Clinical trials: Non-standard Therapy
Hepatitis C
Safety and Efficacy of Decentralized HCV Treatment vs Standard-of-Care in Rio de Janeiro (Brazil)
Up to 650,000 people in Brazil are living with chronic hepatitis c virus (HCV) infection. Hepatitis C is a silent disease, and up to 20% of cases can progress to liver cirrhosis and its complications.
- Trial name
- HCVPCL05/20 (NCT06306300)
- Testing
- Specialist - Epclusa 400Mg-100Mg Tablet, Non- specialist - Epclusa 400Mg-100Mg Tablet, HCV Self-Testing kit (Ora-Quick HCV ST or Wond-Foo HCV ST)
- Where
- 2 sites in Brazil
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Cornea
Healing of Persistent Epithelial Defects
The purpose of this study is to compare the relative efficacy of four different treatment modalities (i.e. aggressive lubrication, bandage contact lens, Ambiodisk amniotic membrane, Prokera amniotic membrane) in the healing of…
- Trial name
- NCT02395952
- Testing
- carboxymethylcellulose sodium, Acuvue Oasys Bandage Contact Lens, Ambiodisk
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Periodontitis, Halitosis
The Additional Effect of Tongue Scraping on Halitosis Parameters in Initial Periodontal Therapy
Periodontitis can lead to tooth loss which may impair chewing ability and aesthetics. In addition, periodontitis can give rise to halitosis.
- Conditions
- Periodontitis, Halitosis, Tongue Condition
- Trial name
- NCT06091228
- Testing
- tongue scraper
- Where
- Belgium
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cardiopulmonary
Observational, Non-Interventional Study Supporting Validation of eVO2peak Using Results in Patients Receiving Standard of Care Cardiopulmonary Exercise Tests (CPET)
In this study, the hypothesis being explored is that peak VO2 and potentially other CPET parameters can be accurately estimated from biosignals (namely, motion from accelerometers and cardiopulmonary variables from EKG) collected…
- Trial name
- NCT05678530
- Where
- 16 sites in United States, Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Prolaio
Postoperative Pain; Knee Arthroscopy; Acupuncture
Acupuncture for Pain Control After Ambulatory Knee Arthroscopy
Aim of the study: To investigate whether acupuncture with indwelling fixed needles reduces pain and analgesic requirement and foster mobilization in patients after arthroscopic knee surgery (AKS) Design: Prospective pilot…
- Trial name
- AcuK-Scope (NCT04134702)
- Testing
- Acupuncture
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Fever
Comparative Efficacy of Single-dose Doxycycline Versus Standard 5- Day Amoxicillin Treatment
Abstract: Background The current practice in Senegal is to use broad-spectrum antibiotics including amoxicillin and/or cotrimoxazole in case of non-malarial fevers. First-line treatment with doxycycline has cured such patients.
- Trial name
- NCT03765931
- Testing
- Doxycycline, Amoxicillin
- Where
- Senegal
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Target Drug-related Adverse Events
Standard of Care Versus Urine Testing With Selective PHarmacogenomics for Effective Drug and Dosing REgimens
The purpose of this study is to determine whether the addition of selective pharmacogenomic (PGx) testing as determined by Urine Drug Testing (UDT) adds a clinical benefit as evidenced by a reduction in Target Drug-related…
- Trial name
- SPHERE (NCT02625155)
- Testing
- Urine diagnostic testing as SOC, drug regimen changes per SOC, Urine diagnostic testing with selective PGx testing, drug regimen changes based on PGx test results
- Where
- United States
- Volunteers
- 14,000 people, healthy volunteers welcome
- Sponsor
- InSource Diagnostics
Blood Oxygen Desaturations, Sleep-Disordered Breathing
Assessment of the Accuracy of the Non-invasive Wireless Armband Gabi Baby Band for Continuous Vital Parameters Monitoring in Infants and Young Children
During a polysomnography test (PSG) previously prescribed by a physician, the patient also wears the Gaby Baby Band (GBB) during an entire night of sleep.
- Trial name
- WAGSC1 (NCT04886583)
- Testing
- Gabi Baby Band
- Where
- 3 sites in Belgium
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Gabi SmartCare
Healthy Volunteers
Gas Composition in the Hypopharynx During High-flow or Standard Oxygen Therapy Through Face Mask in Healthy Volunteers
The COVID-19 pandemic has become a huge global problem, affecting all spheres of human life, resulting in enormous social, economic consequences and human tragedies.
- Trial name
- O2-OXIMETRY (NCT07019701)
- Testing
- High flow oxygen through nasal cannula and face mask and standard oxygen therapy through non-rebreather face mask, and measurement of oxygen and carbon dioxide fraction in the hypopharynx
- Where
- Russia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
the Eradication Rates of Helicobacter Pylori
Standard or Short-course Vonoprazan Non-bismuth Triple Therapy or High-dose Dual Therapy Versus Rabeprazole-bismuth Quadruple Therapy for Primary Helicobacter Pylori Eradication
The goal of this clinical trial is to compare eradication rates of Helicobacter pylori in patients aged 18-70 years with first infection.
- Trial name
- NCT06168214
- Testing
- Rabeprazloe+bismuth+amoxicillin+clarithromycin, Vonoprazan+amoxicillin+clarithromycin 14 days, Vonoprazan+amoxicillin+clarithromycin 7 days
- Where
- China
- Volunteers
- 1,404 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Periodontitis
Effect of Novel Oral Hygiene Regimen on Non-surgical Treatment of Stage II and III Periodontitis
Achievement of adequate oral hygiene standards is critical to the successful treatment of gum disease. The improvement of the patient's adherence to good oral hygiene is of great importance to obtain the satisfactory treatment…
- Trial name
- NCT05137392
- Testing
- oral hygiene instruction
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Prostate Cancer
Immediate Curative vs Conservative Treatment in Older Men With M0, High-risk Prostate Cancer
It is currently unclear if immediate curative treatment (radiotherapy or surgery) of high-risk prostate cancer without metastasis in older men (>=75 years) generates the same survival benefits as in younger patients or if the…
- Trial name
- GrandP/SPCG19 (NCT05448547)
- Testing
- Radiotherapy or surgery, initial observation, Hormone therapy
- Where
- 26 sites in Denmark, Finland and 2 more
- Volunteers
- 980 people, healthy volunteers welcome
- Sponsor
- Sven Löffeler
Colon Cancer, Breast Cancer
A Digimed Oncology PharmacoTherapy Registry
DigiMeds™ are medications with FDA-approved ingestible sensors (IS), a wearable sensor patch (patch), and a mobile app, which records time-stamped medication type and dose alongside biometric activity.
- Conditions
- Colon Cancer, Breast Cancer, Rectal Cancer
- Trial name
- ADOPTR (NCT04088955)
- Testing
- DigiMeds
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Proteus Digital Health, Inc.
Monotherapy, Dolutegravir
Early Simplified: A Trial to Compare the Efficacy of Standard of Care Combination Antiretroviral Therapy With a Simplified Dolutegravir Monotherapy in Patients With a Primary HIV-1 Infection
Long term toxicity of combination antiretroviral therapy (cART) is a substantial contributor to morbidity and mortality in chronically infected HIV positive individuals.
- Conditions
- Monotherapy, Dolutegravir, Primary HIV Infection, Treatment Efficacy
- Trial name
- NCT02551523
- Testing
- Dolutegravir, Standard of care combinational antiretroviral therapy
- Where
- Switzerland
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Zurich