Clinical trials: Non-smoker
Smoking, Lung Diseases
Evaluation of Lungs of Normal Individuals by Lung Lavage, Brushing and Bronchial Wall Biopsy
The purpose of this study is to obtain biologic materials from the blood and lungs of normal individuals to establish a set of normal range for various parameters.
- Trial name
- NCT00224185
- Testing
- Bronchopulmonary Lung Lavage, Bronchial Brushing, Bronchial Wall Biopsy
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Periodontal Disease, Periodontitis (Stage 3)
Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis
This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker…
- Conditions
- Periodontal Disease, Periodontitis (Stage 3), Smoking Behaviors
- Trial name
- OASP (NCT07673185)
- Testing
- Omega-3 Fatty Acids (EPA plus DHA) plus low dose aspirin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Healthy Non-smoker
Matrix on Fruit Constituent Bioavailability
Primary objective is to evaluate the influence of matrix on the bioavailability of key phytochemical constituents in fruits and their subsequent effect on chronic disease risk factors.
- Trial name
- FRT (NCT01908634)
- Testing
- Milk-based Strawberry Beverage without meal, Water-Based Strawberry Beverage without meal, Milk-based strawberry Beverage with meal
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
COVID-19
Prospective Natural History Study of Smoking, Immune Cell Profiles, Epigenetics and COVID-19
Background: Early evidence in the COVID-19 pandemic suggests that smokers are at a higher risk of having severe effects or dying from the disease. Smoking causes changes in immune cells.
- Trial name
- NCT04403386
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Substance Related Disorder, Nicotine Dependence
Effects of Nicotine on Elements of Attentions in Smokers and Nonsmokers
Background: Many cigarette smokers claim that smoking helps them stay alert and improves their concentration, and have reported problems in attention and concentration after quitting smoking.
- Trial name
- NCT01034020
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Oropharyngeal Cancer
EValuating the Safety Of De-escaLated Head and Neck Irradiation in HPV positivE Oropharynx Cancer in Non-smokers/Minimal Smokers
A prospective, observational study evaluating the durability of local/regional control of previously published de-escalated radiotherapy protocols for patients with P16 positive oropharynx cancers who have minimal nicotine…
- Trial name
- NCT03777384
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Sanford Health
Healthy Subjects, Smokers
Multiple Breath Washout (MBW) Using Sulfur Hexafluoride Reference Values and Influence of Anthropometric Parameters
Multiple breath washout (MBW) using Sulphur hexafluoride (SF6) has the potential to reveal ventilation heterogeneity in obstructive lung disease which is frequent in patients with small airway disease.
- Conditions
- Healthy Subjects, Smokers, Non-smokers
- Trial name
- NCT04099225
- Testing
- Multiple breath washout (MBW) testing
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Lung Cancer
Carboplatin, Pemetrexed Disodium, and Bevacizumab for Patients With Stage III or IV Non-Small Cell Lung Cancer Who Are Light/Never Smokers
RATIONALE: Drugs used in chemotherapy, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01344824
- Testing
- bevacizumab, carboplatin, erlotinib hydrochloride
- Where
- 4 sites in United States
- Volunteers
- 38 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Lung Cancer
Internet-Based Clinical Information and Blood Sample Collection From Patients With Non-Small Cell Lung Cancer Who Never Smoked Cigarettes
RATIONALE: Gathering health information about patients with non-small cell lung cancer who never smoked cigarettes may help doctors learn more about the disease.
- Trial name
- NCT01141218
- Testing
- internet-based protocol and physician referral
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Respiratory Disorders
A Study to Test if a Third Dose of the Vaccine is Safe in Current and Former Smokers Aged 40 to 80 Years Old and to Gather Information on the Immune Response Following the Third Dose of the Vaccine
The purpose of this study is to test two different vaccine schedules to be used for administering the investigational NTHi Mcat vaccine that will be targeting patients with chronic obstructive pulmonary disease (COPD) to prevent…
- Trial name
- NCT03443427
- Testing
- NTHi Mcat investigational vaccine (GSK3277511A)
- Where
- 8 sites in Canada, Germany and 1 more
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cigarette Smoking, Coronary Heart Disease
Exercise and Coronary Heart Disease Risk Markers in Male Smokers and Non-Smokers
The present study will investigate the effect of acute exercise on fasting and postprandial risk markers for coronary heart disease (CHD) in healthy male cigarette smokers and non-smokers.
- Conditions
- Cigarette Smoking, Coronary Heart Disease, Cardiovascular Risk Factor, Insulin Resistance
- Trial name
- NCT03735186
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Lung Cancer Patients, Caregivers
Project PEER: Understanding the Lung Cancer Patient ExperiEnce in the Real-World Setting
LUNGevity Foundation, a non-profit lung cancer organization, wants to learn about living with lung cancer from the point of view of people with lung cancer and their family and friends who provide care.
- Trial name
- PEER (NCT05826756)
- Testing
- There are no interventions in this study. All participants complete online surveys.
- Where
- United States
- Volunteers
- 1,300 people
- Sponsor
- LUNGevity Foundation
Chronic Periodontitis
Effect of Probiotics on Chronic Periodontitis in Smoker and Non- Smokers
Periodontitis is one of the most common chronic inflammatory disease with the etiology of bacterial plaque and is associated with a number of putative bacterial species.
- Trial name
- NCT02329353
- Testing
- Lactobacillus brevis CD2 Lozenges
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Next Gen Pharma India Pvt. Ltd.
Smoking
Very-Low Nicotine Cigarettes and Non-Daily Smokers
The purpose of this research study is to investigate the impact of different nicotine levels in cigarettes among non-daily smokers.
- Trial name
- NCT02228824
- Testing
- Very low nicotine content cigarettes, Normal nicotine content cigarettes
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- Saul Shiffman
Asthma, COPD
ATP/AMP Challenge in Healthy Non-smokers, Smokers, Patients With Asthma, and Patients With Chronic Obstructive Pulmonary Disease (COPD)
In this randomised, cross-over, controlled study, a total of 84 subjects will be included: 12 healthy non-smoking volunteers; 12 current smokers; 30 patients with mild steroid-naïve asthma; and 30 patients with mild-moderate…
- Conditions
- Asthma, COPD, Smoking
- Trial name
- NCT00159315
- Testing
- Inhalation Challenge with ATP, Inhalation Challenge with AMP
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Health Risk Behaviors
A Prospective Study for the Early Diagnosis of Lung Cancer in Korean Females
This is a single-arm prospective pilot study in a single institution. The target accrual is 200 participants of Korean, female sex, never smoker status, and family history of lung cancer.
- Trial name
- NCT06181929
- Testing
- Low dose CT
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sang-Won Um
COPD, Emphysema
Leukocyte Function in Chronic Obstructive Pulmonary Disease (COPD)
The aim of this study is to investigate the mechanisms whereby leukocytes are recruited to the lung in chronic obstructive pulmonary disease (COPD) and cause tissue destruction.
- Conditions
- COPD, Emphysema, Chronic Bronchitis
- Trial name
- NCT00147082
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Schizophrenia Disorders
Effect of AQW051 on Cognitive Function in Patients With Chronic Stable Schizophrenia
This PoC study is designed to assess the cognitive effects of doses of AQW051 in patients with chronic stable schizophrenia.
- Trial name
- NCT01163227
- Testing
- AQW051 2 mg (single and multiple doses), AQW051 15mg (single and multiple doses), AQW051 100mg (single dose), and 50mg (multiple doses)
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- Novartis Pharmaceuticals
Smoking, Tobacco Use
IQOS (Non-Cigarette Tobacco Product) Pilot Study
A novel type of non-cigarette tobacco product was recently approved for sale in the US, the heated tobacco product (HTP) IQOS. IQOS may be less harmful than cigarettes, and there are some reports that it may produce more…
- Trial name
- NCT04357379
- Testing
- IQOS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Smoking
Effects of Sulforaphane (SFN) on Immune Response to Live Attenuated Influenza Virus in Smokers and Nonsmokers
Vegetables such as broccoli, cauliflower, kale and cabbage are particularly rich in a plant chemical called sulforaphane (SFN) which boosts production of certain "defense" enzymes that increase the activity of antioxidants.
- Trial name
- NCT01269723
- Testing
- Broccoli sprout homogenate, Alfalfa sprout homogenate
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill