Clinical trials: Non-paroxysmal Atrial Fibrillation
Paroxysmal Atrial Fibrillation
Electrical Coupling Information From The RHYTHMIA HDx Mapping System and DIRECTSENSE Technology In The Treatment of Paroxysmal Atrial Fibrillation (LOCALIZE CF)
The objective of this study is to evaluate whether local impedance (DIRECTSENSE™) drop on the INTELLANAV STABLEPOINT™ ablation catheter is associated with late pulmonary vein (PV) reconnections and durable conduction block in…
- Trial name
- LOCALIZE CF (NCT04740801)
- Testing
- Ablation procedure
- Where
- 5 sites in Germany, Italy and 1 more
- Volunteers
- 60 people
- Sponsor
- Boston Scientific Corporation
Non-paroxysmal Atrial Fibrillation
LAA Clipping Versus NOACs to Prevent Stroke in Non-paroxysmal Atrial Fibrillation.
This trial is designed to examine the hypothesis that thoracoscopic LAA clipping is superior to NOACs for stroke, systemic embolism, all-cause mortality, major bleeding events and clinically relevant nonmajor bleeding events in…
- Trial name
- NCT06021808
- Testing
- Thoracoscopic LAA clipping, Novel oral anticoagulant
- Where
- China
- Volunteers
- 290 people
- Sponsor
- China National Center for Cardiovascular Diseases
Atrial Fibrillation (AF)
The Modified "Pills-in-the-Pocket" Strategy
This is a multicentre, prospective, randomised controlled study of 328 patients with non-paroxysmal AF (within 5 years of first diagnosis of AF) with recurrent atrial arrhythmias after first catheter ablation, randomly divided in…
- Trial name
- ABD-AF (NCT06657404)
- Testing
- use Amiodarone, Bisoprolol and Digoxin
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Yumei Xue
Atrial Fibrillation (AF), Paroxysmal AF
Dose Escalation Study to Assess Safety, Tolerability, and Efficacy of Budiodarone Treatment With Non-permanent Atrial Fibrillation
This multicenter, open-label study aims to assess the safety, tolerability and efficacy of budiodarone in treating participants with non-permanent AF, in particular paroxysmal atrial fibrillation (PAF).
- Trial name
- Harbor-AF (NCT07792239)
- Testing
- Budiodarone 200 mg BID, Budiodarone 400 mg BID, Budiodarone 600 mg BID
- Where
- 4 sites in Poland
- Volunteers
- 100 people
- Sponsor
- Xyra, LLC
Atrial Fibrillation
CPVI Alone Versus. CPVI Plus Electrophysiological Substrate Ablation in the LA During SR for the Treatment of Non-PAF
The primary objective of this investigation is to compare the efficacy of two different AF ablation strategies in patients with non-paroxysmal AF: CPVI plus electrophysiologic substrate ablation in the left atrium during sinus…
- Trial name
- STABLE-SR_II (NCT03448562)
- Testing
- CPVI, STABLE-SR
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Atrial Fibrillation
Substrate Ablation and Remodelling in Non-paroxysmal Atrial Fibrillation (AF)
The investigators hypothesise that modification of the Atrial Fibrillation (AF) substrate by radiofrequency ablation would improve single procedure success rates for Radio Frequency Ablation (RFA) for Non-paroxysmal AF when…
- Trial name
- SMAAN-PAF (NCT01445925)
- Testing
- Pulmonary vein isolation (PVI), Pulmonary vein isolation + linear lesions, Pharmacological Substrate modification
- Where
- 2 sites in United Kingdom
- Volunteers
- 130 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Women and Men Over 18 Years Old, AF Ablation (ECS recommendation2020&ACS2014) Either for Paroxysmal AF Unresponsive to Anti-arrhythmic Treatment Either for Persisting Symptomatic AF
Predictive Properties of Myocardial Fibrosis Biomarkers on the Outcome of Atrial Fibrillation Ablation
Atrial fibrillation (AF) is the most common cardiac arrhythmia. As an independent predictor of cardiovascular mortality, particularly for stroke, its management is a real public health issue.
- Conditions
- Women and Men Over 18 Years Old, AF Ablation (ECS recommendation2020&ACS2014) Either for Paroxysmal AF Unresponsive to Anti-arrhythmic Treatment Either for Persisting Symptomatic AF, Able to Give His Non Opposition to Participate to the Study
- Trial name
- PROFIB-AF (NCT05179902)
- Where
- France
- Volunteers
- 190 people
- Sponsor
- University Hospital, Clermont-Ferrand
Atrial Fibrillation
Effect of Cryoballoon and RF Ablation on Left Atrial Function
120 consecutive patients with paroxysmal AF, slated for PV isolation, will be randomly assigned to RF or cryoballoon ablation (in a 1:2 allocation scheme).
- Trial name
- CryoLAEF (NCT02611869)
- Testing
- Cryoballoon, RF ablation
- Where
- 2 sites in Greece
- Volunteers
- 120 people
- Sponsor
- G.Gennimatas General Hospital
Atrial Fibrillation
Effect of Prolonged Use of Dronedarone on Recurrence in Patients With Non-paroxysmal Atrial Fibrillation After Radiofrequency Ablation
Recurrence rate remains high after radiofrequency ablation in patients with non-paroxysmal atrial fibrillation(AF). Prolonged use of anti-arrhythmic drugs (AAD) beyond the post-ablation blanking has been adopted as a solution but…
- Trial name
- DORIS (NCT05655468)
- Testing
- Dronedarone
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Shanghai East Hospital
Atrial Fibrillation, Catheter Ablation
Registry Evaluating AF Ablation Techniques
The purpose of this observational registry is to prospectively collect procedure efficiency, safety and acute and long term outcome data from catheter ablation procedures as treatment of paroxysmal atrial fibrillation, using the…
- Trial name
- PRIME-AF (NCT03695484)
- Where
- 3 sites in Belgium, Netherlands and 1 more
- Volunteers
- 212 people
- Sponsor
- Erasmus Medical Center
Symptomatic Paroxysmal Atrial Fibrillation (PAF)
FIRE AND ICE: Comparative Study of Two Ablation Procedures in Patients With Atrial Fibrillation
Comparing efficacy and safety of isolation of the pulmonary veins (PV) using a Cryoballoon catheter versus a radiofrequency ablation with a ThermoCool catheter in patients with paroxysmal atrial fibrillation.
- Trial name
- NCT01490814
- Testing
- Electrical isolation of the pulmonary veins, Electrical isolation of pulmonary veins
- Where
- 19 sites in Czechia, France and 6 more
- Volunteers
- 769 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Atrial Fibrillation, Paroxysmal or Persistent, Mitral Valve Disease
Safety and Efficacy of the CoolCryo System for Cardiac Cryoablation in the Treatment of Atrial Fibrillation
The study involves endocardial cryoablation of the left and/or right atrium of the heart using the CoolCryo system as an adjunct to mitral valve surgery, with the aim of eliminating atrial fibrillation (AF), which is a common…
- Trial name
- CoolCryo (NCT06557616)
- Where
- 2 sites in Poland
- Volunteers
- 20 people
- Sponsor
- Medinice S.A.
Atrial Fibrillation, Atrial Fibrillation, Persistent
Left Roof Linear, Mitral Isthmus Linear and Left Anterior Septal Linear Ablation for Non-paroxysmal AF: PROMISED Trial.
The purpose of this prospective randomized study is to assess whether a new treatment strategy consisting of circumferential Pulmonary vein isolation (PVI), left ROof linear (RL), Mitral Isthmus linear (MIL), and left anterior…
- Trial name
- NCT06249347
- Testing
- PROMISED, CPVI and LAAC, Radiofrequency ablation catheter
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Persistent Atrial Fibrillation
Efficacy and Safety Study of the Estech COBRA® Surgical System to Treat Patients With a History of Irregular Heart Beats
The purpose of this study is to demonstrate that the Estech COBRA Surgical System is an effective treatment for patients with irregular heart beats who are undergoing heart surgery.
- Trial name
- NCT01683045
- Testing
- The Estech COBRA® Surgical System
- Where
- 13 sites in United States
- Volunteers
- 6 people
- Sponsor
- Endoscopic Technologies, Inc
Atrial Fibrillation New Onset, Atrial Fibrillation Paroxysmal
Rhythm Control Versus Rate Control for New Onset Atrial Fibrillation
Adult patients who are diagnosed new onset atrial fibrillation with rapid ventricular response within 7 days after non-cardiac non-thoracic surgery are enrolled.
- Trial name
- NCT05950971
- Testing
- Amiodarone, diltiazem or esmolol
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- Seoul National University Hospital
Non-paroxysmal Atrial Fibrillation, Left Atrial Tachycardia
EnSite™ HD Grid Catheter AF/AT Mapping Study
In this clinical investigation, the safety, feasibility and performance of the novel EnSite™ HD Grid Catheter mapping system for advanced high-density three-dimensional mapping will be studied in patients undergoing catheter…
- Trial name
- NCT02656537
- Testing
- EnSite™ HD Grid Catheter mapping system
- Where
- 7 sites in Australia, France and 3 more
- Volunteers
- 82 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation, Atrial Flutter
Comparison of ATI-5923, a Novel Vitamin K Antagonist, With Warfarin in Patients Requiring Chronic Anticoagulation
The purpose of this research study is to test an experimental drug ATI-5923 vs Coumadin. The study is intended to demonstrate ATI-5923 is superior to Coumadin for keeping INR values in the desired therapeutic range.
- Conditions
- Atrial Fibrillation, Atrial Flutter, Venous Thromboembolic Disease, Myocardial Infarction
- Trial name
- EmbraceAC (NCT00691470)
- Testing
- ATI-5923, Coumadin (warfarin)
- Where
- 41 sites in United States
- Volunteers
- 600 people
- Sponsor
- ARYx Therapeutics
Atrial Fibrillation Paroxysmal
Atrial Fibrillation Lifestyle Project
The objectives of the investigators are to demonstrate a reduction in frequency and symptoms of AF and improvements in cardiovascular risk factors following a lifestyle intervention in patients with paroxysmal AF.
- Trial name
- ALP (NCT03724383)
- Testing
- Risk Factor Management Consult, Diet Classes, Stress Management Classes
- Where
- 7 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Teddi Orenstein Lyall
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Medtronic Terminate AF Study
The purpose of this study is to demonstrate the safety and effectiveness of the Cardioblate iRF and CryoFlex hand held devices for the treatment of non-paroxysmal atrial fibrillation (AF).
- Trial name
- NCT03546374
- Testing
- Surgical Ablation, Cardioblate and Cryoflex hand held devices
- Where
- 15 sites in United States
- Volunteers
- 160 people
- Sponsor
- Medtronic Cardiac Surgery
Paroxysmal Atrial Fibrillation
SINGLE SHOT CHAMPION
Pulmonary vein isolation (PVI) is an effective treatment for atrial fibrillation (AF). Currently, Medtronic Arctic Front Cryoballoon is the most frequently used single shot technology and hence is the benchmark for upcoming…
- Trial name
- NCT05534581
- Testing
- PVI using the Arctic Front Cryoballoon (Medtronic), PVI using FARAPULSE Pulsed Field Ablation (Boston Scientific)
- Where
- 2 sites in Switzerland
- Volunteers
- 210 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern