Clinical trials: Noncardiac Surgery
Antiplatelet Drugs
Perioperative Antiplatelet Therapy in Patients With Drug-eluting Stent Undergoing Noncardiac Surgery
The purpose of this study is to evaluate the safety and effectiveness of perioperative antiplatelet therapy in patients with drug-eluting stent undergoing non-cardiac surgery.
- Trial name
- ASSURE-DES (NCT02797548)
- Testing
- Aspirin only, No antiplatelet therapy
- Where
- 35 sites in India, South Korea and 1 more
- Volunteers
- 1,010 people
- Sponsor
- Jung-min Ahn
Surgical Procedure, Non-cardiac, Cardiovascular Disease Patients
Perioperative Ischemia Versus Perioperative Bleeding During Non-cardiac Surgery in Cardiac Patients
The aim of the study is to analyze the present use of antithrombotic therapy on a large cohort of consecutive cardiacs undergoing non-cardiac surgery.
- Conditions
- Surgical Procedure, Non-cardiac, Cardiovascular Disease Patients, Perioperative Period
- Trial name
- PRAGUE-14 (NCT01897220)
- Where
- 2 sites in Czechia
- Volunteers
- 1,200 people
- Sponsor
- Charles University, Czech Republic
Anesthesia, Surgery With General Anesthesia
The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient…
- Conditions
- Anesthesia, Surgery With General Anesthesia, Noncardiac Surgery, Hypotension During Surgery
- Trial name
- VEGA-2 (NCT06802224)
- Testing
- Norepinephrine, Phenylephrine
- Where
- 10 sites in United States, Canada
- Volunteers
- 18,000 people
- Sponsor
- University of California, San Francisco
Length of Stay, Anti Cholinergics
Anticholinergic Risk Scale and Resource Use After Elective Noncardiac Surgery
This study investigates the association of preoperative anticholinergic medication exposure with healthcare resource utilization in a population-based sample of older patients enrolled in a universal pharmacare program
- Conditions
- Length of Stay, Anti Cholinergics, Surgical Procedure, Operative, Aged
- Trial name
- NCT03151616
- Testing
- anticholinergic risk scale
- Where
- Canada
- Volunteers
- 244,976 people
- Sponsor
- Ottawa Hospital Research Institute
Postoperative Acute Kidney Injury
Machine Learning Models for Prediction of Acute Kidney Injury After Noncardiac Surgery
Acute kidney injury (AKI) is a common surgical complication characterized by a rapid decline in renal function. Patients with AKI are at an increased risk of developing chronic kidney disease and end-stage renal disease, which…
- Trial name
- NCT06146829
- Testing
- no intervention
- Where
- China
- Volunteers
- 88,367 people
- Sponsor
- Rao Sun
MYOCARD INFARCTUS, Non Cardiac Surgery
Myocardial Injury After Noncardiac Surgery (MINS) in Lumbar Surgery Patients
The aim of this study is to evaluate the incidence of myocardial injury after noncardiac surgery (MINS) in patients undergoing lumbar surgery, and to investigate the associated risk factors.
- Conditions
- MYOCARD INFARCTUS, Non Cardiac Surgery, Lumbar Surgery, Anesthesia
- Trial name
- NCT07081009
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Postoperative Recovery, Postoperative Delirium
The Effect of Desflurane Versus Sevoflurane on Postoperative Recovery
Patients over the age of 65 years are at increased risk for developing delirium and cognitive complications in the immediate postoperative period after noncardiac surgeries, resulting in increased morbidity and mortality.
- Conditions
- Postoperative Recovery, Postoperative Delirium, Difference in Pharmakokinetics of Volatile Anesthetics
- Trial name
- RAPID (NCT05331027)
- Testing
- Desflurane, Sevoflurane
- Where
- Austria
- Volunteers
- 190 people
- Sponsor
- Medical University of Vienna
Moderate to High-risk Noncardiac Surgery
SMART TRENDS Study
A multicenter, interventional, feasibility comparison with historical controls
- Trial name
- NCT05957406
- Testing
- Acumen HPI Smart Alerts and Smart Trends Software, The HemoSphere advanced monitoring platform with Acumen HPI software, and Acumen IQ sensor and Acumen IQ cuff
- Where
- 8 sites in United States
- Volunteers
- 296 people
- Sponsor
- Becton, Dickinson and Company
Atrial Fibrillation
Prevention of Atrial Fibrillation Following Noncardiac Thoracic Surgery
The investigators hypothesize that the medication amiodarone decreases the incidence of atrial fibrillation (AF) following non-cardiac open-chest surgery.
- Trial name
- NCT00127712
- Testing
- Amiodarone
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Indiana University
Vascular Death, Myocardial Infarction
Vascular Events In Noncardiac Surgery Patients Cohort Evaluation Study (VISION)
The investigators' study has 4 primary objectives. Among patients undergoing noncardiac surgery the investigators will determine: (1) the incidence of major perioperative vascular events; (2) the optimal clinical model to predict…
- Conditions
- Vascular Death, Myocardial Infarction, Cardiac Arrest, Stroke
- Trial name
- VISION (NCT00512109)
- Where
- 8 sites in Brazil, Canada and 5 more
- Volunteers
- 40,060 people
- Sponsor
- McMaster University
Myocardial Injury After Noncardiac Surgery (MINS), Postoperative Complications
Prediction Model for MINS After Major Hepatobiliary Surgery
This multi-center, prospective observational study aims to develop and validate an interpretable prediction model for Myocardial Injury After Noncardiac Surgery (MINS) in patients undergoing major hepatobiliary surgery.
- Conditions
- Myocardial Injury After Noncardiac Surgery (MINS), Postoperative Complications, Liver Neoplasm, Hepatobiliary Diseases
- Trial name
- NCT07335042
- Testing
- Major Hepatobiliary Surgery
- Where
- 6 sites in China
- Volunteers
- 1,800 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Surgical Procedures, Telemedicine
The Risk of Surgical Cancellation in Adult Patients Assessed by Telephone Versus In-person for Scheduled Non-cardiac Elective Surgery.
Telemedicine has been regulated in Colombia since 2006, with applications in anesthesia being explored since 2004 to improve accessibility and reduce costs.
- Conditions
- Surgical Procedures, Telemedicine, Preanesthetic Medication, Preoperative Care
- Trial name
- NCT06693869
- Where
- Colombia
- Volunteers
- 1,176 people
- Sponsor
- Universidad de Antioquia
Reliability
Inter-rater Reliability of Preoperative Mortality Risk Calculators
The goal of this study is to investigate the inter-rater variability of mortality risk calculations for high-risk non-cardiac surgical patients. For this purpose patient information from health care files were used.
- Trial name
- NCT06410183
- Testing
- no intervention
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Rijnstate Hospital
Myocardial Injury After Noncardiac Surgery (MINS)
Management of Myocardial Injury After Noncardiac Surgery Trial
Patients who have myocardial injury after noncardiac surgery are at a higher risk of dying than those who do not. One in 10 patients with myocardial injury will die within 30 days of surgery.
- Trial name
- MANAGE (NCT01661101)
- Testing
- Dabigatran, Omeprazole
- Where
- 82 sites in United States, Argentina and 17 more
- Volunteers
- 1,754 people
- Sponsor
- Population Health Research Institute
Cardiovascular Diseases
POISE Trial: Perioperative Ischemic Evaluation Study
This trial will evaluate the ability of metoprolol (a beta-blocker drug) to prevent heart attacks and deaths around the time of surgery.
- Trial name
- POISE (NCT00182039)
- Testing
- Metoprolol controlled release (CR)
- Where
- Canada
- Volunteers
- 8,351 people
- Sponsor
- Hamilton Health Sciences Corporation
Noncardiac Surgery
Machine Learning Model to Predict Postoperative Respiratory Failure
The main objective of this study is to develop a machine learning model that predicts postoperative respiratory failure within 7 postoperative day using a real-world, local preoperative and intraoperative electronic health…
- Trial name
- NCT04527094
- Testing
- Prediction of postoperative respiratory failure using a machine learning
- Where
- South Korea
- Volunteers
- 22,250 people
- Sponsor
- Seoul National University Hospital
Anesthesia, Surgery-Complications
REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry
The goal of this randomized controlled trial is to compare total intravenous anesthesia with remimazolam vs total intravenous anesthesia with propofol in moderate-to-high risk patients undergoing major elective noncardiac surgery…
- Trial name
- REPOSE-2 (NCT05728775)
- Testing
- Remimazolam, Propofol
- Where
- 44 sites in China
- Volunteers
- 7,188 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Surgery, Angiotensin Hypertension
Management of Angiotensin Inhibitors During the Perioperative Period
This is a multicenter randomized clinical trial to determine the effect of continuation versus withdrawal of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) in the perioperative period on…
- Conditions
- Surgery, Angiotensin Hypertension, Perioperative Complication
- Trial name
- AIPOP (NCT04506372)
- Testing
- Perioperative withdrawal of angiotensin converting enzyme inhibitors and angiotenin receptor blockers, Blood draw, Diary to register drug adherence
- Where
- 7 sites in Canada, Netherlands
- Volunteers
- 342 people
- Sponsor
- UMC Utrecht
Coronary Stent Occlusion
Use of Optical Coherence Tomography to Determine the Optimal Management of Patients With Drug-eluting Stents Who Need Non-cardiac Surgery
The specific aim of this proposal is to examine the impact of OCT and IVUS-guided management of patients with prior DES implantation who need major non-cardiac surgery and discontinuation of dual antiplatelet therapy on the…
- Trial name
- NCT01288105
- Testing
- Optical coherence tomography
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- North Texas Veterans Healthcare System
Postoperative Delirium
Predictors for Postoperative Delirium After Major Noncardiac Surgery in Adults
This research project is an observational cohort study by retrospective chart review of patients that underwent major noncardiac surgery at University Hospital Basel, Switzerland, in the years 2011-2015.
- Trial name
- PODMAS (NCT04460716)
- Testing
- Major noncardiac surgery
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Basel, Switzerland