Clinical trials: Norepinephrine
Postural Tachycardia Syndrome
POTS NET mRNA Functional Correlation With NET Activity
DNA Acetylation can be responsible for significant down-regulation of transcription of the Norepinephrine Transporter (NET). NET is an important clearance transporter that removes norepinephrine (NE) from sympathetic neuronal…
- Trial name
- NCT03218761
- Testing
- NET mRNA level, Plasma catechols, Urine Catechols
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Healthy Aging and Parkinson's Disease
In Vivo Noradrenergic System and Aging
The main goal of this research proposal is to provide, for the first time in humans, a wider understanding of the role of the noradrenergic system both in health and illness (here Parkinson's disease) through the use of a newly…
- Trial name
- NA2C-PET-MRI (NCT07569120)
- Testing
- PET/MRI scanning session, Neuropsychological examination, Olfactory screening
- Where
- France
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Major Depressive Disorder
A Study of LY03005 vs Pristiq
The objective of this study is to evaluate relative bioavailability between 80 mg LY03005 oral tablets and 50 mg Pristiq® oral tablets after a single dose of each drug in a cross-over 2-period design under fasting condition in…
- Trial name
- NCT03733574
- Testing
- LY03005, Pristiq
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Maternal Hypotension
Norepinephrine Consumption After Prophylactic Ondansetron
This study evaluates the effect of prophylactic ondansetron on the incidence of spinal hypotension and vasopressor consumption in caesarean section patients using norepinephrine treatment.
- Trial name
- NCT02928601
- Testing
- Ondansetron, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Post-Traumatic Stress Disorder
Study of the Safety and Efficacy of Nabiximols Oromucosal Spray Versus Placebo in Patients With Post-traumatic Stress Disorder
This study will be conducted to evaluate the efficacy of nabiximols for the treatment of symptoms of post-traumatic stress disorder (PTSD) in participants receiving selective serotonin reuptake inhibitor (SSRI) or…
- Trial name
- NCT04592159
- Testing
- Nabiximols
- Sponsor
- Jazz Pharmaceuticals
Blood Pressure Management, Intraoperative Hypotension
Noradrenaline Versus Standard Blood Pressure Management for Perioperative Hypotension in Non-cardiac Surgery
The effect of noradrenaline infusion versus standard blood pressure management on perioperative HYPotension in NOn-caRdiac surgery.
- Conditions
- Blood Pressure Management, Intraoperative Hypotension, Non-cardiac Surgery
- Trial name
- HYP-NOR (NCT06885268)
- Testing
- noradrenaline infusion for management blood pressure, standard blood pressure management
- Where
- 5 sites in Poland
- Volunteers
- 750 people
- Sponsor
- Jagiellonian University
Sleep Apnea, Obstructive
Reboxetine for Sleep Apnoea After ENT Surgery
This pilot study will establish the feasibility of a larger trial to investigate whether reboxetine, a medication used to treat depression, can reduce the severity of obstructive sleep apnea (OSA) including increased blood…
- Trial name
- RENTOSA (NCT05978505)
- Testing
- Reboxetine 4 MG Oral Tablet
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Flinders University
ADHD
Forward Treatment of Attention Deficit and Hyperactivity Using Solriamfetol (FOCUS-2)
This study is a Phase 3, multi-center, randomized, 6-week, double-blind, placebo-controlled, parallel-group trial to assess the efficacy and safety of solriamfetol in children aged 6 to <12 years with ADHD.
- Trial name
- NCT07717879
- Testing
- Solriamfetol Dose A, Solriamfetol Dose B
- Where
- 30 sites in United States
- Volunteers
- 468 people
- Sponsor
- Axsome Therapeutics, Inc.
Alzheimer Disease
The Locus Coeruleus, Norepinephrine and Cognitive Aging
The locus coeruleus (LC) has recently been identified as one of the earliest sites of damage in AD with pathological lesions appearing as early as the mid-20s.
- Trial name
- NCT06880510
- Testing
- t-VNS transcutaneous auricular vagus nerve stimulator
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cornell University
Vasopressor Agents, Endarterectomy, Carotid
Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Artery Surgery
This will be a prospective, randomized, double-blinded, cross-over clinical trial to compare the effects of phenylephrine or norepinephrine on cardiac function during carotid artery surgery in patients under general anesthesia.
- Conditions
- Vasopressor Agents, Endarterectomy, Carotid, Echocardiography, Transesophageal
- Trial name
- NCT00294606
- Testing
- Comparison of Effects of Phenylephrine and Norepinephrine
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Alcoholism
Testing Doxazosin to Treat Stress Mechanisms in Alcoholism
Double-blind, placebo controlled, randomized controlled trial (RCT) for Alcohol Use Disorder examining the effects of doxazosin, a norepinephrine alpha1 receptor antagonist, on stress reactivity and clinical outcomes.
- Trial name
- NCT02989493
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Wisconsin, Madison
Hemodynamic Instability
Maternal Cardiac Output Response to Rescue Norepinephrine and Phenylephrine Boluses in Patients With Severe Preeclampsia
The purpose of this study is to investigate the maternal cardiac output response to rescue norepinephrine and phenylephrine boluses for postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean…
- Trial name
- NCT05035485
- Testing
- Phenylephrine, Norepinephrine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- General Hospital of Ningxia Medical University
Post Spinal Anaesthesia Hypotension
This is a Study That Aims to Estimate the Effect of Maternal Body Mass Index on the Prophylactic Dose of Norepinephrine Infusion for Preventing Hypotension in Parturient After Spinal Anesthesia
This is a randomized, double-blinded controlled study that aims to estimate the effect of maternal body mass index on the prophylactic dose of norepinephrine infusion for preventing hypotension in parturient after spinal…
- Trial name
- NCT07706426
- Testing
- Nor-epinephrine, Normal Saline
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Septic Shock
Use of Vassopresin in Septic Shock Prospective Multicenter Observational Study With Medication
The aim of this observational study is to examine real-world clinical practice regarding the use of vasopressin as a second-line vasopressor in adult patients admitted to Intensive Care Units (ICUs) with septic shock.
- Trial name
- VASO-2024 (NCT07255378)
- Testing
- Usage of vasopressin (VAP) as a second-line vasopressor in septic shock patients.
- Where
- 12 sites in Spain
- Volunteers
- 1,200 people
- Sponsor
- Jamil Cedeño Mora
Hypotension Symptomatic, Obstetric Anesthesia Problems
Prevention of Hypotension During Cesarean Section
The aim of this double-blind randomized study will be to compare a fixed-rate prophylactic noradrenaline infusion to a fixed-rate prophylactic phenylephrine infusion during elective cesarean section under combined spinal-epidural…
- Conditions
- Hypotension Symptomatic, Obstetric Anesthesia Problems, Cesarean Section Complications, Vasoconstriction
- Trial name
- NOR-PHEN (NCT03842046)
- Testing
- phenylephrine infusion, norepinephrine infusion
- Where
- 2 sites in Greece
- Volunteers
- 82 people
- Sponsor
- Aretaieion University Hospital
Gastroparesis, Shock
Gastric Emptying and Enteral Nutrition Tolerance According to Vasopressor Dose in ICU Patients
This study investigates whether the dose of vasopressor medications (drugs that maintain blood pressure in shock) affects gastric emptying during tube feeding in the intensive care unit (ICU).
- Conditions
- Gastroparesis, Shock, Critical Illness, Gastric Emptying
- Trial name
- NCT07802379
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Spinal Shock
the Effect of Oral Vasopressors for Liberation From IV Vasopressors in Spinal Shock
the study is developed to evaluate the effect of use of oral vasopressors (midodrine versus minirin) on weaning ICU patients from IV vasopressors (noradrenaline) and compare between them for efficacy in shortage the duration of…
- Trial name
- NCT04586790
- Testing
- Midodrine Oral Tablet, Minirin oral tablet, Nor-Adrenaline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ahmed talaat ahmed aly
Hypotension, Cesarean Section
Norepinephrine for Hypotension in Cesarean Section
Hypotension is a very common consequence of the sympathetic vasomotor block caused by spinal anesthesia for cesarean section. Maternal symptoms such as nausea, vomiting and dyspnea frequently accompany severe hypotension, and…
- Trial name
- NCT04367103
- Testing
- Norepinephrine, Phenylephrine
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Assiut University
Cesarean Section Complications
Norepinephrine Infusion Different Doses in Cesarean Delivery
three doses (0.025 mcg/Kg/min, 0.050 mcg/Kg/min, and 0.075 mcg/Kg/min) of norepinephrine will be compared for prophylaxis against Post-spinal anesthesia hypotension during Cesarean delivery.
- Trial name
- NCT03182088
- Testing
- norepinephrine infusion (0.025 mcg/Kg/min), norepinephrine infusion (0.050 mcg/Kg/min), norepinephrine infusion (0.075 mcg/Kg/min)
- Where
- Egypt
- Volunteers
- 284 people
- Sponsor
- Cairo University
Hypotension
A Comparison of Intermittent Intravenous Boluses of Phenylephrine and Norepinephrine to Prevent Spinal-induced Hypotension in Cesarean Deliveries
Hypotension is a very common complication of spinal anesthesia for cesarean delivery, and can have unwanted side effects on both mother and fetus if not treated promptly.
- Trial name
- NCT02962986
- Testing
- Norepinephrine, Phenylephrine
- Where
- Canada
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital