Clinical trials: Nonunion of Fracture of Tibia
Fracture Non Union, Infection
Antibiotic Loaded Calcium Sulfate RCT
This is a multi-centered, prospective, randomized controlled trial comparing current standard of care for defect management to placement of antibiotic loaded Stimulan as a bone void filler in patients undergoing treatment of…
- Trial name
- NCT03875963
- Testing
- Antibiotic loaded bone filler
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Nonunion of Fracture of Tibia (Diagnosis)
Risk Factors for Post-Operative Nonunion of Tibial Shaft Fractures Based on a Path Analysis Model
Tibial shaft fractures is common long tubular fracture that account for about 13.7% of all fractures. And the incidence of nonunion of tibial shaft fracture varied from 1% to 80%.
- Trial name
- NCT03928912
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Tibial Fractures, Nonunion of Fracture
Intramedullary Bone Grafting for Open Tibial Shaft Fractures
This study will examine if there is a difference between the time to full union between the control group and the study group. Each group will be composed of patients who have an open fracture in the mid tibia.
- Conditions
- Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
- Trial name
- NCT03891888
- Testing
- Intramedullary Bone Graft
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Louisville
Fractures, Bone, Fractures, Closed
Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening System
This is an open-label, prospective, observational, post-market, uncontrolled, multi-center study intended to evaluate the safety and clinical performance of the FITBONE Transport and Lengthening Nail when used according to the…
- Conditions
- Fractures, Bone, Fractures, Closed, Fractures, Open, Fracture of Femur
- Trial name
- NCT06400732
- Testing
- Fitbone Transport and Lengthening System
- Where
- 9 sites in United States
- Volunteers
- 1 people
- Sponsor
- Orthofix Inc.
Nonunion of Fracture
Evaluation the Treatment of Nonunion of Long Bone Fracture of Lower Extremities (Femur and Tibia) Using Mononuclear Stem Cells From the Iliac Wing Within a 3-D Tissue Engineered Scaffold
Because the rate of non union of long bone in lower extremities specially in tibia in this two last decade due to malnutrition and smoking and other risk factors was increased, so many patient in our country suffer from non…
- Trial name
- NCT01958502
- Testing
- surgical treatment of non union with mesenchymal stem cells with BMP2 within a 3-D tissue engineered scaffold
- Where
- Iran
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Emdadi Kamyab Hospital
Tibial Delayed Healing
Tibial Delayed Healing Pivotal Clinical Trial
Evaluate the INFUSE/MASTERGRAFT™ Delayed Healing Device as an alternative/replacement to autograft in the treatment of tibial delayed healing.
- Trial name
- NCT01016067
- Testing
- INFUSE/MASTERGRAFT, Autograft bone
- Where
- 16 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Medtronic Spinal and Biologics
Femur Fracture, Tibial Fractures
Distal Targeter vs Free-hand
This study is a randomized controlled trial comparing the use of two different surgical techniques--free-hand versus distal targeting jig-based for distal interlock screw--placement and their effects on total operative time and…
- Conditions
- Femur Fracture, Tibial Fractures, Nonunion of Fracture, Nonunion of Fracture of Tibia
- Trial name
- NCT05613257
- Testing
- Distal targeting jig, Free-hand/perfect circles technique
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Cedars-Sinai Medical Center
Fracture Non Union, Fracture Healing
Prospective Validation Study of the CD8+TEMRA Cells As a Prognostic Biomarker of Healing Outcome After Fracture
In approx. 10-15% of all fracture patients, there is a prolonged healing time or even a complete absence of fracture healing (non-union).
- Conditions
- Fracture Non Union, Fracture Healing, Long Bone Delayed-Union Fracture, Humerus Shaft Fracture
- Trial name
- BioBone (NCT06658379)
- Testing
- CD8+TEMRA
- Where
- 7 sites in Germany
- Volunteers
- 640 people
- Sponsor
- Charite University, Berlin, Germany
Nonunion Fracture
The Efficacy of Mesenchymal Stem Cells for Stimulate the Union in Treatment of Non-united Tibial and Femoral Fractures in Shahid Kamyab Hospital
Because the rate of non union of long bone in lower extremities specially in tibia in this two last decade due to malnutrition and smoking and other risk factors was increased, so many patient in our country suffer from non union…
- Trial name
- NCT01788059
- Testing
- injection the mesenchymal stem cell in non union site
- Where
- Iran
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Emdadi Kamyab Hospital
Tibia Fracture
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures
The proposed study is a two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial. 1,000 patients with tibia fractures treated with intramedullary (IM) nail will be randomized into two treatment arms.
- Trial name
- NCT05000281
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Major Extremity Trauma Research Consortium
Fractures, Bone, Nonunion of Fracture
Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care
Prospective registry and retrospective data collection study to assess the efficacy and safety of Vivigen Cellular Bone Matrix (Vivigen) in orthopaedic trauma patients who require bone grafting in the acute, delayed, non-union…
- Conditions
- Fractures, Bone, Nonunion of Fracture, Fractures, Open, Fractures, Ununited
- Trial name
- NCT04299022
- Testing
- Vivigen Cellular Bone Matrix
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- LifeNet Health
Tibia Distal Fracture, Nonunion of Fracture of Tibia
Is Far Cortical Locking More Effective Than Bicortical Locking in Treating AO 43A1-3 Fractures?
Delayed union or nonunion, which is a common complication of periarticular fractures repaired with angled locking plate systems, may be due to the unintentionally rigid formation of this system.
- Trial name
- NCT06005090
- Testing
- Far Cortical Locking Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Saglik Bilimleri Universitesi
Tibia Fracture Non Union Bone
Study to Analyze the Effects of EBI OsteoGen™ on the Surgical Reconstruction of Tibia Non-unions
The purpose of this clinical outcomes collection study is to analyze the effect of the EBI OsteoGen™ Direct Current Stimulator upon surgical reconstruction of tibia nonunion (no visible progressive signs of healing) fracture in a…
- Trial name
- NCT00726193
- Testing
- OsteoGen
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Zimmer Biomet
Nonunion of Bone Graft, Fractures Non Union
Reamer Irrigator Aspirator (RIA) vs Autogenous Iliac Crest Bone Graft (AICBG) for the Treatment of Non-unions
The specific question the investigators will seek to answer is: can the Reamer Irrigator Aspirator (RIA) provide a bone graft source for the treatment of nonunions that is equally effective to Autogenous Iliac Crest Bone Graft…
- Trial name
- NCT01382485
- Testing
- RIA harvesting group, AICBG harvesting group
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto