Clinical trials: Non-invasive
Respiratory Insufficiency
BIPAP Vision Versus OPTIFLOW System Comparison in Acute Respiratory Failure After Cardio Thoracic Surgery
The OPTIFLOW ™ use is becoming more common in acute respiratory failure cases, but its place in relation to VNI (Bi-PAP mode) is not yet defined.
- Trial name
- OPTIFLOW (NCT01458444)
- Testing
- Non invasive ventilation (VNI), Non invasive ventilation
- Where
- France
- Volunteers
- 830 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Stress Urinary Incontinence
Non-ablative Er:Yttrium Aluminum Garnet Laser for Stress Urinary Incontinence (SUI)
Stress urinary incontinence (SUI) is a common complaint in women after childbirth. The aim of this study was to evaluate the efficacy and safety of non-ablative Er:YAG laser therapy in the treatment of SUI and improvement of…
- Trial name
- NCT03296241
- Testing
- laser
- Volunteers
- 114 people
- Sponsor
- Dr Adolf Lukanovič
Bladder Cancer
BCG Modulation of the recMAGE-A3 + AS15 ASCI Response in the Treatment of Non Muscle Invasive Bladder Cancer (NMIBC) Patients
In this study, the investigators would like to assess how intravesical BCG schedules after immunization of non muscle invasive bladder patients with the recMAGE-A3 protein, together with adjuvant AS15 (recMAGE-A3 + AS15 ASCI)…
- Trial name
- NCT01498172
- Testing
- MAGE-A3 ASCI, BCG
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- Patrice Jichlinski
COVID-19
Respiratory Supports and COVID-19 Mortality
Critically ill COVID-19 patients have a relatively high mortality rate (~30%). Most critically ill COVID-19 patients require respiratory supports.
- Trial name
- NCT04832061
- Testing
- Respiratory supports
- Where
- United States
- Volunteers
- 2,300 people
- Sponsor
- Yale University
Stability & Variability of Lipid-derived Molecules in Sweat
Investigating the Stability, Variability and Mechanism of Incorporation of Lipid Mediators Into Eccrine Sweat
The purpose of this study is to see what the differences are in sweat (amount and small molecule content) collected from different sites of the body and by different methods of sweat stimulation.
- Trial name
- NCT02935894
- Testing
- Ibuprofen, Physiological induction of sweating, Pilocarpine
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Goal Directed Therapy, Postoperative Complications
Feasibility of Extended Non-invasive Haemodynamic Monitoring in the PACU
Post-operative monitoring of all patients after anaesthesia in the post anaesthesia care unit (PACU) is standard of care today. It helps to reduce morbidity and even mortality in high-risk patients.
- Conditions
- Goal Directed Therapy, Postoperative Complications, Complications, Ultrasound Therapy
- Trial name
- NCT04814966
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital Schleswig-Holstein
Delirium
Non-Invasive Eye Tracking for the Diagnosis of Delirium on ICU
In this trial, the investigators seek to demonstrate the feasibility of a system in continuously detecting 'inattention' as a subset of CAM-ICU in a small representative sample of patients in the Intensive Care Unit (ICU) at…
- Trial name
- CONfuSED (NCT04589169)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Type2diabetes
Validation of Existing Diabetes Risk Models in a Swedish Population
The goal of this observational study is to validate existing non-invasive diabetes clinical prediction models in a Swedish population.
- Trial name
- NCT05609266
- Volunteers
- 115,642 people, healthy volunteers welcome
- Sponsor
- Umeå University
Haemophilia, Arthropathy
Biomechanical Determinants and Patterns Associated to the Pathophysiological Cascade of Ankle Arthropathy in Children With Haemophilia: Non-invasive In-vivo Measurement of Foot Joints in Children With Haemophilia During Gait.
Haemophilia is a rare X chromosome-linked coagulation disorder resulting from a congenital deficiency or absence of circulating factor VIII (Haemophilia A) or factor IX (Haemophilia B).As a consequence, patients with haemophilia…
- Trial name
- 3DMKFM (NCT02229331)
- Testing
- Gait analysis
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Carcinoma of Urinary Bladder, Superficial
Value of Immediate Post-operative Intravesical Epirubicin in Intermediate&High Risk Non Muscle Invasive Bladder Cancer
The aim of the study is to test the value of immediate post-operative intravesical instillation of epirubicin in patients with intermediate and high risk non muscle invasive bladder cancer (NMIBC).
- Trial name
- NMIBCIVT (NCT02214602)
- Testing
- Epirubicin
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Mansoura University
Brain Injuries
Invasive and Non-Invasive Assessment of Cerebral Oxygenation in Patients With Severe Traumatic Brain Injury (TBI)
The purpose of this study is to investigate the relationship among regional transcranial oxygen saturation (rSO2), brain tissue oxygen pressure (PbtO2) and cerebral perfusion pressure (CPP) in patients with severe traumatic brain…
- Trial name
- NCT00703495
- Testing
- transcranial oxygen saturation measurement (INVOS Somanetics 5100C)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Anesthesia, Local, Anesthesia
Non-invasive Measurement of Arterial Stiffness
Reducing the risk of perioperative cardiovascular complications is a major issue for anesthesiology practice and research. Carotid-Femoral Pulse Wave Velocity (PWVcf)is a predictive, early and independent biomarker of…
- Trial name
- NIVOP (NCT05654402)
- Testing
- Non-invasive measurement of carotid-femoral transit time by Doppler velocimetry (Athys Medical©) - WAKIe R3 2TC®) (PWV in cm/s)
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vasospasm, Intracranial, Subarachnoid Hemorrhage
An Evaluation of Non-invasive Acoustic Approach to Detect and Monitor Cerebral Vasospasm
HeadSense (HS)-1000 device, a proprietary non-invasive brain monitor, is expected to safely and accurately monitor physiological signs of the brain with minimal discomfort to patients, providing information about normal or…
- Trial name
- NCT02704637
- Testing
- HS-1000
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- HeadSense Medical
Spinal Cord Injury, Spinal Cord Injury Subacute
Spinal Stimulation With Gait Training to Improve Lower Limbs Motor Recovery in Spinal Cord Injury
Spinal cord injury (SCI) often results in partial or complete loss of movement. In the subacute phase (< 6 months), the central nervous system shows increased potential for neuroplasticity, making it more responsive to…
- Conditions
- Spinal Cord Injury, Spinal Cord Injury Subacute, Locomotion, Gait Disorder, Sensorimotor
- Trial name
- CIMELocomotion (NCT07375745)
- Testing
- Protocol 2: Gait training combined with an effective tSCS
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Rectal Adenocarcinoma
Avoiding Surgery in Rectal Cancer After Pre-Operative Therapy
The objective of Timing and Deferral of Rectal Surgery Following a Continued Response to Pre-operative CRT study is to establish the time to maximum tumour response following CRT, and to investigate whether surgery can be safely…
- Trial name
- NCT01047969
- Testing
- Adjuvant Chemotherapy, Surgery
- Where
- United Kingdom
- Volunteers
- 99 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Non-muscle Invasive Bladder Cancer, Cystoscopy
Biomarkers of Recurrence and Progression in Non-muscle Invasive Bladder Cancer
Bladder cancer (BC) is one of the most common type of cancer globally. Due to its high incidence rate, high risk of recurrence and progression, and frequent cystoscopy surveillance, BC contributes to major healthcare costs across…
- Conditions
- Non-muscle Invasive Bladder Cancer, Cystoscopy, Recurrence, Progression
- Trial name
- NCT06235853
- Testing
- Blood serum: sUPAR, PAI-1, IL-8., Urine: IL-8, APOE, VEGF.
- Where
- Poland
- Volunteers
- 240 people
- Sponsor
- Wroclaw Medical University
Premature Ventricular Contraction, Ventricular Tachycardia
Ventricular Arrhythmia Ablation With the Use of Non-Invasive ECG Imaging Technology
Researchers are trying to determine if the use of software called VIVO, made by Catheter Precision, Inc. can shorten the length of time it takes to perform an ablation procedure for either premature ventricular contractions…
- Trial name
- NCT04219501
- Testing
- VIVO
- Where
- United States
- Sponsor
- Mayo Clinic
Miscarriage in First Trimester
Non-invasive Monitoring of Miscarriage
cfDNA is extremely useful to ascertain chromosomal causes of miscarriages at the point of miscarriage diagnosis by a simple blood test.
- Trial name
- NCT06581692
- Testing
- This is a routine procedure, no intervention will be provided.
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Stuttering, Fluency Disorders
Enhancing Speech Fluency With Non-invasive Brain Stimulation in Developmental Stuttering
This study aims to test whether the addition of transcranial direct current stimulation (TDCS) to speech fluency training results in improvements in speech fluency in adults with developmental stuttering.
- Conditions
- Stuttering, Fluency Disorders, Speech Disorders
- Trial name
- NCT02288598
- Testing
- Anodal TDCS, Fluency Training
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Oxford
Paroxysmal Atrial Fibrillation.
Atrial Fibrillation: Ablation or Surgical Treatment II: FAST II
The purpose of this study is to compare two invasive treatments of symptomatic paroxysmal atrial fibrillation: Percutaneous radiofrequency catheter ablation and mini invasive thoracoscopic radiofrequency ablation in patients…
- Trial name
- NCT01336075
- Testing
- Percutaneous radiofrequency catheter ablation, Mini invasive thoracoscopic radiofrequency ablation
- Where
- 3 sites in Denmark, Netherlands
- Volunteers
- 26 people
- Sponsor
- Aalborg University Hospital
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