Non-Fluent Primary Progressive Aphasia
Primary progressive aphasia (PPA) is a neurodegenerative disease that affects first and foremost language abilities. There are three different variants of PPA, each a relatively distinct speech and language profile.
- Trial name
- NCT04486586
- Testing
- Active tDCS plus Speech-Language Therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Stroke
Fluoxetine for Motor, Aphasia, and Neglect Recovery After Ischemic Stroke
This pilot study will recruit 25 subjects to assess the feasibility of replicating the FLAME study (Chollet, et al. Lancet 2011), a randomized controlled trial (RCT) that assessed the effect of fluoxetine vs placebo on motor…
- Trial name
- FLAN (NCT01674868)
- Testing
- fluoxetine
- Where
- United States
- Sponsor
- Spaulding Rehabilitation Hospital
Aphasia Non Fluent, Stroke
Effectiveness of TDCS Over Broca's Area in Verb Naming: a Randomized, Double-Blind, Crossover Study
This clinical trial investigated whether transcranial direct current stimulation (tDCS) over Broca's area (F5) could improve verb naming abilities in adults with aphasia.
- Trial name
- NCT06776978
- Testing
- Active treatment
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Aphasia, Stroke
Melodic-Intonation-Therapy and Speech-Repetition-Therapy for Patients With Non-fluent Aphasia
We are doing this clinical trial in order to evaluate two different treatments for non-fluent aphasia: Melodic Intonation Therapy (MIT) and Speech Repetition Therapy (SRT).
- Conditions
- Aphasia, Stroke, Cerebrovascular Accident, Apoplexy
- Trial name
- NCT00903266
- Testing
- Melodic Intonation Therapy, Speech-Repetition-Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Beth Israel Deaconess Medical Center
Aphasia, Broca
Effects of PACE Technique in Patients With Aphasia
Aphasia, a communication disorder often resulting from him brain injury such as stroke, impacts an individual's ability to understand or produce language.
- Trial name
- NCT07521098
- Testing
- experimental, control group conventional therapy
- Where
- Pakistan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Primary Tauopathies, Corticobasal Degeneration Syndrome
BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES
A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Parallel Cohort Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of Intravenously Infused BIIB092 in Patients with Four Different…
- Conditions
- Primary Tauopathies, Corticobasal Degeneration Syndrome, Frontotemporal Lobar Degeneration With Tau Inclusions, MAPT Mutation Carriers, Symptomatic
- Trial name
- TauBasket (NCT03658135)
- Testing
- BIIB092
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, San Francisco
Stroke, Aphasia, Non-fluent
Repetitive Transcranial Magnetic Stimulation and Multi-modality Aphasia Therapy for Post-stroke Non-fluent Aphasia
Many stroke survivors experience aphasia, a loss or impairment of language affecting the production or understanding of speech. One common type of aphasia is known as non-fluent aphasia.
- Trial name
- REMAP (NCT04102228)
- Testing
- 1Hz inhibitory rTMS, Multi-Modality Aphasia Therapy (M-MAT)
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University of Calgary
Nonfluent Aphasia, Stroke
Augmenting Language Therapy for Aphasia: Levodopa
The purpose of this study is to evaluate the effectiveness of the medication levodopa, in combination with speech-language treatment, on the language outcome of study subjects with nonfluent aphasia (i.e.
- Trial name
- NCT01429077
- Testing
- levodopa/carbidopa
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Acute, Expressive Aphasia
Music After Stroke To Enhance Rehabilitation
Music that is familiar and preferred by patients has been shown to heighten neuroplasticity and can mitigate these disabilities.
- Conditions
- Stroke, Acute, Expressive Aphasia, Movement, Abnormal, Depressive Disorder
- Trial name
- MASTER (NCT04441515)
- Testing
- Ipod with music, ipod with books to listen, ipod only with usual care
- Volunteers
- 12 people
- Sponsor
- Pace University