Clinical trials: Nontuberculous Mycobacteria
Muscle Injury, Nerve Injury
Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer
Foot drop deformity is a life limiting condition characterized by loss of ankle dorsiflexion and eversion. Main condition leading to drop foot condition include irrecoverable muscle and nerve injuries, poliomyelitis, drug…
- Conditions
- Muscle Injury, Nerve Injury, Poliomyelitis, Leprosy
- Trial name
- NCT01751503
- Testing
- Interosseous route of TPTT, Extra membranous route of TPTT
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Iva Hauptmannova
Leprosy
Molecular and Immunological Tools for Detection of Strain Diversity, Drug Resistance and Immunological Responses
The purpose of this study is to determine what factors contribute to the continued incidence of leprosy in Colombia. Study participants will include volunteering and consenting individuals, older than 4 years of age, representing…
- Trial name
- NCT00138437
- Where
- 2 sites in Colombia
- Volunteers
- 1,554 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Leprosy
Leprosy Active Searching Trial in Brazil
The goal of this clinical trial is to assess whether a multifactorial active case-finding strategy improves the detection of leprosy cases in Brazil compared to usual screening practices.
- Trial name
- LAST•Br (NCT06761469)
- Testing
- Implementing active-case finding strategies
- Where
- Brazil
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- Hospital Alemão Oswaldo Cruz
Lung Diseases, Pulmonary Disease
A Study of the Safety and Tolerability of Inhaled SNSP113 in Healthy Subjects and Subjects With Stable Cystic Fibrosis
Although Cystic Fibrosis is a complex genetic disease affecting many organs, lung disease is the primary cause of mortality. The objective of this study is to determine the safety and tolerability of SNSP113 in healthy subjects…
- Conditions
- Lung Diseases, Pulmonary Disease, Cystic Fibrosis, Cystic Fibrosis Lung
- Trial name
- NCT03309358
- Testing
- Inhaled SNSP113
- Where
- 2 sites in United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Synspira, Inc.
Leprosy
Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy
There will be two study arms. Arm 1 will be the intervention arm in which there will be provided BE-PEP to all persons residing within 100 meters of an index case, to be repeated after four weeks for household contacts.
- Trial name
- BE-PEOPLE P3 (NCT05597280)
- Testing
- BE-PEP Bedaquiline, SDR-PEP Rifampicin, BE-PEP Rifampicin
- Where
- Comoros
- Volunteers
- 124,000 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Leprosy
Phase 1b/2a Trial to Evaluate LEP-F1 + GLA-SE in Healthy Adults and Leprosy Patients
This is a phase 1b/2a, double-blind, randomized, placebo-controlled clinical trial to evaluate the safety, tolerability, and immunogenicity of the LEP-F1 + GLA-SE investigational vaccine compared to placebo.
- Trial name
- NCT03947437
- Testing
- LEP-F1 + GLA-SE
- Where
- Brazil
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Leprosy
Trial LEP-F1 + GLA-SE in Healthy Adult in Areas Endemic for Leprosy
This is a phase 1b, double-blind, randomized, placebo-controlled clinical trial to evaluate the safety, tolerability, and immunogenicity of LEP-F1 + GLA-SE compared to placebo administered as three intramuscular (IM) injections…
- Trial name
- NCT06627257
- Testing
- LepVax (2 μg LEP-F1 + 5 μg GLA-S): Low dose, LepVax (10 μg LEP-F1 + 5 μg GLA-SE): High dose
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Leprosy
Phase 1 LEP-F1 + GLA-SE Vaccine Trial in Healthy Adult Volunteers
The purpose of this study is to compare the safety, tolerability, and immunogenicity in healthy adult subjects of an investigational vaccine being developed for the prevention of leprosy.
- Trial name
- NCT03302897
- Testing
- LEP-F1 + GLA-SE
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Access to Advanced Health Institute (AAHI)
Chronic Obstructive Pulmonary Disease, Asthma
Controls for Respiratory Diseases
This is the registry of control participants for patients with various respiratory diseases. We screened healthy volunteers who visited Seoul National Hospital Healthcare System Gangnam Center for routine health check-up, and…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Idiopathic Pulmonary Fibrosis, Nontuberculous Mycobacterium Infection
- Trial name
- NCT03120481
- Testing
- no intervation
- Where
- South Korea
- Volunteers
- 1,572 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Leprosy
TGF β 1 Expression Related Gene Polymorphism
Leprosy is one of the oldest human infectious diseases. It is a chronic infectious contagious, granulomatous disease caused by intracellular bacillus.
- Trial name
- NCT06683690
- Testing
- Measurement of TGF- β1 in leprosy patients
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aswan University