Clinical trials: Non-obstructive Azoospermia
Azoospermia, Nonobstructive, Oligozoospermia
Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia.
The investigators hope to learn if Letrozole is effective and safe in improving severe male infertility by increasing testosterone, decreasing oestradiol and stimulating sperm production thereby improving sperm motility…
- Trial name
- NCT02900105
- Testing
- Letrozole
- Where
- Singapore
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Azoospermia, Nonobstructive
Interest of Clomiphene Citrate in Patients With Non-obstructive Azoospermia on the Quantity of Sperm Cells
In the absence of sperm in the semen (azoospermia), there is no chance of natural paternity. It is found in about 1% of men and is either due to an obstruction of the seminal tracks (obstructive azoospermia (OA)) in 1/3 of the…
- Trial name
- CLOMINOA (NCT03615547)
- Testing
- Clomifene Citrate
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Obstructive Azoospermia, Non-obstructive Azoospermia
Reproductive and Obstetric Outcomes in TESE-ICSI Cycles for Azoospermia
A comparison of reproductive and obstetrical outcomes is retrospectively performed among couples that underwent ICSI-TESE cycles for obstructive and non obstructive azoospermia between January 2001 and December 2019.
- Conditions
- Obstructive Azoospermia, Non-obstructive Azoospermia, Obstetric Complication
- Trial name
- AZOOCOMES (NCT04894136)
- Testing
- ICSI-TESE; embryo-transfer
- Volunteers
- 520 people
- Sponsor
- Istituto Clinico Humanitas
Male Infertility
Spermatogonial Stem Cells in Azoospermic Patients: a Comparison Between Obstructive and Non-obstructive Azoospermia
The researchers hypothesized that nonobstructive azoospermia might be associated with a reduction OF SSCs in seminiferous tubules as compared with obstructive azoospermia.
- Trial name
- NCT01178463
- Testing
- Biospecimen staining
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Hillel Yaffe Medical Center
Varicocele, Male Infertility
Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele
Varicose veins in the scrotum (varicocele) are responsible for >20% of male infertility in the US. Varicocele are associated with decreased sperm number and markedly reduced sperm fertilizing ability.
- Conditions
- Varicocele, Male Infertility, Hypospermatogenesis, Non-Obstructive Azoospermia
- Trial name
- NCT00044369
- Testing
- Varicocele repair
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Non-obstructive Azoospermia With Testicular Biopsy for Spermatozoa Extraction
Estradiol and Testosterone Levels in Seminal Plasma of Men With Non-obstructive Azoospermia
Estradiol and Testosterone are two important hormones for the regulation of an effective spermatogenesis in human testis. The evaluation of levels of estradiol and testosterone in seminal plasma of men with non-obstructive…
- Trial name
- NCT02255396
- Testing
- ESTRADIOL
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Non Obstructive Azoospermia, Cryptozoospermia
Identifying Candidates for Limited Dissection at Microdissection TESE.
The goal of this retrospective observational study is to learn whether certain clinical characteristics can help predict which infertile men may successfully have sperm retrieved using a less-invasive "mini-incision" version of…
- Conditions
- Non Obstructive Azoospermia, Cryptozoospermia, Oligoasthenoteratozoospermia, Male Infertility
- Trial name
- NCT07286279
- Where
- Canada
- Volunteers
- 248 people
- Sponsor
- Clinique Ovo
Non-obstructive Azoospermia
Intra-Testicular Transplantation of Autologous Stem Cells for Treatment of Non-Obstructive Azoospermia Male Infertility.
This is an open label, single arm, single center investigation to assess the safety and efficacy of purified adult autologous, bone marrow derived, highly specialized, differentiation specific into spermatogonial lineages, and…
- Trial name
- NCT02641769
- Testing
- Stem Cell Transplantation
- Where
- Jordan
- Volunteers
- 600 people
- Sponsor
- Stem Cells Arabia
Male Infertility, Azoospermia, Nonobstructive
Management of Non Obstructive Azoospermia in Men
this study predicts the factors of successful micro testicular sperm extraction in azoospermia patients in male infertility
- Trial name
- azoospermia (NCT06983626)
- Testing
- micro-dissection testicular sperm extraction
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- South Valley University
Non-obstructive Azoospermia
Anti-mullerian Hormone,Testesterone,Esrtadiol,Testesterone/Esrtadiol Ratio as Predictive Values for TESA and TESE Outcome in Non Obstructive Azoospermia
*Evaluate the predictive value of AMH, Testosterone,Estradiol,Testosterone Estradiol ratio for TESA and TESE outcome in non obstructive azoospermic patients.
- Trial name
- NCT04308486
- Volunteers
- 50 people
- Sponsor
- Assiut University
Cancer, Hematologic Diseases
Autologous Transplantation of Human Cryopreserved Testis Tissue
For pre-pubertal boys undergoing gonadotoxic therapies, freezing immature testicular tissue (ITT) containing spermatogonial stem cells (SSCs) is currently the only option to potentially preserve future fertility.
- Conditions
- Cancer, Hematologic Diseases, Infertility, Male, Azoospermia, Nonobstructive
- Trial name
- ReSTORE (NCT07364409)
- Testing
- Autologous Transplantation of Testis Tissue
- Where
- Denmark
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital
Non-obstructive Azoospermia
Effect of Age on Sperm Recovery of Microdissection Testicular Sperm Extraction in Nonobstructive Azoospermia Patients
Males with non-obstructive azoospermia (NOA) have an opportunity to obtain sperm by treatment with microdissection testicular sperm extraction (mTESE), gold-standard surgical technique for them.
- Trial name
- NCT05958576
- Where
- China
- Volunteers
- 3,104 people
- Sponsor
- Peking University Third Hospital
Azoospermia, Nonobstructive, Non-obstructive Azoospermia
Inhibin B/FSH Ratio as a Predictor of Testicular Pathology in NOA
This retrospective observational study evaluated the diagnostic and predictive value of serum Inhibin B (INHB), follicle-stimulating hormone (FSH), and the INHB/FSH ratio in differentiating histopathological subtypes of…
- Trial name
- NCT07415928
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
APHRODITE Group
Gonadotropin Therapy in Idiopathic Hypogonadal Non-Obstructive
The goal of this clinical trial is to determine whether short-term gonadotropin therapy (hCG + FSH) can increase sperm availability for ICSI in men with idiopathic non-obstructive azoospermia (NOA) and hypogonadism.
- Trial name
- GTIHNO (NCT07540611)
- Testing
- No intervention, hCG + FSH therapy
- Where
- 8 sites in India
- Volunteers
- 860 people, healthy volunteers welcome
- Sponsor
- Indira IVF Hospital Pvt Ltd
Testicular Sperm Extraction in Azoospermic Patients
Laterality Success Determination of Microscopic Testicular Sperm Extraction in Non Obstructive Azoopsermia Patients
Determination of percentage of successful sperm retrieval in single testis in cases who will do bilateral TESE and identification factors mostly associated with successful sperm retrieval
- Trial name
- NCT07259967
- Testing
- Testicular sperm extraction
- Volunteers
- 80 people
- Sponsor
- Assiut University
Male Infertility
FSH in Azoospermic Men
This study was designed in 2015, but since funds were not obtained, the study was not performed.
- Trial name
- NCT02275169
- Testing
- Follicle Stimulating Hormone
- Volunteers
- healthy volunteers welcome
- Sponsor
- Azienda Sanitaria Locale Bari