Clinical trials: Non-operative Treatment
Low Back Pain
Lumbar Fusion or Non-operative Care for Treatment of Presumed Discogenic Pain
Title and abstract 1 a. Title: Lumbar fusion or non-operative care for treatment of presumed discogenic pain. A randomized study. 1 b. Structured summary: Authors: B. Nyström, B. Schillberg, E. Svensson, T. Stiles.
- Trial name
- NCT02695576
- Testing
- Lumbar Fusion Surgery, Physiotherapy, Cognitive behavioral therapy
- Volunteers
- 74 people
- Sponsor
- Spinal Surgery Clinic, Strängnäs
Peroneal Palsy (Foot Drop)
Acute Nerve Decompression Versus Non-operative Treatment for Peroneal Nerve Palsy Following Primary Total Knee Arthroplasty
The purpose of this study is to compare acute nerve decompression versus nonoperative treatment in the management of peroneal nerve palsy after total knee arthroplasty (TKA).
- Trial name
- NCT02856958
- Testing
- Nerve decompression, Non-operative
- Where
- United States
- Sponsor
- Rush University Medical Center
High Energy Midshaft Clavicle Fractures
Non-Operative Versus Operative Treatment for High-Energy Midshaft Clavicle Fractures
Clavicle (collar bone) fractures account for about 33% of all fractures around the shoulder. Some surgeons suggest that surgical treatment is the best option, while others suggest that nonoperative care is the best treatment.
- Trial name
- NCT00590850
- Testing
- ORIF with Plate and Screws, Pin Fixation
- Where
- United States
- Volunteers
- 412 people
- Sponsor
- Prisma Health-Upstate
Ruptured Achilles Tendon
Operative vs. Non-Operative Treatment of Acute Ruptures of the Achilles Tendon
The proposed trial is a multi-centre prospective randomized controlled trial comparing outcomes of patients with acute Achilles tendon ruptures treated either non-operatively or with open operative tendon repair.
- Trial name
- AchillesRCT (NCT01711307)
- Testing
- operative, non-operative
- Where
- Canada
- Volunteers
- 220 people
- Sponsor
- Mark Glazebrook
Proximal Humeral Fractures
Comparison of Early and Late Therapy for Adults With Non-Operatively Treated Proximal Humerus Fractures
The purpose of the study is to compare two common ways of rehabilitating after proximal humerus fractures treated non-operatively.
- Trial name
- NCT00438633
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Massachusetts General Hospital
Medication-related Osteonecrosis of the Jaw, Bisphosphonate-related Osteonecrosis of the Jaw
Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ)
The overall purpose of this project is to answer the following clinical question: Among Medication-Related Osteonecrosis of the Jaw (MRONJ) patients, do those who are treated with the Pentoxifylline and Tocopherol (PENTO) regimen…
- Conditions
- Medication-related Osteonecrosis of the Jaw, Bisphosphonate-related Osteonecrosis of the Jaw, Avascular Necrosis
- Trial name
- NCT03040778
- Testing
- Pentoxifylline, Tocopherol
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Necrotic Pulp
Incidence of Post-Operative Pain After Single Visit Root Canal Treatment in Necrotic Teeth Using Two Different Rotary Systems (Protaper Nex t& Neolix File)
this prospective in vivo randomized clinical is to evaluate the post operative pain (incidence ,degree and duration) with multiple full rotation file (protaper next ®) and single full rotation file (Neolix®) in treating maxillary…
- Trial name
- NCT03059290
- Testing
- neolix file
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Head and Neck Cancer, Non-melanomatous Skin Cancer
Radiation Therapy in Treating Patients With Head and Neck Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which regimen of radiation therapy is more effective for head and neck cancer.
- Trial name
- NCT00021125
- Testing
- adjuvant therapy, radiation therapy
- Where
- United Kingdom
- Volunteers
- 460 people
- Sponsor
- Medical Research Council
Appendicitis
Appendectomy Versus Non-Operative Treatment For Acute Non-Perforated Appendicitis in Children
Rationale and Aim: The standard treatment for acute appendicitis in children is appendectomy. An increasing body of evidence from the adult literature suggests that acute appendicitis may be treated effectively with antibiotics…
- Trial name
- APPY (NCT02687464)
- Testing
- Non-operative treatment, Appendectomy
- Where
- United States
- Volunteers
- 978 people
- Sponsor
- Children's Mercy Hospital Kansas City
Lumbar Spinal Stenosis
Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant
Neurogenic intermittent claudication is a specific symptom complex occurring in patients with lumbar spinal stenosis. Characteristic of this disease is the occurrence of increasing leg, buttock or groin pain with or without lower…
- Trial name
- NCT01057641
- Testing
- Spacer, physiotherapy
- Where
- 2 sites in Germany
- Volunteers
- 22 people
- Sponsor
- University of Cologne
Root Canal Treatment, Irrigation Activation
Treatment Outcome and Patient-reported Outcomes in Patient Undergoing Non-surgical Root Canal Treatment With Different Irrigation Protocols
This study aims to evaluate and compare the clinical and patient-reported outcomes of passive ultrasonic irrigation (PUI) and laser-activated irrigation (LAI) versus conventional syringe irrigation in adult patients undergoing…
- Conditions
- Root Canal Treatment, Irrigation Activation, Oral Health Quality of Life (OHQoL) Was Assessed, Post Operative Pain After Root Canal Therapy
- Trial name
- NCT07453134
- Testing
- root canal treatment and intracanal medicament
- Where
- Thailand
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Uterine Fibroids
A Prospective Multicenter Non-interventional Study of Women Treated With ESMYA (Ulipristal Acetate) as Pre-operative Treatment of Moderate to Severe Symptoms of Uterine Fibroids
This is a multi-center, prospective, non-interventional study of patients who have been diagnosed with moderate to severe symptoms of uterine fibroids and are initiating a pre-operative treatment with ESMYA.
- Trial name
- PREMYA (NCT01635452)
- Where
- 75 sites in Austria, France and 8 more
- Volunteers
- 1,500 people
- Sponsor
- PregLem SA
Sacral Fracture
Operative vs Non-Operative Treatment of Sacral Fractures
The purpose of this study is to compare percutaneous trans-iliac trans-sacral screw fixation to non-operative management for the treatment of symptomatic, sacral fragility fractures in elderly patients.
- Trial name
- NCT04044300
- Testing
- Single screw fixation, Conservative
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- More Foundation
Humerusshaft Fractures
Non Randomized Humerusshaft Fracture
The aim of the study is to radiologically compare the fracture healing as well as the functional treatment outcome of conservative and operative treatment of defined humerusshaft fractures after 6w./12w./and 12 month based on the…
- Trial name
- NCT00205972
- Testing
- Humerus Nail or LC Plate
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Rotator Cuff Tear
Comparative Effectiveness of Operative Versus Non-Operative Treatments for Rotator Cuff Tears
Rotator cuff tears are one of the most common causes of shoulder pain. Evidence-based guidance on optimal diagnostic and treatment strategies for rotator cuff tears is lacking.
- Trial name
- ROW (NCT02287090)
- Testing
- Observational Cohort
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Vanderbilt University Medical Center
Rectal Cancer
Planned Non-operative Management for Rectal Cancer
The investigators propose to conduct an observational study on consecutive patients with low-lying or mid rectal cancers smaller than 5 cm in length and less than 50% of rectal circumferential extent.
- Trial name
- NCT05241574
- Testing
- Radiotherapy boost, Additional consolidation chemotherapy
- Where
- Poland
- Volunteers
- 23 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Proximal Humerus Fracture, 2 Part Fracture
Two- Part Proximal Humerus - Conservative vs Operative
The proximal humerus fracture (PHFs) is the third most common fracture type in the elderly, and represents 5% of the overall fractures. The incidence is increasing.
- Trial name
- NCT04106674
- Testing
- Open reduction internal stabilisation (ORIF)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Post-operative Pain, Acute, Cesarean Section
Management of Postoperative Pain After Cesarean Delivery Using Bridge Auricular Percutaneous Nerve Field Stimulator
Post-cesarean section (CS) pain is commonly treated with acetaminophen, ibuprofen, and opioid medications as needed following delivery.
- Conditions
- Post-operative Pain, Acute, Cesarean Section, Opioid Use Disorder, Opioids; Harmful Use
- Trial name
- NCT06434714
- Testing
- Auricular percutaneous nerve field stimulator
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Inova Health Care Services
Appendicitis
Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children
OBJECTIVE The aim of this study is to compare the effectiveness of initial non-operative treatment strategy (reserving appendectomy for those not responding or with recurrent disease) with immediate appendectomy in children from…
- Trial name
- APAC (NCT02848820)
- Testing
- Augmentin + Gentamicin, Appendectomy
- Where
- 15 sites in Netherlands
- Volunteers
- 302 people
- Sponsor
- Ramon Gorter
Osteoarthritis of the Knee
Structured Non-operative Treatment of Knee Osteoarthritis
The purpose of this study is to test whether an algorithm for systematic non-surgical treatment consisting of corrective insoles, neuromuscular training, weight loss, patient education and pharmacological treatment with…
- Trial name
- NCT01535001
- Testing
- Neuromuscular training (NEMEX-TJR), Information, Paracetamol
- Where
- 3 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Northern Orthopaedic Division, Denmark