Clinical trials: Non-invasive Ventilation
Respiratory Distress Syndrome, Premature Infants
Effects of Non-invasive Ventilation With Helium-oxygen Mixture in Premature Infants With Respiratory Distress Syndrome
The use of a mixture of helium with oxygen (heliox) as a breathing gas may be beneficial due to its unique physical properties, such as low density and high carbon dioxide (CO2) diffusion coefficient.
- Trial name
- NCT04404816
- Testing
- heliox
- Where
- Poland
- Volunteers
- 23 people
- Sponsor
- Poznan University of Medical Sciences
Cystic Fibrosis
Non Invasive Ventilation During Physical Training in Cystic Fibrosis
Patients with cystic fibrosis older than 18 years will performance a Bruce test with non invasive ventilation (once) after 30 minutes they perform the same test with oxygen supplementation.
- Trial name
- NCT02684552
- Testing
- Non invasive ventilation, Oxygen
- Where
- 2 sites in Sweden
- Volunteers
- 8 people
- Sponsor
- Karolinska University Hospital
Chronic Respiratory Failure
Ambulatory Adaptation to Non-Invasive Mechanical Ventilation
A randomised study to assess the effectiveness of ambulatory adaptation to non-invasive mechanical ventilation in patient with hypercapnic respiratory failure secondary to neuromuscular diseases or alterations in thoracic cage in…
- Trial name
- NCT00698958
- Testing
- Ambulatory adaptation to non- invasive mechanical ventilation for 7 days, Hospital based adaptation to non- invasive mechanical ventilation for 7 days
- Volunteers
- 52 people
- Sponsor
- Hospital Clinic of Barcelona
Hypercapnic Respiratory Failure
Use of TpCO2 (Transcutaneous CO2 Measurement) as PaCO2 Predictor During NIV in Case of Acute Hypercapnic Respiratory Failure
In patients suffering from hypercapnic respiratory failure and treated by non invasive ventilation (NIV), the interest of using transcutaneous CO2 measurement to evaluate PaCO2 and PaCO2 variation over time is unknown and will be…
- Trial name
- TpCO2-NIV (NCT01857635)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Lausanne Hospitals
Chronic Obstructive Pulmonary Disease
Impact of a Telemonitoring Program on the Rate of Hospitalizations for Worsening of Cardio-respiratory Symptoms in COPD Patients Treated at Home by Long-term Non-invasive Ventilation (NIV)
COPD is characterized by non-reversible chronic airway obstruction. Its evolution is punctuated by successive exacerbations precipitating the progression of the disease and its co-morbidities.
- Trial name
- EXA-VNI2 (NCT02756533)
- Testing
- Telemonitoring of daily parameters recorded by NIV
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Cystic Fibrosis
HFN Versus NIV in Cystic Fibrosis. The HIFEN Study
Many patients with cystic fibrosis (CF) require hospitalization and/or Intensive Care Unit (ICU) admission because of acute exacerbation of chronic respiratory failure or for any acute deterioration of clinical status.
- Trial name
- NCT02262871
- Testing
- High flow nasal oxygen cannula, Noninvasive ventilation
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Unity Health Toronto
Prematurity, Respiratory Distress Syndrome
Trial of Non Invasive Ventilation for Respiratoy Distress Syndrome
The purpose of this study is to evaluate the hypothesis that nasal intermittent positive pressure(NIPP), used as a primary mode of ventilation in preterm infants with RDS, will decrease the need for conventional endotracheal…
- Trial name
- NCT00821119
- Testing
- nasal intermittent positive pressure ventilation
- Where
- 2 sites in Brazil
- Volunteers
- 200 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Severe Sepsis, Septic Shock
A Non-invasive Approach to the Assessment of Volume Status in Mechanically Ventilated Septic Patients.
To evaluate the use of sonographic inferior caval vein assessment in mechanically ventilated septic patients. Volume assessment in mechanically ventilated patients with inflammation is of major importance to guide fluid therapy.
- Trial name
- NCT00398736
- Testing
- sonographic measurement of inferior caval vein diameter
- Sponsor
- Charite University, Berlin, Germany
Noninvasive Ventilation
Chest Pressure for Intubated Peds Patients
We previously showed that a gentle chest pressure technique could be used on children over a year old to generate around 20% of the volume of air inhaled or exhaled in a single normal breath (also known as tidal volume).
- Trial name
- NCT02615834
- Testing
- Gentle chest pressure
- Where
- Canada
- Sponsor
- University of Alberta
Neuromuscular Diseases, Obesity Hypoventilation Syndrome
Effectiveness Monitoring of Home Non-invasive Mechanical Ventilation by Digital Diagnosis Platform
The main objective will be to determine the effectiveness of home non-invasive ventilation by flow-time and time-pressure curves analysis in a cohort of patients with this treatment by digital diagnosis platform.
- Conditions
- Neuromuscular Diseases, Obesity Hypoventilation Syndrome, Lung Disease, Restrictive
- Trial name
- PRE-HVNI (NCT03085537)
- Where
- 3 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Corporacion Parc Tauli
Bariatric Surgery, Obesity
Acute Effect of EPAP and Noninvasive Ventilation on Pulmonary Function and Lung Regional Ventilation on Bariatric Surgery
Obesity is a non-communicable chronic disease of multifactorial, involving biological, historical, ecological, economic, social, cultural and political.
- Conditions
- Bariatric Surgery, Obesity, Physical Therapy Modalities
- Trial name
- NCT02577744
- Testing
- Noninvasive Ventilation, Expiratory Positive Air Pressure
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Pernambuco
Pulmonary Embolism
High-Flow Nasal Cannula Versus Non-Invasive Ventilation for Acute Respiratory Failure in Pulmonary Embolism.
Acute pulmonary embolism (PE) often causes hypoxemic respiratory failure through ventilation-perfusion mismatch and right-ventricular (RV) strain; supportive oxygenation plus prompt anticoagulation are crucial to care .
- Trial name
- NCT07381712
- Testing
- High-Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Noninvasive Ventilation, Speech Intelligibility
Facilitating Patient Communication During Noninvasive Ventilation
Assessing speech intelligibility in a pilot study of patients speaking with a mask microphone while being treated with standard of care non-invasive ventilation.
- Trial name
- NCT04912544
- Testing
- Noninvasive Ventilation Mask Microphone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Utah
Acute Respiratory Failure, Exacerbation of COPD
Multicenter National Randomized Controlled Open Label Study Assessing Interest of Non Invasive Ventilation in out-of Hospital Setting During Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Patients. VeNIS BPCO
Goal of the study: To show that prehospital NPPV use for COPD decompensation, as compared to only standard medical treatment, might enable a decrease in intubation rate.
- Conditions
- Acute Respiratory Failure, Exacerbation of COPD, Non Invasive Positive Pressure Ventilation, Out of Hospital Setting
- Trial name
- VeNIS BPCO (NCT01626937)
- Testing
- Non invasive ventilation, conventional medical treatment
- Volunteers
- 398 people
- Sponsor
- Centre Hospitalier d'Agen
Amyotrophic Lateral Sclerosis, Chronic Respiratory Failure
Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis
Non-invasive mechanical ventilation (NIV) has been increasingly used as a treatment of chronic hypercapnic respiratory failure. Its use in patients affected by chronic obstructive pulmonary disorders is still controversial, while…
- Trial name
- NCT00560287
- Testing
- Non invasive ventilation delivered with one of the ventilator specifically designed for NIV and given to the patient by the home care providers, Non invasive ventilation
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Salvatore Maugeri
Noninvasive Ventilation
Low Versus High PEEP in Noninvasive Ventilation for Hypoxemic Respiratory Failure
Current study aimed to explore the effect of high PEEP during noninvasive ventilation among hypoxemic patients with acute respiratory failure.
- Trial name
- NCT05193786
- Testing
- Different level of PEEP
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Chongqing Medical University
Asthma Acute
Analysis of Non-invasive Ventilatory Support Modes: High Flow Nasal Cannula and Non-invasive Ventilation
This study compares two types of noninvasive treatments for asthma attacks with the objective of analyzing the efficacy of each therapy during the period of exacerbations in infants and asthmatics hospitalized.
- Trial name
- NCT04033666
- Testing
- High Flow Nasal cannula, NIV Noninvasive Ventilation
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Nove de Julho
COPD, Non-invasive Ventilation
Effect of Noninvasive High Frequency Oscillatory Ventilation on Improving Carbon Dioxide Clearance in AECOPD Patients
High-frequency oscillatory ventilation (HFOV), as an ideal lung-protecting ventilation method, has been gradually used in neonatal critical care treatment, and is currently recommended as a rescue method for neonatal acute…
- Trial name
- NCT05435183
- Testing
- Non-invasive high-frequency oscillatory ventilation, Noninvasive Bilevel Positive Pressure Ventilation
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Covid19, Acute Respiratory Failure
Noninvasive Respiratory Support in COVID-19 (CATCOVID-AIR)
COVID-19 pneumonia can cause severe acute hypoxemic respiratory failure. The usefulness of noninvasive respiratory support (NIRS), by means of nasal high-flow oxygen (NHFO), continuous positive airway pressure (CPAP), or…
- Conditions
- Covid19, Acute Respiratory Failure, Corona Virus Infection
- Trial name
- CATCOVID-AIR (NCT04668196)
- Testing
- High-flow nasal cannula treatment, Continuous positive airway pressure (CPAP) treatment, Noninvasive ventilation treatment
- Where
- 10 sites in Spain
- Volunteers
- 367 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Chronic Obstructive Pulmonary Disease
Initiation of Long-term Non-invasive Ventilation in COPD
Rationale: Application of long-term non-invasive ventilation (NIV) in stable chronic obstructive pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure (CHRF) has recently been shown to improve survival…
- Trial name
- RECONSIDER (NCT02652559)
- Testing
- Transcutaneous measurements of PCO2, Telemonitoring, EMG
- Where
- Netherlands
- Volunteers
- 67 people
- Sponsor
- University Medical Center Groningen