Clinical trials: Norepinephrine
Stroke, Acute, Stroke, Ischemic
Induced Hypertension in Acute PRogrESsive Perforating Artery Stroke Using Peripheral Dilute noREpinephrine
PRESSURE is a multicenter, prospective, randomized, open, blinded end-point assessed (PROBE) trial, that aims to evaluate the efficacy and safety of drug-induced hypertension using peripheral dilute norepinephrine, in patients…
- Trial name
- PRESSURE (NCT06059144)
- Testing
- Peripheral intravenous norepinephrine
- Where
- France
- Volunteers
- 358 people
- Sponsor
- University Hospital, Bordeaux
Depressive Disorder
Comparison of Esketamine Nasal Spray vs.Aripiprazole in Treat.Resistant Major Depressive Disorder in Elderly Patients
Phase III, open label, randomised, multicentre, blind for evaluators clinical trial to evaluate the efficacy of esketamine nasal spray at flexible dosis compared to aripiprazole in elderly participants (>60 years) who suffer from…
- Trial name
- CESAR (NCT07153406)
- Testing
- Experimental regimen, Control regimen
- Where
- 9 sites in Spain
- Volunteers
- 220 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Alopecia, Radiodermatitis
Exploratory Study of Norepinephrine to Prevent Alopecia in Head and Neck Cancer Patients Treated With Radiotherapy
The study will evaluate the safety of topical norepinephrine in head and neck cancer patients who are receiving treatment with intensity modulated radiotherapy (IMRT).
- Trial name
- NCT01367990
- Testing
- Norepinephrine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- ProCertus BioPharm, Inc
Cesarean Section Complications, Spinal Anesthesia
Phenylephrine Versus Norepinephrine for Maintenance of Hemodynamic During Cesarean Section Under Spinal Anesthesia
Comparison between prophylactic continuous variable infusion of phenylephrine (starting dose 0,5mcg/kg/min) and norepinephrine tartrate (starting dose 0,1mcg/kg/min) to prevent hypotension and maintain cardiac output under spinal…
- Trial name
- PHENAD (NCT03849508)
- Testing
- Norepinephrine, Phenylephrine
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Post Spinal Anesthesia Hypotension
Preoperative Oral Midodrine Versus Intraoperative Intravenous Norepinephrine in Preventing Post-spinal Anesthesia Hypotension in Cesarean Section: A Prospective Double-blind Randomized Clinical Trial
Neuraxial blockade such as spinal anaesthesia can cause severe hypotension due to pharmacological sympathectomy resulting in potential deleterious consequences for the patient, Prevention of this spinal anaesthesia induced…
- Trial name
- NCT06213935
- Testing
- Norepinephrine, Midodrine
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Fibromyalgia
Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design
The study is a Phase 3, double-blind, placebo-controlled, randomized withdrawal study to assess the efficacy and safety of AXS-14 in the management of fibromyalgia.
- Trial name
- FORWARD (NCT07398417)
- Testing
- AXS-14 (Esreboxetine)
- Where
- 53 sites in United States
- Volunteers
- 620 people
- Sponsor
- Axsome Therapeutics, Inc.
Sexual Dysfunction
Efficacy of Exercise for Sexual Side Effects of Antidepressants
The major aim of the this study is to replicate findings of previous research that examined the effects of acute exercise on sexual arousal in women in a novel population, namely, women taking antidepressants of the selective…
- Trial name
- NCT01189825
- Testing
- Exercise
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Texas at Austin
Autonomic Nervous System Diseases
PET Scan in Patients With Neurocardiologic Disorders
This study is designed to use PET scans in order to measure activity of the sympathetic nervous system. The sympathetic nervous system is the portion of the nervous system that maintains a normal supply of blood and fuel to…
- Trial name
- NCT00001418
- Where
- United States
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hypotension
Safety of Norepinephrine Administered Through Peripheral Venous Catheter
Norepinephrine is a drug that elevates the blood pressure. It is routinely administered through peripheral catheters during surgery.
- Trial name
- NCT03695445
- Testing
- Peripheral administration of Norepinephrine
- Where
- 3 sites in Sweden
- Volunteers
- 1,004 people
- Sponsor
- Christer Svensen
Septic Shock, Severe Sepsis
Early Use of Norepinephrine in Septic Shock Resuscitation
Current septic shock guideline recommends fluid resuscitation as the first treatment. Vasopressors, including norepinephrine is recommended to start after achieve adequate fluid therapy.
- Trial name
- CENSER (NCT01945983)
- Testing
- Early norepinephrine
- Where
- Thailand
- Volunteers
- 310 people
- Sponsor
- Mahidol University
Mood Disorder, Substance-Related Disorders
Pharmacological Interaction Between Carvedilol and Methylenedioxymethamphetamine (MDMA)
The purpose of this study is to determinate the effect of a pre-treatment with carvedilol, a alpha- and beta-adrenergic receptor blocker, on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA…
- Conditions
- Mood Disorder, Substance-Related Disorders, Amphetamine-Related Disorders
- Trial name
- NCT01270672
- Testing
- 3,4-Methylenedioxymethamphetamine, carvedilol
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Hypotension After Spinal Anesthesia, Hypotension During Cesarean Delivery
Comparison of the Efficacy of Continuous Metaraminol Infusion Versus Continuous Norepinephrine Infusion for the Prevention of Hypotension During Cesarean Section Under Spinal Anaesthesia. A Randomised Controlled Trial.
The aim of this double-blind randomised study will be to compare a fixed-rate prophylactic metaraminol infusion to a fixed-rate prophylactic norepinephrine infusion during elective cesarean section under combined spinal-epidural…
- Trial name
- NCT07363109
- Testing
- Metaraminol infusion, Norepinephrine infusion
- Volunteers
- 80 people
- Sponsor
- Aretaieion University Hospital
Septic Shock
Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock
We are performing a prospective, randomized, controlled trial of dopamine versus norepinephrine for septic shock. The trial will enroll patients with suspected or documented site of infection and having 2 out of the three SIRS…
- Trial name
- NCT00604019
- Testing
- Dopamine, Norepinephrine
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- Rush University Medical Center
Hypotension
Norepinephrine To Prevent Hypotension After Spinal Anesthesia For Cesarean Delivery: A Dose Finding Study
Spinal anesthesia is the most common anesthetic technique for elective Cesarean delivery (CD), but the most frequent unwanted side effect is hypotension, which can cause nausea and vomiting, as well as effects on the fetus.
- Trial name
- NCT02654847
- Testing
- Norepinephrine, Normal Saline
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Hemodynamic Instability
Hemodynamic Optimalization in Pediatric Patients
Hemodynamic unstability, defined by macrocirculation and/or microcirculation dysfunction or alteration is common in critically ill pediatric patients.
- Trial name
- HOPED (NCT04227821)
- Testing
- Vasopressor and/inotrope therapy
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Septic Shock
The Construction and Application of Therapeutic System of Intelligent Decision-Oriented Hemodynamic Organized Therapy for Shock Patients
Patients with septic shock with norepinephrine >0.25ug/kg/min were enrolled. Informed consent was obtained for inclusion in the study and random assignment into the combination or norepinephrine group.
- Trial name
- NCT05886192
- Testing
- norepinephrine+vasopressin, Norepinephrine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Septic Shock, Hypertension
Effect of Different Strategies for Titrating a High MAP on Microcirculation
Assess the effect of fluids and norepinephrine for mean arterial pressure titration to patients' usual level on the microcirculation of initial resuscitated hypertensive septic shock patients.
- Trial name
- NCT02085291
- Testing
- Norepinephrine, Crystalloid
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Southeast University, China
Intraoperative Hypotension, Postoperative Pulmonary Complications (PPCs)
PRO STRESS Trial: Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery
Intraoperative hypotension is commonly treated with fluid administration; however, excessive fluid therapy may contribute to postoperative pulmonary complications.
- Conditions
- Intraoperative Hypotension, Postoperative Pulmonary Complications (PPCs), Fluid Over-load
- Trial name
- PRO STRESS (NCT07627360)
- Testing
- Norepinephrine
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Suez Canal University
Heart Failure, Obstructive Sleep Apnea
ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.
Obstructive sleep apnea (OSA), central sleep apnea (CSA) and heart failure (HF) are states of metabolic demand and sympathetic nervous system (SNS) activation.
- Conditions
- Heart Failure, Obstructive Sleep Apnea, Central Sleep Apnea
- Trial name
- AMEND (NCT02116140)
- Testing
- [C11]Acetate and HED PET
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Norepinephrine, Glypressin, Tourniquet Deflation, Hypotension
Noradrenaline Versus Glypressin for Prevention of Hypotension After Deflation of Tourniquet in Knee Arthroplasty
Pneumatic tourniquet is usually used in orthopedic surgeries, as it helps to decrease operative bed bleeding, and thus, maintaining a clean and dry surgical field allowing easy and clear identification of the anatomical…
- Trial name
- NCT05774067
- Testing
- Saline, Norepinephrine, glypressin
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- Tanta University