Clinical trials: Non-obstructive Azoospermia
Non-obstructive Azoospermia
Effect of Age on Sperm Recovery of Microdissection Testicular Sperm Extraction in Nonobstructive Azoospermia Patients
Males with non-obstructive azoospermia (NOA) have an opportunity to obtain sperm by treatment with microdissection testicular sperm extraction (mTESE), gold-standard surgical technique for them.
- Trial name
- NCT05958576
- Where
- China
- Volunteers
- 3,104 people
- Sponsor
- Peking University Third Hospital
Non-obstructive Azoospermia With Testicular Biopsy for Spermatozoa Extraction
Estradiol and Testosterone Levels in Seminal Plasma of Men With Non-obstructive Azoospermia
Estradiol and Testosterone are two important hormones for the regulation of an effective spermatogenesis in human testis. The evaluation of levels of estradiol and testosterone in seminal plasma of men with non-obstructive…
- Trial name
- NCT02255396
- Testing
- ESTRADIOL
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Non-obstructive Azoospermia
Use of Semen TEX101 to Improve Sperm Retrieval Rates for Men With Non-obstructive Azoospermia
The investigators hypothesize that sperm production varies with time in men with no sperm in semen (non-obstructive azoospermia, NOA) and that the semen protein, TEX101, is able to monitor these changes.
- Trial name
- NCT02851966
- Testing
- mTESE
- Where
- 3 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Mount Sinai Hospital, Canada
Non-obstructive Azoospermia
Gabapentin for Post-Operative Pain Control and Narcotic Reduction in Scrotal Surgery
The use of non-narcotic multi-modal analgesia to be used in the pre-operative, peri-operative and post-operative period to reduce or potentially eliminate narcotic usage following scrotal surgery.
- Trial name
- NCT04230980
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Weill Medical College of Cornell University
Azoospermia
GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia
Preliminary reports showed that hormonal treatment may improve the chance of retrieving viable testicular sperm from men with NOA.
- Trial name
- NCT02544191
- Testing
- GnRHa/ hCG/ hMG
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jinling Hospital, China
Testicular Sperm Extraction in Azoospermic Patients
Laterality Success Determination of Microscopic Testicular Sperm Extraction in Non Obstructive Azoopsermia Patients
Determination of percentage of successful sperm retrieval in single testis in cases who will do bilateral TESE and identification factors mostly associated with successful sperm retrieval
- Trial name
- NCT07259967
- Testing
- Testicular sperm extraction
- Volunteers
- 80 people
- Sponsor
- Assiut University
Non-obstructive Azoospermia
Surgical Sperm Retrieval in Non-obstructive Azoospermic Men: mTESE vs. TESA
Infertility is a significant social- and health problem in the Western World and at the moment in Denmark one in ten babies are born with the help of assisted reproduction.
- Trial name
- NCT03550716
- Testing
- mTESE, TESA
- Where
- 4 sites in Denmark, Sweden
- Volunteers
- 110 people
- Sponsor
- Herlev and Gentofte Hospital
APHRODITE Group
Gonadotropin Therapy in Idiopathic Hypogonadal Non-Obstructive
The goal of this clinical trial is to determine whether short-term gonadotropin therapy (hCG + FSH) can increase sperm availability for ICSI in men with idiopathic non-obstructive azoospermia (NOA) and hypogonadism.
- Trial name
- GTIHNO (NCT07540611)
- Testing
- No intervention, hCG + FSH therapy
- Where
- 8 sites in India
- Volunteers
- 860 people, healthy volunteers welcome
- Sponsor
- Indira IVF Hospital Pvt Ltd
Male Infertility
Spermatogonial Stem Cells in Azoospermic Patients: a Comparison Between Obstructive and Non-obstructive Azoospermia
The researchers hypothesized that nonobstructive azoospermia might be associated with a reduction OF SSCs in seminiferous tubules as compared with obstructive azoospermia.
- Trial name
- NCT01178463
- Testing
- Biospecimen staining
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Hillel Yaffe Medical Center
Non-obstructive Azoospermia
Testicular Proteins for Sperm Retrieval Prediction Protein1, Testis-Expressed Gene 101, and Lectin Galactoside-binding Protein in Predicting Surgical Sperm Retrieval in Men With Non-Obstructive Azoospermia
Generally, azoospermia is characterized as obstructive (OA) or nonobstructive (NOA). Surgical spermatozoa retrieval results vary in success rates.
- Trial name
- Genomics (NCT06154954)
- Testing
- Semen analysis
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Cancer, Hematologic Diseases
Autologous Transplantation of Human Cryopreserved Testis Tissue
For pre-pubertal boys undergoing gonadotoxic therapies, freezing immature testicular tissue (ITT) containing spermatogonial stem cells (SSCs) is currently the only option to potentially preserve future fertility.
- Conditions
- Cancer, Hematologic Diseases, Infertility, Male, Azoospermia, Nonobstructive
- Trial name
- ReSTORE (NCT07364409)
- Testing
- Autologous Transplantation of Testis Tissue
- Where
- Denmark
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital
Infertility, Azoospermia
IntelliWell: An AI-Assisted Imaging Platform for Detection and Location of Ultra-Rare Testicular Sperm in Surgical Specimens
This study will help determine whether an AI-assisted microwell platform (IntelliWell) can identify rare sperm cells in testicular samples found to not have sperm by conventional analysis.
- Trial name
- NCT07074015
- Testing
- Use of IntelliWell to identify and localize sperm for ICSI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Azoospermia, Nonobstructive, Non-obstructive Azoospermia
Inhibin B/FSH Ratio as a Predictor of Testicular Pathology in NOA
This retrospective observational study evaluated the diagnostic and predictive value of serum Inhibin B (INHB), follicle-stimulating hormone (FSH), and the INHB/FSH ratio in differentiating histopathological subtypes of…
- Trial name
- NCT07415928
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Azoospermia, Nonobstructive
Interest of Clomiphene Citrate in Patients With Non-obstructive Azoospermia on the Quantity of Sperm Cells
In the absence of sperm in the semen (azoospermia), there is no chance of natural paternity. It is found in about 1% of men and is either due to an obstruction of the seminal tracks (obstructive azoospermia (OA)) in 1/3 of the…
- Trial name
- CLOMINOA (NCT03615547)
- Testing
- Clomifene Citrate
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Infertility, Male
NT-NOA - Novel Treatment of Some Men With Non-Obstructive Azoospermia
This clinical interventional study aims to assess whether treatment with denosumab in combination with letrozole can improve sperm production in infertile men with non-obstructive azoospermia selected by serum anti-mullerian…
- Trial name
- NT-NOA (NCT06706414)
- Testing
- Denosumab (Prolia), Letrozole (Aromatase Inhibitors)
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Martin Blomberg Jensen
Varicocele, Male Infertility
Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele
Varicose veins in the scrotum (varicocele) are responsible for >20% of male infertility in the US. Varicocele are associated with decreased sperm number and markedly reduced sperm fertilizing ability.
- Conditions
- Varicocele, Male Infertility, Hypospermatogenesis, Non-Obstructive Azoospermia
- Trial name
- NCT00044369
- Testing
- Varicocele repair
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Non-obstructive Azoospermia, Hormone Deficiency
Sperm Retrieval Rates in Non-obstructive Azoospermic Men Subjected to Gonadotropin Therapy
Azoospermia is defined as the complete absence of spermatozoa in the ejaculate. Two-thirds of azoospermic patients have non-obstructive azoospermia (NOA); the latter comprises up to 10% of infertile men overall.
- Conditions
- Non-obstructive Azoospermia, Hormone Deficiency, Hypogonadism, Male, Male Infertility
- Trial name
- NCT05110391
- Testing
- Hormonal Therapy Agent
- Where
- Brazil
- Volunteers
- 616 people
- Sponsor
- ANDROFERT - Clinica de Andrologia e Reproducao Humana
Azoospermia, Nonobstructive, Oligozoospermia
Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia.
The investigators hope to learn if Letrozole is effective and safe in improving severe male infertility by increasing testosterone, decreasing oestradiol and stimulating sperm production thereby improving sperm motility…
- Trial name
- NCT02900105
- Testing
- Letrozole
- Where
- Singapore
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Obstructive Azoospermia, Non-obstructive Azoospermia
Reproductive and Obstetric Outcomes in TESE-ICSI Cycles for Azoospermia
A comparison of reproductive and obstetrical outcomes is retrospectively performed among couples that underwent ICSI-TESE cycles for obstructive and non obstructive azoospermia between January 2001 and December 2019.
- Conditions
- Obstructive Azoospermia, Non-obstructive Azoospermia, Obstetric Complication
- Trial name
- AZOOCOMES (NCT04894136)
- Testing
- ICSI-TESE; embryo-transfer
- Volunteers
- 520 people
- Sponsor
- Istituto Clinico Humanitas
Non Obstructive Azoospermia, Hypogonadism
Assessing the Efficacy of Clomiphene Citrate in Patients With Azoospermia and Hypoandrogenism
Hypothesis: Prescribed clomiphene citrate to azoospermic patients with hypoandrogenism could improve the sperm retrieval in either fresh sperm or after surgical sperm extraction.
- Trial name
- NCT02137265
- Testing
- Clomiphene
- Where
- Spain
- Sponsor
- University of Illinois Chicago