Clinical trials: Non-smoker
Lung Cancer
First-line Gefitinib Versus Chemotherapy for Lung Adenocarcinoma in Never Smoker
The investigators will conduct the randomized trial to determine the role of Gefitinib monotherapy as first-line setting in adenocarcinoma patients with no history of smoking, as compared with the standard combination…
- Trial name
- NCT00455936
- Testing
- Gefitinib, chemotherapy
- Where
- 3 sites in South Korea
- Volunteers
- 315 people
- Sponsor
- National Cancer Center, Korea
Postoperative Nausea and Vomiting
Study of Nicotine for the Prevention of PONV
The purpose of this study is to determine whether nicotine is effective in the prevention of nausea and vomiting in non-smokers undergoing surgery
- Trial name
- NicoPONV (NCT00553709)
- Testing
- Nicotine
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Geneva
Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer
Carboplatin, Paclitaxel, and Bevacizumab With or Without Erlotinib Hydrochloride in Treating Non-Smokers With Advanced Non-Small Cell Lung Cancer
This randomized phase II trial studies how well carboplatin, paclitaxel, and bevacizumab work with or without erlotinib hydrochloride in treating non-smokers with advanced non-small cell lung cancer.
- Conditions
- Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
- Trial name
- NCT00976677
- Testing
- erlotinib hydrochloride, paclitaxel, carboplatin
- Where
- 108 sites in United States
- Volunteers
- 10 people
- Sponsor
- National Cancer Institute (NCI)
Cigarette Smoking, Smoking Behaviors
Switch or Quit R01
This study evaluates whether non-cigarette tobacco products (e-cigarettes) can help smokers quit smoking as compared to traditional quit methods (nicotine replacement therapy or varenicline/Chantix).
- Trial name
- NCT06373679
- Testing
- Switching to E-Cigarette, Switching using Medication
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Smoking
Young Smokers Have Impaired Airway Defense
Background: Smoking is a key factor for development and progression of chronic obstructive pulmonary disease (COPD). Although persons with COPD often have concomitant nasal disease, there are few studies that report physiological…
- Trial name
- NCT01877291
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Diabetes Type 2
Clamp Study Comparing Inhalation of Technosphere®/Insulin in Smokers and Non-Smokers With Type 2 Diabetes
Twelve smoking and twelve non-smoking subjects with Type 2 Diabetes Mellitus will be enrolled in this study to determine the effect of Technosphere® Insulin Inhalation Powder on insulin in the body during a clamp procedure.
- Trial name
- NCT00934414
- Testing
- Technosphere Insulin Inhalation Powder
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mannkind Corporation
Lung Cancer, Tobacco Use Disorder
Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of phenethyl isothiocyanate may prevent lung cancer in people who smoke cigarettes.
- Trial name
- NCT00691132
- Testing
- phenethyl isothiocyanate
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Minnesota
HIV/AIDS, Vitamin D Deficiency
Effect of High-Dose Vitamin D3 in Smokers and Non-Smokers With and Without HIV
Supplementation with vitamin D improves HIV+ macrophages phagocytosis in vitro. There is evidence to suggest that administering vitamin D can in fact improve immune function in individuals.
- Conditions
- HIV/AIDS, Vitamin D Deficiency, Smoker Lung
- Trial name
- NCT03270709
- Testing
- Vitamin D3 450,000 IU orally
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Emory University
Schizophrenia
Nicotinic Receptor Density in Smoking and Nonsmoking Schizophrenics
Background: Previous studies have suggested that smoking cigarettes affects the number of receptors in the brain for nicotine, a chemical present in cigarette smoke.
- Trial name
- NCT01246128
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Premalignant Lesion, Head and Neck Squamous Cell Carcinoma (HNSCC)
A Clinical and Biological Umbrella Protocol for Smoker or Non-smoker Patients With OPML or HNSCC
This is a multicenter minimal risk or burden prospective 3-cohort follow-up and monitoring study that aims to collect clinical, socio-psychological, medico-economics data and biospecimens for patients with oral potentially…
- Trial name
- UMBRELLA (NCT03276819)
- Testing
- Samples collection, Psychological and Sociological evaluation, Intensive and sustained smoking cessation program
- Where
- 10 sites in France
- Volunteers
- 53 people
- Sponsor
- Centre Leon Berard
Nicotine Dependence, Healthy
Test-retest Reproducibility of [11C]PHNO PET Using the Constant Infusion Paradigm
A research study designed to examine amphetamine-induced dopamine release using the PET imaging agent [11C]PHNO in tobacco smokers while currently smoking and during acute withdrawal and in nonsmokers.
- Trial name
- phno_amth (NCT01699607)
- Testing
- Amphetamine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yale University
Periodontitis, Periodontitis Stage III
Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers
This study investigated the adjunctive effects of diode laser therapy in smokers with severe periodontitis. Thirty-three patients were randomized to non-surgical periodontal therapy (SRP) with or without diode laser.
- Conditions
- Periodontitis, Periodontitis Stage III, Periodontal Disease, Diode Laser Therapy
- Trial name
- NCT07213752
- Testing
- Diode Laser Application in Deep Periodontal Pockets, Professional Mechanical Plaque Removal, Scaling and Root Planing
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Cigarette Smoker, Current Smoker
Nicotine Delivery From Novel Non-Tobacco Electronic System in Smokers
This randomized pilot clinical trial studies nicotine delivery from novel non-tobacco electronic system (ENDS) in smokers. Studying the levels of nicotine delivered by various types and brands of ENDS to the bloodstream, and…
- Conditions
- Cigarette Smoker, Current Smoker, Healthy Subject
- Trial name
- ENDS (NCT02575885)
- Testing
- Electronic Cigarette, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Respiratory Disorders
A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of GSK Biologicals' Non-typeable Haemophilus Influenzae (NTHi) Investigational Vaccine (GSK2838497A) in Current and Former Smokers
The purpose of this study is to assess the safety, reactogenicity and immunogenicity of 8 different formulations of investigational NTHI vaccine in current and former smokers, 50-70 years of age.
- Trial name
- NCT01678677
- Testing
- NTHI vaccine GSK2838500A (formulation 1), NTHI vaccine GSK2838501A (formulation 2), NTHI vaccine GSK2838502A (formulation 3)
- Where
- 3 sites in Belgium
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COPD, Lung Cancer (NSCLC)
Tumors and Respiratory System Diseases Due to Air Pollution: New Biomarkers of Exposure and Effects
This study aims to examine the exposure to atmospheric pollutants in a group of non-smoking patients suffering from lung cancer, chronic obstructive pulmonary disease (COPD), and leukemia.
- Conditions
- COPD, Lung Cancer (NSCLC), Leukemia
- Trial name
- RECAP (NCT06800586)
- Where
- 3 sites in Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Smoking, Non-smoking
Smoking Research Study
The purpose of this study is to develop a fit-for-purpose biochemical verification tool that can be used to detect concomitant use of a few (less than 5) conventional cigarettes.
- Trial name
- NCT01465880
- Testing
- Part A
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Vaping, Nicotine Dependence
Varenicline for Nicotine Vaping Cessation in Adolescents
The study will test the hypothesis that varenicline, when added to behavioral and texting support for vaping cessation, will improve vaping abstinence rates in adolescents dependent on vaped nicotine over placebo plus behavioral…
- Trial name
- ViVA (NCT05367492)
- Testing
- Double Blind Varenicline, QuitVaping, This Is Quitting
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Massachusetts General Hospital
Tobacco Dependence
Cooling Agent Pilot Among Adult Menthol Smokers
Recent studies and market monitoring have shown that in places where menthol cigarettes are no longer available, tobacco companies have started marketing "non-menthol cooling cigarettes".
- Trial name
- NCT06477601
- Testing
- Assigning cooling agent type cigarettes, Assigning traditional tobacco type cigarettes, Assigning menthol type cigarettes
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Healthy Smokers, Healthy Non-smokers
Biomarkers of iNOS Activity in COPD, Asthma, Healthy Control
This pilot study will measure the baseline levels and the intra- and inter-subject variability of exhaled (alveolar and bronchial) and nasal NO in smoking subjects with mild and moderate COPD on or off steroid treatment, smoking…
- Conditions
- Healthy Smokers, Healthy Non-smokers, Patients With Mild Asthma, Patints With COPD (GOLD II)
- Trial name
- NCT00159302
- Testing
- Induced Sputum, Exhaled Nitric Oxide, Nasal Nitric Oxide
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Imperial College London
Smoking ( Cigarette), Cardiovascular Disease
SMOKING AND PRESENCE OF FRANK'S SIGN
In this study, the effect of cigarette smoking-one of the major risk factors for cardiovascular diseases-on the development of Frank's sign (DELC) was investigated.
- Trial name
- NCT07427745
- Testing
- To obtain bilateral ear photographs, To take a medical history
- Where
- Turkey (Türkiye)
- Volunteers
- 404 people, healthy volunteers welcome
- Sponsor
- Samsun University