Clinical trials: Nontuberculous Mycobacteria
Bronchiectasis
Comparative Effectiveness and Safety of Inhaled Corticosteroids and Antimicrobial Compounds for Non-CF Bronchiectasis
The purpose of this study is to provide patients and their physicians with greater understanding of the risks and benefits of commonly used therapies for treatment of non-CF bronchiectasis
- Trial name
- NCT02714283
- Testing
- inhaled corticosteroid therapy, macrolide therapy
- Volunteers
- 90,089 people
- Sponsor
- Oregon Health and Science University
Mycobacterium Abscessus Infection, Adult-Onset Immunodeficiency With Acquired Anti-Interferon-Gamma Autoantibodies
Treatment Outcome Between Mycobacterium Abscessus Infection in Chronic Lung Disease and Acquired Interferon-gamma Autoantibody Syndrome
The treatment outcome of Mycobacterium abscessus infection in acquired interferon-gamma autoantibody syndrome has not been well studied.
- Conditions
- Mycobacterium Abscessus Infection, Adult-Onset Immunodeficiency With Acquired Anti-Interferon-Gamma Autoantibodies, Nontuberculous Mycobacterial Pulmonary Infection
- Trial name
- NCT05354583
- Testing
- Appropriate treatment
- Where
- Thailand
- Volunteers
- 36 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Leprosy
Leprosy Skin Test Antigens Phase 1
This is a small Phase I trial to evaluate the safety of the use as skin test antigens of the immunologically active proteins from the soluble/cytosol and insoluble cell wall of Mycobacterium leprae.
- Trial name
- NCT01920750
- Testing
- MLCwA, MLSA-LAM, Mock Antigen
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Leprosy, Disability Evaluation
Prevention of Disability: Proposal for a Guidance Manual for Leprosy Patients
Leprosy is an infectious disease of slow evolution, manifested primarily by signs and symptoms dermatoneurological with skin lesions and peripheral nerve, especially in the eyes, hands and feet.
- Conditions
- Leprosy, Disability Evaluation, Quality of Life
- Trial name
- NCT01006759
- Testing
- exercise and orientation
- Where
- Brazil
- Volunteers
- 55 people
- Sponsor
- University of Sao Paulo
Mycobacterium Avium-Intracellulare Infection, HIV Infections
The Effects of Treatment for Mycobacterium Avium Complex (MAC) on the Cells of HIV-Infected Patients
To determine if treatment of MAC infection in HIV-1 infected persons is associated with the decreases in plasma levels of TNF-alpha. Infection with MAC is a poor prognostic indicator in persons with AIDS.
- Trial name
- NCT00000860
- Where
- 11 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Immune Modulation, Tuberculosis
CD8 Reactivity to Microorganisms in Blood and Breast Milk
Background: When a person is exposed to something that causes an infection, the body sends a type of cell called CD8 T cells to attack it. Those cells are also found in breast milk.
- Conditions
- Immune Modulation, Tuberculosis, Leprosy, Pertussis
- Trial name
- NCT03084614
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cystic Fibrosis
Epidemiology and Clinical Characteristics of Non-Tuberculous Mycobacteria Infections in Cystic Fibrosis Patients.
An increase in the prevalence of infections due to non-tuberculous mycobacteria (NTM) is observed in many countries and recent data suggest the circulation of dominant clones with a possibility of human-to-human contamination.
- Trial name
- CIMENT (NCT03312075)
- Testing
- Sputum and blood samples
- Where
- 14 sites in France
- Volunteers
- 848 people
- Sponsor
- University Hospital, Brest
Mycobacterium Avium-intracellulare Infection, Mycobacterium Infections, Nontuberculous
Safety, Immunogenicity, and Efficacy of Therapeutic Mycobacterium Bovis BCG (BOOST)
The purpose of this study is to find out if the Mycobacterium bovis Bacillus Calmette Guerin (BCG) vaccine can be used safely to treat Mycobacterium avium complex (MAC) lung disease.
- Trial name
- BOOST (NCT07094711)
- Testing
- Mycobacterium bovis Bacillus Calmette Guerin (BCG) vaccine, preservative-free saline
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Virginia
Leprosy
Trial LEP-F1 + GLA-SE in Healthy Adult in Areas Endemic for Leprosy
This is a phase 1b, double-blind, randomized, placebo-controlled clinical trial to evaluate the safety, tolerability, and immunogenicity of LEP-F1 + GLA-SE compared to placebo administered as three intramuscular (IM) injections…
- Trial name
- NCT06627257
- Testing
- LepVax (2 μg LEP-F1 + 5 μg GLA-S): Low dose, LepVax (10 μg LEP-F1 + 5 μg GLA-SE): High dose
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Bronchiectasis, Non-tuberculous Mycobacterial
Prevalence and Characteristics of Patients With Bronchiectasis Comorbid Nontuberculous Mycobacteria
The purpose of this study is to Understand the prevalence of non-tuberculous mycobacterial(NTM) infections in the middle-aged and old women patients with bronchiectasis in Mainland China, and explore the characteristics of…
- Trial name
- NCT03594032
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Bin Cao
Mycobacterium Ulcerans Disease, Buruli Ulcer
Timing of Surgical Intervention in Buruli Ulcer Patients Treated With Antibiotics
SUMMARY Rationale: Buruli ulcer, caused by Mycobacterium ulcerans, is an ulcerative disease endemic in West Africa. It often leads to functional limitations.
- Trial name
- Burulitime (NCT01432925)
- Testing
- surgical intervention on Buruli ulcer
- Where
- 2 sites in Benin
- Volunteers
- 119 people
- Sponsor
- University Medical Center Groningen
Nontuberculous Mycobacteria, Bronchiectasis
Evaluation Of The Lung Microbiome In NTM Bronchiectasis
A biomarker cohort study design is proposed to study whether specific airway microbiota alterations are associated with pulmonary Non-tuberculous mycobacteria (NTM) disease.
- Trial name
- NCT02779478
- Testing
- Bronchoscopy
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- NYU Langone Health
Cystic Fibrosis, Pediatrics
A Prospective, Multicenter, Collaborative Study to Determine the Prevalence of Nontuberculous Mycobacteria (NTM) in Pediatric Patients With Cystic Fibrosis in Florida
To determine the prevalence of nontuberculous mycobacterial infection (NTM) in pediatric patients with cystic fibrosis in the State fo Florida.
- Trial name
- NCT02198079
- Testing
- Sputum
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Miami
Atypical; Mycobacterium, Pulmonary, Tuberculous
Treatment of Mycobacterium Xenopi Pulmonary Infection
The purpose of this study is to determine the 6-months sputum conversion rate with a clarithromycin or moxifloxacin containing regimen in patients with a M. xenopi pulmonary infection.
- Trial name
- CAMOMY (NCT01298336)
- Testing
- Clarithromycin, Moxifloxacin
- Where
- 52 sites in France
- Volunteers
- 92 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Mycobacterium Infections, Nontuberculous
Study to Evaluate Efficacy of LAI When Added to Multi-drug Regimen Compared to Multi-drug Regimen Alone
A study to evaluate the effectiveness of Liposomal Amikacin for Inhalation (LAI) 590 mg administered once daily (QD) when added to multi-drug regimen (MDR) in participants with Nontuberculous Mycobacterial (NTM) lung infection…
- Trial name
- CONVERT (NCT02344004)
- Testing
- LAI (Liposomal Amikacin for Inhalation) 590 mg
- Volunteers
- 336 people
- Sponsor
- Insmed Incorporated
Leprosy, Hansen's Disease
The Effect of "Jinchuang Ointment" (JCO) on the Treatment of Wounds in Patients With Hansen's Disease.
This study aimed to evaluate the effect of a Chinese herb complex "Jinchuang ointment" (JCO) on the treatment of chronic nonhealing wounds in patients with Hansen's disease and its mechanism.
- Conditions
- Leprosy, Hansen's Disease, Wounds
- Trial name
- NCT05047809
- Testing
- "Jingchuang Ointment"(JCO), Regular Treatment
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Lo-Sheng Sanatorium
Monotherapy, Mycobacterium Abscessus Infection
Clinical Study on the Early Bactericidal Activity of Contezolid Against Mycobacterium Abscessus Disease
This study is a single-center, randomized, controlled, open-label clinical trial designed to assess the early bactericidal activity of a single agent, contezolid, in patients with Mycobacterium abscessus infections.
- Trial name
- NCT07372781
- Testing
- Contezolid, linezolid
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Beijing Chest Hospital
Nontuberculous Mycobacteria, Mycobacterium Tuberculosis
Mycobacterial and Opportunistic Infections in HIV-Negative Thai and Taiwanese Patients Associated With Autoantibodies to Interferon-gamma
Opportunistic infections are caused by bacteria, mycobacteria, fungi or viruses that do not normally cause infections in people with healthy immune systems.
- Conditions
- Nontuberculous Mycobacteria, Mycobacterium Tuberculosis, Opportunistic Infections
- Trial name
- NCT00814827
- Where
- 5 sites in China, Taiwan and 1 more
- Volunteers
- 224 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Leprosy
Leprosy Active Searching Trial in Brazil
The goal of this clinical trial is to assess whether a multifactorial active case-finding strategy improves the detection of leprosy cases in Brazil compared to usual screening practices.
- Trial name
- LAST•Br (NCT06761469)
- Testing
- Implementing active-case finding strategies
- Where
- Brazil
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- Hospital Alemão Oswaldo Cruz
Mycobacterium Avium-Intracellulare Infection, HIV Infections
A Study of Viracept in AIDS Patients With Mycobacterium Avium Complex Disease (MAC)
The purpose of this study is to see if it is safe and effective to give Viracept to AIDS patients who are being treated for MAC.
- Trial name
- NCT00002170
- Testing
- Nelfinavir mesylate
- Where
- 5 sites in United States
- Sponsor
- Agouron Pharmaceuticals