Clinical trials: Noncardiac Surgery, open to volunteers
Anesthesia, Surgery With General Anesthesia
The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient…
- Conditions
- Anesthesia, Surgery With General Anesthesia, Noncardiac Surgery, Hypotension During Surgery
- Trial name
- VEGA-2 (NCT06802224)
- Testing
- Norepinephrine, Phenylephrine
- Where
- 10 sites in United States, Canada
- Volunteers
- 18,000 people
- Sponsor
- University of California, San Francisco
Delirium in Old Age
Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery
Investigators propose this multi-center randomised controlled study to test the preventive effect of intravenouse acetaminophen in delirium over 5 postoperative days among older patients recovering from major non-cardiac surgery.
- Trial name
- NCT06653465
- Testing
- Acetaminophen, Saline
- Volunteers
- 1,930 people
- Sponsor
- RenJi Hospital
Myocardial Injury After Noncardiac Surgery (MINS), Bleeding Independently Associated With Mortality After Noncardiac Surgery (BIMS)
Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study 2
VISION-2 is an international, multi-site, prospective observational cohort study of 20,000 patients undergoing noncardiac surgery.
- Conditions
- Myocardial Injury After Noncardiac Surgery (MINS), Bleeding Independently Associated With Mortality After Noncardiac Surgery (BIMS), Sepsis, Infection Without Sepsis
- Trial name
- VISION-2 (NCT07300579)
- Testing
- Continuous vital signs measurement device
- Where
- 3 sites in Canada
- Volunteers
- 20,000 people
- Sponsor
- Hamilton Health Sciences Corporation
Antiplatelet Agents, Perioperative Care
Optimal PERioperative Antiplatelet Therapy Investigation ON Abdominal Surgery After Coronary Stent Implantation
The purpose of this study is to evaluate the impact of perioperative aspirin continuation on clinical outcomes in patients with a history of coronary stent implantation who are scheduled for abdominal surgery.
- Trial name
- OPERATION (NCT06723145)
- Testing
- Aspirin, Aspirin interruption
- Where
- Japan
- Volunteers
- 1,200 people
- Sponsor
- Kyoto University
Anesthesia, Sedation
The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes
Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful.
- Conditions
- Anesthesia, Sedation, Monitored Anesthesia Care, Procedure
- Trial name
- MACS (NCT07022951)
- Testing
- Preoperative fasting
- Where
- United States
- Volunteers
- 1,200,000 people
- Sponsor
- Massachusetts General Hospital
Preoperative Care, Surgery--Complications
Vascular Events In Patients Undergoing Same-day Noncardiac Surgery (VALIANCE) Study
The proportion of noncardiac surgeries performed as same-day surgery is increasing worldwide, with more complex surgeries being performed on higher risk patients in the outpatient setting.
- Conditions
- Preoperative Care, Surgery--Complications, Myocardial Infarction
- Trial name
- VALIANCE (NCT04973397)
- Where
- 16 sites in United States, Canada and 2 more
- Volunteers
- 15,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Pain Management, Noncardiac Surgery
Preemptive Analgesia Of Dexmedetomidine Reduces Per-operation Pain
Background:Preemptive analgesia is the initiation of analgesic regimen before the onset of nociceptive stimulation, preventing the amplification of pain due to peripheral and central sensitization and thereby reducing subsequent…
- Trial name
- NCT06671327
- Testing
- Preemptive Dexmedetomidine injection, Sodium Chloride 0.9% Inj
- Where
- China
- Volunteers
- 208 people
- Sponsor
- China International Neuroscience Institution
Emergence Time
Effects of Preoperative Sleep Disorders on Perioperative Anesthesia Depth and Recovery Quality in Patients Undergoing Noncardiac Surgery
A Single-Center, Prospective Observational Cohort Study Comparing Perioperative Electroencephalographic Anesthesia Depth Parameters (Electroencephalographic Index, SE/RE Entropy, Burst Suppression Ratio) Between Patients With…
- Trial name
- NCT07675993
- Testing
- Exposed cohort (sleep disorder group), Control cohort (non-sleep disorder group)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Atrial Fibrillation, Atrial Flutter
DETECTion of PeriOperative Atrial Fibrillation After Noncardiac Surgery
This is a multicentre prospective cohort study where patients will receive up to 14 days of continuous ECG monitoring by wearing a portable monitoring device, starting within 72 hours after noncardiac surgery.
- Trial name
- DETECT-POAF (NCT06519747)
- Testing
- Cardiac monitoring device
- Where
- 6 sites in Canada
- Volunteers
- 750 people
- Sponsor
- Population Health Research Institute
Myocardial Injury After Noncardiac Surgery (MINS)
SecondarY Prevention and maNagement of Myocardial Injury aftER Noncardiac surGerY (SYNERGY) Pilot Trial
Cardiac complications, particularly myocardial injury after noncardiac surgery (MINS), significantly contribute to 30-day mortality, affecting about 1 in 10 patients after noncardiac surgery.
- Trial name
- NCT06768034
- Testing
- Intervention Group
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Coronary Artery Disease, Noncardiac Surgery
Preoperative vs Postoperative Revascularization in Coronary Heart Disease Patients Undergoing Time-Sensitive Non-Cardiac Surgery (CHRONOS-PCI)
To compare the safety and efficacy of preoperative versus postoperative revascularization strategies in patients with coronary heart disease undergoing time-sensitive non-cardiac surgery.
- Trial name
- CHRONOS-PCI (NCT07175870)
- Testing
- Non-cardiac surgery followed by postoperative PCI, Preoperative PCI followed by delayed non-cardiac surgery ~3 months later
- Where
- China
- Volunteers
- 140 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Myocardial Injury After Noncardiac Surgery (MINS), Postoperative Complications
Prediction Model for MINS After Major Hepatobiliary Surgery
This multi-center, prospective observational study aims to develop and validate an interpretable prediction model for Myocardial Injury After Noncardiac Surgery (MINS) in patients undergoing major hepatobiliary surgery.
- Conditions
- Myocardial Injury After Noncardiac Surgery (MINS), Postoperative Complications, Liver Neoplasm, Hepatobiliary Diseases
- Trial name
- NCT07335042
- Testing
- Major Hepatobiliary Surgery
- Where
- 6 sites in China
- Volunteers
- 1,800 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Hip Fracture, Perioperative Myocardial Injury
Nerve Block and Perioperative Myocardial Injury in Elderly Hip Fracture
This single-center, retrospective cohort study evaluates whether a single preoperative peripheral nerve block can reduce the risk of perioperative myocardial injury in elderly patients undergoing delayed hip fracture surgery…
- Conditions
- Hip Fracture, Perioperative Myocardial Injury, Myocardial Injury After Noncardiac Surgery
- Trial name
- PNB-CARD (NCT07751146)
- Testing
- PNB, Non-PNB
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Cardiovascular Diseases (CVD), Postoperative
Evaluate the Value of Modified Shock Index in Predicting the Incidence of Cardiovascular Events After Non-cardiac Surgery in Cardiac Patients
The objective of this study is to evaluate the efficacy of the modified shock index (MSI) in predicting the incidence of postoperative cardiovascular events (PCEs) in patients with pre-existing cardiac disease undergoing…
- Trial name
- NCT07735689
- Volunteers
- 1,500 people
- Sponsor
- Fujian Medical University Union Hospital
Chronic Kidney Diseases, Acute Kidney Injury
Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial
The BRACKETS pilot study is a multicentre, prospective, randomized controlled trial of prophylactic preoperative tranexamic acid (TXA) versus placebo and, using a partial factorial design, of prophylactic preoperative…
- Conditions
- Chronic Kidney Diseases, Acute Kidney Injury, Bleeding, Surgery
- Trial name
- BRACKETS (NCT06337838)
- Testing
- Desmopressin Injectable Solution, Tranexamic Acid Injectable Product
- Where
- 3 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Hamilton Health Sciences Corporation
Noncardiac Surgery
Prediction of Vascular Events After Major Non-Cardiac Surgery : an Observational Prospective Cohort Study
This observational study includes patients at medium-to-high cardiovascular risks undergoing major noncardiac surgery, measures their baseline demographic and clinical characteristics, preoperative cardiac biomarkers and…
- Trial name
- PREVENGE-CB-2 (NCT05812248)
- Testing
- Perioperative cardiac biomarker measurement
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Breast Cancer, Myocardial Injury After Noncardiac Surgery (MINS)
Impact of Propranolol Strategies on Myocardial Injury After Breast Cancer Surgery
This study aims to evaluate the impact of using propranolol, a non-selective beta-blocker, on preventing myocardial injury after non-cardiac surgery (MINS) in breast cancer patients who also have hypertension or angina.
- Trial name
- B-BIT (NCT07583134)
- Testing
- propranolol, Usual Care
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Chang-Ik Yoon
Vagus Nerve Stimulation, Transcutaneous Electric Nerve Stimulation
Transcutaneous Auricular Vagus Nerve Stimulation and Quality of Recovery After Major Noncardiac Surgery
Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel non-invasive neuromodulation technique. Existing evidence suggested that taVNS improves pain management, sleep quality, inflammatory responses, and…
- Conditions
- Vagus Nerve Stimulation, Transcutaneous Electric Nerve Stimulation, Noncardiac Surgery, Quality of Recovery
- Trial name
- NCT06957912
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Peking University First Hospital
Postoperative Delirium, Major Noncardiac Surgery
The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium
Patients over the age of 65 years are at increased risk for developing delirium after noncardiac surgeries, resulting in increased morbidity and mortality.
- Conditions
- Postoperative Delirium, Major Noncardiac Surgery, Postoperative Cognitive Dysfunction
- Trial name
- RAPID-II (NCT05990790)
- Testing
- Desflurane, Sevoflurane, Propofol
- Where
- 2 sites in Austria
- Volunteers
- 1,332 people
- Sponsor
- Medical University of Vienna
Elective Surgical Procedure
Perioperative Management & Outcome Following Preoperative Transthoracic Echocardiography in Noncardiac Surgery Patients
In August 2022 the European Society of Cardiology published updated guidelines including recommendations on preoperative transthoracic echocardiography.
- Trial name
- NCT06409234
- Testing
- Transthoracic Echocardiography Recieved
- Where
- Germany
- Volunteers
- 8,250 people
- Sponsor
- European Society of Anaesthesiology