Clinical trials: Noncardiac Surgery
Post-induction Hypotension (PIH), Postprandial Hypotension
Postprandial Hypotension, Frailty and Post-Induction Hypotension in Older Patients Undergoing Noncardiac Surgery
The goal of this observational study is to learn whether a drop in blood pressure after a meal (postprandial hypotension) and frailty are linked to low blood pressure after the start of general anesthesia (post-induction…
- Conditions
- Post-induction Hypotension (PIH), Postprandial Hypotension, Frailty
- Trial name
- NCT07914920
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Konya City Hospital
Postoperative Hypoxia
HI-VISION Pilot Study
A prospective cohort pilot study of non-cardiac patients to determine the feasibility of recruiting 150 patients to undergo postoperative continuous hemodynamic monitoring for up to 3 days.
- Trial name
- HI-VISION (NCT02300441)
- Testing
- ECG, blood pressure and oximetry
- Where
- Canada
- Volunteers
- 133 people
- Sponsor
- McMaster University
Older Patients, Noncardiac Surgery
Intranasal Dexmedetomidine-esketamine Combination and Postoperative Cognitive Recovery in Older Patients
Postoperative neurocognitive disorders, including postoperative delirium (POD) and delayed neurocognitive recovery (dNCR), are common in older patients undergoing surgery and are associated with worse outcomes.
- Conditions
- Older Patients, Noncardiac Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT07914803
- Testing
- Intranasal dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 732 people
- Sponsor
- Peking University First Hospital
Peripheral Perfusion Index
Predictor of Postoperative Complications After Lengthy Noncardiac Surgery
Many patients undergoing long time surgery will manifest increased level of blood lactate. Hyperlactacidemia can cause disturbance of internal environment, then leading to increased complications and longer ICU stay, even death.
- Trial name
- complication (NCT04680663)
- Testing
- Peripheral Perfusion index, serum lactate level
- Where
- Egypt
- Volunteers
- 235 people
- Sponsor
- Cairo University
Myocardial Injury After Noncardiac Surgery (MINS), Hypotension During Surgery
Study on the Correlation Between Intraoperative Hypotension and Postoperative Myocardial Injury
The investigators are conducting an important study aimed at better understanding and predicting a potential complication after non-cardiac surgery: myocardial injury.
- Trial name
- NCT07094321
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- China-Japan Friendship Hospital
Hypothermia, Perioperative
Prevalence Survey in France of Unintentional Perioperative Hypothermia and Its Impact on Two Outcomes
The primary objectives of the study are to perform a survey on the clinical management of unintentional hypothermia during surgery in France. to assess the impact of perioperative hypothermia on anemia and myocardial injury.
- Trial name
- HYPOTHERMIE (NCT02790086)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Société Française d'Anesthésie et de Réanimation
Venous Thromboembolism
Graduated Compression Stockings (GCS) Pilot Substudy
This is a pilot substudy to the PeriOperative ISchemic Evaluation-2 Trial (POISE-2), to assess the feasibility of adding graduated compression stockings (GCS) to POISE-2 as an intervention.
- Trial name
- NCT01234064
- Testing
- Anti-Embolism Graduated Pressure Stockings (by BSN-Jobst), No Graduated Compression Stockings
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Hamilton Health Sciences Corporation
Myocardial Injury After Noncardiac Surgery
Post-Operative Biomarker-Guided Precision Medicine For Cardiovascular Risk Reduction
The goal of this pilot study is to assess enrollment feasibility of a randomized trial of direct oral anticoagulant and high-intensity statin therapy versus usual care in patients with Myocardial Injury after Noncardiac Surgery…
- Trial name
- NCT06961630
- Testing
- Rivaroxaban, Atorvastatin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Covert Postoperative Stroke
Detection and Neurological Impact of CerebroVascular Events In Noncardiac Surgery PatIents: A COhort EvaluatioN
The NeuroVISION Study will characterize the incidence, impact, and risk factors of covert stroke in adults undergoing noncardiac surgery.
- Trial name
- NeuroVISION (NCT01980511)
- Where
- 11 sites in United States, Canada and 7 more
- Volunteers
- 1,116 people
- Sponsor
- McMaster University
Coronary Artery Disease
The Role Of Noninvasive 320-Row Multidetector Computer Tomography
Computer tomography coronary angiogram (CTCA) has emerged as a noninvasive alternative to assessing coronary artery luminal disease.
- Trial name
- NCT01405690
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Myocardial Injury After Noncardiac Surgery (MINS)
SecondarY Prevention and maNagement of Myocardial Injury aftER Noncardiac surGerY (SYNERGY) Pilot Trial
Cardiac complications, particularly myocardial injury after noncardiac surgery (MINS), significantly contribute to 30-day mortality, affecting about 1 in 10 patients after noncardiac surgery.
- Trial name
- NCT06768034
- Testing
- Intervention Group
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Emergence Time
Effects of Preoperative Sleep Disorders on Perioperative Anesthesia Depth and Recovery Quality in Patients Undergoing Noncardiac Surgery
A Single-Center, Prospective Observational Cohort Study Comparing Perioperative Electroencephalographic Anesthesia Depth Parameters (Electroencephalographic Index, SE/RE Entropy, Burst Suppression Ratio) Between Patients With…
- Trial name
- NCT07675993
- Testing
- Exposed cohort (sleep disorder group), Control cohort (non-sleep disorder group)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Cardiac Complication, Myocardial Infarction
Cellular precOnditioning for Post-Surgical Myocardial Ischemic Complications - Observational Study
The goal of this observational study is to collect health data on people who are at high risk of having heart complications and are having a surgery that is not on the heart.
- Conditions
- Cardiac Complication, Myocardial Infarction, Myocardial Ischemia, Myocardial Injury
- Trial name
- COSMIC (NCT05762601)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Ottawa Hospital Research Institute
Intraoperative Arterial Hypotension
Association of Intraoperative Blood Pressure Excursions Below Cerebral Autoregulatory Boundaries With Organ Injury Following Major Noncardiac Surgery
The aim of study is to investigate the clinical relevance of blood pressure (BP) excursions below cerebral autoregulatory boundaries in major noncardiac surgery.
- Trial name
- AR-NONCARDIAC (NCT05336864)
- Testing
- Non-invasive cerebral oximetry monitoring, additional perioperative blood sampling, clinical & telephone assessments
- Where
- 3 sites in Switzerland
- Volunteers
- 650 people
- Sponsor
- University Hospital, Basel, Switzerland
Thrombosis, Bleeding
Complications and Antiplatelet and Anticoagulant Therapy in Vascular Surgery.
The goal of this retrospective clinical trial is to find out association antiplatelet and anticoagulant therapy with perioperative complications in non-cardiac vascular surgery in patients .
- Conditions
- Thrombosis, Bleeding, Cerebral Hypoxia During and/or Resulting From A Procedure
- Trial name
- NCT07358416
- Testing
- Aspirin, Clopidogrel, Ticagrelor
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Cardiovascular Diseases (CVD), Postoperative
Evaluate the Value of Modified Shock Index in Predicting the Incidence of Cardiovascular Events After Non-cardiac Surgery in Cardiac Patients
The objective of this study is to evaluate the efficacy of the modified shock index (MSI) in predicting the incidence of postoperative cardiovascular events (PCEs) in patients with pre-existing cardiac disease undergoing…
- Trial name
- NCT07735689
- Volunteers
- 1,500 people
- Sponsor
- Fujian Medical University Union Hospital
Pre-operative, High-risk Patient
Practice Variation in Preoperative Multidisciplinary Team Discussions
Preoperative multidisciplinary team (MDT)discussions are recommended by national and international guidelines. However, no guidance is given on how to organise and execute an MDT discussion.
- Conditions
- Pre-operative, High-risk Patient, Frailty
- Trial name
- NCT05305053
- Testing
- preoperative MDT discussion
- Where
- 9 sites in Netherlands
- Volunteers
- 225 people
- Sponsor
- Rijnstate Hospital
Noncardiac Surgery
Patient-Centred Outcomes and Resource Utilisation After Noncardiac Surgery-D(Eutschland) (PACORUS-D)
The PACORUS-D project aims at 1) quantifying the 30-days and 1-year disability burden (assessed using the 12-item WHODAS 2 [WHO Disability Assessment Schedule] questionnaire) after inhospital noncardiac nonneurosurgical…
- Trial name
- PACORUS-D (NCT04675905)
- Testing
- no intervention (cohort study)
- Volunteers
- 1,200 people
- Sponsor
- PD Dr. med. MSc Giovanna Lurati Buse
Postoperative Delirium, Postoperative Cognitive Dysfunction
Intraoperative Infusion of Methylene Blue for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery
Postoperative neurocognitive impairments often occur in elderly patients undergoing anesthesia and non-cardiac surgery, including postoperative delirium (POD) and postoperative cognitive dysfunction (POCD).
- Trial name
- NCT04341844
- Testing
- Methylene Blue
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Fudan University
High Sensitive Troponin T Release
Cardioprotection by Sevoflurane Preconditioning in Noncardiac Thoracic Surgery
It has been shown that the use of volatile anaesthetics, that are usually used to perform a general anesthesia, have cardioprotective properties.
- Trial name
- NCT02217319
- Testing
- Sevoflurane, TIVA
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Dr. Horst Schmidt Klinik GmbH