Clinical trials: Nontraumatic Injury
Acute Kidney Injury (Nontraumatic)
Comparison Between Right and Left Ventricular Systolic Dysfunction as a Risk Factors for Aki in Critical Care Patients
The cardio renal syndrome generally focuses on left ventricular function, and the importance of the right ventricle as a determinant of renal function is described less frequently.
- Trial name
- NCT03369561
- Testing
- Serum urea and creatinine and the calculated e GFR
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Kidney Injury (Nontraumatic), Dialysis; Complications
WISDOM UK: Low Dose-intensity Versus Standard Dose-intensity CRRT in Critically Ill Patients
Acute kidney injury is a potentially life threatening condition which affects 1 in 2 patients in the Intensive Care Unit (ICU). Patients often need dialysis treatment, also called renal replacement therapy.
- Trial name
- WISDOM UK (NCT07447791)
- Testing
- low intensity of CRRT, usual intensity of CRRT
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Brain Injury
Intermediate Size Patient Population Expanded Access Protocol to Evaluate HB-adMSCs for the Treatment of Patients With Traumatic or Nontraumatic Brain Injury
This expanded access protocol is part of IND 031942 to evaluate efficacy and safety of multiple intravenous administrations of allogeneic HB-adMSCs for the treatment of nontraumatic or traumatic brain injury for up to 8 patients…
- Trial name
- NCT07164482
- Testing
- HB- adMSCs (Hope Biosciences adipose derived mesenchymal stem cells)
- Where
- United States
- Sponsor
- Hope Biosciences Research Foundation
Surgical Wound, Wound Heal
Evaluating the Outcomes for Incisional Application of Negative Pressure for Nontraumatic Amputations
The purpose of this study is to evaluate how well subjects heal after surgery who receive standard dressings or incisional negative pressure wound therapy for non-traumatic amputation sites.
- Conditions
- Surgical Wound, Wound Heal, Amputation
- Trial name
- NCT03250442
- Testing
- PrevenaTM Device, Standard Dry Dressing
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Acute Kidney Injury (Nontraumatic), Contrast-induced Nephropathy
Maastricht Investigation of Renal Function in Absence of- and Post- Contrast in Patients With eGFR LEss Than 30
Intravascular iodinated contrast administration has become crucial to modern medicine. Currently it is estimated that over 250 million injections are given each year worldwide during medical scans and interventions.
- Conditions
- Acute Kidney Injury (Nontraumatic), Contrast-induced Nephropathy, Renal Insufficiency
- Trial name
- MIRACLE (NCT04598516)
- Testing
- serum creatinine assay
- Where
- Netherlands
- Sponsor
- Maastricht University Medical Center
Acute Kidney Injury (Nontraumatic)
Study of CXA-10 in Healthy Volunteers
This will be the first-in-human (FIH) study with CXA-10. The main purpose of this trial is to demonstrate the tolerability, safety and pharmacokinetics (PK) of CXA-10 at various incremental doses, and to demonstrate the safety…
- Trial name
- NCT02127190
- Testing
- CXA-10 emulsion
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Complexa, Inc.
Acute Kidney Injury (Nontraumatic), Critical Illness
Impact of CRRT on Serum Carnitine and Micronutrient Levels
This study aims to investigate the changes in blood levels of micronutrients and carnitine in critically ill patients with Acute Kidney Injury (AKI) who are undergoing Continuous Renal Replacement Therapy (CRRT).
- Trial name
- NCT07467889
- Testing
- Continuous Renal Replacement Therapy (CRRT), Standard of Care (Non-CRRT Management)
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Gulhane Training and Research Hospital
Injuries; Muscle, Nontraumatic
Treatment of Muscle Injuries With Physium Therapy.
Muscle injuries are currently particularly frequent among people who participate in sports. The diagnosis is easily made with an ultrasound study and Shear Wave Elastography.
- Trial name
- Physium (NCT03762720)
- Testing
- Physium treatment
- Volunteers
- 20 people
- Sponsor
- University of Cadiz
Orthopedic Disorder, Nontraumatic Injury
Web-based Mind-body Program to Improve Resilience Among Risky Substance Users With Persistent Upper Extremity Pain
The investigator aims to conduct a feasibility randomized controlled trial (RCT) (N=50) to test the feasibility, acceptability, and credibility of an asynchronous web-based mind-body intervention (Toolkit for Resilient Life…
- Conditions
- Orthopedic Disorder, Nontraumatic Injury, Upper Extremity Pain, Risky Substance Use
- Trial name
- NCT06991205
- Testing
- Web-TIRELESS, Web-MEUC
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Jafar Bakhshaie
Acute Kidney Injury (Nontraumatic)
Effect of an Intervention to Prevent Acute Kidney Injury Versus Standard Care in High-risk Patients After Major Surgery
There is no specific therapy for acute kidney injury. It is presumed that supportive measures improve the care and outcome of patients with acute kidney injury.
- Trial name
- PrevProgAKI (NCT05275218)
- Testing
- Implementation of the KDIGO bundle)
- Where
- Germany
- Volunteers
- 480 people
- Sponsor
- University Hospital Muenster
Acute Kidney Injury (Nontraumatic), Coronary Artery Disease
Contrast RISK (Reducing Injury Sustained by Kidneys)
Diagnostic and therapeutic cardiac catheterization procedures are important interventions to reduce the risk of death, avoid future cardiovascular events, and improve quality of life of people with heart disease.
- Trial name
- Contrast RISK (NCT03453996)
- Testing
- Intervention, Control
- Where
- 3 sites in Canada
- Volunteers
- 7,280 people
- Sponsor
- University of Calgary
Acute Kidney Injury (Nontraumatic)
Exploring the Relationship Among BNP, Fluid Status and Acute Kidney Injury in Critically Ill Patients
B-type natriuretic peptide (BNP) is rapidly released by the ventricles of the heart in response to myocardial stretch. This cardiac neurohormone is mostly elevated in patients with fluid overload or myocardium dysfunction.
- Trial name
- NCT02095275
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Acute Kidney Injury (Nontraumatic), Pneumoperitoneum
A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)
In our study, to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these…
- Trial name
- NCT05612802
- Testing
- IGF-1
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Baskent University
Acute Kidney Injury (Nontraumatic), Contrast-induced Nephropathy
Data on the Prevention of Complications of Prophylactic Intravenous Hydration in Patients With eGFR < 30
At Maastricht University Medical Centre (Maastricht UMC+) a specialised unit was established where a dual screening process including both renal and cardiac parameters is used to minimize the risk of contrast-induced acute kidney…
- Trial name
- CVP (NCT04592406)
- Testing
- CVP screening
- Where
- Netherlands
- Volunteers
- 443 people
- Sponsor
- Maastricht University Medical Center
Orthopedic Disorder, Nontraumatic Injury
Web-based Mind-body Program for Comorbid Nontraumatic Upper-extremity Condition and Risky Substance Use
The investigator aims to conduct an open pilot study (N=6; 5 completers) to test the feasibility, acceptability, and credibility of an asynchronous web-based mind-body intervention (Toolkit for Resilient Life beyond Pain and…
- Conditions
- Orthopedic Disorder, Nontraumatic Injury, Substance Use, Upper Extremity Problem
- Trial name
- NCT06366633
- Testing
- Web-TIRELESS
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Jafar Bakhshaie
Acute Kidney Injury (Nontraumatic)
Open-Label Safety, Tolerability, PK Study of IV CXA-10 Emulsion in Subjects in Chronic Kidney Injury
The main purpose of this trial is to demonstrate the safety, tolerability and pharmacokinetics (PK) of CXA-10, at potentially therapeutic doses, in the target patient population comprised of subjects with Stage 3 and 4 chronic…
- Trial name
- NCT02248051
- Testing
- CXA-10
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Complexa, Inc.
Acute Kidney Injury (Nontraumatic)
Biomarker-guided Implementation of the AKI Bundle
There is no specific therapy for acute kidney injury. It is presumed that supportive measures improve the care and outcome of patients with acute kidney injury.
- Trial name
- PrevAKI-mc (NCT03244514)
- Testing
- Intervention
- Where
- 12 sites in Belgium, Germany and 3 more
- Volunteers
- 280 people
- Sponsor
- University Hospital Muenster
Acute Kidney Injury (Nontraumatic), Hypotension Drug-Induced
AKI Risk Factors Analysis After Intentional Hypotensive Anesthesia
This project investigates intentionally hypotensive management such as NTG (nitroglycerin) or NTG+Trandate during general anesthesia in patients undergoing orthognathic surgery.
- Trial name
- NCT06259760
- Testing
- Nitroglycerin
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Sepsis, Acute Kidney Injury Due to Sepsis
Renin Angiotensin Aldosterone System In Septic Kids
Prospective observational cohort study; pediatric sepsis vs. healthy pediatric subjects and pediatric sepsis with acute kidney injury (AKI) vs without AKI.
- Conditions
- Sepsis, Acute Kidney Injury Due to Sepsis, Acute Kidney Injury (Nontraumatic)
- Trial name
- RISK (NCT06295393)
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Neonatal Cerebral Leukomalacia, Intracranial Nontraumatic Haemorrhage of Fetus and Newborn
The Role of Cerebral NIRS in Preventing Brain Injury of Very Low Birth Weight Preterm Infants
This study determines the effectiveness of cerebral Near Infrared Spectroscopy (NIRS) as a monitoring device combined with a SafeboosC treatment guideline in order to prevent brain injury in very low birth weight preterm…
- Conditions
- Neonatal Cerebral Leukomalacia, Intracranial Nontraumatic Haemorrhage of Fetus and Newborn, Neonatal Mortality
- Trial name
- NCT06729398
- Testing
- NIRS, SafeboosC
- Where
- Indonesia
- Volunteers
- 129 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital